NITE - Chemical Management Field

Latest GHS Classification Results by the Japanese Government (edited by NITE)

GENERAL INFORMATION

Item	Information
CAS RN	554-00-7
Chemical Name	2,4-Dichloroaniline
Substance ID	m-nite-554-00-7_v1
Download of Excel format	Excel file

REFERENCE INFORMATION

Item	Information
Guidance used for the classification (External link)	To Guidance List
UN GHS document (External link)	To UN GHS document
FAQ（GHS classification results by the Japanese Government）	To FAQ
List of Information Sources (Excel file)	List of Information Sources
List of Definitions/Abbreviations	Definitions/Abbreviations
Sample Label by MHLW (External link)	To Workplace Safety Site (MHLW)
Sample SDS by MHLW (External link)	To Workplace Safety Site (MHLW)
OECD/eChemPortal (External link)	To OECD/eChemPortal (External link)

PHYSICAL HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification	Classification year (FY)	GHS Classification Guidance for the Japanese Government
1	Explosives	Not classified (Not applicable)	- -	-	-	There are no chemical groups associated with explosive properties present in the molecule.	FY2010	GHS Classification Guidance by the Japanese Government （July, 2010）
2	Flammable gases	Not classified (Not applicable)	- -	-	-	Solid (GHS definition)	FY2010	GHS Classification Guidance by the Japanese Government （July, 2010）
3	Aerosols	Not classified (Not applicable)	- -	-	-	Not aerosol products.	FY2010	GHS Classification Guidance by the Japanese Government （July, 2010）
4	Oxidizing gases	Not classified (Not applicable)	- -	-	-	Solid (GHS definition)	FY2010	GHS Classification Guidance by the Japanese Government （July, 2010）
5	Gases under pressure	Not classified (Not applicable)	- -	-	-	Solid (GHS definition)	FY2010	GHS Classification Guidance by the Japanese Government （July, 2010）
6	Flammable liquids	Not classified (Not applicable)	- -	-	-	Solid (GHS definition)	FY2010	GHS Classification Guidance by the Japanese Government （July, 2010）
7	Flammable solids	Classification not possible	- -	-	-	No data available.	FY2010	GHS Classification Guidance by the Japanese Government （July, 2010）
8	Self-reactive substances and mixtures	Classification not possible	- -	-	-	Classification is not possible since no data are available though it contains chemical groups (Inter-reacting groups: haloanilines) associated with self-reactive properties.	FY2010	GHS Classification Guidance by the Japanese Government （July, 2010）
9	Pyrophoric liquids	Not classified (Not applicable)	- -	-	-	Solid (GHS definition)	FY2010	GHS Classification Guidance by the Japanese Government （July, 2010）
10	Pyrophoric solids	Classification not possible	- -	-	-	No data available.	FY2010	GHS Classification Guidance by the Japanese Government （July, 2010）
11	Self-heating substances and mixtures	Classification not possible	- -	-	-	Test methods applicable to solid (melting point <= 140 degC) substances are not available.	FY2010	GHS Classification Guidance by the Japanese Government （July, 2010）
12	Substances and mixtures which, in contact with water, emit flammable gases	Not classified (Not applicable)	- -	-	-	The chemical structure of the substance does not contain metals or metalloids (B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At).	FY2010	GHS Classification Guidance by the Japanese Government （July, 2010）
13	Oxidizing liquids	Not classified (Not applicable)	- -	-	-	Solid (GHS definition)	FY2010	GHS Classification Guidance by the Japanese Government （July, 2010）
14	Oxidizing solids	Not classified (Not applicable)	- -	-	-	The substance is an organic compound containing chlorine which is chemically bonded only to carbon.	FY2010	GHS Classification Guidance by the Japanese Government （July, 2010）
15	Organic peroxides	Not classified (Not applicable)	- -	-	-	Organic compounds containing no bivalent -O-O- structure	FY2010	GHS Classification Guidance by the Japanese Government （July, 2010）
16	Corrosive to metals	Classification not possible	- -	-	-	Test methods applicable to solid substances are not available.	FY2010	GHS Classification Guidance by the Japanese Government （July, 2010）
17	Desensitized explosives	-	- -	-	-	-	-	-

HEALTH HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification	Classification year (FY)	GHS Classification Guidance for the Japanese Government
1	Acute toxicity (Oral)	Category 4	Warning	H302	P301+P312 P264 P270 P330 P501	Based on the rat LD50 value of 1600 mg/kg bw (PATTY, 5th (2001), BUA 140 (1993)), the substance was classified as Category 4. As relevant information, the substance was classified as "R23/24/25" as chloroanilines in the EU classification (EC-JRC (ESIS) (Access on Jan. 2011)). [For health hazards, refer also to 2,5-dichloroaniline (CAS No. 95-82-9) and 3,4-dichloroaniline (CAS No. 95-76-1).]	FY2010	GHS Classification Guidance by the Japanese Government （July, 2010）
1	Acute toxicity (Dermal)	Classification not possible	- -	-	-	No data were available. As relevant information, the substance was classified as "R23/24/25" as chloroanilines in the EU classification (EC-JRC (ESIS) (Access on Jan. 2011)).	FY2010	GHS Classification Guidance by the Japanese Government （July, 2010）
1	Acute toxicity (Inhalation: Gases)	Not classified (Not applicable)	- -	-	-	Solid (GHS definition)	FY2010	GHS Classification Guidance by the Japanese Government （July, 2010）
1	Acute toxicity (Inhalation: Vapours)	Classification not possible	- -	-	-	No data were available. As relevant information, the substance was classified as "R23/24/25" as chloroanilines in the EU classification (EC-JRC (ESIS) (Access on Jan. 2011)).	FY2010	GHS Classification Guidance by the Japanese Government （July, 2010）
1	Acute toxicity (Inhalation: Dusts and mists)	Classification not possible	- -	-	-	No data were available. As relevant information, the substance was classified as "R23/24/25" as chloroanilines in the EU classification (EC-JRC (ESIS) (Access on Jan. 2011)).	FY2010	GHS Classification Guidance by the Japanese Government （July, 2010）
2	Skin corrosion/irritation	Classification not possible	- -	-	-	It was reported that the substance caused moderate irritation to rabbit skin (BUA 140 (1993)), but no details of testing methods were provided. It is also reported that 24-hour application of the substance caused moderate irritation (BUA 140 (1993)), but no details such as test species were provided. Thus, since sufficient data were not available, the classification was not possible. As relevant information, irritation was not reported with isomer of the substance, 2,5-Dichloroaniline (CAS No. 95-82-9) and 3,4-Dichloroaniline (CAS No. 95-76-1) (BUA 140 (1993)).	FY2010	GHS Classification Guidance by the Japanese Government （July, 2010）
3	Serious eye damage/eye irritation	Classification not possible	- -	-	-	No data were available. As relevant information, as for its isomers, strong irritation for 2,5-Dichloroaniline (CAS No. 95-82-9) and irritation for 3,4-Dichloroaniline (CAS No. 95-76-1) was reported (BUA 140 (1993)).	FY2010	GHS Classification Guidance by the Japanese Government （July, 2010）
4	Respiratory sensitization	Classification not possible	- -	-	-	No data available.	FY2010	GHS Classification Guidance by the Japanese Government （July, 2010）
4	Skin sensitization	Classification not possible	- -	-	-	No data were available. As relevant information, positive results in the maximization tests were reported for isomers, 2,5-Dichloroaniline (CAS No. 95-82-9) and 3,4-Dichloroaniline (CAS No. 95-76-1) (BUA 140 (1993)).	FY2010	GHS Classification Guidance by the Japanese Government （July, 2010）
5	Germ cell mutagenicity	Classification not possible	- -	-	-	The classification was not possible due to lack of in vivo test data. As relevant information, as for in vitro mutagenicity studies, negative results in the Ames test with rat S9 and positive results in the Ames test with hamster S9 were reported (NTP DB (Access on Jan. 2011)).	FY2010	GHS Classification Guidance by the Japanese Government （July, 2010）
6	Carcinogenicity	Classification not possible	- -	-	-	No data available.	FY2010	GHS Classification Guidance by the Japanese Government （July, 2010）
7	Reproductive toxicity	Classification not possible	- -	-	-	No data were available. As relevant information, in the teratology study in rats with the isomer of the substance, 3,4-dichloroaniline (CAS No. 95-76-1), the increase in resorptions (not statistically significant) and delayed ossification were observed at the dose levels that induce maternal toxicity. However, it was reported that the toxicity and malformation were not seen in fetuses at the dose levels that no toxicity was noted in maternal animals (EU-RAR 65 (2006)).	FY2010	GHS Classification Guidance by the Japanese Government （July, 2010）
8	Specific target organ toxicity - Single exposure	Category 1 (blood system)	Danger	H370	P308+P311 P260 P264 P270 P321 P405 P501	No specific, detailed data on the animal studies and information on humans were available for this substance. The substance, however, was one of the methemoglobin forming substances as likely as 2,5-dichloroaniline (CAS No. 95-82-9) or 3,4-dichloroaniline (CAS No. 95-76-1) (EU-RAR 65 (2006)), and it was reported that acute symptoms of intoxication were methemoglobinemia (cyanosis, fatigue, dyspnea, muscle weakness) (PATTY, 5th (2001)). As for the data on the animal study of 3,4-dichloroaniline (CAS No. 95-76-1), the isomer of the substance, it was reported in the dermal toxicity study in rats that cyanosis was noted in all exposure groups treated at the dose levels of 130-1500 mg/kg equivalent to Category 1 or 2 (EU-RAR 65 (2006)). Based on the information, since methemoglobinemia was also taken into account for the evaluation of this substance, the substance was classified as Category 1 (blood system).	FY2010	GHS Classification Guidance by the Japanese Government （July, 2010）
9	Specific target organ toxicity - Repeated exposure	Category 1 (blood system)	Danger	H372	P260 P264 P270 P314 P501	No specific detail data on the animal studies and information on humans was available for this substance. The substance, however, was one of the methemoglobin forming substances as likely as 2,5-dichloroaniline (CAS No. 95-82-9) or 3,4-dichloroaniline (CAS No. 95-76-1) (EU-RAR 65 (2006)), and it was reported that in human case of cyanosis, the cause was exposure to dichloroaniline (EU-RAR 65 (2006)). As for the data on the animal study of 3,4-dichloroaniline (CAS No. 95-76-1), the isomer of the substance, it was reported in the 2-week vapor inhalation study in rats that raised methemoglobin level and accumulation of hemosiderin in the spleen were found at concentrations of 0.045 mg/L/6hrs (converted value as that of 90-day study: 0.007 mg/L/6hrs: equivalent to Category 1) or higher (EU-RAR 65 (2006)). Based on the information, since methemoglobinemia was also taken into account for the evaluation of this substance, the substance was classified as Category 1 (blood system).	FY2010	GHS Classification Guidance by the Japanese Government （July, 2010）
10	Aspiration hazard	Classification not possible	- -	-	-	No data available.	FY2010	GHS Classification Guidance by the Japanese Government （July, 2010）

ENVIRONMENTAL HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification	Classification year (FY)	GHS Classification Guidance for the Japanese Government
11	Hazardous to the aquatic environment Short term (Acute)	Category 2	- -	H401	P273 P501	Classified into Category 2 from its 48h-EC50 = 4.2 mg/L for crustacea (Daphnia magna) (Test for the Ecological Effect of Chemical Substances (Ministry of the Environment), 1995).	FY2010	GHS Classification Guidance by the Japanese Government （July, 2010）
11	Hazardous to the aquatic environment Long term (Chronic)	Category 2	-	H411	P273 P391 P501	Classified into Category 2 since its acute toxicity is Category 2 and it is not rapidly degradable (4w-BOD degradation rate tested by OECD TG301C = 0% (Biodegradation and Bioconcentration of Existing Chemical Substances under the Chemical Substances Control Law, 1990)).	FY2010	GHS Classification Guidance by the Japanese Government （July, 2010）
12	Hazardous to the ozone layer	Classification not possible	- -	-	-	This substance is not listed in Annexes to the Montreal Protocol.	FY2010	GHS Classification Guidance by the Japanese Government （July, 2010）

NOTE:

GHS Classification Result by the Japanese Government is intended to provide a reference for preparing a GHS label or SDS for users. To include the same classification result in a label or SDS for Japan is NOT mandatory.
Users can cite or copy this classification result when preparing a GHS label or SDS. Please be aware, however, that the responsibility for a label or SDS prepared by citing or copying this classification result lies with users.
This GHS classification was conducted based on the information sources and the guidance for classification and judgement which are described in the GHS Classification Guidance for the Japanese Government etc. Using other literature, test results etc. as evidence and including different content from this classification result in a label or SDS are allowed.
Hazard statement and precautionary statement will show by hovering the mouse cursor over a code in the column of "Hazard statement" and "Precautionary statement," respectively. In the excel file, both the codes and statements are provided.
A blank or "-" in the column of "Classification" denotes that a classification for the hazard class was not conducted in the year.
An asterisk “*” in the column of “Classification” denotes that “Not classified (or No applicable)” and/or “Classification not possible” is applicable. Details are described in the column of “Rationale for the classification”. If no English translation is available for “Rationale for the classification,” please refer to the Japanese version of the results.

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