Item | Information |
---|---|
CAS RN | 56-04-2 |
Chemical Name | 6-Methyl-2-thiouracil; Methylthiouracil |
Substance ID | m-nite-56-04-2_v1 |
Download of Excel format | Excel file |
Item | Information |
---|---|
Guidance used for the classification (External link) | To Guidance List |
UN GHS document (External link) | To UN GHS document |
FAQ(GHS classification results by the Japanese Government) | To FAQ |
List of Information Sources (Excel file) | List of Information Sources |
List of Definitions/Abbreviations | Definitions/Abbreviations |
Sample Label by MHLW (External link) | MHLW Website (in Japanese Only) |
Sample SDS by MHLW (External link) | MHLW Website (in Japanese Only) |
OECD/eChemPortal (External link) | To OECD/eChemPortal (External link) |
Hazard class | Classification | Pictogram Signal word |
Hazard statement (code) |
Precautionary statement (code) |
Rationale for the classification | Classification year (FY) | GHS Classification Guidance for the Japanese Government | |
---|---|---|---|---|---|---|---|---|
1 | Explosives | Not classified (Not applicable) |
- |
- | - | There are no chemical groups associated with explosive properties present in the molecules. | FY2007 | GHS Classification Manual (10 Feb, 2006)/Technical Guidance Document on the GHS Classification (6 Dec, 2005) |
2 | Flammable gases | Not classified (Not applicable) |
- |
- | - | Solid (GHS definition) | FY2007 | GHS Classification Manual (10 Feb, 2006)/Technical Guidance Document on the GHS Classification (6 Dec, 2005) |
3 | Aerosols | Not classified (Not applicable) |
- |
- | - | Not aerosol products. | FY2007 | GHS Classification Manual (10 Feb, 2006)/Technical Guidance Document on the GHS Classification (6 Dec, 2005) |
4 | Oxidizing gases | Not classified (Not applicable) |
- |
- | - | Solid (GHS definition) | FY2007 | GHS Classification Manual (10 Feb, 2006)/Technical Guidance Document on the GHS Classification (6 Dec, 2005) |
5 | Gases under pressure | Not classified (Not applicable) |
- |
- | - | Solid (GHS definition) | FY2007 | GHS Classification Manual (10 Feb, 2006)/Technical Guidance Document on the GHS Classification (6 Dec, 2005) |
6 | Flammable liquids | Not classified (Not applicable) |
- |
- | - | Solid (GHS definition) | FY2007 | GHS Classification Manual (10 Feb, 2006)/Technical Guidance Document on the GHS Classification (6 Dec, 2005) |
7 | Flammable solids | Classification not possible |
- |
- | - | No data available. | FY2007 | GHS Classification Manual (10 Feb, 2006)/Technical Guidance Document on the GHS Classification (6 Dec, 2005) |
8 | Self-reactive substances and mixtures | Not classified (Not applicable) |
- |
- | - | There are no chemical groups present in the molecule associated with explosive or self-reactive properties. | FY2007 | GHS Classification Manual (10 Feb, 2006)/Technical Guidance Document on the GHS Classification (6 Dec, 2005) |
9 | Pyrophoric liquids | Not classified (Not applicable) |
- |
- | - | Solid (GHS definition) | FY2007 | GHS Classification Manual (10 Feb, 2006)/Technical Guidance Document on the GHS Classification (6 Dec, 2005) |
10 | Pyrophoric solids | Classification not possible |
- |
- | - | No data available. | FY2007 | GHS Classification Manual (10 Feb, 2006)/Technical Guidance Document on the GHS Classification (6 Dec, 2005) |
11 | Self-heating substances and mixtures | Classification not possible |
- |
- | - | No data available. | FY2007 | GHS Classification Manual (10 Feb, 2006)/Technical Guidance Document on the GHS Classification (6 Dec, 2005) |
12 | Substances and mixtures which, in contact with water, emit flammable gases | Not classified (Not applicable) |
- |
- | - | The chemical structure of the substance does not contain metals or metalloids (B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At). | FY2007 | GHS Classification Manual (10 Feb, 2006)/Technical Guidance Document on the GHS Classification (6 Dec, 2005) |
13 | Oxidizing liquids | Not classified (Not applicable) |
- |
- | - | Solid (GHS definition) | FY2007 | GHS Classification Manual (10 Feb, 2006)/Technical Guidance Document on the GHS Classification (6 Dec, 2005) |
14 | Oxidizing solids | Not classified (Not applicable) |
- |
- | - | The substance contains oxygen (but not fluorine or chlorine) which is chemically bonded only to carbon or hydrogen. | FY2007 | GHS Classification Manual (10 Feb, 2006)/Technical Guidance Document on the GHS Classification (6 Dec, 2005) |
15 | Organic peroxides | Not classified (Not applicable) |
- |
- | - | Organic compounds containing no bivalent -O-O- structure | FY2007 | GHS Classification Manual (10 Feb, 2006)/Technical Guidance Document on the GHS Classification (6 Dec, 2005) |
16 | Corrosive to metals | Classification not possible |
- |
- | - | No data available. | FY2007 | GHS Classification Manual (10 Feb, 2006)/Technical Guidance Document on the GHS Classification (6 Dec, 2005) |
17 | Desensitized explosives | - |
- |
- | - | - | - | - |
Hazard class | Classification | Pictogram Signal word |
Hazard statement (code) |
Precautionary statement (code) |
Rationale for the classification | Classification year (FY) | GHS Classification Guidance for the Japanese Government | |
---|---|---|---|---|---|---|---|---|
1 | Acute toxicity (Oral) | Category 4 |
Warning |
H302 | P301+P312 P264 P270 P330 P501 |
Based on the LD50 of 1500 mg/kg obtained in a rat oral administration test (RTECS, accessed in August 2007), the substance was classified into Category 4. | FY2007 | GHS Classification Manual (10 Feb, 2006)/Technical Guidance Document on the GHS Classification (6 Dec, 2005) |
1 | Acute toxicity (Dermal) | Classification not possible |
- |
- | - | No data available. | FY2007 | GHS Classification Manual (10 Feb, 2006)/Technical Guidance Document on the GHS Classification (6 Dec, 2005) |
1 | Acute toxicity (Inhalation: Gases) | Not classified (Not applicable) |
- |
- | - | Since the substance is a solid (GHS definition), it was classified into the "Not applicable" category. | FY2007 | GHS Classification Manual (10 Feb, 2006)/Technical Guidance Document on the GHS Classification (6 Dec, 2005) |
1 | Acute toxicity (Inhalation: Vapours) | Classification not possible |
- |
- | - | No data available. | FY2007 | GHS Classification Manual (10 Feb, 2006)/Technical Guidance Document on the GHS Classification (6 Dec, 2005) |
1 | Acute toxicity (Inhalation: Dusts and mists) | Classification not possible |
- |
- | - | No data available. | FY2007 | GHS Classification Manual (10 Feb, 2006)/Technical Guidance Document on the GHS Classification (6 Dec, 2005) |
2 | Skin corrosion/irritation | Classification not possible |
- |
- | - | No data available. | FY2007 | GHS Classification Manual (10 Feb, 2006)/Technical Guidance Document on the GHS Classification (6 Dec, 2005) |
3 | Serious eye damage/eye irritation | Classification not possible |
- |
- | - | No data available. | FY2007 | GHS Classification Manual (10 Feb, 2006)/Technical Guidance Document on the GHS Classification (6 Dec, 2005) |
4 | Respiratory sensitization | Classification not possible |
- |
- | - | No data available. | FY2007 | GHS Classification Manual (10 Feb, 2006)/Technical Guidance Document on the GHS Classification (6 Dec, 2005) |
4 | Skin sensitization | Classification not possible |
- |
- | - | No data available. | FY2007 | GHS Classification Manual (10 Feb, 2006)/Technical Guidance Document on the GHS Classification (6 Dec, 2005) |
5 | Germ cell mutagenicity | Not classified |
- |
- | - | Among in vivo mutagenicity tests using somatic cell, micronucleus tests using mouse peripheral blood cells and micronucleus tests using bone marrow cells of pregnant mice gave negative results (IARC 79 (2001)). Thus, the substance was classified into the "Not classified" category. As additional background information, a micronucleus test using blood cells of fetal mice gave weak positive results (IARC 79 (2001)). However, the IARC questioned the reliability of the test and treated it as a negative test. | FY2007 | GHS Classification Manual (10 Feb, 2006)/Technical Guidance Document on the GHS Classification (6 Dec, 2005) |
6 | Carcinogenicity | Category 2 |
Warning |
H351 | P308+P313 P201 P202 P280 P405 P501 |
Since the substance is rates as Group 2B by IARC 79 (2001), it was classified into Category 2. | FY2007 | GHS Classification Manual (10 Feb, 2006)/Technical Guidance Document on the GHS Classification (6 Dec, 2005) |
7 | Reproductive toxicity | Classification not possible |
- |
- | - | Classification not possible due to lack of data. According to IARC 79 (2001), methylthiouracil crossed the placental barrier and was excreted in the milk. Since these effects on infants are not known, classification is not possible. | FY2007 | GHS Classification Manual (10 Feb, 2006)/Technical Guidance Document on the GHS Classification (6 Dec, 2005) |
8 | Specific target organ toxicity - Single exposure | Classification not possible |
- |
- | - | No data available. | FY2007 | GHS Classification Manual (10 Feb, 2006)/Technical Guidance Document on the GHS Classification (6 Dec, 2005) |
9 | Specific target organ toxicity - Repeated exposure | Category 1 (blood system) |
Danger |
H372 | P260 P264 P270 P314 P501 |
According to IARC 79 (2001), human exposure to methylthiouracil is associated with a high frequency of granulocytopenia. Since an effect of this substance on the blood system is detected, it was classified into Category 1 (blood system). | FY2007 | GHS Classification Manual (10 Feb, 2006)/Technical Guidance Document on the GHS Classification (6 Dec, 2005) |
10 | Aspiration hazard | Classification not possible |
- |
- | - | No data available. | FY2007 | GHS Classification Manual (10 Feb, 2006)/Technical Guidance Document on the GHS Classification (6 Dec, 2005) |
Hazard class | Classification | Pictogram Signal word |
Hazard statement (code) |
Precautionary statement (code) |
Rationale for the classification | Classification year (FY) | GHS Classification Guidance for the Japanese Government | |
---|---|---|---|---|---|---|---|---|
11 | Hazardous to the aquatic environment Short term (Acute) | Classification not possible |
- |
- | - | No data available. | FY2007 | GHS Classification Manual (10 Feb, 2006)/Technical Guidance Document on the GHS Classification (6 Dec, 2005) |
11 | Hazardous to the aquatic environment Long term (Chronic) | Classification not possible |
- |
- | - | No data available. | FY2007 | GHS Classification Manual (10 Feb, 2006)/Technical Guidance Document on the GHS Classification (6 Dec, 2005) |
12 | Hazardous to the ozone layer | - |
- |
- | - | - | - | - |
|