NITE - Chemical Management Field

Latest GHS Classification Results by the Japanese Government (edited by NITE)

GENERAL INFORMATION

Item	Information
CAS RN	556-67-2
Chemical Name	2,2,4,4,6,6,8,8-Octamethylcyclotetrasiloxane
Substance ID	m-nite-556-67-2_v1
Download of Excel format	Excel file

REFERENCE INFORMATION

Item	Information
Guidance used for the classification (External link)	To Guidance List
UN GHS document (External link)	To UN GHS document
FAQ（GHS classification results by the Japanese Government）	To FAQ
List of Information Sources (Excel file)	List of Information Sources
List of Definitions/Abbreviations	Definitions/Abbreviations
Sample Label by MHLW (External link)	To Workplace Safety Site (MHLW)
Sample SDS by MHLW (External link)	To Workplace Safety Site (MHLW)
OECD/eChemPortal (External link)	To OECD/eChemPortal (External link)

PHYSICAL HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification	Classification year (FY)	GHS Classification Guidance for the Japanese Government
1	Explosives	Not classified (Not applicable)	- -	-	-	There are no chemical groups associated with explosive properties present in the molecule.	FY2011	GHS Classification Guidance by the Japanese Government （July, 2010）
2	Flammable gases	Not classified (Not applicable)	- -	-	-	"Liquids" according to GHS definition.	FY2011	GHS Classification Guidance by the Japanese Government （July, 2010）
3	Aerosols	Not classified (Not applicable)	- -	-	-	Not an aerosol product.	FY2011	GHS Classification Guidance by the Japanese Government （July, 2010）
4	Oxidizing gases	Not classified (Not applicable)	- -	-	-	"Liquids" according to GHS definition.	FY2011	GHS Classification Guidance by the Japanese Government （July, 2010）
5	Gases under pressure	Not classified (Not applicable)	- -	-	-	"Liquids" according to GHS definition.	FY2011	GHS Classification Guidance by the Japanese Government （July, 2010）
6	Flammable liquids	Category 3	Warning	H226	P303+P361+P353 P370+P378 P403+P235 P210 P233 P240 P241 P242 P243 P280 P501	A flash point of 51 degrees C [closed-cup] (IUCLID (2000)), which is >= 23 degrees C and <= 60 degrees C, corresponds to Category 3.	FY2011	GHS Classification Guidance by the Japanese Government （July, 2010）
7	Flammable solids	Not classified (Not applicable)	- -	-	-	"Liquids" according to GHS definition.	FY2011	GHS Classification Guidance by the Japanese Government （July, 2010）
8	Self-reactive substances and mixtures	Not classified (Not applicable)	- -	-	-	There are no chemical groups present in the molecule associated with explosive or self-reactive properties.	FY2011	GHS Classification Guidance by the Japanese Government （July, 2010）
9	Pyrophoric liquids	Classification not possible	- -	-	-	No data.	FY2011	GHS Classification Guidance by the Japanese Government （July, 2010）
10	Pyrophoric solids	Not classified (Not applicable)	- -	-	-	"Liquids" according to GHS definition.	FY2011	GHS Classification Guidance by the Japanese Government （July, 2010）
11	Self-heating substances and mixtures	Classification not possible	- -	-	-	No established test method suitable for liquid substances.	FY2011	GHS Classification Guidance by the Japanese Government （July, 2010）
12	Substances and mixtures which, in contact with water, emit flammable gases	Not classified	- -	-	-	It contains a semimetal (Si), but it is conceivable that it does not react vigorously with water from data on water solubility as 0.005 mg/L (SRC (2011)).	FY2011	GHS Classification Guidance by the Japanese Government （July, 2010）
13	Oxidizing liquids	Classification not possible	- -	-	-	An organic compound that contains oxygen which is chemically bonded to Si. But the classification is not possible due to no data on oxidizing properties.	FY2011	GHS Classification Guidance by the Japanese Government （July, 2010）
14	Oxidizing solids	Not classified (Not applicable)	- -	-	-	"Liquids" according to GHS definition.	FY2011	GHS Classification Guidance by the Japanese Government （July, 2010）
15	Organic peroxides	Not classified (Not applicable)	- -	-	-	An organic compound that does not contain -O-O- structure.	FY2011	GHS Classification Guidance by the Japanese Government （July, 2010）
16	Corrosive to metals	Classification not possible	- -	-	-	No data.	FY2011	GHS Classification Guidance by the Japanese Government （July, 2010）
17	Desensitized explosives	-	- -	-	-	-	-	-

HEALTH HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification	Classification year (FY)	GHS Classification Guidance for the Japanese Government
1	Acute toxicity (Oral)	Not classified	- -	-	-	On the basis of 3 LD50 values for rats (>2000 mg/kg, >4600 mg/kg, >5000 mg/kg) (IUCLID (2000)), it was classified as "Not classified."	FY2011	GHS Classification Guidance by the Japanese Government （July, 2010）
1	Acute toxicity (Dermal)	Not classified	- -	-	-	From an LD50 value of >2400 mg/kg for rats and an LD50 value of >4640 mg/kg for rabbits (IUCLID (2000)), it was classified as "Not classified" in JIS classification (corresponding to Category 5 or "Not classified" in UN GHS classification).	FY2011	GHS Classification Guidance by the Japanese Government （July, 2010）
1	Acute toxicity (Inhalation: Gases)	Not classified (Not applicable)	- -	-	-	"Liquids" according to GHS definition.	FY2011	GHS Classification Guidance by the Japanese Government （July, 2010）
1	Acute toxicity (Inhalation: Vapours)	Classification not possible	- -	-	-	The classification is not possible because the category can not be determined from an LC50 value of >12.17 mg/L/4h = 1003 ppm/4h for rats (IUCLID (2000)). Besides, a reference value of gasses as vapour with hardly included mist was applied because the test concentration (12.17 mg/L) is lower than 90 % of the saturated vapour pressure concentration (16.76 mg/L).	FY2011	GHS Classification Guidance by the Japanese Government （July, 2010）
1	Acute toxicity (Inhalation: Dusts and mists)	Classification not possible	- -	-	-	The classification is not possible because the category can not be determined from an LC50 value of >17.6 mg/L/1h = 4.4 mg/L/4h for rats (IUCLID (2000)). Besides, it was considered to be a test by mist because the test concentration (17.6 mg/L) is higher than the saturated vapour pressure concentration (16.76 mg/L).	FY2011	GHS Classification Guidance by the Japanese Government （July, 2010）
2	Skin corrosion/irritation	Not classified	- -	-	-	A semi-occlusive application test of 500 micro L of the test substance to rabbit auricular skins for 24 hours resulted in "not irritating." (IUCLID (2000)) The other test using rabbits resulted in "slightly irritating." (IUCLID (2000)) From the results, it was classified as "Not classified" in JIS classification (corresponding to Category 3 or "Not classified" in UN GHS classification).	FY2011	GHS Classification Guidance by the Japanese Government （July, 2010）
3	Serious eye damage/eye irritation	Not classified	- -	-	-	On the basis that both of 2 tests using rabbits reported not irritating (IUCLID (2000)), it was classified as "Not classified."	FY2011	GHS Classification Guidance by the Japanese Government （July, 2010）
4	Respiratory sensitization	Classification not possible	- -	-	-	No data.	FY2011	GHS Classification Guidance by the Japanese Government （July, 2010）
4	Skin sensitization	Classification not possible	- -	-	-	Obtained results are not sensitizing in a human repeated insult patch test using 50 subjects (IUCLID (2000)) and not sensitizing in a guinea pig maximization test (IUCLID (2000)). But the classification is not possible because the obtained results are List 2 information.	FY2011	GHS Classification Guidance by the Japanese Government （July, 2010）
5	Germ cell mutagenicity	Not classified	- -	-	-	In addition to a negative result in a rat dominant lethal test (in vivo heritable germ cell mutagenicity test) (IUCLID (2000)), on the basis of the negative result in a rat chromosomal aberration test (in vivo mutagenicity test) by 5-day inhalation exposures (HSDB (2006)), it was classified as "Not classified." Besides, negatives in all of an Ames test, a chromosomal aberration test using CHO cells, and a gene mutation test using L5178Y mouse lymphoma cells were reported as in vitro tests (IUCLID (2000)).	FY2011	GHS Classification Guidance by the Japanese Government （July, 2010）
6	Carcinogenicity	Classification not possible	- -	-	-	No data.	FY2011	GHS Classification Guidance by the Japanese Government （July, 2010）
7	Reproductive toxicity	Category 2	Warning	H361	P308+P313 P201 P202 P280 P405 P501	In an inhalation test exposed to male and female rats for at least 70 consecutive days prior to mating, and females throughout gestation and on lactation periods, extended parturition, dystocia, reductions in mean live litter sizes and a mean number of offspring born in both F0 and F1 generations were observed (HSDB (2006)). In another inhalation test exposed to female rats from 1 month before mating throughout a gestation period, reductions in a number of implantation sites and viable fetuses, increases in pre-implantation and post-implantation losses, a decreased number of corpora lutea were observed (HSDB (2006)), and decreases in food consumption and weight gains in parent animals at a same dose as general toxicity were reported (IUCLD (2000)), therefore, on the basis of adverse effects on reproduction, it was classified in Category 2. Besides, in a test in which male rats were exposed by inhalation prior to mating and during mating and were mated with unexposed females, no adverse effects in reproductive parameters such as days between pairing and coitus, mating indices, fertility indices, and duration of gestation and parturition were observed. Therefore, the above reproductive toxicity was reported to be caused by exposures to females (HSDB (2006)). Besides, it is classified in Repr. Cat. 3; R62 in EC (CLP/GHS) (EC-JRC (ESIS) (2008)).	FY2011	GHS Classification Guidance by the Japanese Government （July, 2010）
8	Specific target organ toxicity - Single exposure	Classification not possible	- -	-	-	No data.	FY2011	GHS Classification Guidance by the Japanese Government （July, 2010）
9	Specific target organ toxicity - Repeated exposure	Not classified	- -	-	-	IUCLID reported that female rats showed decreases in weight gains and food consumption in 28-day oral administration of 2000 mg/kg/day but no adverse effects were found in macroscopic findings in necropsy (IUCLID (2000)), also IUCLID said that rats showed no effect other than decreased weight gains and increased liver weights in the 14-day oral administration of 25 to 1600 mg/kg/day, but did not remark on the other effects (IUCLID (2000)). Therefore, from the conclusion that no adverse effects were found in 28-day administration of 2000 mg/kg/day (converted to a 90-day equivalent value: 622 mg/kg/day) and 14-day administration of 1600 mg/kg/day (converted to a 90-day equivalent value: 249 mg/kg/day), it corresponds to "Not classified" in the oral route. On the other hand, increased liver weights as common findings, and changes in female genetic organs such as increased ovarian weights, and inflammations in the lung were observed in 3 tests of 13-week inhalation exposure (vapour) to rats (HSDB (2006)). All of them are found at the concentrations of 500 to more than 900 ppm (6 to 11 mg/L) above the upper limit of guidance values (1 mg/L). Therefore, it corresponds to "Not classified" in the inhalation route. Furthermore, no adverse effects were found at the maximal dose of 960 mg/kg/day (converted to a 90-day equivalent: 221 mg/kg/day) in a 3-week dermal administration test in rabbits. Therefore, it corresponds to "Not classified" in the dermal route. From the above, it was classified as "Not classified" in specific target organ toxicity (repeated exposures) because all 3 of oral, inhalation, and dermal routes were classified as "Not classified."	FY2011	GHS Classification Guidance by the Japanese Government （July, 2010）
10	Aspiration hazard	Classification not possible	- -	-	-	No data.	FY2011	GHS Classification Guidance by the Japanese Government （July, 2010）

ENVIRONMENTAL HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification	Classification year (FY)	GHS Classification Guidance for the Japanese Government
11	Hazardous to the aquatic environment Short term (Acute)	Not classified	- -	-	-	Because acute toxicity data for algae, crustacea, and fish near concentrations around the water solubility were not reported (IUCLID (2000)), It was classified as "Not classified."	FY2011	GHS Classification Guidance by the Japanese Government （July, 2010）
11	Hazardous to the aquatic environment Long term (Chronic)	Category 1	Warning	H410	P273 P391 P501	If chronic toxicity data are used, then it is classified in Category 1 due to lack of rapid degradability (BIOWIN), and due to 93-day NOEC＝0.0044 mg/L for fish (Oncorhynchus mykiss) (AQUIRE, 2012). If acute toxicity data are used for a trophic level for which chronic toxicity data are not obtained, then it is classified as "Not classified" due to no reported acute toxicity data for algae and crustacea in concentrations up to the water solubility. However, it is classified in Category 4 due to poor water solubility (water solubility, 0.005 mg/L (PHYSPROP Database, 2012), lack of rapid degradability (BIOWIN), and log Kow＞4 (a measured value: 5.1 (PHYSPROP Database, 2012)), and 93-day NOEC＝0.0044 mg/L for fish (Oncorhynchus mykiss) (<1 mg/L, AQUIRE, 2012). It was classified in Category 1 by a comparison between the above results.	FY2011	GHS Classification Guidance by the Japanese Government （July, 2010）
12	Hazardous to the ozone layer	Classification not possible	- -	-	-	This substance is not listed in Annexes to the Montreal Protocol.	FY2011	GHS Classification Guidance by the Japanese Government （July, 2010）

NOTE:

GHS Classification Result by the Japanese Government is intended to provide a reference for preparing a GHS label or SDS for users. To include the same classification result in a label or SDS for Japan is NOT mandatory.
Users can cite or copy this classification result when preparing a GHS label or SDS. Please be aware, however, that the responsibility for a label or SDS prepared by citing or copying this classification result lies with users.
This GHS classification was conducted based on the information sources and the guidance for classification and judgement which are described in the GHS Classification Guidance for the Japanese Government etc. Using other literature, test results etc. as evidence and including different content from this classification result in a label or SDS are allowed.
Hazard statement and precautionary statement will show by hovering the mouse cursor over a code in the column of "Hazard statement" and "Precautionary statement," respectively. In the excel file, both the codes and statements are provided.
A blank or "-" in the column of "Classification" denotes that a classification for the hazard class was not conducted in the year.
An asterisk “*” in the column of “Classification” denotes that “Not classified (or No applicable)” and/or “Classification not possible” is applicable. Details are described in the column of “Rationale for the classification”. If no English translation is available for “Rationale for the classification,” please refer to the Japanese version of the results.

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