NITE - Chemical Management Field

Latest GHS Classification Results by the Japanese Government (edited by NITE)

GENERAL INFORMATION

Item	Information
CAS RN	41593-38-8
Chemical Name	Propylene glycol phenyl ether (mixed isomer)
Substance ID	m-nite-41593-38-8_v1
Download of Excel format	Excel file

REFERENCE INFORMATION

Item	Information
Guidance used for the classification (External link)	To Guidance List
UN GHS document (External link)	To UN GHS document
FAQ（GHS classification results by the Japanese Government）	To FAQ
List of Information Sources (Excel file)	List of Information Sources
List of Definitions/Abbreviations	Definitions/Abbreviations
Sample Label by MHLW (External link)	MHLW Website (in Japanese Only)
Sample SDS by MHLW (External link)	MHLW Website (in Japanese Only)
OECD/eChemPortal (External link)	To OECD/eChemPortal (External link)

PHYSICAL HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification	Classification year (FY)	GHS Classification Guidance for the Japanese Government
1	Explosives	Not classified (Not applicable)	- -	-	-	There are no chemical groups associated with explosive properties present in the molecule.	FY2011	GHS Classification Guidance by the Japanese Government （July, 2010）
2	Flammable gases	Not classified (Not applicable)	- -	-	-	"Liquids" according to GHS definition.	FY2011	GHS Classification Guidance by the Japanese Government （July, 2010）
3	Aerosols	Not classified (Not applicable)	- -	-	-	Not an aerosol product.	FY2011	GHS Classification Guidance by the Japanese Government （July, 2010）
4	Oxidizing gases	Not classified (Not applicable)	- -	-	-	"Liquids" according to GHS definition.	FY2011	GHS Classification Guidance by the Japanese Government （July, 2010）
5	Gases under pressure	Not classified (Not applicable)	- -	-	-	"Liquids" according to GHS definition.	FY2011	GHS Classification Guidance by the Japanese Government （July, 2010）
6	Flammable liquids	Not classified	- -	-	-	A flash point of 120 degrees C [closed cup] (SIDS (2004)) is above 93 degrees C.	FY2011	GHS Classification Guidance by the Japanese Government （July, 2010）
7	Flammable solids	Not classified (Not applicable)	- -	-	-	"Liquids" according to GHS definition.	FY2011	GHS Classification Guidance by the Japanese Government （July, 2010）
8	Self-reactive substances and mixtures	Not classified (Not applicable)	- -	-	-	There are no chemical groups present in the molecule associated with explosive or self-reactive properties.	FY2011	GHS Classification Guidance by the Japanese Government （July, 2010）
9	Pyrophoric liquids	Not classified	- -	-	-	It is conceivable that it does not ignite at normal temperatures from an ignition point of 490 degrees C (SIDS (2004)).	FY2011	GHS Classification Guidance by the Japanese Government （July, 2010）
10	Pyrophoric solids	Not classified (Not applicable)	- -	-	-	"Liquids" according to GHS definition.	FY2011	GHS Classification Guidance by the Japanese Government （July, 2010）
11	Self-heating substances and mixtures	Classification not possible	- -	-	-	No established test method suitable for liquid substances.	FY2011	GHS Classification Guidance by the Japanese Government （July, 2010）
12	Substances and mixtures which, in contact with water, emit flammable gases	Not classified (Not applicable)	- -	-	-	Not containing metals or semimetals (B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At).	FY2011	GHS Classification Guidance by the Japanese Government （July, 2010）
13	Oxidizing liquids	Not classified (Not applicable)	- -	-	-	An organic compound does not contain fluorine or chlorine but contains oxygen which is not chemically bonded to elements other than carbon or hydrogen.	FY2011	GHS Classification Guidance by the Japanese Government （July, 2010）
14	Oxidizing solids	Not classified (Not applicable)	- -	-	-	"Liquids" according to GHS definition.	FY2011	GHS Classification Guidance by the Japanese Government （July, 2010）
15	Organic peroxides	Not classified (Not applicable)	- -	-	-	An organic compound that does not contain -O-O- structure.	FY2011	GHS Classification Guidance by the Japanese Government （July, 2010）
16	Corrosive to metals	Classification not possible	- -	-	-	No data.	FY2011	GHS Classification Guidance by the Japanese Government （July, 2010）
17	Desensitized explosives	-	- -	-	-	-	-	-

HEALTH HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification	Classification year (FY)	GHS Classification Guidance for the Japanese Government
1	Acute toxicity (Oral)	Not classified	- -	-	-	On the basis of 3 LD50 values for rats (>2000 mg/kg, 2830 mg/kg (males), 3730 mg/kg (females)) (SIDS (2004)), it was classified as "Not classified" in JIS classification (corresponding to Category 5 in UN GHS classification).	FY2011	GHS Classification Guidance by the Japanese Government （July, 2010）
1	Acute toxicity (Dermal)	Not classified	- -	-	-	From no death after administration at 2000 mg/kg and an LD50 value of >2000 mg/kg bw in rats (SIDS (2004)), it was classified as "Not classified."	FY2011	GHS Classification Guidance by the Japanese Government （July, 2010）
1	Acute toxicity (Inhalation: Gases)	Not classified (Not applicable)	- -	-	-	"Liquids" according to GHS definition.	FY2011	GHS Classification Guidance by the Japanese Government （July, 2010）
1	Acute toxicity (Inhalation: Vapours)	Classification not possible	- -	-	-	No data.	FY2011	GHS Classification Guidance by the Japanese Government （July, 2010）
1	Acute toxicity (Inhalation: Dusts and mists)	Not classified	- -	-	-	From no death after a 4-hour exposure to 5.4 mg/L (mist) (OECD TG 403; GLP) and an LC50 value of >5.4 mg/L/4h in rats (SIDS (2004)), it was classified as "Not classified."	FY2011	GHS Classification Guidance by the Japanese Government （July, 2010）
2	Skin corrosion/irritation	Not classified	- -	-	-	In a semi-occlusive test applied 0.5 mL of undiluted this substance to 3 rabbits for 4 hours (OECD TG 404; GLP), the only irritation score higher than 0 was an erythema score of 1 in 1 animal observed 30 to 60 minutes after a removal of a patch. A score of 0 in all animals observed after 24, 48, and 72 hours resulted in not irritating. (SIDS (2004)) Therefore, it was classified as "Not classified."	FY2011	GHS Classification Guidance by the Japanese Government （July, 2010）
3	Serious eye damage/eye irritation	Category 2A	Warning	H319	P305+P351+P338 P337+P313 P264 P280	In a test applied 0.1 mL of undiluted this substance to eyes of 3 rabbits (OECD TG 405; GLP), average scores in 3 animals at time points of 24, 48, and 72 hours after application were 1 for corneal opacity, 0.4 for iritis, 2.0 for conjunctival redness, and 0.9 for chemosis. And it was assessed as highly irritating from a score of 1 in corneal opacity and scores of 2 and 3 in conjunctival redness observed in 2 out of 3 animals after 23 days. (SIDS (2004)) Threfore, it was classified in Category 2A. Besides, another test applied undiluted this substance to eyes of 3 rabbits reported that produced slight conjunctival irritation, and slight and transient corneal injury reversed within a few days to 1 week. (ECETOC 95 (2005))	FY2011	GHS Classification Guidance by the Japanese Government （July, 2010）
4	Respiratory sensitization	Classification not possible	- -	-	-	No data.	FY2011	GHS Classification Guidance by the Japanese Government （July, 2010）
4	Skin sensitization	Not classified	- -	-	-	On the basis that it was not sensitizing as a result of a skin sensitization test using guinea pigs (Buehler method: OECD TG 406, GLP) with a positive rate of 0% (0/20) (SIDS (2004)), it was classified as "Not classified."	FY2011	GHS Classification Guidance by the Japanese Government （July, 2010）
5	Germ cell mutagenicity	Not classified	- -	-	-	In a micronucleus test using bone marrow after an oral administration to mice (in vivo somatic cell mutagenicity test), the slightly increased frequency of micronuclei in animals in a high dose group (2000 mg/kg) was statistically significant in the first test but was not significant in the second (indicated a similar tendency). The author of this study attributed this fact to hypothermia. Causing hypothermia only in animals at the high dose and increased micronuclei as its indirect effects were clarified by other chemicals. It seems reasonable to conclude that the negative in vitro results and the equivocal in vivo results at a very high dose level that may be due to physiological stress indicate that propylene glycol phenyl ether does not pose a genotoxicity hazard at a possible exposure dose in the environment (SIDS (2004)). From the above information, it was classified as "Not classified." Besides, an Ames test and a chromosomal aberration test using human lymphocytes resulted in negatives as in vitro tests (SIDS (2004)).	FY2011	GHS Classification Guidance by the Japanese Government （July, 2010）
6	Carcinogenicity	Classification not possible	- -	-	-	No data.	FY2011	GHS Classification Guidance by the Japanese Government （July, 2010）
7	Reproductive toxicity	Not classified	- -	-	-	In a two-generation reproductive toxicity test by drinking water administration to rats (OECD TG 416, GLP), no adverse effects on fertility and reproductive organs/tissue in each generation at a dose (5000 ppm) where general toxicity (decreases in water and food consumption, decreased body weight gain) was observed in parent animals, and no adverse developmental effects except decreased body weight, changes in organ weights, and delayed sexual maturation in fetuses at the same dose were reported. (SIDS (2004)) Besides, in an oral administration test to pregnant rabbits during an organogenetic period (OECD TG 414, GLP), no adverse developmental effects including teratogenicity except increased skeletal variations in fetuses (an increase in 13th ribs) at a dose (540 mg/kg/day) where maternal animals showed general toxicity (decreases in food consumption and body weight gain) were observed (SIDS (2004)). From the above, it was classified as "Not classified" because neither adverse effects on sexual function and fertility nor fetal development was observed.	FY2011	GHS Classification Guidance by the Japanese Government （July, 2010）
8	Specific target organ toxicity - Single exposure	Category 3 (Narcotic effects)	Warning	H336	P304+P340 P403+P233 P261 P271 P312 P405 P501	A death of a male in a 1000 mg/kg group and toxic signs of apathy, staggering gait, atonia, and absence of pain and corneal reflex after oral administration of 1000 and 2000 mg/kg (5 each of male and female rats per each dose) to rats were described. And the disappearance of these signs on the day of administration or later was reported. (SIDS (2004)) Therefore, it was classified in Category 3 (narcotic effects).	FY2011	GHS Classification Guidance by the Japanese Government （July, 2010）
9	Specific target organ toxicity - Repeated exposure	Classification not possible	- -	-	-	In a two-generation reproductive toxicity test by oral administration to rats for 26 weeks (drinking water) (OECD TG 416: GLP), no serious effects observation in parent animals and NOAEL of 1000 ppm (114 mg/kg/day) were reported. (SIDS (2004)) Besides, in a 28-week dermal administration toxicity test using rabbits, a NOAEL of 1000 mg/kg/day (converted to a 90-day equivalent: 311 mg/kg/day) was reported. (SIDS (2004)) NOAELs above the upper limit in Guidance values in both oral and dermal routes correspond to "Not classified," but the classification not possible due to no data on inhalation route.	FY2011	GHS Classification Guidance by the Japanese Government （July, 2010）
10	Aspiration hazard	Classification not possible	- -	-	-	No data.	FY2011	GHS Classification Guidance by the Japanese Government （July, 2010）

ENVIRONMENTAL HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification	Classification year (FY)	GHS Classification Guidance for the Japanese Government
11	Hazardous to the aquatic environment Short term (Acute)	Not classified	- -	-	-	From above 100 mg/L in the acute toxicity tests for fish, crustacea, and algae (SIDS 2004), it was classified as "Not classified."	FY2011	GHS Classification Guidance by the Japanese Government （July, 2010）
11	Hazardous to the aquatic environment Long term (Chronic)	Not classified	- -	-	-	If chronic toxicity data are used, then it is classified as "Not classified" from 72-hour NOEC = 12.5 mg/L for algae (Scenedesmus subspicatus) (SIDS (2004)) despite not obtaining appropriate data on rapid degradability. If acute toxicity data are used for trophic levels for which chronic toxicity data are not obtained, then it is classified as "Not classified" because acute toxicity for both crustacea and fish corresponds to "Not classified" and it is not water-insoluble (water solubility = 10,000 mg/L, SIDS (2004)). From the above results, it was classified as "Not classified."	FY2011	GHS Classification Guidance by the Japanese Government （July, 2010）
12	Hazardous to the ozone layer	Classification not possible	- -	-	-	This substance is not listed in Annexes to the Montreal Protocol.	FY2011	GHS Classification Guidance by the Japanese Government （July, 2010）

NOTE:

GHS Classification Result by the Japanese Government is intended to provide a reference for preparing a GHS label or SDS for users. To include the same classification result in a label or SDS for Japan is NOT mandatory.
Users can cite or copy this classification result when preparing a GHS label or SDS. Please be aware, however, that the responsibility for a label or SDS prepared by citing or copying this classification result lies with users.
This GHS classification was conducted based on the information sources and the guidance for classification and judgement which are described in the GHS Classification Guidance for the Japanese Government etc. Using other literature, test results etc. as evidence and including different content from this classification result in a label or SDS are allowed.
Hazard statement and precautionary statement will show by hovering the mouse cursor over a code in the column of "Hazard statement" and "Precautionary statement," respectively. In the excel file, both the codes and statements are provided.
A blank or "-" in the column of "Classification" denotes that a classification for the hazard class was not conducted in the year.
An asterisk “*” in the column of “Classification” denotes that “Not classified (or No applicable)” and/or “Classification not possible” is applicable. Details are described in the column of “Rationale for the classification”. If no English translation is available for “Rationale for the classification,” please refer to the Japanese version of the results.

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