NITE - Chemical Management Field

Latest GHS Classification Results by the Japanese Government (edited by NITE)

GENERAL INFORMATION

Item	Information
CAS RN	34590-94-8
Chemical Name	Dipropylene glycol methyl ether
Substance ID	m-nite-34590-94-8_v1
Download of Excel format	Excel file

REFERENCE INFORMATION

Item	Information
Guidance used for the classification (External link)	To Guidance List
UN GHS document (External link)	To UN GHS document
FAQ（GHS classification results by the Japanese Government）	To FAQ
List of Information Sources (Excel file)	List of Information Sources
List of Definitions/Abbreviations	Definitions/Abbreviations
Sample Label by MHLW (External link)	MHLW Website (in Japanese Only)
Sample SDS by MHLW (External link)	MHLW Website (in Japanese Only)
OECD/eChemPortal (External link)	To OECD/eChemPortal (External link)

PHYSICAL HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification	Classification year (FY)	GHS Classification Guidance for the Japanese Government
1	Explosives	Not classified (Not applicable)	- -	-	-	There are no chemical groups associated with explosive properties present in the molecule.	FY2010	GHS Classification Guidance by the Japanese Government （July, 2010）
2	Flammable gases	Not classified (Not applicable)	- -	-	-	Liquid (GHS definition)	FY2010	GHS Classification Guidance by the Japanese Government （July, 2010）
3	Aerosols	Not classified (Not applicable)	- -	-	-	Not aerosol products.	FY2010	GHS Classification Guidance by the Japanese Government （July, 2010）
4	Oxidizing gases	Not classified (Not applicable)	- -	-	-	Liquid (GHS definition)	FY2010	GHS Classification Guidance by the Japanese Government （July, 2010）
5	Gases under pressure	Not classified (Not applicable)	- -	-	-	Liquid (GHS definition)	FY2010	GHS Classification Guidance by the Japanese Government （July, 2010）
6	Flammable liquids	Category 4	- Warning	H227	P370+P378 P210 P280 P403 P501	Since its flash point reported 79 degC (closed-cup) (BUA 174 (1995)) is > 60 degC and <= 93 degC, the substance corresponds to Category 4.	FY2010	GHS Classification Guidance by the Japanese Government （July, 2010）
7	Flammable solids	Not classified (Not applicable)	- -	-	-	Liquid (GHS definition)	FY2010	GHS Classification Guidance by the Japanese Government （July, 2010）
8	Self-reactive substances and mixtures	Not classified (Not applicable)	- -	-	-	There are no chemical groups present in the molecule associated with explosive or self-reactive properties.	FY2010	GHS Classification Guidance by the Japanese Government （July, 2010）
9	Pyrophoric liquids	Not classified	- -	-	-	Since its autoignition temperature is 270 degC (SIDS (2001)), it is considered that the substance does not ignite at room temperature.	FY2010	GHS Classification Guidance by the Japanese Government （July, 2010）
10	Pyrophoric solids	Not classified (Not applicable)	- -	-	-	Liquid (GHS definition)	FY2010	GHS Classification Guidance by the Japanese Government （July, 2010）
11	Self-heating substances and mixtures	Classification not possible	- -	-	-	Test methods applicable to liquid substances are not available.	FY2010	GHS Classification Guidance by the Japanese Government （July, 2010）
12	Substances and mixtures which, in contact with water, emit flammable gases	Not classified (Not applicable)	- -	-	-	The chemical structure of the substance does not contain metals or metalloids (B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At).	FY2010	GHS Classification Guidance by the Japanese Government （July, 2010）
13	Oxidizing liquids	Not classified (Not applicable)	- -	-	-	The substance is an organic compound containing oxygen (but not fluorine or chlorine) which is chemically bonded only to carbon or hydrogen.	FY2010	GHS Classification Guidance by the Japanese Government （July, 2010）
14	Oxidizing solids	Not classified (Not applicable)	- -	-	-	Liquid (GHS definition)	FY2010	GHS Classification Guidance by the Japanese Government （July, 2010）
15	Organic peroxides	Not classified (Not applicable)	- -	-	-	Organic compounds containing no bivalent -O-O- structure.	FY2010	GHS Classification Guidance by the Japanese Government （July, 2010）
16	Corrosive to metals	Classification not possible	- -	-	-	No data available.	FY2010	GHS Classification Guidance by the Japanese Government （July, 2010）
17	Desensitized explosives	-	- -	-	-	-	-	-

HEALTH HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification	Classification year (FY)	GHS Classification Guidance for the Japanese Government
1	Acute toxicity (Oral)	Not classified	- -	-	-	Three LD50 values for rats of 5230 mg/kg, 5180 mg/kg and 5400 mg/kg were reported (SIDS (2001)), and all data exceeded 5000 mg/kg bw. Therefore, the substance was classified as "Not classified".	FY2010	GHS Classification Guidance by the Japanese Government （July, 2010）
1	Acute toxicity (Dermal)	Not classified	- -	-	-	Three LD50 values for rabbits of 13000 - 14000 mg/kg, > 19000 mg/kg and 9500 mg/kg were reported (SIDS (2001)), and all data exceeded 5000 mg/kg. Therefore, the substance was classified as "Not classified".	FY2010	GHS Classification Guidance by the Japanese Government （July, 2010）
1	Acute toxicity (Inhalation: Gases)	Not classified (Not applicable)	- -	-	-	Liquid (GHS definition)	FY2010	GHS Classification Guidance by the Japanese Government （July, 2010）
1	Acute toxicity (Inhalation: Vapours)	Classification not possible	- -	-	-	According to the result that the 7-hour exposure to rats at 500 ppm (3.1 mg/L) caused no mortality (SIDS (2001)), converted LC50 value as that of 4-hour exposure was considered to be over 661 ppm (4.1 mg/L). However, because the category could not be specified, the substance was classified as "Classification not possible". As for the test substance, in the evaluation document (SIDS (2001)), there was an information that the test substance was saturated vapor (fog) atmosphere. Therefore, it was judged that the substance was vapor mixed with mist, and the criterion values for vapor were adopted for classification.	FY2010	GHS Classification Guidance by the Japanese Government （July, 2010）
1	Acute toxicity (Inhalation: Dusts and mists)	Classification not possible	- -	-	-	No data available.	FY2010	GHS Classification Guidance by the Japanese Government （July, 2010）
2	Skin corrosion/irritation	Not classified	- -	-	-	Several studies using rabbits were reported that the substance was not a skin irritant (SIDS (2001)). In the human case, because the result of no irritating was reported by application of the undiluted substance to the skin for 5 days (SIDS (2001)), it was concluded that the substance was not a skin irritant (SIDS (2001)). Based on the information, the substance was classified as "Not classified".	FY2010	GHS Classification Guidance by the Japanese Government （July, 2010）
3	Serious eye damage/eye irritation	Category 2B	- Warning	H320	P305+P351+P338 P337+P313 P264	In the rabbit test, instillation of 0.1 mL of undiluted test substance caused irritation to the conjunctiva and eyelid. These effects recovered within 7 days. As additional findings, it was also reported that slight effect of the anterior epithelium of the cornea was observed (SIDS (2001)). Based on the document, the substance was classified as Category 2B. As relevant notes, in another rabbit test, instillation of 500 mg of test substance caused no irritation (SIDS (2001)). Application of 20% aqueous solution to eyes of ten male volunteers produced slight stabbing pain, lacrimation and mild hyperemia of the conjunctiva (ECETOC TR95 (2005)).	FY2010	GHS Classification Guidance by the Japanese Government （July, 2010）
4	Respiratory sensitization	Classification not possible	- -	-	-	No data available.	FY2010	GHS Classification Guidance by the Japanese Government （July, 2010）
4	Skin sensitization	Not classified	- -	-	-	The substance was classified as "Not classified" based on the documented case that no sensitization was reported in the skin sensitization test for 200 human subjects with application to their dorsal skin, and the substance was concluded as not skin sensitizer (SIDS (2001)).	FY2010	GHS Classification Guidance by the Japanese Government （July, 2010）
5	Germ cell mutagenicity	Classification not possible	- -	-	-	The classification was not possible due to lack of in vivo data. As relevant information, as for in vitro studies, negative results in the Ames test and the chromosome aberration test using CHL cells were reported (SIDS (2001)).	FY2010	GHS Classification Guidance by the Japanese Government （July, 2010）
6	Carcinogenicity	Classification not possible	- -	-	-	No data available.	FY2010	GHS Classification Guidance by the Japanese Government （July, 2010）
7	Reproductive toxicity	Classification not possible	- -	-	-	In the inhalation studies using pregnant rats or rabbits during the organogenetic period, both animal species didn't show the embryotoxicity or teratogenicity in the highest concentration of 300 ppm, which was realizable to expose under standard temperature and pressure, and the adverse influence was not observed in the development of offspring (SIDS (2001)). However, since no information was provided regarding sexual functions and fertility of parent animals, the classification was not possible.	FY2010	GHS Classification Guidance by the Japanese Government （July, 2010）
8	Specific target organ toxicity - Single exposure	Category 3 (narcotic effects, respiratory tract irritation)	Warning	H336 H335	P304+P340 P403+P233 P261 P271 P312 P405 P501	Depression of central nervous system was observed in rats by oral administration, and a mild narcosis was seen in rats exposed by inhalation for 7 hours (SIDS (2001)). In addition, the transient narcotic effect was also reported in rabbits by the dermal application (SIDS (2001)). Therefore, the substance was classified as Category 3 (narcotic effects). Furthermore, it was reported that the substance cause slight irritation in the nose in humans and it was also referred to the probable minimum concentrations of irritating to the throat and respiratory tract (SIDS (2001)). It was also reported that, at the concentration above 100 ppm, torment by irritation of nose, throat or respiratory tract occurred prior to the first signs of CNS impairments (ACGIH (2001)). Based on these descriptions, the substance was classified as Category 3 (respiratory tract irritation).	FY2010	GHS Classification Guidance by the Japanese Government （July, 2010）
9	Specific target organ toxicity - Repeated exposure	Not classified	- -	-	-	In the 4-week oral study in rats, transient salivation and liver effects (significant increase in liver weight and centrilobular hypertrophy) were observed in the high dose group at 1000 mg/kg/day (converted dose level as that of 90-day study: 308 mg/kg/day). However, no other treatment-related effects were reported (SIDS (2001)). Because the liver effects found in the study were concluded to be adaptive changes (SIDS (2001)), it was considered that no adverse effects were seen up to the highest dose beyond the range of the guidance values. Thus, the classification was considered as equivalent to "Not classified" for oral route. Furthermore, it was reported that the NOEL in the 4-week dermal application study in rats was 1000 mg/kg/day (converted dose level as that of 90-day study: 308 mg/kg/day), and that NOEL in the 90-day dermal application in rabbits was 2850 mg/kg/day (SIDS (2001)). Both of which were over the range of guidance values. Furthermore, the NOELs in the 13-week inhalation studies in rats or rabbits (as vapors, 6 hours/day, 5 days/week) were reported as 200 ppm (1.212 mg/L) or higher in each study (SIDS (2001)), and these were over the upper limit of the guidance values. Thus, the classification for each route via dermal and inhalation was also equivalence to "Not classified" category. Therefore, the classification for specific target organ toxicity (repeated exposure) was concluded as "Not classified".	FY2010	GHS Classification Guidance by the Japanese Government （July, 2010）
10	Aspiration hazard	Classification not possible	- -	-	-	No data available.	FY2010	GHS Classification Guidance by the Japanese Government （July, 2010）

ENVIRONMENTAL HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification	Classification year (FY)	GHS Classification Guidance for the Japanese Government
11	Hazardous to the aquatic environment Short term (Acute)	Not classified	- -	-	-	Classified as "Not classified" since all LC50 and EC50 values exceeded 100 mg/L in acute toxicity tests for fish, crustacea and algae (SIDS, 2003).	FY2010	GHS Classification Guidance by the Japanese Government （July, 2010）
11	Hazardous to the aquatic environment Long term (Chronic)	Not classified	- -	-	-	Classified as "Not classified" since its acute toxicity is "Not Classified" and it is not non-water soluble (water solubility = 1000000 mg/L (PHYSPROP Database, 2011)).	FY2010	GHS Classification Guidance by the Japanese Government （July, 2010）
12	Hazardous to the ozone layer	Classification not possible	- -	-	-	This substance is not listed in Annexes to the Montreal Protocol.	FY2010	GHS Classification Guidance by the Japanese Government （July, 2010）

NOTE:

GHS Classification Result by the Japanese Government is intended to provide a reference for preparing a GHS label or SDS for users. To include the same classification result in a label or SDS for Japan is NOT mandatory.
Users can cite or copy this classification result when preparing a GHS label or SDS. Please be aware, however, that the responsibility for a label or SDS prepared by citing or copying this classification result lies with users.
This GHS classification was conducted based on the information sources and the guidance for classification and judgement which are described in the GHS Classification Guidance for the Japanese Government etc. Using other literature, test results etc. as evidence and including different content from this classification result in a label or SDS are allowed.
Hazard statement and precautionary statement will show by hovering the mouse cursor over a code in the column of "Hazard statement" and "Precautionary statement," respectively. In the excel file, both the codes and statements are provided.
A blank or "-" in the column of "Classification" denotes that a classification for the hazard class was not conducted in the year.
An asterisk “*” in the column of “Classification” denotes that “Not classified (or No applicable)” and/or “Classification not possible” is applicable. Details are described in the column of “Rationale for the classification”. If no English translation is available for “Rationale for the classification,” please refer to the Japanese version of the results.

To GHS Information