NITE - Chemical Management Field

Latest GHS Classification Results by the Japanese Government (edited by NITE)

GENERAL INFORMATION

Item	Information
CAS RN	3268-49-3
Chemical Name	3-(Methylsulfanyl)propanal
Substance ID	m-nite-3268-49-3_v1
Download of Excel format	Excel file

REFERENCE INFORMATION

Item	Information
Guidance used for the classification (External link)	To Guidance List
UN GHS document (External link)	To UN GHS document
FAQ（GHS classification results by the Japanese Government）	To FAQ
List of Information Sources (Excel file)	List of Information Sources
List of Definitions/Abbreviations	Definitions/Abbreviations
Sample Label by MHLW (External link)	MHLW Website (in Japanese Only)
Sample SDS by MHLW (External link)	MHLW Website (in Japanese Only)
OECD/eChemPortal (External link)	To OECD/eChemPortal (External link)

PHYSICAL HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification	Classification year (FY)	GHS Classification Guidance for the Japanese Government
1	Explosives	Not classified (Not applicable)	- -	-	-	There are no chemical groups associated with explosive properties present in the molecules.	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
2	Flammable gases	Not classified (Not applicable)	- -	-	-	Liquid	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
3	Aerosols	Not classified (Not applicable)	- -	-	-	Not aerosol products	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
4	Oxidizing gases	Not classified (Not applicable)	- -	-	-	Liquid	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
5	Gases under pressure	Not classified (Not applicable)	- -	-	-	Liquid	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
6	Flammable liquids	Category 4	- Warning	H227	P370+P378 P210 P280 P403 P501	Since the flash point by IUCLID(2000) is 63degC(closed type), it was classified into Category 4.	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
7	Flammable solids	Not classified (Not applicable)	- -	-	-	Liquid	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
8	Self-reactive substances and mixtures	Not classified (Not applicable)	- -	-	-	There are no chemical groups associated with explosive or self-reactive properties present in the molecule.	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
9	Pyrophoric liquids	Not classified	- -	-	-	Even if it contacts the normal temperature air, it does not ignite spontaneously (ignition point 255degC (ICSC,1997)).	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
10	Pyrophoric solids	Not classified (Not applicable)	- -	-	-	Liquid	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
11	Self-heating substances and mixtures	Classification not possible	- -	-	-	The test method suitable for liquid substances is not established.	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
12	Substances and mixtures which, in contact with water, emit flammable gases	Not classified (Not applicable)	- -	-	-	Metals or metalloids (B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At) are not included.	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
13	Oxidizing liquids	Not classified (Not applicable)	- -	-	-	Although it is an organic compound including oxygen, not fluorine and chlorine, this oxygen has not chemically bound to any elements other than carbon and hydrogen.	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
14	Oxidizing solids	Not classified (Not applicable)	- -	-	-	Liquid	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
15	Organic peroxides	Not classified (Not applicable)	- -	-	-	The organic compound not including peroxy group in molecule.	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
16	Corrosive to metals	Classification not possible	- -	-	-	Classification not possible due to lack of data	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
17	Desensitized explosives	-	- -	-	-	-	-	-

HEALTH HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification	Classification year (FY)	GHS Classification Guidance for the Japanese Government
1	Acute toxicity (Oral)	Category 4	Warning	H302	P301+P312 P264 P270 P330 P501	From LD50 value 490 mg/kg (male), 1,050 mg/kg (female) (SIDS (2003)) of the acute oral toxicity test (OECD TG 401, GLP) employing a rat, it was classified into Category 4.	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
1	Acute toxicity (Dermal)	Category 3	Danger	H311	P302+P352 P361+P364 P280 P312 P321 P405 P501	Among LD50 value with 2,631 mg/kg (SIDS (2003)) of the dermal administration test employing rats (OECD TG 402), and LD50 value with 748-1,700 mg (SIDS (2003)) of the dermal administration test employing rabbits (OECD TG 402), it was classified into Category 3 from 748 mg/kg whose test year was new, and value was low.	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
1	Acute toxicity (Inhalation: Gases)	Not classified (Not applicable)	- -	-	-	Since it was a solid by the definition of GHS and inhalation in gas was not assumed, it was classified into "Not applicable".	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
1	Acute toxicity (Inhalation: Vapours)	Category 3	Danger	H331	P304+P340 P403+P233 P261 P271 P311 P321 P405 P501	It is written that LC50 values are 1,036-1,105 ppm (male) and >1,105 ppm (female) in 4-hour inhalation exposure test employing rats (OECD TG 403, GLP) (SIDS (2003)), LC50 value is judged to be 1,036-1,105 ppm in SIDS (2003). Since saturated vapor pressure level of this substance (20degC)is 1,970 ppm, it was classified into Category 3 by applying the gas standard.	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
1	Acute toxicity (Inhalation: Dusts and mists)	Classification not possible	- -	-	-	Classification not possible due to lack of data	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
2	Skin corrosion/irritation	Category 2	Warning	H315	P302+P352 P332+P313 P362+P364 P264 P280 P321	A result of "slight irritation" and that of "necrosis" are described in SIDS (2003) for the 4-hour skin irritation test using rabbits. Since SIDS (2003) has drawn a conclusion, "There is skin irritation," based on many experimental results including these, it was classified in Category 2.	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
3	Serious eye damage/eye irritation	Category 1	Danger	H318	P305+P351+P338 P280 P310	Since in SIDS (2003), there is a description of "The conjunctival edema which was not recovered during the observation and the corneal opacity were seen" in the eye irritation/corrosion test employing rabbits (OECD TG 405) and SIDS (2003) has concluded as "It causes irreversibly damage" based on this experiment result, it was classified into Category 1.	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
4	Respiratory sensitization	Classification not possible	- -	-	-	Classification is not possible since there is no data.	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
4	Skin sensitization	Category 1	Warning	H317	P302+P352 P333+P313 P362+P364 P261 P272 P280 P321 P501	It was classified as Category 1 since it was described as "skin sensitizing potential" SIDS (2003) in the Maximization tests (OECD TG406) employing guinea pig by GLP and non-GLP, and it was concluded as "mild skin sensitizing" in SIDS (2003).	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
5	Germ cell mutagenicity	Not classified	- -	-	-	From a description of "negative" (SIDS (2003)) in the body cell in vivo mutagenicity test (micronucleus test employing a mouse) (OECD TG 474, GLP), it was classified into "Not classified".	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
6	Carcinogenicity	Classification not possible	- -	-	-	Since no evaluation by major international evaluation agencies is made and there is no data, classification is not possible.	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
7	Reproductive toxicity	Classification not possible	- -	-	-	There are descriptions as follows in SIDS (2003), "No effect was found on genital organs" in the 28 day oral administration study using rats and "No effect was found on reproductive organs" in the 9 day inhalation exposure test using male and female rats. Moreover, there is a description as follows, "No effect has been found on implantation, embryos and fetuses at the dose level where reduction in mother animals' body weight and food consumptions, " in the pre-birth developmental toxicity study (OECD TG 414, GLP). Since there is no data, however, for the effect on reproductive organs and post-birth children, classification is not possible.	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
8	Specific target organ toxicity - Single exposure	Category 1 (systemic)	Danger	H370	P308+P311 P260 P264 P270 P321 P405 P501	Although there were descriptions of "breathing difficulty, nasal mucus, crackle, ataxia, and locomotor activity reduction" (SIDS (2003)) in the acute oral toxicity test employing rats (OECD TG 401, GLP) and "locomotor activity reduction and ataxia" (SIDS (2003)) in the dermal administration test employing rabbits (OECD TG 402), since the dose was unknown, it classified into Category 1/2 (systemic toxicity).	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
9	Specific target organ toxicity - Repeated exposure	Category 2 (liver, central nervous system)	Warning	H373	P260 P314 P501	It is written in 28-day oral administration test in rats (OECD TG 407) that" there were decrease in the number of red blood cells, fall in hemoglobin level, increase in bilirubin, and deposition of pigment and blood to red pulp in the histopathological examination in males and females of 521 mg/kg (90-day equivalent : 162 mg/kg) group, and slight increase in creatinine in males of 104 mg/kg and 521 mg/kg groups" (SIDS (2003)), and it is concluded in SIDS (2003) that" 521 mg/kg group occurs slight hemolyzing property NOAEL: 104 mg/kg". Moreover, it is written in 21-day dermal administration test in rats that "there were no hematological, biochemical, and histological changes by administration of up to 1,650 mg/kg" (IUCLID (2000)). On the other hand, in 100- day inhalation exposure test in rats, " effects on redox function of liver (decrease in oxygen demand, decrease in catalase activity, and decrease in blood lactic acid and pyruvic acid), and central nervous system effect" (IUCLID (2000)) correspond to Category 1by judging from the guidance value, however, it was classified into Category 2 (liver, and central nervous system) according to this guidance, since it is data of List2, and does not comply with the acceptance criteria 1b3).	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
10	Aspiration hazard	Classification not possible	- -	-	-	Classification not possible due to lack of data	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）

ENVIRONMENTAL HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification	Classification year (FY)	GHS Classification Guidance for the Japanese Government
11	Hazardous to the aquatic environment Short term (Acute)	Category 1	Warning	H400	P273 P391 P501	It was classified into Category 1 from 72 hours EC50=0.99mg/L of the algae (Pseudokirchneriella subcapitata) (MOE eco-toxicity tests of chemicals (1998)).	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
11	Hazardous to the aquatic environment Long term (Chronic)	Not classified	- -	-	-	Although acute toxicity was Category 1, since there were rapid degradability (the decomposition by DOC: 92% (SIDS (2005))) and there were no bio-accumulation (Logk=0.34 (IUCLID (2000))), it was classified into Not classified.	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
12	Hazardous to the ozone layer	-	- -	-	-	-	-	-

NOTE:

GHS Classification Result by the Japanese Government is intended to provide a reference for preparing a GHS label or SDS for users. To include the same classification result in a label or SDS for Japan is NOT mandatory.
Users can cite or copy this classification result when preparing a GHS label or SDS. Please be aware, however, that the responsibility for a label or SDS prepared by citing or copying this classification result lies with users.
This GHS classification was conducted based on the information sources and the guidance for classification and judgement which are described in the GHS Classification Guidance for the Japanese Government etc. Using other literature, test results etc. as evidence and including different content from this classification result in a label or SDS are allowed.
Hazard statement and precautionary statement will show by hovering the mouse cursor over a code in the column of "Hazard statement" and "Precautionary statement," respectively. In the excel file, both the codes and statements are provided.
A blank or "-" in the column of "Classification" denotes that a classification for the hazard class was not conducted in the year.
An asterisk “*” in the column of “Classification” denotes that “Not classified (or No applicable)” and/or “Classification not possible” is applicable. Details are described in the column of “Rationale for the classification”. If no English translation is available for “Rationale for the classification,” please refer to the Japanese version of the results.

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