Item | Information |
---|---|
CAS RN | 528-29-0 |
Chemical Name | o-Dinitrobenzene |
Substance ID | m-nite-528-29-0_v1 |
Download of Excel format | Excel file |
Item | Information |
---|---|
Guidance used for the classification (External link) | To Guidance List |
UN GHS document (External link) | To UN GHS document |
FAQ(GHS classification results by the Japanese Government) | To FAQ |
List of Information Sources (Excel file) | List of Information Sources |
List of Definitions/Abbreviations | Definitions/Abbreviations |
Sample Label by MHLW (External link) | To Workplace Safety Site (MHLW) |
Sample SDS by MHLW (External link) | To Workplace Safety Site (MHLW) |
OECD/eChemPortal (External link) | To OECD/eChemPortal (External link) |
Hazard class | Classification | Pictogram Signal word |
Hazard statement (code) |
Precautionary statement (code) |
Rationale for the classification | Classification year (FY) | GHS Classification Guidance for the Japanese Government | |
---|---|---|---|---|---|---|---|---|
1 | Explosives | Not classified |
- |
- | - | There is a nitro group, a chemical group associated with explosive properties, present in the molecule, but because it is classified in Division 6.1 in UNRTDG (UN3443), and it was considered to be not applicable to explosives, hazards of the highest precedence, it was classified as "Not classified." | FY2019 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
2 | Flammable gases | Not classified (Not applicable) |
- |
- | - | Solid (GHS definition). It was classified as "Not classified (Not applicable)." | FY2019 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
3 | Aerosols | Not classified (Not applicable) |
- |
- | - | Not aerosol products. It was classified as "Not classified (Not applicable)." | FY2019 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
4 | Oxidizing gases | Not classified (Not applicable) |
- |
- | - | Solid (GHS definition). It was classified as "Not classified (Not applicable)." | FY2019 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
5 | Gases under pressure | Not classified (Not applicable) |
- |
- | - | Solid (GHS definition). It was classified as "Not classified (Not applicable)." | FY2019 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
6 | Flammable liquids | Not classified (Not applicable) |
- |
- | - | Solid (GHS definition). It was classified as "Not classified (Not applicable)." | FY2019 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
7 | Flammable solids | Classification not possible |
- |
- | - | There is information that it is combustible (Hommel (1991)), but the classification is not possible due to no data. | FY2019 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
8 | Self-reactive substances and mixtures | Type G |
- |
- | - | There is a nitro group, a chemical group associated with explosive properties, present in the molecule, but because it is classified in Division 6.1 in UNRTDG (UN3443), and it was considered to be not applicable to self-reactive substances and mixtures, hazards of the highest precedence, it was classified as Type G. | FY2019 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
9 | Pyrophoric liquids | Not classified (Not applicable) |
- |
- | - | Solid (GHS definition). It was classified as "Not classified (Not applicable)." | FY2019 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
10 | Pyrophoric solids | Not classified |
- |
- | - | It was classified as "Not classified" because it is classified in Division 6.1 in UNRTDG (UN3443), and it was considered to be not applicable to pyrophoric solids, hazards of the highest precedence. | FY2019 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
11 | Self-heating substances and mixtures | Classification not possible |
- |
- | - | Classification is not possible because test methods applicable to solid (melting point <= 140 deg C) substances are not available. | FY2019 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
12 | Substances and mixtures which, in contact with water, emit flammable gases | Not classified (Not applicable) |
- |
- | - | The chemical structure of the substance does not contain metals or metalloids (B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At). It was classified as "Not classified (Not applicable)." | FY2019 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
13 | Oxidizing liquids | Not classified (Not applicable) |
- |
- | - | Solid (GHS definition). It was classified as "Not classified (Not applicable)." | FY2019 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
14 | Oxidizing solids | Classification not possible |
- |
- | - | The substance is an organic compound containing oxygen (but not fluorine or chlorine), which is chemically bonded to an element (N) other than carbon or hydrogen. However, the classification is not possible due to no data. | FY2019 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
15 | Organic peroxides | Not classified (Not applicable) |
- |
- | - | Organic compounds containing no bivalent -O-O- structure in the molecule. It was classified as "Not classified (Not applicable)." | FY2019 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
16 | Corrosive to metals | Classification not possible |
- |
- | - | Classification is not possible because test methods applicable to solid substances are not available. | FY2019 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
17 | Desensitized explosives | Not classified |
- |
- | - | It was classified as "Not classified" because it is not desensitized by wetting, dilution, etc. | FY2019 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
Hazard class | Classification | Pictogram Signal word |
Hazard statement (code) |
Precautionary statement (code) |
Rationale for the classification | Classification year (FY) | GHS Classification Guidance for the Japanese Government | |
---|---|---|---|---|---|---|---|---|
1 | Acute toxicity (Oral) | Classification not possible |
- |
- | - | [Rationale for the Classification] Classification not possible due to lack of data. |
FY2019 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
1 | Acute toxicity (Dermal) | Classification not possible |
- |
- | - | [Rationale for the Classification] Classification not possible due to lack of data. |
FY2019 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
1 | Acute toxicity (Inhalation: Gases) | Not classified (Not applicable) |
- |
- | - | [Rationale for the Classification] Solid (GHS definition). It was classified as "Not classified (Not applicable)." |
FY2019 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
1 | Acute toxicity (Inhalation: Vapours) | Classification not possible |
- |
- | - | [Rationale for the Classification] Classification not possible due to lack of data. |
FY2019 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
1 | Acute toxicity (Inhalation: Dusts and mists) | Classification not possible |
- |
- | - | [Rationale for the Classification] Classification not possible due to lack of data. |
FY2019 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
2 | Skin corrosion/irritation | Classification not possible |
- |
- | - | [Rationale for the Classification] There was a description of (1), but it was classified as "Classification not possible" due to lack of data. The classification was changed because no clear evidence corresponding to the classification was obtained. [Reference Data, etc.] (1) m-Dinitrobenzene (CAS RN 99-65-0), an isomer of this substance, caused slight irritation to the eyes, and no irritation to the skin. Since the physicochemical properties of this substance are similar to those of m-dinitrobenzene, suggesting that the irritating properties of this substance are also limited (GESTIS (Access on July 2019)). |
FY2019 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
3 | Serious eye damage/eye irritation | Classification not possible |
- |
- | - | [Rationale for the Classification] There were descriptions of (1) and (2), but it was classified as "Classification not possible" due to lack of data. The category was changed because no clear evidence corresponding to the classification was obtained. [Reference Data, etc.] It was reported that this substance caused no irritation in a test with guinea pigs (GESTIS (Access on July 2019)). (2) m-Dinitrobenzene (CAS RN 99-65-0), an isomer of this substance, caused slight irritation to the eyes, and no irritation to the skin. Since the physicochemical properties of this substance are similar to those of m-dinitrobenzene, suggesting that the irritating properties of this substance are also limited (GESTIS (Access on July 2019)). |
FY2019 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
4 | Respiratory sensitization | Classification not possible |
- |
- | - | [Rationale for the Classification] Classification not possible due to lack of data. |
FY2019 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
4 | Skin sensitization | Classification not possible |
- |
- | - | [Rationale for the Classification] Classification not possible due to lack of data. |
FY2019 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
5 | Germ cell mutagenicity | Classification not possible |
- |
- | - | [Rationale for the Classification] There were no in vivo data, therefore, classification was not possible due to lack of data. [Evidence Data] (1) As for in vitro, there was a report that the result was negative in a bacterial reverse mutation test (DFGOT Vol. 1 (1990)). |
FY2019 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
6 | Carcinogenicity | Classification not possible |
- |
- | - | [Rationale for the Classification] Based on classification results by other organizations of (1), it was classified as "Classification not possible" in accordance with the GHS Classification Guidance for the Japanese Government. [Evidence Data] (1) It was classified as D by EPA in classification results by domestic and international organizations (IRIS (1992)). |
FY2019 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
7 | Reproductive toxicity | Classification not possible |
- |
- | - | [Rationale for the Classification] Classification not possible due to lack of data. [Reference Data, etc.] It was reported that m-dinitrobenzene (CAS RN 99-65-0), an isomer of this substance, caused testicular toxicity in rats, but this substance did not lead to testicular toxicity at the same dose as m-dinitrobenzene (PATTY (6th, 2012)). |
FY2019 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
8 | Specific target organ toxicity - Single exposure | Category 1 (blood system) |
Danger |
H370 | P308+P311 P260 P264 P270 P321 P405 P501 |
[Rationale for the Classification] Although there were no reports of a single dose of the substance itself in humans, based on descriptions of the possible methemoglobinemia in humans in (1)-(3) and the fact that in (4) methemoglobin production was confirmed in experimental animals, although it was an intraperitoneal administration, it was classified in Category 1 (blood system) on the whole. The information used as the basis for respiratory tract irritation in the previous classification was not adopted because it was derived from the information source in List 3. Therefore, the classification result was changed. [Evidence Data] (1) It is described that although this substance has the lowest toxicity among the three isomers of dinitrobenzene, it is absorbed from the skin and can cause methemoglobinemia (PATTY (6th, 2012)). (2) There are descriptions that this substance was expected to have very similar toxic effects to technical dinitrobenzene, and that attention should be given to systemic toxicity mainly resulting from formation of methemoglobin (GESTIS (Access on July 2019)). (3) In the Ministry of Health, Labor and Welfare notification "Certification Criteria for diseases caused by nitro or amino derivatives of aromatic compounds," methemoglobinemia was defined as "high risk of occurrence" for dinitrobenzene (all isomers) (Notification No. 565 dated August 4, 1976). (4) In a single intraperitoneal dose test with rats, this substance caused induction of methemoglobin production at doses of 60-75 mg/kg (DFGOT vol.1 (1990)). [Reference Data, etc.] (5) It was reported that though m-dinitrobenzene (CAS RN 99-65-0), an isomer of this substance, revealed testicular toxicity in rats, this substance did not lead to testicular toxicity at the same dose as m-dinitrobenzene (PATTY (6th, 2012)). |
FY2019 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
9 | Specific target organ toxicity - Repeated exposure | Category 1 (blood system) |
Danger |
H372 | P260 P264 P270 P314 P501 |
[Rationale for the Classification] Although there is no information on the substance itself, based on (1) and (2), it was classified in Category 1 (blood system). Since the information used as the basis for classification in the previous classification was considered to be information on isomer mixtures containing this substance, the classification result was changed from the previous classification. [Evidence Data] (1) Although this substance has the lowest toxicity among the three isomers of dinitrobenzene, it is absorbed from the skin and can cause methemoglobinemia. This substance did not lead to testicular damage in rats at the same dose where m-dinitrobenzene (CAS RN 99-65-0), an isomer of this substance, had such an effect (PATTY (6th, 2012)). (2) In the Ministry of Health, Labor and Welfare notification "Certification Criteria for diseases caused by nitro or amino derivatives of aromatic compounds," methemoglobinemia was defined as "high risk of occurrence" for dinitrobenzene (all isomers) (Notification No. 565 dated August 4, 1976). [Reference Data, etc.] (3) In the GHS classification at fiscal year 2019, m-dinitrobenzene (CAS RN 99-65-0), the isomer of this substance, was classified in Category 1 (visual organs, central nervous system, blood system, liver, kidney, reproductive organs (men)). |
FY2019 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
10 | Aspiration hazard | Classification not possible |
- |
- | - | [Rationale for the Classification] Classification not possible due to lack of data. |
FY2019 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
Hazard class | Classification | Pictogram Signal word |
Hazard statement (code) |
Precautionary statement (code) |
Rationale for the classification | Classification year (FY) | GHS Classification Guidance for the Japanese Government | |
---|---|---|---|---|---|---|---|---|
11 | Hazardous to the aquatic environment Short term (Acute) | Category 1 |
Warning |
H400 | P273 P391 P501 |
It was classified in Category 1 from 72-hour ErC50 = 0.48 mg/L for algae (Pseudokirchneriella subcapitata) (Results of Aquatic Toxicity Tests of Chemicals conducted by Ministry of the Environment in Japan (Ministry of the Environment, 2012)). | FY2019 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
11 | Hazardous to the aquatic environment Long term (Chronic) | Category 1 |
Warning |
H410 | P273 P391 P501 |
If chronic toxicity data are used, then it is classified in Category 1 due to being not rapidly degradable (BIOWIN), and 72-hour NOEC = 0.021 mg/L for algae (Pseudokirchneriella subcapitata) (Results of Aquatic Toxicity Tests of Chemicals conducted by Ministry of the Environment in Japan (Ministry of the Environment, 2012)). If acute toxicity data are used for a trophic level for which chronic toxicity data are not obtained, then it is classified in Category 2 due to being not rapidly degradable (BIOWIN), 48-hour EC50 = 3.0 mg/L for crustacea (Daphnia magna), and 96-hour LC50 = 1.3 mg/L for fish (Oryzias latipes) (both, Results of Aquatic Toxicity Tests of Chemicals conducted by Ministry of the Environment in Japan (Ministry of the Environment, 2012)). By drawing a comparison between the above results, it was classified in Category 1. |
FY2019 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
12 | Hazardous to the ozone layer | Classification not possible |
- |
- | - | Classification not possible due to lack of data. | FY2019 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
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