Item | Information |
---|---|
CAS RN | 4067-16-7 |
Chemical Name | Pentaethylenehexamine |
Substance ID | m-nite-4067-16-7_v1 |
Download of Excel format | Excel file |
Item | Information |
---|---|
Guidance used for the classification (External link) | To Guidance List |
UN GHS document (External link) | To UN GHS document |
FAQ(GHS classification results by the Japanese Government) | To FAQ |
List of Information Sources (Excel file) | List of Information Sources |
List of Definitions/Abbreviations | Definitions/Abbreviations |
Sample Label by MHLW (External link) | MHLW Website (in Japanese Only) |
Sample SDS by MHLW (External link) | MHLW Website (in Japanese Only) |
OECD/eChemPortal (External link) | To OECD/eChemPortal (External link) |
Hazard class | Classification | Pictogram Signal word |
Hazard statement (code) |
Precautionary statement (code) |
Rationale for the classification | Classification year (FY) | GHS Classification Guidance for the Japanese Government | |
---|---|---|---|---|---|---|---|---|
1 | Explosives | Not classified (Not applicable) |
- |
- | - | There are no chemical groups associated with explosive properties present in the molecule. | FY2011 | GHS Classification Guidance by the Japanese Government (July, 2010) |
2 | Flammable gases | Not classified (Not applicable) |
- |
- | - | "Liquids" according to GHS definition. | FY2011 | GHS Classification Guidance by the Japanese Government (July, 2010) |
3 | Aerosols | Not classified (Not applicable) |
- |
- | - | Not an aerosol product. | FY2011 | GHS Classification Guidance by the Japanese Government (July, 2010) |
4 | Oxidizing gases | Not classified (Not applicable) |
- |
- | - | "Liquids" according to GHS definition. | FY2011 | GHS Classification Guidance by the Japanese Government (July, 2010) |
5 | Gases under pressure | Not classified (Not applicable) |
- |
- | - | "Liquids" according to GHS definition. | FY2011 | GHS Classification Guidance by the Japanese Government (July, 2010) |
6 | Flammable liquids | Not classified |
- |
- | - | A flash point of 166 degrees C [closed cup] (Dictionary of Organic Compounds (1985)) is above 93 degrees C. | FY2011 | GHS Classification Guidance by the Japanese Government (July, 2010) |
7 | Flammable solids | Not classified (Not applicable) |
- |
- | - | "Liquids" according to GHS definition. | FY2011 | GHS Classification Guidance by the Japanese Government (July, 2010) |
8 | Self-reactive substances and mixtures | Not classified (Not applicable) |
- |
- | - | There are no chemical groups present in the molecule associated with explosive or self-reactive properties. | FY2011 | GHS Classification Guidance by the Japanese Government (July, 2010) |
9 | Pyrophoric liquids | Not classified |
- |
- | - | It is conceivable that it does not ignite at normal temperatures from an ignition point of 360 degrees C (NITE Chemical Risk Information Platform (Merck reagent catalog Chem DAT) Access on Nov. 2011). | FY2011 | GHS Classification Guidance by the Japanese Government (July, 2010) |
10 | Pyrophoric solids | Not classified (Not applicable) |
- |
- | - | "Liquids" according to GHS definition. | FY2011 | GHS Classification Guidance by the Japanese Government (July, 2010) |
11 | Self-heating substances and mixtures | Classification not possible |
- |
- | - | No established test method suitable for liquid substances. | FY2011 | GHS Classification Guidance by the Japanese Government (July, 2010) |
12 | Substances and mixtures which, in contact with water, emit flammable gases | Not classified (Not applicable) |
- |
- | - | Not containing metals or semimetals (B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At). | FY2011 | GHS Classification Guidance by the Japanese Government (July, 2010) |
13 | Oxidizing liquids | Not classified (Not applicable) |
- |
- | - | An organic compound that does not contain oxygen, fluorine, or chlorine. | FY2011 | GHS Classification Guidance by the Japanese Government (July, 2010) |
14 | Oxidizing solids | Not classified (Not applicable) |
- |
- | - | "Liquids" according to GHS definition. | FY2011 | GHS Classification Guidance by the Japanese Government (July, 2010) |
15 | Organic peroxides | Not classified (Not applicable) |
- |
- | - | An organic compound that does not contain -O-O- structure. | FY2011 | GHS Classification Guidance by the Japanese Government (July, 2010) |
16 | Corrosive to metals | Classification not possible |
- |
- | - | No data. | FY2011 | GHS Classification Guidance by the Japanese Government (July, 2010) |
17 | Desensitized explosives | - |
- |
- | - | - | - | - |
Hazard class | Classification | Pictogram Signal word |
Hazard statement (code) |
Precautionary statement (code) |
Rationale for the classification | Classification year (FY) | GHS Classification Guidance for the Japanese Government | |
---|---|---|---|---|---|---|---|---|
1 | Acute toxicity (Oral) | Category 4 |
Warning |
H302 | P301+P312 P264 P270 P330 P501 |
From an LD50 value of 1600 mg/kg for rats (Reproductive test, METI (Access on Nov. 2011), equivalent to List 2), it was classified in Category 4. | FY2011 | GHS Classification Guidance by the Japanese Government (July, 2010) |
1 | Acute toxicity (Dermal) | Classification not possible |
- |
- | - | No data. | FY2011 | GHS Classification Guidance by the Japanese Government (July, 2010) |
1 | Acute toxicity (Inhalation: Gases) | Not classified (Not applicable) |
- |
- | - | "Liquids" according to GHS definition. | FY2011 | GHS Classification Guidance by the Japanese Government (July, 2010) |
1 | Acute toxicity (Inhalation: Vapours) | Classification not possible |
- |
- | - | No data. | FY2011 | GHS Classification Guidance by the Japanese Government (July, 2010) |
1 | Acute toxicity (Inhalation: Dusts and mists) | Classification not possible |
- |
- | - | No data. | FY2011 | GHS Classification Guidance by the Japanese Government (July, 2010) |
2 | Skin corrosion/irritation | Classification not possible |
- |
- | - | Lack of data. Besides, it is regarded as corrosive to eyes, skin, and respiratory tract (Reproductive test, METI (Access on Nov. 2011)) but details are unknown. It is classified in R34 in EU classification (EC-JRC (ESIS) (Access on No. 2011)). |
FY2011 | GHS Classification Guidance by the Japanese Government (July, 2010) |
3 | Serious eye damage/eye irritation | Classification not possible |
- |
- | - | Lack of data. Besides, it is regarded as corrosive to eyes, skin, and respiratory tract (Reproductive test, METI (Access on Nov. 2011)) but details are unknown. |
FY2011 | GHS Classification Guidance by the Japanese Government (July, 2010) |
4 | Respiratory sensitization | Classification not possible |
- |
- | - | No data. | FY2011 | GHS Classification Guidance by the Japanese Government (July, 2010) |
4 | Skin sensitization | Classification not possible |
- |
- | - | No data. Besides, it is classified in R43 in EU classification (EC-JRC (ESIS) (Access on Nov. 2011)). |
FY2011 | GHS Classification Guidance by the Japanese Government (July, 2010) |
5 | Germ cell mutagenicity | Classification not possible |
- |
- | - | The classification is not possible due to no in vivo test data. Besides, an Ames test reported a negative as an in vitro test (NTP DB ID449184 (1982)). |
FY2011 | GHS Classification Guidance by the Japanese Government (July, 2010) |
6 | Carcinogenicity | Classification not possible |
- |
- | - | No data. | FY2011 | GHS Classification Guidance by the Japanese Government (July, 2010) |
7 | Reproductive toxicity | Classification not possible |
- |
- | - | As a result of an oral administration combined repeated dose toxicity study with reproductive/developmental toxicity test in rats (OECD TG422), deteriorated general condition or a marked decrease in body weights, abnormal nursing behaviors, deaths of maternal animals or all pups born at the highest dose of 400 mg/kg were observed. But a significant difference from the control group in sex cycle, copulation index, fertility index, the length of gestation, numbers of corpora lutea and implantation, implantation index, birth index, and delivery index were not shown. (Reproductive test, METI (Access on Nov. 2011)). Child animals showed a low number of alive pups and a low survival rate of 4 days after birth in the highest-dose group. But they were not used as bases for classification because it is explained that they were considered to be effects associated with deteriorated general condition of maternal animals. There were no other dose-related effects on numbers of pups born and alive pups born, a sex ratio, a birth rate, an external test, and necropsy (Reproductive test, METI (Access on Nov. 2011)). Accordingly, the test did not find adverse effects on sexual function and fertility. But it was classified as "Classification not possible" due to lacking data on adverse effects on development of the offspring including teratogenicity. |
FY2011 | GHS Classification Guidance by the Japanese Government (July, 2010) |
8 | Specific target organ toxicity - Single exposure | Classification not possible |
- |
- | - | No data. | FY2011 | GHS Classification Guidance by the Japanese Government (July, 2010) |
9 | Specific target organ toxicity - Repeated exposure | Category 2 (kidney) |
Warning |
H373 | P260 P314 P501 |
As a result of an oral administration combined repeated dose toxicity study with reproductive/developmental toxicity test in rats (doses: 25, 100, 400 mg/kg/day; OECD TG422), dead males and females at 400 mg/kg/day showed signs including soft stool, diarrhea, dirt lower abdomen, and dirt perirhinal part, a hunched posture, decreased spontaneous motility, or hypothermia. From vacuolar degeneration, regeneration or degeneration/necrosis of tubular epithelium in the kidney of males and females at 100 mg/kg/day in a histopathological examination (converted to a 90-day equivalent value: about 47 mg/kg/day) or higher (Reproductive test, METI (Access on Nov. 2011)), it was classified in Category 2 (kidney). Besides, focal inflammatory cellular infiltration in the lung observed in males only at 100 mg/kg/day or higher was reported to be an unknown mode of action in the same test. (Reproductive test, METI (Access on Nov. 2011)) |
FY2011 | GHS Classification Guidance by the Japanese Government (July, 2010) |
10 | Aspiration hazard | Classification not possible |
- |
- | - | No data. | FY2011 | GHS Classification Guidance by the Japanese Government (July, 2010) |
Hazard class | Classification | Pictogram Signal word |
Hazard statement (code) |
Precautionary statement (code) |
Rationale for the classification | Classification year (FY) | GHS Classification Guidance for the Japanese Government | |
---|---|---|---|---|---|---|---|---|
11 | Hazardous to the aquatic environment Short term (Acute) | Category 1 |
Warning |
H400 | P273 P391 P501 |
It was classified in Category 1 from 72-hour ErC50 = 0.42 mg/L for algae (Pseudokirchneriella subcapitata) (Results of Eco-toxicity tests of chemicals conducted by Ministry of the Environment in Japan, 2006). | FY2011 | GHS Classification Guidance by the Japanese Government (July, 2010) |
11 | Hazardous to the aquatic environment Long term (Chronic) | Category 1 |
Warning |
H410 | P273 P391 P501 |
If chronic toxicity data are used, then it is classified in Category 1 from non-rapidly degradable (a degradation rate by BOD: 0 % (the existing chemicals survey program, 2002)) and 72-hour NOEC = 0.072 mg/L for algae (Pseudokirchneriella subcapitata) (Results of Eco-toxicity tests of chemicals conducted by Ministry of the Environment in Japan, 2006). If acute toxicity data are used for trophic levels for which chronic toxicity data are lacking, then it is classified in Category 2 from non-rapidly degradable (a degradation rate by BOD: 0 % (the existing chemicals survey program, 2002)) and 48-hour EC50 = 8.0 mg/L for crustacea (Daphnia magna) (Results of Eco-toxicity tests of chemicals conducted by Ministry of the Environment in Japan, 2006). It was classified in Category 1 by a comparison between the above results. |
FY2011 | GHS Classification Guidance by the Japanese Government (July, 2010) |
12 | Hazardous to the ozone layer | Classification not possible |
- |
- | - | This substance is not listed in Annexes to the Montreal Protocol. | FY2011 | GHS Classification Guidance by the Japanese Government (July, 2010) |
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