Item | Information |
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CAS RN | 4098-71-9 |
Chemical Name | Cyclohexane, 5-isocyanato-1-(isocyanatomethyl)-1,3,3-trimethyl- |
Substance ID | m-nite-4098-71-9_v1 |
Download of Excel format | Excel file |
Item | Information |
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Guidance used for the classification (External link) | To Guidance List |
UN GHS document (External link) | To UN GHS document |
FAQ(GHS classification results by the Japanese Government) | To FAQ |
List of Information Sources (Excel file) | List of Information Sources |
List of Definitions/Abbreviations | Definitions/Abbreviations |
Sample Label by MHLW (External link) | MHLW Website (in Japanese Only) |
Sample SDS by MHLW (External link) | MHLW Website (in Japanese Only) |
OECD/eChemPortal (External link) | To OECD/eChemPortal (External link) |
Hazard class | Classification | Pictogram Signal word |
Hazard statement (code) |
Precautionary statement (code) |
Rationale for the classification | Classification year (FY) | GHS Classification Guidance for the Japanese Government | |
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1 | Explosives | Not classified (Not applicable) |
- |
- | - | There are no chemical groups associated with explosive properties present in the molecule. | FY2011 | GHS Classification Guidance by the Japanese Government (July, 2010) |
2 | Flammable gases | Not classified (Not applicable) |
- |
- | - | Liquid (GHS definition) | FY2011 | GHS Classification Guidance by the Japanese Government (July, 2010) |
3 | Aerosols | Not classified (Not applicable) |
- |
- | - | Not aerosol products. | FY2011 | GHS Classification Guidance by the Japanese Government (July, 2010) |
4 | Oxidizing gases | Not classified (Not applicable) |
- |
- | - | Liquid (GHS definition) | FY2011 | GHS Classification Guidance by the Japanese Government (July, 2010) |
5 | Gases under pressure | Not classified (Not applicable) |
- |
- | - | Liquid (GHS definition) | FY2011 | GHS Classification Guidance by the Japanese Government (July, 2010) |
6 | Flammable liquids | Not classified |
- |
- | - | A flash point of 155 deg C [closed-cup] (ICSC (2008)) is above 93 deg C. | FY2011 | GHS Classification Guidance by the Japanese Government (July, 2010) |
7 | Flammable solids | Not classified (Not applicable) |
- |
- | - | Liquid (GHS definition) | FY2011 | GHS Classification Guidance by the Japanese Government (July, 2010) |
8 | Self-reactive substances and mixtures | Not classified (Not applicable) |
- |
- | - | There are no chemical groups present in the molecule associated with explosive or self-reactive properties. | FY2011 | GHS Classification Guidance by the Japanese Government (July, 2010) |
9 | Pyrophoric liquids | Not classified |
- |
- | - | It is estimated that it does not ignite at normal temperatures from an autoignition temperature of 430 deg C (ICSC (2008)). | FY2011 | GHS Classification Guidance by the Japanese Government (July, 2010) |
10 | Pyrophoric solids | Not classified (Not applicable) |
- |
- | - | Liquid (GHS definition) | FY2011 | GHS Classification Guidance by the Japanese Government (July, 2010) |
11 | Self-heating substances and mixtures | Classification not possible |
- |
- | - | Test methods applicable to liquid substances are not available. | FY2011 | GHS Classification Guidance by the Japanese Government (July, 2010) |
12 | Substances and mixtures which, in contact with water, emit flammable gases | Not classified (Not applicable) |
- |
- | - | The chemical structure of the substance does not contain metals or metalloids (B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At). | FY2011 | GHS Classification Guidance by the Japanese Government (July, 2010) |
13 | Oxidizing liquids | Not classified (Not applicable) |
- |
- | - | The substance is an organic compound containing oxygen (but not fluorine or chlorine) which is chemically bonded only to carbon. | FY2011 | GHS Classification Guidance by the Japanese Government (July, 2010) |
14 | Oxidizing solids | Not classified (Not applicable) |
- |
- | - | Liquid (GHS definition) | FY2011 | GHS Classification Guidance by the Japanese Government (July, 2010) |
15 | Organic peroxides | Not classified (Not applicable) |
- |
- | - | Organic compounds containing no bivalent -O-O- structure. | FY2011 | GHS Classification Guidance by the Japanese Government (July, 2010) |
16 | Corrosive to metals | Classification not possible |
- |
- | - | No data available. | FY2011 | GHS Classification Guidance by the Japanese Government (July, 2010) |
17 | Desensitized explosives | - |
- |
- | - | - | - | - |
Hazard class | Classification | Pictogram Signal word |
Hazard statement (code) |
Precautionary statement (code) |
Rationale for the classification | Classification year (FY) | GHS Classification Guidance for the Japanese Government | |
---|---|---|---|---|---|---|---|---|
1 | Acute toxicity (Oral) | Not classified |
- |
- | - | All four LD50 values for rats [4,814 mg/kg, 5,490 mg/kg, > 2,645 mg/kg (the above, SIDS (2006)), 4,825 mg/kg (Environmental Risk Assessment for Chemical Substances vol. 3 (Ministry of the Environment, 2004))] correspond to "Not classified" in the Classification JIS (Category 5 in UN GHS classification or "Not classified"). | FY2011 | GHS Classification Guidance by the Japanese Government (July, 2010) |
1 | Acute toxicity (Dermal) | Not classified |
- |
- | - | It was classified as "Not classified" based on an LD50 value of > 7,000 mg/kg for rats [OECD TG 402] (SIDS (2006)). | FY2011 | GHS Classification Guidance by the Japanese Government (July, 2010) |
1 | Acute toxicity (Inhalation: Gases) | Not classified (Not applicable) |
- |
- | - | Liquid (GHS definition) | FY2011 | GHS Classification Guidance by the Japanese Government (July, 2010) |
1 | Acute toxicity (Inhalation: Vapours) | Classification not possible |
- |
- | - | No data available. | FY2011 | GHS Classification Guidance by the Japanese Government (July, 2010) |
1 | Acute toxicity (Inhalation: Dusts and mists) | Category 1 |
Danger |
H330 | P304+P340 P403+P233 P260 P271 P284 P310 P320 P405 P501 |
Both LC50 values (mist) for rats of 0.04 mg/L/4 hours and 0.031 mg/L/4 hours [OECD TG 403; GLP] (SIDS (2006)) correspond to Category 1. | FY2011 | GHS Classification Guidance by the Japanese Government (July, 2010) |
2 | Skin corrosion/irritation | Category 1 |
Danger |
H314 | P301+P330+P331 P303+P361+P353 P305+P351+P338 P304+P340 P260 P264 P280 P310 P321 P363 P405 P501 |
In three tests by 4-hour occlusive (semi-occlusive) application of 0.5 mL of the undiluted test substance to the rabbit skin (all, OECD TG 404), the primary dermal irritation index (PDII) was 6.87, 4.5, and 3.71, and it was all judged as corrosive (SIDS (2006)). Therefore, it was classified in Category 1. Besides, the EU classified it in R36/37/38 (EC-JRC (ESIS) (Access on Sept. 2011)). | FY2011 | GHS Classification Guidance by the Japanese Government (July, 2010) |
3 | Serious eye damage/eye irritation | Category 2A |
Warning |
H319 | P305+P351+P338 P337+P313 P264 P280 |
It was assessed as corrosive in a test in which 0.1 mL of the undiluted test substance was applied to the rabbit eye (OECD TG 405) (SIDS (2006)), but the irritation index (equivalent to AOI) was 36.4 (/110). It was classified in Category 2A based on the irritation index. Besides, it was reported to be not irritating with the irritation index (equivalent to AOI) of 9.96 (/110) in another test with rabbits (OECD TG 405), and exudation in the eye was seen at 1 and 24 hours in the test. Also, it is mentioned that all the animals showed loss of hair around the eye and incrustation at the eyelid associated with thickening after ten days after treatment, which was not reflected in the scores (SIDS (2006)). By considering this, it was concluded in SIDS (2006) that this substance is severely irritating to the eye as a whole (SIDS (2006)). | FY2011 | GHS Classification Guidance by the Japanese Government (July, 2010) |
4 | Respiratory sensitization | Category 1 |
Danger |
H334 | P304+P340 P342+P311 P261 P284 P501 |
In humans, there is a case report in which a person developed severe asthma after occupational exposure, a bronchial inhalation test gave a positive response to this substance, and he had respiratory hypersensitivity (Environmental Risk Assessment for Chemical Substances vol. 3 (Ministry of the Environment, 2004), SIDS (2006)). Furthermore, this substance is listed as a respiratory sensitizer by the Japanese Society of Occupational and Environmental Allergy (List of sensitizing substances by ALGY society), Deutsche Forschungsgemeinschaft (DFG) (MAK/BAT (2010)), and the American Conference of Governmental Industrial Hygienists (ACGIH (2001)), and the EU classified it in R42/43 (EC-JRC (ESIS) (Access on Sept. 2011)). Based on the above knowledge, it was classified in Category 1. | FY2011 | GHS Classification Guidance by the Japanese Government (July, 2010) |
4 | Skin sensitization | Category 1 |
Warning |
H317 | P302+P352 P333+P313 P362+P364 P261 P272 P280 P321 P501 |
It is reported that in two maximization tests with guinea pigs (OECD TG 406), it was sensitizing in both with positive rates of 75% (15/20) and 95% (19/20) (SIDS (2006)), and also in two Buehler tests with guinea pigs, it was sensitizing in both with positive rates of 75% (15/20) and 95% (19/20) (SIDS (2006)). On the other hand, anomalies in the skin were also seen after exposure in humans, and there are reports on multiple cases in which persons were patch tested positive to this substance (Environmental Risk Assessment for Chemical Substances vol. 3 (Ministry of the Environment, 2004), SIDS (2006)). It was classified in Category 1 based on the above knowledge of animals and humans. | FY2011 | GHS Classification Guidance by the Japanese Government (July, 2010) |
5 | Germ cell mutagenicity | Not classified |
- |
- | - | It was classified as "Not classified" based on a negative result in a micronucleus test with erythrocytes after inhalation administration to mice (in vivo somatic cell mutagenicity test) (SIDS (2006)). Besides, as for in vitro tests, there are reports on a negative result in an Ames test (SIDS (2006), NTP DB Study ID 225422 (1982)) and a positive result in a chromosomal aberration test with Chinese hamster ovary cells (SIDS (2006)). | FY2011 | GHS Classification Guidance by the Japanese Government (July, 2010) |
6 | Carcinogenicity | Classification not possible |
- |
- | - | No data available. | FY2011 | GHS Classification Guidance by the Japanese Government (July, 2010) |
7 | Reproductive toxicity | Classification not possible |
- |
- | - | In a developmental toxicity test by inhalation exposure of rats on gestational days 6-19, general toxicity was seen in maternal animals, including reduced weight gain, decreased food consumption, and effects on the respiratory tract, in the highest dose, while developmental toxicity was limited to decreased fetal body weight, delayed descensus testis, and retarded ossification found at the same dose, and no other effects, including teratogenicity, were observed (SIDS (2006)). Therefore, there were no adverse effects on the development of offspring, but effects on sexual function and fertility are unknown, and it was classified as "Classification not possible" due to insufficient data. | FY2011 | GHS Classification Guidance by the Japanese Government (July, 2010) |
8 | Specific target organ toxicity - Single exposure | Category 1 (respiratory system) |
Danger |
H370 | P308+P311 P260 P264 P270 P321 P405 P501 |
After inhalation exposure (mist) of rats, signs of respiratory tract distress (tachypnea, bradypnea, stridor) were seen at or above 0.020 mg/L/4 hours, and six out of ten animals died at 0.533 mg/L/4 hours. In necropsy of dead animals, a less collapsed lung and some focal discoloration of the lung were sporadically observed, and the nose/muzzle with red incrustations, mucous membranes of the nose with reddening, the pleural cavity filled with liquid, and the lung less collapsed emphysematous were seen (SIDS (2006)). Furthermore, after inhalation exposure (mist) of mice, bradypnea, labored breathing, and stridor were found at or above 0.005 mg/L/6 hours (converted 4-hour equivalent value: 0.0075 mg/L) (SIDS (2006)). Because the above findings were seen at doses corresponding to the guidance value range for Category 1, it was classified in Category 1 (respiratory system). Besides, in a test by exposure of human volunteers for 1-5 minutes, strong irritation of the respiratory tract was reported at 0.00137 mg/L (Environmental Risk Assessment for Chemical Substances vol. 3 (Ministry of the Environment, 2004)). | FY2011 | GHS Classification Guidance by the Japanese Government (July, 2010) |
9 | Specific target organ toxicity - Repeated exposure | Category 1 (respiratory system) |
Danger |
H372 | P260 P264 P270 P314 P501 |
In a 4-week inhalation exposure test with rats (vapour), pulmonary edema was observed at 1.37 mg/m3/4 hours (converted guidance value: 0.31 mg/m3/6 hours/day) (Environmental Risk Assessment for Chemical Substances vol. 3 (Ministry of the Environment, 2004)). Furthermore, in another 4-week inhalation exposure test with rats (OECD TG 412; GLP), at 4 mg/m3/6 hours (converted guidance value: about 1.3 mg/m3/6 hours), in addition to respiratory tract irritation found, the pharynx, trachea, and lung were affected, and recovery in the lung and trachea was complete during the 4-week recovery period, but lesions in the nasal cavity, pharynx, and larynx still occurred in some animals with minimal or slight degree (SIDS (2006)). Because the above findings were seen at doses corresponding to the guidance value range for Category 1, it was classified in Category 1 (respiratory system). | FY2011 | GHS Classification Guidance by the Japanese Government (July, 2010) |
10 | Aspiration hazard | Classification not possible |
- |
- | - | No data available. | FY2011 | GHS Classification Guidance by the Japanese Government (July, 2010) |
Hazard class | Classification | Pictogram Signal word |
Hazard statement (code) |
Precautionary statement (code) |
Rationale for the classification | Classification year (FY) | GHS Classification Guidance for the Japanese Government | |
---|---|---|---|---|---|---|---|---|
11 | Hazardous to the aquatic environment Short term (Acute) | Category 3 |
- |
H402 | P273 P501 |
It was classified in Category 3 from 24-hour EC50 = 83.7 mg/L for crustacea (Daphnia magna) (IUCLID, 2000). | FY2011 | GHS Classification Guidance by the Japanese Government (July, 2010) |
11 | Hazardous to the aquatic environment Long term (Chronic) | Category 3 |
- |
H412 | P273 P501 |
Reliable chronic toxicity data were not obtained. Because it is not rapidly degradable (in a 2-week test on a degradation rate, it changes in the test solution to generate 3-aminomethyl-3,5,5-trimethylcyclohexylamine (not readily degradable (Biodegradation and Bioconcentration Results of Existing Chemical Substances under the Chemical Substances Control Law, 2000)) and its intermediates (3-isocyanatomethyl-3,5,5-trimethylcyclohexylamine or 3-aminomethyl-3,5,5-trimethylcyclohexylisocyanate) (Biodegradation and Bioconcentration Results of Existing Chemical Substances under the Chemical Substances Control Law, 2002)), and it was classified in Category 3 in acute toxicity, it was classified in Category 3. | FY2011 | GHS Classification Guidance by the Japanese Government (July, 2010) |
12 | Hazardous to the ozone layer | Classification not possible |
- |
- | - | This substance is not listed in the Annexes to the Montreal Protocol. | FY2011 | GHS Classification Guidance by the Japanese Government (July, 2010) |
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