Item | Information |
---|---|
CAS RN | 3691-35-8 |
Chemical Name | chlorophacinone |
Substance ID | m-nite-3691-35-8_v1 |
Download of Excel format | Excel file |
Item | Information |
---|---|
Guidance used for the classification (External link) | To Guidance List |
UN GHS document (External link) | To UN GHS document |
FAQ(GHS classification results by the Japanese Government) | To FAQ |
List of Information Sources (Excel file) | List of Information Sources |
List of Definitions/Abbreviations | Definitions/Abbreviations |
Sample Label by MHLW (External link) | MHLW Website (in Japanese Only) |
Sample SDS by MHLW (External link) | MHLW Website (in Japanese Only) |
OECD/eChemPortal (External link) | To OECD/eChemPortal (External link) |
Hazard class | Classification | Pictogram Signal word |
Hazard statement (code) |
Precautionary statement (code) |
Rationale for the classification | Classification year (FY) | GHS Classification Guidance for the Japanese Government | |
---|---|---|---|---|---|---|---|---|
1 | Explosives | Not classified (Not applicable) |
- |
- | - | There are no chemical groups associated with explosive properties present in the molecules. | FY2006 | GHS Classification Manual (10 Feb, 2006) |
2 | Flammable gases | Not classified (Not applicable) |
- |
- | - | Solid (GHS definition) | FY2006 | GHS Classification Manual (10 Feb, 2006) |
3 | Aerosols | Not classified (Not applicable) |
- |
- | - | Not aerosol products | FY2006 | GHS Classification Manual (10 Feb, 2006) |
4 | Oxidizing gases | Not classified (Not applicable) |
- |
- | - | Solid (GHS definition) | FY2006 | GHS Classification Manual (10 Feb, 2006) |
5 | Gases under pressure | Not classified (Not applicable) |
- |
- | - | Solid (GHS definition) | FY2006 | GHS Classification Manual (10 Feb, 2006) |
6 | Flammable liquids | Not classified (Not applicable) |
- |
- | - | Solid (GHS definition) | FY2006 | GHS Classification Manual (10 Feb, 2006) |
7 | Flammable solids | Classification not possible |
- |
- | - | No data available | FY2006 | GHS Classification Manual (10 Feb, 2006) |
8 | Self-reactive substances and mixtures | Not classified (Not applicable) |
- |
- | - | There are no chemical groups associated with explosive or self-reactive properties present in the molecule. | FY2006 | GHS Classification Manual (10 Feb, 2006) |
9 | Pyrophoric liquids | Not classified (Not applicable) |
- |
- | - | Solid (GHS definition) | FY2006 | GHS Classification Manual (10 Feb, 2006) |
10 | Pyrophoric solids | Not classified |
- |
- | - | Non-pyrophoric when in contact with air at a room temperature and used as agricultural chemicals (raticides). | FY2006 | GHS Classification Manual (10 Feb, 2006) |
11 | Self-heating substances and mixtures | Not classified |
- |
- | - | Since PM (13th, 2003) had the description "it is very stability", it carried out the outside of Category. | FY2006 | GHS Classification Manual (10 Feb, 2006) |
12 | Substances and mixtures which, in contact with water, emit flammable gases | Not classified (Not applicable) |
- |
- | - | The chemical structure of the substance does not contain metals or metaloids(B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At). | FY2006 | GHS Classification Manual (10 Feb, 2006) |
13 | Oxidizing liquids | Not classified (Not applicable) |
- |
- | - | Solid (GHS definition) | FY2006 | GHS Classification Manual (10 Feb, 2006) |
14 | Oxidizing solids | Not classified (Not applicable) |
- |
- | - | Organic compounds containing oxygen and chlorine and these elements are chemically bonded only to carbon (but not to other elements). | FY2006 | GHS Classification Manual (10 Feb, 2006) |
15 | Organic peroxides | Not classified (Not applicable) |
- |
- | - | Organic compounds containing no -0-0- structure | FY2006 | GHS Classification Manual (10 Feb, 2006) |
16 | Corrosive to metals | Classification not possible |
- |
- | - | Test methods applicable to solid substances are not available. | FY2006 | GHS Classification Manual (10 Feb, 2006) |
17 | Desensitized explosives | - |
- |
- | - | - | - | - |
Hazard class | Classification | Pictogram Signal word |
Hazard statement (code) |
Precautionary statement (code) |
Rationale for the classification | Classification year (FY) | GHS Classification Guidance for the Japanese Government | |
---|---|---|---|---|---|---|---|---|
1 | Acute toxicity (Oral) | Category 2 |
Danger |
H300 | P301+P310 P264 P270 P321 P330 P405 P501 |
Category 2 based on SPECIES: Rat; ENDPOINT: LD50; VALUE: 20.5mg/kg; REFERENCE SOURCE: EHC 175 (1995), PDS 62 (1985), HSDB (2003) | FY2006 | GHS Classification Manual (10 Feb, 2006) |
1 | Acute toxicity (Dermal) | Category 2 |
Danger |
H310 | P302+P352 P361+P364 P262 P264 P270 P280 P310 P321 P405 P501 |
It was set as Category 2 based on rabbit LD50 = 200mg/kg (PDS 62, 1985;RTECS, 2006) of the dermal administration test. | FY2006 | GHS Classification Manual (10 Feb, 2006) |
1 | Acute toxicity (Inhalation: Gases) | Not classified (Not applicable) |
- |
- | - | Solid (GHS definition) | FY2006 | GHS Classification Manual (10 Feb, 2006) |
1 | Acute toxicity (Inhalation: Vapours) | Classification not possible |
- |
- | - | No data available | FY2006 | GHS Classification Manual (10 Feb, 2006) |
1 | Acute toxicity (Inhalation: Dusts and mists) | Category 1 |
Danger |
H330 | P304+P340 P403+P233 P260 P271 P284 P310 P320 P405 P501 |
Among the values of an rat inhalation administration test which are >0.75mg/L/4H ( >3mg/L/1H) (HSDB, 2003; RTECS, 1997) and 0.007mg/L/4H (7.0microg/L/4H) (HSDB, 2003), the lower value of 0.007mg/L/4H were adopted. And it was set as Category 1. | FY2006 | GHS Classification Manual (10 Feb, 2006) |
2 | Skin corrosion/irritation | Classification not possible |
- |
- | - | No data available | FY2006 | GHS Classification Manual (10 Feb, 2006) |
3 | Serious eye damage/eye irritation | Classification not possible |
- |
- | - | No data available | FY2006 | GHS Classification Manual (10 Feb, 2006) |
4 | Respiratory sensitization | Classification not possible |
- |
- | - | No data available | FY2006 | GHS Classification Manual (10 Feb, 2006) |
4 | Skin sensitization | Classification not possible |
- |
- | - | No data available | FY2006 | GHS Classification Manual (10 Feb, 2006) |
5 | Germ cell mutagenicity | Not classified |
- |
- | - | Since it was negative in the chromosome aberration test in the bone marrow and spermatocyte using mice and rabbits (HSDB, 2003), it is classified as the out of the Category. In addition, also in the in vitro mutagenicity test (a cell tests for gene mutation, an Ames test), it is considered as negative (HSDB, 2003). | FY2006 | GHS Classification Manual (10 Feb, 2006) |
6 | Carcinogenicity | Classification not possible |
- |
- | - | No data available | FY2006 | GHS Classification Manual (10 Feb, 2006) |
7 | Reproductive toxicity | Category 1B |
Danger |
H360 | P308+P313 P201 P202 P280 P405 P501 |
Since malformation and variation of the ureter were seen at the dose which maternal toxicity not occur in rat teratogenicity studies (HSDB, 2003), it was set as Category 1B. In addition, adequate assessment was impossible because of the toxicity in rabbit teratogenicity studies (HSDB, 2003). | FY2006 | GHS Classification Manual (10 Feb, 2006) |
8 | Specific target organ toxicity - Single exposure | Category 1 (blood system), Category 2 (gastrointestinal tract) |
Danger Warning |
H370 H371 |
P308+P311 P260 P264 P270 P321 P405 P501 |
It was considered as Category 1 (blood systems) and Category 2 (gastrointestinal) based on the description of the significant fall of blood coagulationby on 20mg of oral administration to humans (EHC 175, 1995) and the product is anticoagulant (PDS 62, 1985), the factor in the death in humans was bleeding of the gastrointestinal tract (HSDB, 2003). | FY2006 | GHS Classification Manual (10 Feb, 2006) |
9 | Specific target organ toxicity - Repeated exposure | Category 1 (blood system) |
Danger |
H372 | P260 P264 P270 P314 P501 |
Since the significant increase in blood coagulation time was observed in the range of guidance value of Category 1, and the death by anticoagulation was observed with higher dose in a rat repeated oral administration test (HSDB, 2003), it was classified into Category 1 (blood systems). | FY2006 | GHS Classification Manual (10 Feb, 2006) |
10 | Aspiration hazard | Classification not possible |
- |
- | - | No data available | FY2006 | GHS Classification Manual (10 Feb, 2006) |
Hazard class | Classification | Pictogram Signal word |
Hazard statement (code) |
Precautionary statement (code) |
Rationale for the classification | Classification year (FY) | GHS Classification Guidance for the Japanese Government | |
---|---|---|---|---|---|---|---|---|
11 | Hazardous to the aquatic environment Short term (Acute) | Classification not possible |
- |
- | - | No data available | FY2006 | GHS Classification Manual (10 Feb, 2006) |
11 | Hazardous to the aquatic environment Long term (Chronic) | Classification not possible |
- |
- | - | No data available. | FY2006 | GHS Classification Manual (10 Feb, 2006) |
12 | Hazardous to the ozone layer | - |
- |
- | - | - | - | - |
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