Item | Information |
---|---|
CAS RN | 420-46-2 |
Chemical Name | 1,1,1-Trifluoroethane |
Substance ID | m-nite-420-46-2_v1 |
Download of Excel format | Excel file |
Item | Information |
---|---|
Guidance used for the classification (External link) | To Guidance List |
UN GHS document (External link) | To UN GHS document |
FAQ(GHS classification results by the Japanese Government) | To FAQ |
List of Information Sources (Excel file) | List of Information Sources |
List of Definitions/Abbreviations | Definitions/Abbreviations |
Sample Label by MHLW (External link) | To Workplace Safety Site (MHLW) |
Sample SDS by MHLW (External link) | To Workplace Safety Site (MHLW) |
OECD/eChemPortal (External link) | To OECD/eChemPortal (External link) |
Hazard class | Classification | Pictogram Signal word |
Hazard statement (code) |
Precautionary statement (code) |
Rationale for the classification | Classification year (FY) | GHS Classification Guidance for the Japanese Government | |
---|---|---|---|---|---|---|---|---|
1 | Explosives | Not classified (Not applicable) |
- |
- | - | Gas (GHS definition). It was classified as "Not classified (Not applicable)." | FY2019 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
2 | Flammable gases | Category 1 |
Danger |
H220 | P210 P377 P381 P403 |
It was classified in Category 1 based on a lower explosion limit of 7.1 vol% (GESTIS (Access on Sep. 2019)). Besides, it is classified in Division 2.1 in UNRTDG (UN2035). | FY2019 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
3 | Aerosols | Not classified (Not applicable) |
- |
- | - | Not aerosol products. It was classified as "Not classified (Not applicable)." | FY2019 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
4 | Oxidizing gases | Not classified |
- |
- | - | It was classified as "Not classified" because it is classified in Division 2.1 in UNRTDG (UN2035), and Division 5.1 is not assigned, including Subsidiary Risk. | FY2019 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
5 | Gases under pressure | Low pressure liquefied gas |
Warning |
H280 | P410+P403 | It was classified as low-pressure liquefied gases from a critical temperature of 345.89 K (72.9 deg C, HSDB (Access on October 2019)). | FY2019 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
6 | Flammable liquids | Not classified (Not applicable) |
- |
- | - | Gas (GHS definition). It was classified as "Not classified (Not applicable)." | FY2019 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
7 | Flammable solids | Not classified (Not applicable) |
- |
- | - | Gas (GHS definition). It was classified as "Not classified (Not applicable)." | FY2019 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
8 | Self-reactive substances and mixtures | Not classified (Not applicable) |
- |
- | - | Gas (GHS definition). It was classified as "Not classified (Not applicable)." | FY2019 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
9 | Pyrophoric liquids | Not classified (Not applicable) |
- |
- | - | Gas (GHS definition). It was classified as "Not classified (Not applicable)." | FY2019 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
10 | Pyrophoric solids | Not classified (Not applicable) |
- |
- | - | Gas (GHS definition). It was classified as "Not classified (Not applicable)." | FY2019 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
11 | Self-heating substances and mixtures | Not classified (Not applicable) |
- |
- | - | Gas (GHS definition). It was classified as "Not classified (Not applicable)." | FY2019 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
12 | Substances and mixtures which, in contact with water, emit flammable gases | Not classified (Not applicable) |
- |
- | - | Gas (GHS definition). It was classified as "Not classified (Not applicable)." | FY2019 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
13 | Oxidizing liquids | Not classified (Not applicable) |
- |
- | - | Gas (GHS definition). It was classified as "Not classified (Not applicable)." | FY2019 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
14 | Oxidizing solids | Not classified (Not applicable) |
- |
- | - | Gas (GHS definition). It was classified as "Not classified (Not applicable)." | FY2019 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
15 | Organic peroxides | Not classified (Not applicable) |
- |
- | - | Gas (GHS definition). It was classified as "Not classified (Not applicable)." | FY2019 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
16 | Corrosive to metals | Classification not possible |
- |
- | - | Classification is not possible because test methods applicable to gas substances are not available. | FY2019 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
17 | Desensitized explosives | Not classified (Not applicable) |
- |
- | - | Gas (GHS definition). It was classified as "Not classified." | FY2019 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
Hazard class | Classification | Pictogram Signal word |
Hazard statement (code) |
Precautionary statement (code) |
Rationale for the classification | Classification year (FY) | GHS Classification Guidance for the Japanese Government | |
---|---|---|---|---|---|---|---|---|
1 | Acute toxicity (Oral) | Not classified (Not applicable) |
- |
- | - | [Rationale for the Classification] Gas (GHS definition). It was classified as "Not classified (Not applicable)." |
FY2019 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
1 | Acute toxicity (Dermal) | Not classified (Not applicable) |
- |
- | - | [Rationale for the Classification] Gas (GHS definition). It was classified as "Not classified (Not applicable)." |
FY2019 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
1 | Acute toxicity (Inhalation: Gases) | Not classified |
- |
- | - | [Rationale for the Classification] Based on (1)-(3), it was classified as "Not classified." [Evidence Data] (1) LC50 for rats: > 540,000 ppm (PATTY (6th, 2012), ECETOC JACC 52 (2006), HSDB (Access on September 2019)) (2) LC50 for rats: > 591,000 ppm (PATTY (6th, 2012), SIDS (2012)) (3) LC50 for rats: > 600,000 ppm (ECETOC JACC 52 (2006)) |
FY2019 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
1 | Acute toxicity (Inhalation: Vapours) | Not classified (Not applicable) |
- |
- | - | [Rationale for the Classification] Gas (GHS definition). It was classified as "Not classified (Not applicable)." |
FY2019 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
1 | Acute toxicity (Inhalation: Dusts and mists) | Not classified (Not applicable) |
- |
- | - | [Rationale for the Classification] Gas (GHS definition). It was classified as "Not classified (Not applicable)." |
FY2019 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
2 | Skin corrosion/irritation | Classification not possible |
- |
- | - | [Rationale for the Classification] Although there are descriptions of (1) and (2), it was classified as "Classification not possible" due to lack of data. [Reference Data, etc.] (1) No irritation study was conducted with this substance, but no signs of irritation were observed in a 90-day repeated inhalation toxicity test in which rats were given whole-body exposure to this substance (up to 40,000 ppm (137,000 mg/m3)) (ECETOC JACC 52 (2006), GESTIS (Access on September 2019)). (2) It is reported that no irritation was observed in volunteers who were exposed to air containing this substance (HSDB (Access on September 2019)). |
FY2019 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
3 | Serious eye damage/eye irritation | Classification not possible |
- |
- | - | [Rationale for the Classification] Although there are descriptions of (1) and (2), it was classified as "Classification not possible" due to lack of data. [Reference Data, etc.] (1) No irritation study was conducted with this substance, but no signs of irritation were observed in a 90-day repeated inhalation toxicity test in which rats were given whole-body exposure to this substance (up to 40,000 ppm (137,000 mg/m3)) (ECETOC JACC 52 (2006), GESTIS (Access on September 2019)). (2) It is reported that no irritation was observed in volunteers who were exposed to air containing this substance (HSDB (Access on September 2019)). |
FY2019 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
4 | Respiratory sensitization | Classification not possible |
- |
- | - | [Rationale for the Classification] Classification not possible due to lack of data. |
FY2019 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
4 | Skin sensitization | Classification not possible |
- |
- | - | [Rationale for the Classification] Classification not possible due to lack of data. |
FY2019 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
5 | Germ cell mutagenicity | Not classified |
- |
- | - | [Rationale for the Classification] Based on (1) and (2), it was classified as "Not classified." Because all standard combination tests including in vivo and in vitro tests were negative. [Evidence Data] (1) As for in vivo, there was a report of it being negative in a mouse bone marrow micronucleus test (ECETOC JACC 52 (2006), PATTY (6th, 2012), SIDS (2012)). (2) As for in vitro, there are reports of it being negative in bacterial reverse mutation tests and a chromosomal aberration test with human lymphocytes (ECETOC JACC 52 (2006), PATTY (6th, 2012), SIDS (2012)). |
FY2019 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
6 | Carcinogenicity | Classification not possible |
- |
- | - | [Rationale for the Classification] There were no classification results by domestic and international organizations. There are no available reports in humans. The test in (1) had only one dose, the duration of administration was shorter than that of the standard guideline, and there was no information on carcinogenicity by the inhalation route, which is the main exposure route for this substance. Therefore, Classification not possible due to lack of data. [Evidence Data] (1) In a study in which rats were given this substance by gavage for 52 weeks and then observed for 72 weeks, no treatment-related neoplastic lesions were found (SIDS (2012), PATTY (6th, 2012)). |
FY2019 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
7 | Reproductive toxicity | Classification not possible |
- |
- | - | [Rationale for the Classification] Based on (1) and (2), no developmental effects were observed, but there were no data on effects on sexual function and fertility in parental animals. Therefore, classification was not possible due to lack of data. [Evidence Data] (1) No developmental effects were observed in a developmental toxicity test in which female rats were exposed by inhalation at concentrations up to 40,000 ppm (4%) on Days 7 to 16 of gestation (ECETOC JACC.52 (2006), SIDS (2012), PATTY (6th, 2012)). (2) No developmental effects were observed in a developmental toxicity test in which female rabbits were exposed by inhalation at concentrations up to 40,000 ppm (4%) on Days 6 to 18 of gestation (ECETOC JACC.52 (2006), SIDS (2012), PATTY (6th, 2012)). |
FY2019 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
8 | Specific target organ toxicity - Single exposure | Not classified |
- |
- | - | [Rationale for the Classification] Based on (1), since no toxicity effects were observed after inhalation exposure of rats at concentrations exceeding the range of Category 2, it was classified as "Not classified." [Evidence Data] (1) There is a report that in a single 4-hour inhalation exposure test with rats, at up to 591,000 ppm (exceeding the range of Category 2), there was no lethality nor were there any gross observations of abnormalities seen during the gross necropsy (ECETOC JACC 52 (2006), SIDS (2012)). [Reference Data, etc.] (2) There is a report that 9 male volunteers were exposed to 500 ppm of this substance for 2 hours, however, no effects were seen in the electrocardiographic monitoring, and irritative and central nervous system symptoms (ECETOC JACC 52 (2006), SIDS (2012)). |
FY2019 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
9 | Specific target organ toxicity - Repeated exposure | Not classified |
- |
- | - | [Rationale for the Classification] Based on (1), since no toxicity effects were observed after inhalation exposure of rats at concentrations exceeding the range of Category 2, it was classified as "Not classified." [Evidence Data] (1) In a 13-week inhalation exposure test with rats, as a result of whole-body exposure at concentrations of 2,000-40,000 ppm (6 hours/day, 5 days/week), no treatment-related effects were seen at up to 40,000 ppm (converted guidance value: 28,571 ppm, exceeding the range of Category 2) (ECETOC JACC 52 (2006), SIDS (2012)). [Reference Data, etc.] (2) In a 4-week inhalation exposure test with rats, as a result of nose-only inhalation exposure at 2,000-39,000 ppm (6 hours/day, 5 days/week), 1 animal from each exposure group died, and a decrease in testicular weight, small testes and degenerative changes in the testes were observed. In this test, the animals had suffered heat stress due to the design of the nose-only exposure unit (ECETOC JACC 52 (2006)). (3) In a 28-day inhalation exposure test with rats executed to confirm the results of (2), as a result of whole-body exposure (6 hours/day, 5 days/week), effects on testis were not observed at up to 40,000 ppm (ECETOC JACC 52 (2006), SIDS (2012)). |
FY2019 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
10 | Aspiration hazard | Not classified (Not applicable) |
- |
- | - | [Rationale for the Classification] Gas (GHS definition) |
FY2019 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
Hazard class | Classification | Pictogram Signal word |
Hazard statement (code) |
Precautionary statement (code) |
Rationale for the classification | Classification year (FY) | GHS Classification Guidance for the Japanese Government | |
---|---|---|---|---|---|---|---|---|
11 | Hazardous to the aquatic environment Short term (Acute) | Not classified |
- |
- | - | It was classified as "Not classified" from 48-hour EC50 = 300 mg/L for crustacea (Daphnia magna) (SIDS, 2012). | FY2019 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
11 | Hazardous to the aquatic environment Long term (Chronic) | Not classified |
- |
- | - | Reliable chronic toxicity data were not obtained. It was classified as "Not classified" because it is not rapidly degradable (BIOWIN), and due to a low bioaccumulation estimate (log Kow = 1.15 (the web site of the Ministry of Economy, Trade and Industry (METI), 2019)), and classification as "Not classified" in acute toxicity. | FY2019 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
12 | Hazardous to the ozone layer | Category 1 |
Warning |
H420 | P502 | This substance is listed in the Annexes to the Montreal Protocol. | FY2019 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
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