Item | Information |
---|---|
CAS RN | 556-82-1 |
Chemical Name | 3-Methyl-2-buten-1-ol |
Substance ID | m-nite-556-82-1_v1 |
Download of Excel format | Excel file |
Item | Information |
---|---|
Guidance used for the classification (External link) | To Guidance List |
UN GHS document (External link) | To UN GHS document |
FAQ(GHS classification results by the Japanese Government) | To FAQ |
List of Information Sources (Excel file) | List of Information Sources |
List of Definitions/Abbreviations | Definitions/Abbreviations |
Sample Label by MHLW (External link) | To Workplace Safety Site (MHLW) |
Sample SDS by MHLW (External link) | To Workplace Safety Site (MHLW) |
OECD/eChemPortal (External link) | To OECD/eChemPortal (External link) |
Hazard class | Classification | Pictogram Signal word |
Hazard statement (code) |
Precautionary statement (code) |
Rationale for the classification | Classification year (FY) | GHS Classification Guidance for the Japanese Government | |
---|---|---|---|---|---|---|---|---|
1 | Explosives | Not classified (Not applicable) |
- |
- | - | There are no chemical groups associated with explosive properties present in the molecule. | FY2012 | GHS Classification Guidance by the Japanese Government (July, 2010) |
2 | Flammable gases | Not classified (Not applicable) |
- |
- | - | Liquid (GHS definition) | FY2012 | GHS Classification Guidance by the Japanese Government (July, 2010) |
3 | Aerosols | Not classified (Not applicable) |
- |
- | - | Not aerosol products. | FY2012 | GHS Classification Guidance by the Japanese Government (July, 2010) |
4 | Oxidizing gases | Not classified (Not applicable) |
- |
- | - | Liquid (GHS definition) | FY2012 | GHS Classification Guidance by the Japanese Government (July, 2010) |
5 | Gases under pressure | Not classified (Not applicable) |
- |
- | - | Liquid (GHS definition) | FY2012 | GHS Classification Guidance by the Japanese Government (July, 2010) |
6 | Flammable liquids | Category 3 |
Warning |
H226 | P303+P361+P353 P370+P378 P403+P235 P210 P233 P240 P241 P242 P243 P280 P501 |
It corresponds to Category 3 from a flash point of 43 deg C [closed-cup] (MSDS (Sigma-Aldrich) (Access on June 2012)) >= 23 deg C and <= 60 deg C. | FY2012 | GHS Classification Guidance by the Japanese Government (July, 2010) |
7 | Flammable solids | Not classified (Not applicable) |
- |
- | - | Liquid (GHS definition) | FY2012 | GHS Classification Guidance by the Japanese Government (July, 2010) |
8 | Self-reactive substances and mixtures | Type G |
- |
- | - | There is a chemical group associated with self-reactive properties (unsaturated bond) in the molecule. It is reported in SIDS (2003) that the substance was evaluated to be not explosive from its chemical structure, and the expert rated the reliability as valid. Therefore, it was classified as Type G. | FY2012 | GHS Classification Guidance by the Japanese Government (July, 2010) |
9 | Pyrophoric liquids | Not classified |
- |
- | - | It is estimated that it does not ignite at normal temperatures from an autoignition temperature of 305 deg C (ICSC (2010)). | FY2012 | GHS Classification Guidance by the Japanese Government (July, 2010) |
10 | Pyrophoric solids | Not classified (Not applicable) |
- |
- | - | Liquid (GHS definition) | FY2012 | GHS Classification Guidance by the Japanese Government (July, 2010) |
11 | Self-heating substances and mixtures | Classification not possible |
- |
- | - | Test methods applicable to liquid substances are not available. | FY2012 | GHS Classification Guidance by the Japanese Government (July, 2010) |
12 | Substances and mixtures which, in contact with water, emit flammable gases | Not classified (Not applicable) |
- |
- | - | The chemical structure of the substance does not contain metals or metalloids (B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At). | FY2012 | GHS Classification Guidance by the Japanese Government (July, 2010) |
13 | Oxidizing liquids | Not classified (Not applicable) |
- |
- | - | The substance is an organic compound containing oxygen (but not fluorine or chlorine) which is chemically bonded only to carbon or hydrogen. | FY2012 | GHS Classification Guidance by the Japanese Government (July, 2010) |
14 | Oxidizing solids | Not classified (Not applicable) |
- |
- | - | Liquid (GHS definition) | FY2012 | GHS Classification Guidance by the Japanese Government (July, 2010) |
15 | Organic peroxides | Not classified (Not applicable) |
- |
- | - | Organic compounds containing no bivalent -O-O- structure. | FY2012 | GHS Classification Guidance by the Japanese Government (July, 2010) |
16 | Corrosive to metals | Classification not possible |
- |
- | - | No data available. | FY2012 | GHS Classification Guidance by the Japanese Government (July, 2010) |
17 | Desensitized explosives | - |
- |
- | - | - | - | - |
Hazard class | Classification | Pictogram Signal word |
Hazard statement (code) |
Precautionary statement (code) |
Rationale for the classification | Classification year (FY) | GHS Classification Guidance for the Japanese Government | |
---|---|---|---|---|---|---|---|---|
1 | Acute toxicity (Oral) | Category 4 |
Warning |
H302 | P301+P312 P264 P270 P330 P501 |
Both two LD50 values for rats (1,591 mg/kg and 810 mg/kg) (SIDS (2003)) correspond to Category 4. | FY2012 | GHS Classification Guidance by the Japanese Government (July, 2010) |
1 | Acute toxicity (Dermal) | Not classified |
- |
- | - | It was classified as "Not classified" in the Classification JIS (corresponding to Category 5 in UN GHS classification) based on an LD50 value of > 4,000 mg/kg for rats and an LD50 value of 3,900 mg/kg for rabbits (SIDS (2003)). | FY2012 | GHS Classification Guidance by the Japanese Government (July, 2010) |
1 | Acute toxicity (Inhalation: Gases) | Not classified (Not applicable) |
- |
- | - | Liquid (GHS definition) | FY2012 | GHS Classification Guidance by the Japanese Government (July, 2010) |
1 | Acute toxicity (Inhalation: Vapours) | Classification not possible |
- |
- | - | From an LC50 value by 4-hour exposure of > 16.8 mg/L for rats (SIDS (2003)), it corresponds to Category 4 or "Not classified," but the category cannot be determined. Therefore, it was classified as "Classification not possible." Besides, due to the description of exposure to the saturated vapour of an extremely high concentration, a reference value for vapour (mg/L) was applied. | FY2012 | GHS Classification Guidance by the Japanese Government (July, 2010) |
1 | Acute toxicity (Inhalation: Dusts and mists) | Classification not possible |
- |
- | - | No data available. | FY2012 | GHS Classification Guidance by the Japanese Government (July, 2010) |
2 | Skin corrosion/irritation | Category 1 |
Danger |
H314 | P301+P330+P331 P303+P361+P353 P305+P351+P338 P304+P340 P260 P264 P280 P310 P321 P363 P405 P501 |
It was classified in Category 1 because the primary dermal irritation index (PDII) was 6.13, and it was judged as corrosive in a test by a 4-hour occlusive application of 0.5 mL of undiluted this substance to the rabbit skin (SIDS (2003)). Besides, it is reported that it was also judged as corrosive in another test by a 20-hour or 24-hour occlusive application of undiluted this substance to the rabbit skin (SIDS (2003)). | FY2012 | GHS Classification Guidance by the Japanese Government (July, 2010) |
3 | Serious eye damage/eye irritation | Category 2A |
Warning |
H319 | P305+P351+P338 P337+P313 P264 P280 |
In a test in which 0.1 mL of undiluted this substance was applied to the rabbit eye (Federal Register 38, No. 187), the overall irritation score (equivalent to AOI) was 28.7 (maximum value 110), slight to moderate corneal opacity and moderate conjunctival redness and chemosis were observed and were not completely reversible within an 8-day observation period, and it was judged as highly irritating (SIDS (2003)). Therefore, it was classified in Category 2A. | FY2012 | GHS Classification Guidance by the Japanese Government (July, 2010) |
4 | Respiratory sensitization | Classification not possible |
- |
- | - | No data available. | FY2012 | GHS Classification Guidance by the Japanese Government (July, 2010) |
4 | Skin sensitization | Classification not possible |
- |
- | - | In humans, it is reported that it was not sensitizing in a maximization test in 26 volunteers (SIDS (2003)), but the details are unknown. Therefore, it was classified as "Classification not possible." | FY2012 | GHS Classification Guidance by the Japanese Government (July, 2010) |
5 | Germ cell mutagenicity | Not classified |
- |
- | - | It was classified as "Not classified" based on a negative result in a micronucleus test with bone marrow cells after intraperitoneal administration to mice (in vivo somatic cell mutagenicity test) (OECD TG474, GLP-compliant) (SIDS (2003)). Besides, there is a report on the results of a micronucleus test with bone marrow cells after oral administration to mice, and a high incidence of micronucleated polychromatic erythrocytes was observed only at the highest dose, but it was within the range of historical data, and the potential to induce micronuclei of this substance was considered to be of small biological significance (Evaluation of effect for the food safety (Food Safety Commission, 2010)). And as for in vitro test results, it is reported that it was negative (SIDS (2003)) or weakly positive (Evaluation of effect for the food safety (Food Safety Commission, 2010)) in Ames tests, and weekly positive in a chromosomal aberration test with CHL/IU cells (Evaluation of effect for the food safety (Food Safety Commission, 2010)). | FY2012 | GHS Classification Guidance by the Japanese Government (July, 2010) |
6 | Carcinogenicity | Classification not possible |
- |
- | - | No data available. | FY2012 | GHS Classification Guidance by the Japanese Government (July, 2010) |
7 | Reproductive toxicity | Classification not possible |
- |
- | - | In a developmental toxicity test by oral administration to rats on gestational days 6-19 (OECD TG 414; GLP), general toxicity (such as general symptoms, decreased food consumption, and reduced weight gain) was observed in maternal animals at the high dose (600 mg/kg), but there were no effects on reproduction parameters such as conception rate, the numbers of corpus lutea, implantations, resorptions, and live fetuses, or the development of offspring, nor were findings to suggest teratogenicity (SIDS (2003)). However, data are insufficient on effects on sexual function and fertility by the administration from before mating, it was classified as "Classification not possible." | FY2012 | GHS Classification Guidance by the Japanese Government (July, 2010) |
8 | Specific target organ toxicity - Single exposure | Category 2 (systemic) |
Warning |
H371 | P308+P311 P260 P264 P270 P405 P501 |
As symptoms observed after oral administration to rats, there is a description of staggering, dyspnea, and restlessness at or above 172 mg/kg, apathy, abdominal position, and reddened eyes and ears at or above 1,376 mg/kg, and lateral or dorsal position and secretions from the eyes and mouth at or above 1,720 mg/kg. And a dose-response was found, with symptoms getting worse with increasing dose, and recovery occurred within seven days at or below 1,376 mg/kg (SIDS (2003)). From the above, the test doses corresponded to guidance values for Category 2, but it was hard to specify the target organ. Therefore, it was classified in Category 2 (systemic toxicity). | FY2012 | GHS Classification Guidance by the Japanese Government (July, 2010) |
9 | Specific target organ toxicity - Repeated exposure | Classification not possible |
- |
- | - | It is reported that in a 90-day oral administration test by drinking water administration to rats (OECD TG 408; GLP), the only treatment-related findings were a reduction in food and water consumption at the high dose of 5,000 ppm (243.8 (males)-307.2 (females) mg/kg bw/day), which was accompanied by a decrease in body weight and body weight gain, but there were no significant treatment-related changes in other examinations (SIDS (2003)). Because the effects of administration were a reduction in food and water consumption and a decrease in body weight and body weight gain observed at doses above the guidance value range, it corresponds to "Not classified" in the oral route. However, because effects in the other routes (inhalation, dermal) are unknown due to no data, it was classified as "Classification not possible" for specific target organ toxicity (repeated exposure). | FY2012 | GHS Classification Guidance by the Japanese Government (July, 2010) |
10 | Aspiration hazard | Classification not possible |
- |
- | - | No data available. | FY2012 | GHS Classification Guidance by the Japanese Government (July, 2010) |
Hazard class | Classification | Pictogram Signal word |
Hazard statement (code) |
Precautionary statement (code) |
Rationale for the classification | Classification year (FY) | GHS Classification Guidance for the Japanese Government | |
---|---|---|---|---|---|---|---|---|
11 | Hazardous to the aquatic environment Short term (Acute) | Category 3 |
- |
H402 | P273 P501 |
It was classified in Category 3 from 96-hour LC50 = 46 mg/L for fish (Leuciscus idus) (SIDS, 2005). | FY2012 | GHS Classification Guidance by the Japanese Government (July, 2010) |
11 | Hazardous to the aquatic environment Long term (Chronic) | Not classified |
- |
- | - | If chronic toxicity data are used, then it is classified as "Not classified" due to rapid degradability (readily biodegradable: 82% (SIDS, 2005)), and 21-day NOEC = 3.4 mg/L for crustacea (Daphnia magna) (SIDS, 2005). If acute toxicity data are used for a trophic level for which chronic toxicity data are not obtained, then it is classified as "Not classified" due to rapid degradability (readily biodegradable: 82% (SIDS, 2005)), a low bioaccumulation estimate (LogKow = 1.17 (PHYSPROP Database (2009))), although it corresponds to Category 3 in acute toxicity for fish (SIDS, 2005). From the above results, it was classified as "Not classified." |
FY2012 | GHS Classification Guidance by the Japanese Government (July, 2010) |
12 | Hazardous to the ozone layer | Classification not possible |
- |
- | - | This substance is not listed in the Annexes to the Montreal Protocol. | FY2012 | GHS Classification Guidance by the Japanese Government (July, 2010) |
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