Item | Information |
---|---|
CAS RN | 371-40-4 |
Chemical Name | 4-Fluoroaniline |
Substance ID | m-nite-371-40-4_v1 |
Download of Excel format | Excel file |
Item | Information |
---|---|
Guidance used for the classification (External link) | To Guidance List |
UN GHS document (External link) | To UN GHS document |
FAQ(GHS classification results by the Japanese Government) | To FAQ |
List of Information Sources (Excel file) | List of Information Sources |
List of Definitions/Abbreviations | Definitions/Abbreviations |
Sample Label by MHLW (External link) | To Workplace Safety Site (MHLW) |
Sample SDS by MHLW (External link) | To Workplace Safety Site (MHLW) |
OECD/eChemPortal (External link) | To OECD/eChemPortal (External link) |
Hazard class | Classification | Pictogram Signal word |
Hazard statement (code) |
Precautionary statement (code) |
Rationale for the classification | Classification year (FY) | GHS Classification Guidance for the Japanese Government | |
---|---|---|---|---|---|---|---|---|
1 | Explosives | Not classified (Not applicable) |
- |
- | - | There are no chemical groups associated with explosive properties present in the molecule. | FY2011 | GHS Classification Guidance by the Japanese Government (July, 2010) |
2 | Flammable gases | Not classified (Not applicable) |
- |
- | - | "Liquids" according to GHS definition. | FY2011 | GHS Classification Guidance by the Japanese Government (July, 2010) |
3 | Aerosols | Not classified (Not applicable) |
- |
- | - | Not an aerosol product. | FY2011 | GHS Classification Guidance by the Japanese Government (July, 2010) |
4 | Oxidizing gases | Not classified (Not applicable) |
- |
- | - | "Liquids" according to GHS definition. | FY2011 | GHS Classification Guidance by the Japanese Government (July, 2010) |
5 | Gases under pressure | Not classified (Not applicable) |
- |
- | - | "Liquids" according to GHS definition. | FY2011 | GHS Classification Guidance by the Japanese Government (July, 2010) |
6 | Flammable liquids | Category 4 |
Warning |
H227 | P370+P378 P210 P280 P403 P501 |
A flash point of 73 degrees C [closed-cup] (solvents pocket book (1994)) is > 60 degrees C and <= 93 degrees C, therefore it corresponds to Category 4. | FY2011 | GHS Classification Guidance by the Japanese Government (July, 2010) |
7 | Flammable solids | Not classified (Not applicable) |
- |
- | - | "Liquids" according to GHS definition. | FY2011 | GHS Classification Guidance by the Japanese Government (July, 2010) |
8 | Self-reactive substances and mixtures | Not classified (Not applicable) |
- |
- | - | Containing neither chemical groups related to explosibility nor those related to self-reactivity. | FY2011 | GHS Classification Guidance by the Japanese Government (July, 2010) |
9 | Pyrophoric liquids | Classification not possible |
- |
- | - | No data. | FY2011 | GHS Classification Guidance by the Japanese Government (July, 2010) |
10 | Pyrophoric solids | Not classified (Not applicable) |
- |
- | - | "Liquids" according to GHS definition. | FY2011 | GHS Classification Guidance by the Japanese Government (July, 2010) |
11 | Self-heating substances and mixtures | Classification not possible |
- |
- | - | No established test method suitable for liquid substances. | FY2011 | GHS Classification Guidance by the Japanese Government (July, 2010) |
12 | Substances and mixtures which, in contact with water, emit flammable gases | Not classified (Not applicable) |
- |
- | - | Not containing metals or semimetals (B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At). | FY2011 | GHS Classification Guidance by the Japanese Government (July, 2010) |
13 | Oxidizing liquids | Not classified (Not applicable) |
- |
- | - | An organic compound that contains fluorine which is not chemically bonded to elements other than carbon. | FY2011 | GHS Classification Guidance by the Japanese Government (July, 2010) |
14 | Oxidizing solids | Not classified (Not applicable) |
- |
- | - | "Liquids" according to GHS definition. | FY2011 | GHS Classification Guidance by the Japanese Government (July, 2010) |
15 | Organic peroxides | Not classified (Not applicable) |
- |
- | - | An organic compound that does not contain -O-O- structure. | FY2011 | GHS Classification Guidance by the Japanese Government (July, 2010) |
16 | Corrosive to metals | Classification not possible |
- |
- | - | No data. | FY2011 | GHS Classification Guidance by the Japanese Government (July, 2010) |
17 | Desensitized explosives | - |
- |
- | - | - | - | - |
Hazard class | Classification | Pictogram Signal word |
Hazard statement (code) |
Precautionary statement (code) |
Rationale for the classification | Classification year (FY) | GHS Classification Guidance for the Japanese Government | |
---|---|---|---|---|---|---|---|---|
1 | Acute toxicity (Oral) | Category 4 |
Warning |
H302 | P301+P312 P264 P270 P330 P501 |
On the basis of an LD50 value of 460 mg/kg for rats (HSDB (2003)), it was classified in Category 4. | FY2011 | GHS Classification Guidance by the Japanese Government (July, 2010) |
1 | Acute toxicity (Dermal) | Classification not possible |
- |
- | - | An LDLo value of 1250 mg/kg bw for rats (RTECS (2006): original literature National Technical Information Service. OTS0543265) is reported, but the classification is not possible because the category cannot be determined only from this data. | FY2011 | GHS Classification Guidance by the Japanese Government (July, 2010) |
1 | Acute toxicity (Inhalation: Gases) | Not classified (Not applicable) |
- |
- | - | "Liquids" according to GHS definition. | FY2011 | GHS Classification Guidance by the Japanese Government (July, 2010) |
1 | Acute toxicity (Inhalation: Vapours) | Classification not possible |
- |
- | - | No data. | FY2011 | GHS Classification Guidance by the Japanese Government (July, 2010) |
1 | Acute toxicity (Inhalation: Dusts and mists) | Classification not possible |
- |
- | - | No data. | FY2011 | GHS Classification Guidance by the Japanese Government (July, 2010) |
2 | Skin corrosion/irritation | Classification not possible |
- |
- | - | Lack of data. Besides, a standard Draize test in which 0.2 mg was applied to rabbit skin for 24 hours reports that irritation is severe (RTECS (2006)), but it was classified as "Classification not possible" due to the data from List 3 and unknown details. |
FY2011 | GHS Classification Guidance by the Japanese Government (July, 2010) |
3 | Serious eye damage/eye irritation | Category 2A |
Warning |
H319 | P305+P351+P338 P337+P313 P264 P280 |
On the basis of an MMAS (corresponding to AOI) of 69.8 in a test in which instillation of 0.1 ml of a 100 % solution of test substance was dosed into the conjunctival sac of six rabbits (OECD TG405, GLP), all of which showed corneal opacity, and conjunctivae redness and chemosis rating an average score of 1 or higher an hour after application, and five of them showed iritis after 3 days (ECETOC TR48 (1998)), it was classified in Category 2A. | FY2011 | GHS Classification Guidance by the Japanese Government (July, 2010) |
4 | Respiratory sensitization | Classification not possible |
- |
- | - | No data. | FY2011 | GHS Classification Guidance by the Japanese Government (July, 2010) |
4 | Skin sensitization | Classification not possible |
- |
- | - | No data. | FY2011 | GHS Classification Guidance by the Japanese Government (July, 2010) |
5 | Germ cell mutagenicity | Classification not possible |
- |
- | - | No data. | FY2011 | GHS Classification Guidance by the Japanese Government (July, 2010) |
6 | Carcinogenicity | Classification not possible |
- |
- | - | No data. | FY2011 | GHS Classification Guidance by the Japanese Government (July, 2010) |
7 | Reproductive toxicity | Classification not possible |
- |
- | - | No data. | FY2011 | GHS Classification Guidance by the Japanese Government (July, 2010) |
8 | Specific target organ toxicity - Single exposure | Classification not possible |
- |
- | - | "During short-term poisoning via the cutaneous route in rats, p-fluoroaniline causes a significant increase in methemoglobin level" is reported (HSDB (2003)), but the classification is not possible because exposure levels, exposure time, and results are unknown. | FY2011 | GHS Classification Guidance by the Japanese Government (July, 2010) |
9 | Specific target organ toxicity - Repeated exposure | Classification not possible |
- |
- | - | No data. | FY2011 | GHS Classification Guidance by the Japanese Government (July, 2010) |
10 | Aspiration hazard | Classification not possible |
- |
- | - | No data. | FY2011 | GHS Classification Guidance by the Japanese Government (July, 2010) |
Hazard class | Classification | Pictogram Signal word |
Hazard statement (code) |
Precautionary statement (code) |
Rationale for the classification | Classification year (FY) | GHS Classification Guidance for the Japanese Government | |
---|---|---|---|---|---|---|---|---|
11 | Hazardous to the aquatic environment Short term (Acute) | Category 3 |
- |
H402 | P273 P501 |
It was classified in Category 3 from 96-hour LC50 = 16.9 mg/L for fish (Pimephales promelas) (AQUIRE, 2012). | FY2011 | GHS Classification Guidance by the Japanese Government (July, 2010) |
11 | Hazardous to the aquatic environment Long term (Chronic) | Category 3 |
- |
H412 | P273 P501 |
Reliable chronic toxicity data are not obtained. It was classified in Category 3 from lack of rapid degradability (BIOWIN) and acute toxicity Category 3. |
FY2011 | GHS Classification Guidance by the Japanese Government (July, 2010) |
12 | Hazardous to the ozone layer | Classification not possible |
- |
- | - | This substance is not listed in Annexes to the Montreal Protocol. | FY2011 | GHS Classification Guidance by the Japanese Government (July, 2010) |
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