NITE - Chemical Management Field

Latest GHS Classification Results by the Japanese Government (edited by NITE)

GENERAL INFORMATION

Item	Information
CAS RN	53469-21-9,1336-36-3,11097-69-1
Chemical Name	PCB 1254; polychlorobiphenyl; Chlorodiphenyl (42% chlorine)
Substance ID	m-nite-53469-21-9_v1
Download of Excel format	Excel file

REFERENCE INFORMATION

Item	Information
Guidance used for the classification (External link)	To Guidance List
UN GHS document (External link)	To UN GHS document
FAQ（GHS classification results by the Japanese Government）	To FAQ
List of Information Sources (Excel file)	List of Information Sources
List of Definitions/Abbreviations	Definitions/Abbreviations
Sample Label by MHLW (External link)
Sample SDS by MHLW (External link)
OECD/eChemPortal (External link)	To OECD/eChemPortal (External link)

PHYSICAL HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification	Classification year (FY)	GHS Classification Guidance for the Japanese Government
1	Explosives	Not classified (Not applicable)	- -	-	-	There are no chemical groups associated with explosive properties present in the molecules.	FY2006	GHS Classification Manual （10 Feb, 2006）
2	Flammable gases	Not classified (Not applicable)	- -	-	-	Liquid (GHS definition)	FY2006	GHS Classification Manual （10 Feb, 2006）
3	Aerosols	Not classified (Not applicable)	- -	-	-	Not aerosol products	FY2006	GHS Classification Manual （10 Feb, 2006）
4	Oxidizing gases	Not classified (Not applicable)	- -	-	-	Liquid (GHS definition)	FY2006	GHS Classification Manual （10 Feb, 2006）
5	Gases under pressure	Not classified (Not applicable)	- -	-	-	Liquid (GHS definition)	FY2006	GHS Classification Manual （10 Feb, 2006）
6	Flammable liquids	Not classified	- -	-	-	Flash point: >93degC, Non-combustible (ICSC(J), 1999).	FY2006	GHS Classification Manual （10 Feb, 2006）
7	Flammable solids	Not classified (Not applicable)	- -	-	-	Liquid (GHS definition)	FY2006	GHS Classification Manual （10 Feb, 2006）
8	Self-reactive substances and mixtures	Not classified (Not applicable)	- -	-	-	There are no chemical groups associated with explosive or self-reactive properties present in the molecule.	FY2006	GHS Classification Manual （10 Feb, 2006）
9	Pyrophoric liquids	Not classified	- -	-	-	Not combustible (ICSC (J) (1999)	FY2006	GHS Classification Manual （10 Feb, 2006）
10	Pyrophoric solids	Not classified (Not applicable)	- -	-	-	Liquid (GHS definition)	FY2006	GHS Classification Manual （10 Feb, 2006）
11	Self-heating substances and mixtures	Not classified	- -	-	-	Not combustible (ICSC(J) (1999))	FY2006	GHS Classification Manual （10 Feb, 2006）
12	Substances and mixtures which, in contact with water, emit flammable gases	Not classified (Not applicable)	- -	-	-	The chemical structure of the substance does not contain metals or metaloids(B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At).	FY2006	GHS Classification Manual （10 Feb, 2006）
13	Oxidizing liquids	Not classified (Not applicable)	- -	-	-	Organic compounds containing chlorine (but not oxygen and fluorine) chemically bonded only to carbon and hydrogen (but not to other elements).	FY2006	GHS Classification Manual （10 Feb, 2006）
14	Oxidizing solids	Not classified (Not applicable)	- -	-	-	Liquid (GHS definition)	FY2006	GHS Classification Manual （10 Feb, 2006）
15	Organic peroxides	Not classified (Not applicable)	- -	-	-	Containing no -0-0- structure	FY2006	GHS Classification Manual （10 Feb, 2006）
16	Corrosive to metals	Not classified	- -	-	-	UNRTDG Class: 9	FY2006	GHS Classification Manual （10 Feb, 2006）
17	Desensitized explosives	-	- -	-	-	-	-	-

HEALTH HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification	Classification year (FY)	GHS Classification Guidance for the Japanese Government
1	Acute toxicity (Oral)	Category 4	Warning	H302	P301+P312 P264 P270 P330 P501	Calculated based on rat LD50 value of Aroclor 1254: 1010mg/kg (CICAD 55, 2003, ATSDR, 2000, PATTY 4th, 1994, EHC 140, 1992), 4000mg/kg (IARC 18, 1978, EHC 140, 1992), 1300mg/kg (IARC 18, 1978, EHC 140, 1992), 1400mg/kg (EHC 140, 1992), and 2000mg/kg (IARC 18, 1978, EHC 140, 1992). The calculated values became 1057mg/kg, and it was set as Category 4. Classified based on the toxic value of Aroclor 1254, because the toxic value of Aroclor 1254 was lower than Aroclor 1242. (About Aroclor 1242, it is in Category 5 based in rat LD50 values: 4250mg/kg (CICAD 55, 2003, ATSDR, 2000, EHC 140, 1992) and 8700mg/kg (IARC 18, 1978))	FY2006	GHS Classification Manual （10 Feb, 2006）
1	Acute toxicity (Dermal)	Category 3	Danger	H311	P302+P352 P361+P364 P280 P312 P321 P405 P501	It was set as Category 3 based on rabbit percutaneous LD50 (MLD): 800mg/kg (EHC 140, 1992, ATSDR, 2000, IARC 18, 1978).	FY2006	GHS Classification Manual （10 Feb, 2006）
1	Acute toxicity (Inhalation: Gases)	Not classified (Not applicable)	- -	-	-	Liquid (GHS definition)	FY2006	GHS Classification Manual （10 Feb, 2006）
1	Acute toxicity (Inhalation: Vapours)	Classification not possible	- -	-	-	No data available	FY2006	GHS Classification Manual （10 Feb, 2006）
1	Acute toxicity (Inhalation: Dusts and mists)	Classification not possible	- -	-	-	No data available	FY2006	GHS Classification Manual （10 Feb, 2006）
2	Skin corrosion/irritation	Classification not possible	- -	-	-	Since data is insufficient, it cannot be classified. Skin pathological changes, such as chloracne, were caused in the human occupational exposure (exposure to vapor). But there was no data about the stimulativeness at the time of the direct skin contact.	FY2006	GHS Classification Manual （10 Feb, 2006）
3	Serious eye damage/eye irritation	Classification not possible	- -	-	-	There is description that eye irritation is acknowledged in human occupation evidence of exposure (exposure to vapor) (ATSDR (2000) and EHC 140 (1992)). But there is no animal examination data or human case report which attached PCB to eye surface directly. So it cannot be classified due to insufficient data.	FY2006	GHS Classification Manual （10 Feb, 2006）
4	Respiratory sensitization	Classification not possible	- -	-	-	No data available	FY2006	GHS Classification Manual （10 Feb, 2006）
4	Skin sensitization	Classification not possible	- -	-	-	No data available	FY2006	GHS Classification Manual （10 Feb, 2006）
5	Germ cell mutagenicity	Not classified	- -	-	-	The substance was regarded as outside the categories. Because of the negative results from the dominant lethal tests in rats (ATSDR, 2003, IARC 18, 1978, EHC 140, 1992), from chromosome aberration tests in mammalian spermatogenic cells (CICAD 55, 2003, ATSDR, 2000, IARC 18, 1978, EHC 140, 1992), and from the chromosome aberration tests and micronucleus tests using mammalian bone-marrow cells (CICAD 55, 2003, ATSDR, 2000, IARC 18, 1978, EHC 140, 1992, NTP DB, Access on Oct 2005).	FY2006	GHS Classification Manual （10 Feb, 2006）
6	Carcinogenicity	Category 1B	Danger	H350	P308+P313 P201 P202 P280 P405 P501	It is classified into A3 according to ACGIH (7th, 2001) and is classified into B2 according to EPA (IRIS, Access on Oct 2005). But it is classified into 2A according to IARC (Access on Oct 2005) and into 2A according to Japan Society for Occupational Health (2005), and classified into R according to NTP (11th, 2005). So it was set as Category 1B.	FY2006	GHS Classification Manual （10 Feb, 2006）
7	Reproductive toxicity	Category 1A	Danger	H360	P308+P313 P201 P202 P280 P405 P501	There is the description that there were the female reproductive toxicity such as menstrual irregularity, the decrease of reproductive potential of male, and fetal growth abnormality in the human exposure (CICAD 55 (2003), PATTY (4th, 1994), IARC 18 (1978), and ATSDR (2000)), it is classified into Category 1A.	FY2006	GHS Classification Manual （10 Feb, 2006）
8	Specific target organ toxicity - Single exposure	Category 3 (Respiratory tract irritation)	Warning	H335	P304+P340 P403+P233 P261 P271 P312 P405 P501	Due to the description that respiratory irritant is observed in human in ACGIH (7th, 2001), ATSDR (2000), and EHC 140 (1992), it is judged that it has respiratory irritant and it was classified into Category 3.	FY2006	GHS Classification Manual （10 Feb, 2006）
9	Specific target organ toxicity - Repeated exposure	Category 1 (liver, skin, immune system)	Danger	H372	P260 P264 P270 P314 P501	Due to the descriptions that in human exposure example, hepatic dysfunction (ACGIH 7th, 2001, PATTY 4th, 1994, IARC 18, 1978, EHC 140, 1992 and ATSDR, 2000), skin condition, such as chloracne (CICAD 55, 2003, ACGIH 7th, 2001, PATTY 4th, 1994, IARC 18, 1978, EHC 140, 1992 and ATSDR, 2000), and immune dysfunction (CICAD 55, 2003, EHC 140, 1992, ATSDR, 2000) were observed, it is considered that target organs were liver, the skin, and an immunity system and they all were classified into Category 1.	FY2006	GHS Classification Manual （10 Feb, 2006）
10	Aspiration hazard	Classification not possible	- -	-	-	No data available	FY2006	GHS Classification Manual （10 Feb, 2006）

ENVIRONMENTAL HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification	Classification year (FY)	GHS Classification Guidance for the Japanese Government
11	Hazardous to the aquatic environment Short term (Acute)	Category 1	Warning	H400	P273 P391 P501	It was classified into Category 1 from 96-hour LC50=0.008mg/L of fishes (Fathead minnows) (EHC140, 1993).	FY2006	GHS Classification Manual （10 Feb, 2006）
11	Hazardous to the aquatic environment Long term (Chronic)	Category 1	Warning	H410	P273 P391 P501	Classified into Category 1, since acute toxicity is Category 1, stable in environmental, not rapidly degrading and bioaccumulative (BCF=270000 (EHC140, 1993)).	FY2006	GHS Classification Manual （10 Feb, 2006）
12	Hazardous to the ozone layer	-	- -	-	-	-	-	-

NOTE:

GHS Classification Result by the Japanese Government is intended to provide a reference for preparing a GHS label or SDS for users. To include the same classification result in a label or SDS for Japan is NOT mandatory.
Users can cite or copy this classification result when preparing a GHS label or SDS. Please be aware, however, that the responsibility for a label or SDS prepared by citing or copying this classification result lies with users.
This GHS classification was conducted based on the information sources and the guidance for classification and judgement which are described in the GHS Classification Guidance for the Japanese Government etc. Using other literature, test results etc. as evidence and including different content from this classification result in a label or SDS are allowed.
Hazard statement and precautionary statement will show by hovering the mouse cursor over a code in the column of "Hazard statement" and "Precautionary statement," respectively. In the excel file, both the codes and statements are provided.
A blank or "-" in the column of "Classification" denotes that a classification for the hazard class was not conducted in the year.
An asterisk “*” in the column of “Classification” denotes that “Not classified (or No applicable)” and/or “Classification not possible” is applicable. Details are described in the column of “Rationale for the classification”. If no English translation is available for “Rationale for the classification,” please refer to the Japanese version of the results.

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