NITE - Chemical Management Field

Latest GHS Classification Results by the Japanese Government (edited by NITE)

GENERAL INFORMATION

Item	Information
CAS RN	540-59-0
Chemical Name	1,2-Dichloroethylene
Substance ID	m-nite-540-59-0_v1
Download of Excel format	Excel file

REFERENCE INFORMATION

Item	Information
Guidance used for the classification (External link)	To Guidance List
UN GHS document (External link)	To UN GHS document
FAQ（GHS classification results by the Japanese Government）	To FAQ
List of Information Sources (Excel file)	List of Information Sources
List of Definitions/Abbreviations	Definitions/Abbreviations
Sample Label by MHLW (External link)	To Workplace Safety Site (MHLW)
Sample SDS by MHLW (External link)	To Workplace Safety Site (MHLW)
OECD/eChemPortal (External link)	To OECD/eChemPortal (External link)

PHYSICAL HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification	Classification year (FY)	GHS Classification Guidance for the Japanese Government
1	Explosives	Not classified (Not applicable)	- -	-	-	There are no chemical groups associated with explosive properties present in the molecule.	FY2014	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0))
2	Flammable gases	Not classified (Not applicable)	- -	-	-	Liquid (GHS definition)	FY2014	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0))
3	Aerosols	Not classified (Not applicable)	- -	-	-	Not aerosol products.	FY2014	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0))
4	Oxidizing gases	Not classified (Not applicable)	- -	-	-	Liquid (GHS definition)	FY2014	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0))
5	Gases under pressure	Not classified (Not applicable)	- -	-	-	Liquid (GHS definition)	FY2014	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0))
6	Flammable liquids	Category 2	Danger	H225	P303+P361+P353 P370+P378 P403+P235 P210 P233 P240 P241 P242 P243 P280 P501	It was classified in Category 2 based on a flash point of 6 deg C (closed cup) and a boiling point of 55 deg C (ICSC (2003)). Besides, it is classified in Class 3, PG II (UN1150) in UNRTDG.	FY2014	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0))
7	Flammable solids	Not classified (Not applicable)	- -	-	-	Liquid (GHS definition)	FY2014	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0))
8	Self-reactive substances and mixtures	Type G	- -	-	-	There is a chemical group associated with self-reactive properties (unsaturated bond) present in the molecule, but commonly distributed products contain a stabilizer. This substance is classified in Class 3, PG II (UN1150) in UNRTDG. Therefore, the stabilized one was classified in Type G.	FY2014	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0))
9	Pyrophoric liquids	Not classified	- -	-	-	It is estimated that it does not ignite at normal temperatures from an autoignition temperature of 460 deg C (ICSC (2003)).	FY2014	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0))
10	Pyrophoric solids	Not classified (Not applicable)	- -	-	-	Liquid (GHS definition)	FY2014	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0))
11	Self-heating substances and mixtures	Classification not possible	- -	-	-	Test methods applicable to liquid substances are not available.	FY2014	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0))
12	Substances and mixtures which, in contact with water, emit flammable gases	Not classified (Not applicable)	- -	-	-	The chemical structure of the substance does not contain metals or metalloids (B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At).	FY2014	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0))
13	Oxidizing liquids	Not classified (Not applicable)	- -	-	-	The substance is an organic compound containing chlorine (but not fluorine or oxygen) which is chemically bonded only to carbon or hydrogen.	FY2014	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0))
14	Oxidizing solids	Not classified (Not applicable)	- -	-	-	Liquid (GHS definition)	FY2014	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0))
15	Organic peroxides	Not classified (Not applicable)	- -	-	-	Organic compounds containing no bivalent -O-O- structure in the molecule	FY2014	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0))
16	Corrosive to metals	Classification not possible	- -	-	-	Test methods applicable to low-temperature-boiling liquids are not available.	FY2014	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0))
17	Desensitized explosives	-	- -	-	-	-	-	-

HEALTH HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification	Classification year (FY)	GHS Classification Guidance for the Japanese Government
1	Acute toxicity (Oral)	Category 4	Warning	H302	P301+P312 P264 P270 P330 P501	Based on a report of an LD50 value of 770 mg/kg for rats (HSDB (Access on June 2014), GESTIS (Access on July 2014)), it was classified in Category 4. By adding new information sources (HSDB (Access on June 2014), GESTIS (Access on July 2014)), the sentences were reviewed.	FY2014	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0))
1	Acute toxicity (Dermal)	Classification not possible	- -	-	-	Classification not possible due to lack of data. Besides, this substance is a mixture of the trans-isomer and cis-isomer, while trans-1,2-dichloroethylene (CAS RN 156-60-5) corresponds to "Not classified" and cis-1,2-dichloroethylene (CAS RN 156-59-2) corresponds to "Classification not possible."	FY2014	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0))
1	Acute toxicity (Inhalation: Gases)	Not classified (Not applicable)	- -	-	-	Liquid (GHS definition)	FY2014	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0))
1	Acute toxicity (Inhalation: Vapours)	Not classified	- -	-	-	This substance is a mixture of the trans-isomer and cis-isomer, and there were no data on this substance (the mixture of isomers) itself. Since both trans-1,2-dichloroethylene (CAS RN 156-60-5) and cis-1,2-dichloroethylene (CAS RN 156-59-2) were classified as "Not classified," it was classified as "Not classified." Besides, because the LC50 values were lower than 90% of the saturated vapor concentration (348,470 ppm), the reference value in units of ppm was applied as a vapour without a mist.	FY2014	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0))
1	Acute toxicity (Inhalation: Dusts and mists)	Classification not possible	- -	-	-	Classification not possible due to lack of data.	FY2014	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0))
2	Skin corrosion/irritation	Classification not possible	- -	-	-	Classification not possible due to lack of data. Besides, as for trans-1, 2-dichloroethylene (CAS RN 156-60-5), there are reports that after 24-hour occlusive application of 0.5 mL of the undiluted liquid of this substance, mild to moderate erythema was observed (Initial Risk Assessment Report (NITE, CERI, NEDO, 2008), ATSDR (1996), IRIS TR (2010)), and that after applying 5,000 mg/kg to rabbits, although severe skin irritation was observed, reversibility was unknown (ATSDR (1996)). Moreover, also in humans, there is a description that it was irritating to the skin (Environmental Risk Assessment for Chemical Substances Vol.4 (Ministry of the Environment, 2005)). Since the evidence in the previous classification was from the data on trans-1, 2-dichloroethylene, it was not adopted.	FY2014	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0))
3	Serious eye damage/eye irritation	Category 2A	Warning	H319	P305+P351+P338 P337+P313 P264 P280	Based on reports on exposure to humans that pain in the eye with a burning sensation was observed (Initial Risk Assessment Report (NITE, CERI, NEDO, 2008)) and that moderate irritation was observed (OEL Documentations (Japan Society For Occupational Health (JSOH), 1970)), it was classified in Category 2A.	FY2014	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0))
4	Respiratory sensitization	Classification not possible	- -	-	-	Classification not possible due to lack of data.	FY2014	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0))
4	Skin sensitization	Classification not possible	- -	-	-	Classification not possible due to lack of data.	FY2014	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0))
5	Germ cell mutagenicity	Classification not possible	- -	-	-	The substance was classified as "Classification not possible" because it was not possible to classify a substance as "Not classified" according to the revised GHS classification guidance for the Japanese government. As for in vivo, it was negative in a micronucleus test with mouse peripheral blood erythrocytes (IRIS TR (2010)). As for in vitro, it was negative in bacterial reverse mutation tests and a chromosomal aberration test with cultured mammalian cells, and it was positive in a micronucleus test with cultured human cells and a sister chromatid exchange test (IRIS TR (2010), NTP DB (Access on July 2014)).	FY2014	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0))
6	Carcinogenicity	Classification not possible	- -	-	-	Classification not possible due to lack of data.	FY2014	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0))
7	Reproductive toxicity	Classification not possible	- -	-	-	Classification not possible due to lack of data.	FY2014	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0))
8	Specific target organ toxicity - Single exposure	Category 1 (respiratory organs, liver), Category 3 (narcotic effects)	Danger Warning	H370 H336	P308+P311 P260 P264 P270 P321 P405 P501 P304+P340 P403+P233 P261 P271 P312	In humans, inhalation exposure caused vertigo, nausea and severe narcotic effects, and a fatal case was reported after inhalation of the vapour of this substance in a small enclosure (OEL Documentations (Japan Society For Occupational Health (JSOH), 1970), ACGIH (7th, 2001), Initial Risk Assessment Report (NITE, CERI, NEDO, 2008)). As for experimental animals, there are reports that, in a test in which rats were exposed by inhalation to 63.44 mg/L of a mixture of the trans- and cis-isomers, central nervous system depression, balance problems and prostration were observed, that narcotic effects and effects on the central nervous system were observed by inhalation with rats, and that severe pulmonary hyperemia, alveolar septal distention and pulmonary infiltration were observed by inhalation at 3.97 mg/L and 11.90 mg/L with rats (Initial Risk Assessment Report (NITE, CERI, NEDO, 2008)). In addition, there was a report of fatty degeneration of the hepatic lobules and Kupffer cells (ACGIH (7th, 2001)). In a report in which inhibition of propagation and maintenance of the electrically evoked seizure discharge was studied with rats and mice by inhalation exposure to this substance, it was described that the air concentration evoking a 30% depression in the duration of hindlimb tonic extension in rats was 1,810 ppm (converted value: 7.18 mg/L), and that the concentration evoking a 30% increase in the latency for hindlimb tonic extension in mice was 3,400 ppm (converted value: 13.48 mg/L) (ATSDR (1996)). Besides, as for the above findings of experimental animals, effects on the respiratory organs and liver were observed within the guidance value range of Category 1. From the above, it was classified in Category 1 (respiratory organs, liver), Category 3 (narcotic effects). Besides, the description in the previous classification "as for experimental animals, "a 45% decrease in the duration of immobility in the swimming test" (ATSDR (1996))" was deleted from the evidence data, since ATSDR described that "the neurological significance of changes in the duration of swimming immobility is not known."	FY2014	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0))
9	Specific target organ toxicity - Repeated exposure	Classification not possible	- -	-	-	There was no information on humans. As for experimental animals, when male rats were administered by gavage of a mixture of 50:50 (cis-:trans-) isomers at 485 mg/kg/day (162 mg/kg/day (converted guidance value)) for 30 days, an increase in the relative liver weight and blood findings (such as decreased erythrocyte count and hemoglobin concentration) were observed (IRIS TR (2010), ATSDR (1996)). However, it was a test with only 1 dose, and it is unknown whether there are effects within or lower than the dose range of Category 2. In addition, by the inhalation route, although there are reports that, in a test in which rats, rabbits, guinea pigs and dogs were exposed to a mixture of 58:42 (cis-:trans-) isomers by inhalation for 6 months, increased liver weight and/or kidney weight were observed in rats and rabbits at high concentrations exceeding Category 2 (IRIS TR (2010), ATSDR (1996)), effects within or lower of concentration range of Category 2 is similarly unknown. As in the above, since there were no available test data for classification by the oral and inhalation route, it was impossible to classify due to lack of data. Besides, although it was classified in Category 2 (hemal system) in the previous classification based on the description in ATSDR (1996), the description of "a significant depression of the total blood cell count, the red blood cell count, hemoglobin, and hematocrit" was the finding by administration at a dose of 485 mg/kg/day for 30 days, and the converted dose according to the GHS Classification Guidance for the Japanese Government corresponded to "Not classified." Therefore, Category 2 in the previous classification was wrong. As reference information of not a mixture but the isomers themselves, there were no available data on the trans-isomer for classification. Therefore, it was classified as "Classification not possible" in this current classification. On the other hand, as for the cis-isomer, only a test result by the oral route is an oral dose test with rats, which showed increased liver weight and kidney weight without tissue changes at doses equivalent to Category 2 (IRIS TR (2010)), the evidence was inadequate to classify in Category 2 (liver, kidney). Since there were no toxic data by the inhalation route, and similarly due to lack of data for the cis-isomer, it was reasonable to be classified as "Classification not possible."	FY2014	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0))
10	Aspiration hazard	Classification not possible	- -	-	-	Classification not possible due to lack of data.	FY2014	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0))

ENVIRONMENTAL HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification	Classification year (FY)	GHS Classification Guidance for the Japanese Government
11	Hazardous to the aquatic environment Short term (Acute)	Category 2	- -	H401	P273 P501	It was classified into Category 2 from 24 hours LC50=0.07mmol/L of the crustacea (Brine Shrimp) (AQUIRE, 2003).	FY2006	GHS Classification Manual （10 Feb, 2006）
11	Hazardous to the aquatic environment Long term (Chronic)	Category 2	-	H411	P273 P391 P501	Although acute toxicity was Category 2 and the bio-accumulation potential was low (log Kow=2(PHYSPROP Database, 2005)), since there was no rapidly degrading (the decomposition by BOD: 0%(HSDB, 2004)), it was classified into Category 2.	FY2006	GHS Classification Manual （10 Feb, 2006）
12	Hazardous to the ozone layer	-	- -	-	-	-	-	-

NOTE:

GHS Classification Result by the Japanese Government is intended to provide a reference for preparing a GHS label or SDS for users. To include the same classification result in a label or SDS for Japan is NOT mandatory.
Users can cite or copy this classification result when preparing a GHS label or SDS. Please be aware, however, that the responsibility for a label or SDS prepared by citing or copying this classification result lies with users.
This GHS classification was conducted based on the information sources and the guidance for classification and judgement which are described in the GHS Classification Guidance for the Japanese Government etc. Using other literature, test results etc. as evidence and including different content from this classification result in a label or SDS are allowed.
Hazard statement and precautionary statement will show by hovering the mouse cursor over a code in the column of "Hazard statement" and "Precautionary statement," respectively. In the excel file, both the codes and statements are provided.
A blank or "-" in the column of "Classification" denotes that a classification for the hazard class was not conducted in the year.
An asterisk “*” in the column of “Classification” denotes that “Not classified (or No applicable)” and/or “Classification not possible” is applicable. Details are described in the column of “Rationale for the classification”. If no English translation is available for “Rationale for the classification,” please refer to the Japanese version of the results.

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