Item | Information |
---|---|
CAS RN | 36335-67-8 |
Chemical Name | O-Ethyl O-(6-nitro-m-tolyl) sec-butylphosphoramidothioate; Butamifos |
Substance ID | m-nite-36335-67-8_v2 |
Download of Excel format | Excel file |
Item | Information |
---|---|
Guidance used for the classification (External link) | To Guidance List |
UN GHS document (External link) | To UN GHS document |
FAQ(GHS classification results by the Japanese Government) | To FAQ |
List of Information Sources (Excel file) | List of Information Sources |
List of Definitions/Abbreviations | Definitions/Abbreviations |
Sample Label by MHLW (External link) | MHLW Website (in Japanese Only) |
Sample SDS by MHLW (External link) | MHLW Website (in Japanese Only) |
OECD/eChemPortal (External link) | To OECD/eChemPortal (External link) |
Hazard class | Classification | Pictogram Signal word |
Hazard statement (code) |
Precautionary statement (code) |
Rationale for the classification | Classification year (FY) | GHS Classification Guidance for the Japanese Government | |
---|---|---|---|---|---|---|---|---|
1 | Explosives | Classification not possible |
- |
- | - | There is a chemical group associated with explosive properties (nitro group) present in the molecule, and the calculated oxygen balance is -156, higher than the criteria: -200, but the classification is not possible due to no data. | FY2020 | GHS Classification Guidance for the Japanese Government (FY2019 revised edition (Ver. 2.0)) |
2 | Flammable gases | Not classified (Not applicable) |
- |
- | - | Liquid (GHS definition). It was classified as "Not classified." | FY2020 | GHS Classification Guidance for the Japanese Government (FY2019 revised edition (Ver. 2.0)) |
3 | Aerosols | Not classified (Not applicable) |
- |
- | - | Not aerosol products. It was classified as "Not classified." | FY2020 | GHS Classification Guidance for the Japanese Government (FY2019 revised edition (Ver. 2.0)) |
4 | Oxidizing gases | Not classified (Not applicable) |
- |
- | - | Liquid (GHS definition). It was classified as "Not classified." | FY2020 | GHS Classification Guidance for the Japanese Government (FY2019 revised edition (Ver. 2.0)) |
5 | Gases under pressure | Not classified (Not applicable) |
- |
- | - | Liquid (GHS definition). It was classified as "Not classified." | FY2020 | GHS Classification Guidance for the Japanese Government (FY2019 revised edition (Ver. 2.0)) |
6 | Flammable liquids | Not classified |
- |
- | - | It was classified as "Not classified" from a flash point of around 192 deg C (Sumitomo Chemical 1984-I, Japan Crop Protection Association (1984)). | FY2020 | GHS Classification Guidance for the Japanese Government (FY2019 revised edition (Ver. 2.0)) |
7 | Flammable solids | Not classified (Not applicable) |
- |
- | - | Liquid (GHS definition). It was classified as "Not classified." | FY2020 | GHS Classification Guidance for the Japanese Government (FY2019 revised edition (Ver. 2.0)) |
8 | Self-reactive substances and mixtures | Classification not possible |
- |
- | - | There is a chemical group associated with explosive properties (nitro group) present in the molecule, but the classification is not possible due to no data. | FY2020 | GHS Classification Guidance for the Japanese Government (FY2019 revised edition (Ver. 2.0)) |
9 | Pyrophoric liquids | Not classified |
- |
- | - | It was classified as "Not classified" because it is estimated that it does not ignite at normal temperatures from information that it is stable to heat at up to 150 deg C (A pesticide abstract and evaluation report (Food and Agricultural Materials Inspection Center, 2009)). | FY2020 | GHS Classification Guidance for the Japanese Government (FY2019 revised edition (Ver. 2.0)) |
10 | Pyrophoric solids | Not classified (Not applicable) |
- |
- | - | Liquid (GHS definition). It was classified as "Not classified." | FY2020 | GHS Classification Guidance for the Japanese Government (FY2019 revised edition (Ver. 2.0)) |
11 | Self-heating substances and mixtures | Classification not possible |
- |
- | - | Classification is not possible because test methods applicable to liquid substances are not available. | FY2020 | GHS Classification Guidance for the Japanese Government (FY2019 revised edition (Ver. 2.0)) |
12 | Substances and mixtures which, in contact with water, emit flammable gases | Not classified |
- |
- | - | It contains a metalloid (P), but it was classified as "Not classified" because it is estimated that it does not react vigorously with water from water solubility data of 6.19 mg/L (25 deg C) (A pesticide abstract and evaluation report (Food and Agricultural Materials Inspection Center, 2009)). | FY2020 | GHS Classification Guidance for the Japanese Government (FY2019 revised edition (Ver. 2.0)) |
13 | Oxidizing liquids | Classification not possible |
- |
- | - | The substance is an organic compound containing oxygen (but not fluorine or chlorine), which is chemically bonded to elements other than carbon or hydrogen (N, P). However, the classification is not possible due to no data. | FY2020 | GHS Classification Guidance for the Japanese Government (FY2019 revised edition (Ver. 2.0)) |
14 | Oxidizing solids | Not classified (Not applicable) |
- |
- | - | Liquid (GHS definition). It was classified as "Not classified." | FY2020 | GHS Classification Guidance for the Japanese Government (FY2019 revised edition (Ver. 2.0)) |
15 | Organic peroxides | Not classified (Not applicable) |
- |
- | - | Organic compounds containing no bivalent -O-O- structure in the molecule. It was classified as "Not classified." | FY2020 | GHS Classification Guidance for the Japanese Government (FY2019 revised edition (Ver. 2.0)) |
16 | Corrosive to metals | Classification not possible |
- |
- | - | No data available. | FY2020 | GHS Classification Guidance for the Japanese Government (FY2019 revised edition (Ver. 2.0)) |
17 | Desensitized explosives | Classification not possible |
- |
- | - | There is a chemical group associated with explosive properties (nitro group) present in the molecule, but the classification is not possible due to no data. | FY2020 | GHS Classification Guidance for the Japanese Government (FY2019 revised edition (Ver. 2.0)) |
Hazard class | Classification | Pictogram Signal word |
Hazard statement (code) |
Precautionary statement (code) |
Rationale for the classification | Classification year (FY) | GHS Classification Guidance for the Japanese Government | |
---|---|---|---|---|---|---|---|---|
1 | Acute toxicity (Oral) | Category 4 |
Warning |
H302 | P301+P312 P264 P270 P330 P501 |
[Rationale for the Classification] It was classified in Category 4 from (1) - (3). [Evidence Data] (1) LD50 for rats: females: 630 mg/kg, males: 790 mg/kg (Risk Assessment Report (Pesticides) (Food Safety Commission of Japan, 2009), A pesticide abstract and evaluation report (Food and Agricultural Materials Inspection Center, 2009)) (2) LD50 for rats: 630-1,070 mg/kg (Food sanitation research Vol. 47, No. 2 (Japan Crop Protection Association, 1997)) (3) LD50 for rats: females: 845 mg/kg, males: 1,070 mg/kg (Risk Assessment Report (Pesticides) (Food Safety Commission of Japan, 2009), A pesticide abstract and evaluation report (Food and Agricultural Materials Inspection Center, 2009)) |
FY2020 | GHS Classification Guidance for the Japanese Government (FY2019 revised edition (Ver. 2.0)) |
1 | Acute toxicity (Dermal) | Not classified |
- |
- | - | [Rationale for the Classification] It was classified as "Not classified" from (1). [Evidence Data] (1) LD50 for rats: > 5,000 mg/kg (Risk Assessment Report (Pesticides) (Food Safety Commission of Japan, 2009), A pesticide abstract and evaluation report (Food and Agricultural Materials Inspection Center, 2009)) |
FY2020 | GHS Classification Guidance for the Japanese Government (FY2019 revised edition (Ver. 2.0)) |
1 | Acute toxicity (Inhalation: Gases) | Not classified |
- |
- | - | [Rationale for the Classification] Liquid (GHS definition). It was classified as "Not classified." |
FY2020 | GHS Classification Guidance for the Japanese Government (FY2019 revised edition (Ver. 2.0)) |
1 | Acute toxicity (Inhalation: Vapours) | Classification not possible |
- |
- | - | [Rationale for the Classification] Classification not possible due to lack of data. |
FY2020 | GHS Classification Guidance for the Japanese Government (FY2019 revised edition (Ver. 2.0)) |
1 | Acute toxicity (Inhalation: Dusts and mists) | Classification not possible |
- |
- | - | [Rationale for the Classification] The category could not be specified from (1), and it was classified as "Classification not possible." Because an exposure concentration was higher than the saturated vapor pressure concentration (0.011 mg/L), a reference value in the unit of mg/L was applied as mist. [Evidence Data] (1) LC50 for rats (4 hours): > 1.2 mg/L (Risk Assessment Report (Pesticides) (Food Safety Commission of Japan, 2009), A pesticide abstract and evaluation report (Food and Agricultural Materials Inspection Center, 2009)) (2) Vapor pressure of this substance: 6.3E-004 mmHg (27 deg C) (Japan Crop Protection Association (1984)) (converted value for the saturated vapor pressure concentration: 0.011 mg/L) |
FY2020 | GHS Classification Guidance for the Japanese Government (FY2019 revised edition (Ver. 2.0)) |
2 | Skin corrosion/irritation | Not classified |
- |
- | - | [Rationale for the Classification] It was classified as "Not classified" from (1). [Evidence Data] (1) No irritation was observed in a skin irritation test with rabbits (Risk Assessment Report (Pesticides) (Food Safety Commission of Japan, 2009), A pesticide abstract and evaluation report (Food and Agricultural Materials Inspection Center, 2009)). |
FY2020 | GHS Classification Guidance for the Japanese Government (FY2019 revised edition (Ver. 2.0)) |
3 | Serious eye damage/eye irritation | Not classified |
- |
- | - | [Rationale for the Classification] It was classified as "Not classified" from (1). [Evidence Data] (1) No irritation was observed in an eye irritation test with rabbits (Risk Assessment Report (Pesticides) (Food Safety Commission of Japan, 2009), A pesticide abstract and evaluation report (Food and Agricultural Materials Inspection Center, 2009)). |
FY2020 | GHS Classification Guidance for the Japanese Government (FY2019 revised edition (Ver. 2.0)) |
4 | Respiratory sensitization | Classification not possible |
- |
- | - | [Rationale for the Classification] Classification not possible due to lack of data. |
FY2020 | GHS Classification Guidance for the Japanese Government (FY2019 revised edition (Ver. 2.0)) |
4 | Skin sensitization | Classification not possible |
- |
- | - | [Rationale for the Classification] It was presumed that it was classified as "Not classified" based on data in (1) in the previous classification, but because a Draize test was not registered as OECD TG, it was classified as "Classification not possible." [Reference Data, etc.] (1) It was reported to be negative in a skin sensitization test with guinea pigs (Draize test) (Risk Assessment Report (Pesticides) (Food Safety Commission of Japan, 2009), A pesticide abstract and evaluation report (Food and Agricultural Materials Inspection Center, 2009)). |
FY2020 | GHS Classification Guidance for the Japanese Government (FY2019 revised edition (Ver. 2.0)) |
5 | Germ cell mutagenicity | Not classified |
- |
- | - | [Rationale for the Classification] It was classified as "Not classified" from (1), (2). [Evidence Data] (1) As for in vivo, it was reported to be negative in a micronucleus test with mouse bone marrow cells (Risk Assessment Report (Pesticides) (Food Safety Commission of Japan, 2009), Food sanitation research Vol. 47, No. 2 (Japan Crop Protection Association, 1997), A pesticide abstract and evaluation report (Food and Agricultural Materials Inspection Center, 2009)). (2) As for in vitro, it was reported to be negative in a bacterial reverse mutation test. On the other hand, it is reported that it did not induce chromosomal aberrations in cultured mammalian cells but increased polyploidy cells, although at a low frequency (same as the above). |
FY2020 | GHS Classification Guidance for the Japanese Government (FY2019 revised edition (Ver. 2.0)) |
6 | Carcinogenicity | Not classified |
- |
- | - | [Rationale for the Classification] There were no classification results by domestic and international organizations. There was no available report in humans. It was classified as "Not classified" from (1), (2). [Evidence Data] (1) In combined chronic toxicity/carcinogenicity tests by diet administration of this substance to male and female rats for 2 years or 2 years and 1 month, no carcinogenicity was observed (Risk Assessment Report (Pesticides) (Food Safety Commission of Japan, 2009)). (2) In a carcinogenicity test by 16-month diet administration of this substance to male and female mice, no carcinogenicity was observed (Risk Assessment Report (Pesticides) (Food Safety Commission of Japan, 2009)). |
FY2020 | GHS Classification Guidance for the Japanese Government (FY2019 revised edition (Ver. 2.0)) |
7 | Reproductive toxicity | - |
- |
H362 | - | [Rationale for the Classification] Based on (1), a decrease in the number of live pups during the lactation period was observed at a dose at which no parental toxicity was observed. However, based on (1) to (3), other effects on fertility, at birth, or on fetuses, were not observed, and therefore, it was classified in "additional category: effects on or via lactation." [Evidence Data] (1) In a three-generation reproductive study with rats dosed by feeding, a decrease in the number of live pups (on days 12 and 21 of lactation of P, F1 and F2 generations) during the lactation period was observed at a dose (the maximum dose of 300 ppm (males: 24.37 mg/kg/day; females: 31.60 mg/kg/day) at which no parental toxicity was observed (Risk Assessment Report (Pesticides) (Food Safety Commission of Japan, 2009), A pesticide abstract and evaluation report (Food and Agricultural Materials Inspection Center, 2009)). (2) In a developmental toxicity study with female rats dosed by gavage on days 6 to 15 of gestation, maternal toxicity (reduced body weight gain, 1 animal showed rale, dyspnea, and salivation) was observed at the maximum dose of 125 mg/kg/day, but no effect was observed in fetuses (Risk Assessment Report (Pesticides) (Food Safety Commission of Japan, 2009)). (3) In a developmental toxicity study with female rabbits dosed by gavage on days 6 to 18 of gestation, maternal toxicity (death and reduced body weight gain) was observed at the maximum dose of 80 mg/kg/day, but no effect was observed in fetuses (Risk Assessment Report (Pesticides) (Food Safety Commission of Japan, 2009)). |
FY2020 | GHS Classification Guidance for the Japanese Government (FY2019 revised edition (Ver. 2.0)) |
8 | Specific target organ toxicity - Single exposure | Category 1 (nervous system) |
Danger |
H370 | P308+P311 P260 P264 P270 P321 P405 P501 |
[Rationale for the Classification] There was no report on acute exposure to this substance in humans. In experimental animals, based on (1) to (4), it was classified in Category 1 (nervous system). New information sources were used and the classification results were changed from the previous classification. [Evidence Data] (1) In an acute neurotoxicity test by an oral administration to rats (0, 10, 70, 500 mg/kg), a decrease in righting reflex and diarrhea in males, and abnormal gait (toe walking) in females were observed at or above 70 mg/kg (within the range for Category 1); and abnormal gait (toe walking), soiling with urine, and a decrease in locomotor activity in males, and a decrease in righting reflex, diarrhea, and soiling with urine in females were observed at 500 mg/kg (within the range for Category 2) (Risk Assessment Report (Pesticides) (Food Safety Commission of Japan, 2009)). (2) In an acute oral toxicity test with rats, a decrease in locomotor activity, respiratory distress, piloerection, urination, irritability, salivation, lacrimation, exophthalmos, muscular spasms, and limb or systemic ataxia were observed at 385 mg/kg (within the range for Category 2); and in another test, lacrimation, salivation, reddish tear, tremor, ataxic gait, exophthalmos, incontinence of urine, and deep breathing were observed at 500 mg/kg (within the range for Category 2) (Risk Assessment Report (Pesticides) (Food Safety Commission of Japan, 2009)). (3) In an acute dermal application test with rats, at 5,000 mg/kg (exceeding Category 2), tremor was observed (Risk Assessment Report (Pesticides) (Food Safety Commission of Japan, 2009)). (4) In a 4-hour acute inhalation exposure test with rats, a decrease in locomotor activity, irregular breathing, deep breathing (only at 1,200 mg/m3), salivation, lacrimation, nasal discharge, and incontinence of urine were observed at or above 147 mg/m3 (within the range for Category 1) (Risk Assessment Report (Pesticides) (Food Safety Commission of Japan, 2009)). [Reference Data, etc.] (5) Toxic symptoms by an oral administration to test animals were symptoms of excitement of the central or peripheral nervous system (such as irritability, salivation, and muscle spasms), and limb or systemic ataxia (Sumitomo Chemical Co., Ltd. 1984-I (Japan Crop Protection Association, 1984)). |
FY2020 | GHS Classification Guidance for the Japanese Government (FY2019 revised edition (Ver. 2.0)) |
9 | Specific target organ toxicity - Repeated exposure | Category 1 (nervous system) |
Danger |
H372 | P260 P264 P270 P314 P501 |
[Rationale for the Classification] Based on (1) to (4), it was classified in Category 1 (nervous system). As a result of examination using the new information, the classification results were changed from the previous classification. [Evidence Data] (1) It was reported that, as a result of a 90-day test with mice dosed by feeding, inhibition of brain and erythrocyte cholinesterase (ChE) activity in males and females, and increases in phospholipid and total cholesterol in females were observed at or above 250 ppm (37.5 mg/kg/day, within the range for Category 2) (Risk Assessment Report (Pesticides) (Food Safety Commission of Japan, 2009)). (2) As a result of a 90-day subacute neurotoxicity test with rats dosed by feeding, inhibition of brain and erythrocyte ChE activity was observed at or above 100 ppm (5 mg/kg/day, within the range for Category 1), and toe walking, an increase in contact reaction, upward bending of the backbone, reduced body weight gain, and a decrease in feed efficiency in males and females, and increased activity and depressed trunk in females were observed at or above 1,000 ppm (50 mg/kg/day, within the range for Category 2) (Risk Assessment Report (Pesticides) (Food Safety Commission of Japan, 2009)). (3) As a result of a 2-year chronic toxicity study by an oral administration to dogs, inhibition of brain ChE activity in males, and inhibition of brain and erythrocyte ChE activity in females were observed at or above 12.5 mg/kg/day (within the range for Category 2) (Risk Assessment Report (Pesticides) (Food Safety Commission of Japan, 2009)). (4) As a result of a 2-year combined chronic toxicity/carcinogenicity study with rats dosed by feeding, inhibition of erythrocyte ChE activity in males and females was observed at or above 80 ppm (4 mg/kg/day, within the range for Category 1); and inhibition of brain ChE activity in males and females, and decreases in erythrocyte count, hemoglobin, hematocrit levels, and MCV in females were observed at 300 ppm (15 mg/kg/day, within the range for Category 2) (Risk Assessment Report (Pesticides) (Food Safety Commission of Japan, 2009)). |
FY2020 | GHS Classification Guidance for the Japanese Government (FY2019 revised edition (Ver. 2.0)) |
10 | Aspiration hazard | Classification not possible |
- |
- | - | [Rationale for the Classification] Classification not possible due to lack of data. |
FY2020 | GHS Classification Guidance for the Japanese Government (FY2019 revised edition (Ver. 2.0)) |
Hazard class | Classification | Pictogram Signal word |
Hazard statement (code) |
Precautionary statement (code) |
Rationale for the classification | Classification year (FY) | GHS Classification Guidance for the Japanese Government | |
---|---|---|---|---|---|---|---|---|
11 | Hazardous to the aquatic environment Short term (Acute) | Category 1 |
Warning |
H400 | P273 P391 P501 |
It was classified in Category 1 from 72-hour ErC50 = 0.033 mg/L for algae (Raphidocelis subcapitata) (A pesticide abstract and evaluation report (Food and Agricultural Materials Inspection Center, 2009)). | FY2020 | GHS Classification Guidance for the Japanese Government (FY2019 revised edition (Ver. 2.0)) |
11 | Hazardous to the aquatic environment Long term (Chronic) | Category 1 |
Warning |
H410 | P273 P391 P501 |
If chronic toxicity data are used, then it is classified in Category 1 because it is not rapidly degradable (BIOWIN) and due to 72-hour NOErC = 0.01 mg/L for algae (Raphidocelis subcapitata) (A pesticide abstract and evaluation report (Food and Agricultural Materials Inspection Center, 2009)). If acute toxicity data are used for a trophic level for which chronic toxicity data are not obtained, then it is classified in Category 2 because it is not rapidly degradable (BIOWIN) and due to 48-hour EC50 = 1.9 mg/L for crustacea (Daphnia magna) (A pesticide abstract and evaluation report (Food and Agricultural Materials Inspection Center, 2009)). By drawing a comparison between the above results, it was classified in Category 1. |
FY2020 | GHS Classification Guidance for the Japanese Government (FY2019 revised edition (Ver. 2.0)) |
12 | Hazardous to the ozone layer | Classification not possible |
- |
- | - | This substance is not listed in the Annexes to the Montreal Protocol. | FY2020 | GHS Classification Guidance for the Japanese Government (FY2019 revised edition (Ver. 2.0)) |
|