Item | Information |
---|---|
CAS RN | 3282-30-2 |
Chemical Name | 2,2-Dimethylpropanoyl chloride |
Substance ID | m-nite-3282-30-2_v1 |
Download of Excel format | Excel file |
Item | Information |
---|---|
Guidance used for the classification (External link) | To Guidance List |
UN GHS document (External link) | To UN GHS document |
FAQ(GHS classification results by the Japanese Government) | To FAQ |
List of Information Sources (Excel file) | List of Information Sources |
List of Definitions/Abbreviations | Definitions/Abbreviations |
Sample Label by MHLW (External link) | MHLW Website (in Japanese Only) |
Sample SDS by MHLW (External link) | MHLW Website (in Japanese Only) |
OECD/eChemPortal (External link) | To OECD/eChemPortal (External link) |
Hazard class | Classification | Pictogram Signal word |
Hazard statement (code) |
Precautionary statement (code) |
Rationale for the classification | Classification year (FY) | GHS Classification Guidance for the Japanese Government | |
---|---|---|---|---|---|---|---|---|
1 | Explosives | Not classified (Not applicable) |
- |
- | - | There are no chemical groups associated with explosive properties present in the molecule. | FY2011 | GHS Classification Guidance by the Japanese Government (July, 2010) |
2 | Flammable gases | Not classified (Not applicable) |
- |
- | - | "Liquids" according to GHS definition. | FY2011 | GHS Classification Guidance by the Japanese Government (July, 2010) |
3 | Aerosols | Not classified (Not applicable) |
- |
- | - | Not an aerosol product. | FY2011 | GHS Classification Guidance by the Japanese Government (July, 2010) |
4 | Oxidizing gases | Not classified (Not applicable) |
- |
- | - | "Liquids" according to GHS definition. | FY2011 | GHS Classification Guidance by the Japanese Government (July, 2010) |
5 | Gases under pressure | Not classified (Not applicable) |
- |
- | - | "Liquids" according to GHS definition. | FY2011 | GHS Classification Guidance by the Japanese Government (July, 2010) |
6 | Flammable liquids | Category 2 |
Danger |
H225 | P303+P361+P353 P370+P378 P403+P235 P210 P233 P240 P241 P242 P243 P280 P501 |
A flash point of 13 degrees C [closed cup] (SIDS (2011)) which is < 23 degrees C, and an initial boiling point of 107 degrees C (CRC (2010)) which is > 35 degrees C, correspond to Category 2. | FY2011 | GHS Classification Guidance by the Japanese Government (July, 2010) |
7 | Flammable solids | Not classified (Not applicable) |
- |
- | - | "Liquids" according to GHS definition. | FY2011 | GHS Classification Guidance by the Japanese Government (July, 2010) |
8 | Self-reactive substances and mixtures | Not classified (Not applicable) |
- |
- | - | There are no chemical groups present in the molecule associated with explosive or self-reactive properties. | FY2011 | GHS Classification Guidance by the Japanese Government (July, 2010) |
9 | Pyrophoric liquids | Not classified |
- |
- | - | It is conceivable that it does not ignite at normal temperatures from an ignition point of 455 degrees C (Hommel (1996)). | FY2011 | GHS Classification Guidance by the Japanese Government (July, 2010) |
10 | Pyrophoric solids | Not classified (Not applicable) |
- |
- | - | "Liquids" according to GHS definition. | FY2011 | GHS Classification Guidance by the Japanese Government (July, 2010) |
11 | Self-heating substances and mixtures | Classification not possible |
- |
- | - | No established test method suitable for liquid substances. | FY2011 | GHS Classification Guidance by the Japanese Government (July, 2010) |
12 | Substances and mixtures which, in contact with water, emit flammable gases | Not classified (Not applicable) |
- |
- | - | Not containing metals or semimetals (B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At). | FY2011 | GHS Classification Guidance by the Japanese Government (July, 2010) |
13 | Oxidizing liquids | Not classified (Not applicable) |
- |
- | - | An organic compound contains oxygen and chlorine which are not chemically bonded to elements other than carbon or hydrogen. | FY2011 | GHS Classification Guidance by the Japanese Government (July, 2010) |
14 | Oxidizing solids | Not classified (Not applicable) |
- |
- | - | "Liquids" according to GHS definition. | FY2011 | GHS Classification Guidance by the Japanese Government (July, 2010) |
15 | Organic peroxides | Not classified (Not applicable) |
- |
- | - | An organic compound that does not contain -O-O- structure. | FY2011 | GHS Classification Guidance by the Japanese Government (July, 2010) |
16 | Corrosive to metals | Classification not possible |
- |
- | - | There is information that it is not suitable for a container due to highly corrosive to most metals in the presence of humidity (Hommel (1996)), but the category can not be determined due to no numerical data. | FY2011 | GHS Classification Guidance by the Japanese Government (July, 2010) |
17 | Desensitized explosives | - |
- |
- | - | - | - | - |
Hazard class | Classification | Pictogram Signal word |
Hazard statement (code) |
Precautionary statement (code) |
Rationale for the classification | Classification year (FY) | GHS Classification Guidance for the Japanese Government | |
---|---|---|---|---|---|---|---|---|
1 | Acute toxicity (Oral) | Category 4 |
Warning |
H302 | P301+P312 P264 P270 P330 P501 |
On the basis of LD50 values of 630 mg/kg [GLP compliance] and 1470 mg/kg [OECD TG 401] for rats (both SIDS (2011)), it was classified in Category 4. | FY2011 | GHS Classification Guidance by the Japanese Government (July, 2010) |
1 | Acute toxicity (Dermal) | Not classified |
- |
- | - | From an LD50 value of >2010 mg/kg for rabbits [GLP compliance] (SIDS (2011)), it was classified as "Not classified" in JIS classification (Category 5 in UN GHS classification). | FY2011 | GHS Classification Guidance by the Japanese Government (July, 2010) |
1 | Acute toxicity (Inhalation: Gases) | Not classified (Not applicable) |
- |
- | - | "Liquids" according to GHS definition. | FY2011 | GHS Classification Guidance by the Japanese Government (July, 2010) |
1 | Acute toxicity (Inhalation: Vapours) | Category 2 |
Danger |
H330 | P304+P340 P403+P233 P260 P271 P284 P310 P320 P405 P501 |
From LC50 values of 232 to 334 ppm in 4-hour exposure to rats [OECD TG 403; GLP compliance] (SIDS (2011)), it was classified in Category 2. Besides, a reference value of gasses as vapour with hardly included mist was applied because the test concentrations (232 to 334 ppm) are lower than 90 % of the saturated vapour pressure concentration (42632 ppm). |
FY2011 | GHS Classification Guidance by the Japanese Government (July, 2010) |
1 | Acute toxicity (Inhalation: Dusts and mists) | Classification not possible |
- |
- | - | No data. | FY2011 | GHS Classification Guidance by the Japanese Government (July, 2010) |
2 | Skin corrosion/irritation | Category 1 |
Danger |
H314 | P301+P330+P331 P303+P361+P353 P305+P351+P338 P304+P340 P260 P264 P280 P310 P321 P363 P405 P501 |
In a test semi-occlusive applied 0.5 mL of undiluted this substance to six rabbit skins for 4 hours (GLP compliance), erythema and edema were observed until 21 days after application, a maximum irritation score was 7.0/8.0, necrosis was present on the application sites in all six animals, and this substance was assessed as corrosive. (SIDS (2011)) Therefore it was classified in Category 1. |
FY2011 | GHS Classification Guidance by the Japanese Government (July, 2010) |
3 | Serious eye damage/eye irritation | Category 2A |
Warning |
H319 | P305+P351+P338 P337+P313 P264 P280 |
In a test dropped 0.1 mL of undiluted this substance to the conjunctival sac of rabbits, it was assessed as moderately irritating from a maximum average irritation score (equivalent to AOI) of 39.8/110 after 24 hours. (SIDS (2011)) Another test applied 0.05 mL of undiluted this substance to the conjunctival sac of rabbits concluded that the eyes are at risk of severe damage due to marked eye reactions with corneal opacity lasting until the end of an 8-day observation period despite subsided erythema and chemosis. (SIDS (2011)) From the above, it was classified in Category 2A. |
FY2011 | GHS Classification Guidance by the Japanese Government (July, 2010) |
4 | Respiratory sensitization | Classification not possible |
- |
- | - | No data. | FY2011 | GHS Classification Guidance by the Japanese Government (July, 2010) |
4 | Skin sensitization | Classification not possible |
- |
- | - | No data. | FY2011 | GHS Classification Guidance by the Japanese Government (July, 2010) |
5 | Germ cell mutagenicity | Classification not possible |
- |
- | - | The classification is not possible due to no in vivo test data. Besides, an Ames test reported a weakly positive as an in vitro test (SIDS (2011)). |
FY2011 | GHS Classification Guidance by the Japanese Government (July, 2010) |
6 | Carcinogenicity | Classification not possible |
- |
- | - | No data. | FY2011 | GHS Classification Guidance by the Japanese Government (July, 2010) |
7 | Reproductive toxicity | Classification not possible |
- |
- | - | No data. | FY2011 | GHS Classification Guidance by the Japanese Government (July, 2010) |
8 | Specific target organ toxicity - Single exposure | Category 1 (respiratory organs), Category 2 (nervous system) |
Danger Warning |
H370 H371 |
P308+P311 P260 P264 P270 P321 P405 P501 |
In an acute oral toxicity test in rats (500 to 800 mg/kg), an LD50 value of 638 mg/kg and toxicological symptoms such as decreased activity, ataxia, body tremors, constricted pupils, dilated pupils, and ptosis were observed. (SIDS (2011)) And in another acute oral toxicity test in rats (316 to 3160 mg/kg) (OECD TG 401), an LD50 value of 1470 mg/kg, apathy, abnormal agitation, and unsteady gait at 1000 mg/kg, and abnormal positioning, atony, a narcosis-like state with reduced pain and eye reflexes at 1470 mg/kg or higher were observed. (SIDS (2011)) Because above symptoms were observed at doses corresponding to Category 2 in Guidance values, it was classified in Category 2 (nervous system). On the other hand, in a 4-hour inhalation test exposed 1.144 or 1.647 mg/L (vapour) to rats (OECD TG 403; GLP), respiratory distress was observed. And increased weights and inflation of the lungs, and red or dark trachea with white frothy fluid were observed in necropsy in a 1.647 mg/L group where all animal died (SIDS (2011)). Furthermore, epistaxis, gasping, nasal discharge, and respiratory gurgle were observed by an inhalation exposure of 1.14 to 5.15 mg/L/1h (0.57 to 2.58 mg/L/4h) (vapour) to rats. And survived animals showed pale lung and lung edema at 0.74 mg/L/4h and red mottled lung at 1.38 mg/L/4h in the necropsy. (SIDS (2011)) From the above, it was classified in Category 1 (respiratory system) because effects on lung and upper respiratory tract were observed within a range of Category 1 in Guidance values. |
FY2011 | GHS Classification Guidance by the Japanese Government (July, 2010) |
9 | Specific target organ toxicity - Repeated exposure | Classification not possible |
- |
- | - | No data. Besides, according to a report on a 28-day oral administration test given pivalic acid (a hydrolysate of this substance) to rats (OECD TG 407; GLP), only clinical signs were shaking of the head and sneezing with nasal discharge at 100 and 300 mg/kg/day considered to be caused by irritant effects, some slight changes in a biochemical examination and no pathological effect were observed, and acute toxicity is low. (SIDS (2011)) |
FY2011 | GHS Classification Guidance by the Japanese Government (July, 2010) |
10 | Aspiration hazard | Classification not possible |
- |
- | - | No data. | FY2011 | GHS Classification Guidance by the Japanese Government (July, 2010) |
Hazard class | Classification | Pictogram Signal word |
Hazard statement (code) |
Precautionary statement (code) |
Rationale for the classification | Classification year (FY) | GHS Classification Guidance for the Japanese Government | |
---|---|---|---|---|---|---|---|---|
11 | Hazardous to the aquatic environment Short term (Acute) | Classification not possible |
- |
- | - | No data. | FY2011 | GHS Classification Guidance by the Japanese Government (July, 2010) |
11 | Hazardous to the aquatic environment Long term (Chronic) | Classification not possible |
- |
- | - | No data. | FY2011 | GHS Classification Guidance by the Japanese Government (July, 2010) |
12 | Hazardous to the ozone layer | Classification not possible |
- |
- | - | This substance is not listed in Annexes to the Montreal Protocol. | FY2011 | GHS Classification Guidance by the Japanese Government (July, 2010) |
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