NITE - Chemical Management Field

Latest GHS Classification Results by the Japanese Government (edited by NITE)

GENERAL INFORMATION

Item	Information
CAS RN	56-35-9
Chemical Name	Distannoxane, hexabutyl-
Substance ID	m-nite-56-35-9_v1
Download of Excel format	Excel file

REFERENCE INFORMATION

Item	Information
Guidance used for the classification (External link)	To Guidance List
UN GHS document (External link)	To UN GHS document
FAQ（GHS classification results by the Japanese Government）	To FAQ
List of Information Sources (Excel file)	List of Information Sources
List of Definitions/Abbreviations	Definitions/Abbreviations
Sample Label by MHLW (External link)	MHLW Website (in Japanese Only)
Sample SDS by MHLW (External link)	MHLW Website (in Japanese Only)
OECD/eChemPortal (External link)	To OECD/eChemPortal (External link)

PHYSICAL HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification	Classification year (FY)	GHS Classification Guidance for the Japanese Government
1	Explosives	Not classified (Not applicable)	- -	-	-	There are no chemical groups associated with explosive properties present in the molecules.	FY2006	GHS Classification Manual （10 Feb, 2006）
2	Flammable gases	Not classified (Not applicable)	- -	-	-	Liquid (GHS definition)	FY2006	GHS Classification Manual （10 Feb, 2006）
3	Aerosols	Not classified (Not applicable)	- -	-	-	Not aerosol products	FY2006	GHS Classification Manual （10 Feb, 2006）
4	Oxidizing gases	Not classified (Not applicable)	- -	-	-	Liquid (GHS definition)	FY2006	GHS Classification Manual （10 Feb, 2006）
5	Gases under pressure	Not classified (Not applicable)	- -	-	-	Liquid (GHS definition)	FY2006	GHS Classification Manual （10 Feb, 2006）
6	Flammable liquids	Not classified	- -	-	-	Not classified because of its flash point: 190degC(C.C.) (ICSC(J), 1998)	FY2006	GHS Classification Manual （10 Feb, 2006）
7	Flammable solids	Not classified (Not applicable)	- -	-	-	Liquid (GHS definition)	FY2006	GHS Classification Manual （10 Feb, 2006）
8	Self-reactive substances and mixtures	Not classified (Not applicable)	- -	-	-	There are no chemical groups associated with explosive or self-reactive properties present in the molecule.	FY2006	GHS Classification Manual （10 Feb, 2006）
9	Pyrophoric liquids	Not classified	- -	-	-	Uses are sterilization and antifungal agent, a ship's-bottom paint additive agent etc., and even if it contacts the air of normal temperature, it does not ignite spontaneously.	FY2006	GHS Classification Manual （10 Feb, 2006）
10	Pyrophoric solids	Not classified (Not applicable)	- -	-	-	Liquid (GHS definition)	FY2006	GHS Classification Manual （10 Feb, 2006）
11	Self-heating substances and mixtures	Classification not possible	- -	-	-	Test methods applicable to liquid substances are not available	FY2006	GHS Classification Manual （10 Feb, 2006）
12	Substances and mixtures which, in contact with water, emit flammable gases	Not classified	- -	-	-	Stable to water (the water solubility is obtained)	FY2006	GHS Classification Manual （10 Feb, 2006）
13	Oxidizing liquids	Classification not possible	- -	-	-	No data available	FY2006	GHS Classification Manual （10 Feb, 2006）
14	Oxidizing solids	Not classified (Not applicable)	- -	-	-	Liquid (GHS definition)	FY2006	GHS Classification Manual （10 Feb, 2006）
15	Organic peroxides	Not classified (Not applicable)	- -	-	-	Organic compounds containing no -0-0- structure	FY2006	GHS Classification Manual （10 Feb, 2006）
16	Corrosive to metals	Classification not possible	- -	-	-	No data available	FY2006	GHS Classification Manual （10 Feb, 2006）
17	Desensitized explosives	-	- -	-	-	-	-	-

HEALTH HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification	Classification year (FY)	GHS Classification Guidance for the Japanese Government
1	Acute toxicity (Oral)	Category 3	Danger	H301	P301+P310 P264 P270 P321 P330 P405 P501	Because the oral LD50 values in rats are 127-234mg/kg (CICAD 14, 1999) or 92-194mg/kg (DFGOT 1, 1991), the substance was classified as Category 3.	FY2006	GHS Classification Manual （10 Feb, 2006）
1	Acute toxicity (Dermal)	Category 3	Danger	H311	P302+P352 P361+P364 P280 P312 P321 P405 P501	It was set as Category 3 from rat dermal LD50 = 605mg/kg (ACGIH 7th, 2001;DFGOT 1, 1991).	FY2006	GHS Classification Manual （10 Feb, 2006）
1	Acute toxicity (Inhalation: Gases)	Not classified (Not applicable)	- -	-	-	Liquid (GHS definition)	FY2006	GHS Classification Manual （10 Feb, 2006）
1	Acute toxicity (Inhalation: Vapours)	Classification not possible	- -	-	-	No data available	FY2006	GHS Classification Manual （10 Feb, 2006）
1	Acute toxicity (Inhalation: Dusts and mists)	Category 2	Danger	H330	P304+P340 P403+P233 P260 P271 P284 P310 P320 P405 P501	Based on rat inhalation LC50 value 65mg/m3/4H (= 0.065mg/L/4H) (DFGOT 1 (1991); CICAD 14 (1999); ATSDR (2005)), it was set as Category 2.	FY2006	GHS Classification Manual （10 Feb, 2006）
2	Skin corrosion/irritation	Category 2	Warning	H315	P302+P352 P332+P313 P362+P364 P264 P280 P321	Since severe irritation was indicated in the Draize's examination using human and rabbit skin (RTECS, 2004) and it was considered as the powerful skin stimulativeness substance (CICAD 14, 1999), it was set as Category 2.	FY2006	GHS Classification Manual （10 Feb, 2006）
3	Serious eye damage/eye irritation	Category 2A	Warning	H319	P305+P351+P338 P337+P313 P264 P280	Since severe irritation was indicated in the Draize Test using a rabbit eye (RTECS, 2004), and it was considered as the strong eye stimulativeness substance (CICAD 14, 1999; ICSC, 1998), it was set as Category 2A.	FY2006	GHS Classification Manual （10 Feb, 2006）
4	Respiratory sensitization	Classification not possible	- -	-	-	No data available	FY2006	GHS Classification Manual （10 Feb, 2006）
4	Skin sensitization	Classification not possible	- -	-	-	While it was negative (CICAD 14, 1999) in guinea pig skin sensitization test ( Magnussen-Kligman method) and there were findings that allergic was not accepted in humans (ATSDR, 2005), since the contact sensitizing activity was acknowledged in the mouse in recent years, it was presupposed from (ATSDR, 2005; CICAD 14, 1999) that it cannot classify.	FY2006	GHS Classification Manual （10 Feb, 2006）
5	Germ cell mutagenicity	Not classified	- -	-	-	It carried out the outside of Category. Based on the mouse small core test from the negative (ATSDR, 2005;CICAD 14, 1999) , and negative in the Ames test an in vitro mutagenicity test and the cell gene mutation test. So it is classified as the out of the Category. In addition, it is considered as the positive by levels of cytotoxicity concentration in the in vitro chromosome aberration test (CICAD 14, 1999), and the weak reaction occurs by part of mouse small core test. But it is synthetically estimated as negativity (ATSDR, 2005; CICAD 14, 1999).	FY2006	GHS Classification Manual （10 Feb, 2006）
6	Carcinogenicity	Not classified	- -	-	-	The endocrine systems oncogeny was slightly seen in the rat about this product. But it was negative in the mouse (CICAD 14, 1999), and classified into D (it cannot classify into human carcinogenicity) (IRIS, 2002), or I (evidence is inadequate for humans carcinogenicity evaluation) (ATSDR, 2005) according to EPA. Moreover, the organotin compounds was classified into A4 (it cannot classify into a the human carcinogens) in ACGIH. Therefore, it was carried out the outside of category according to the guideline.	FY2006	GHS Classification Manual （10 Feb, 2006）
7	Reproductive toxicity	Not classified	- -	-	-	Although the slight influences on reproductive developments, such as an fetus weight fall, ossification variation, and the number fetus of one mother, were admitted. They were dosage which effect on the maternal toxicity and immune system (IRIS, 2002; CICAD 14, 1999). And since the this product was not considered to be a reproductive developmental toxicity substances (CICAD 14, 1999), it was set as the outside of Category.	FY2006	GHS Classification Manual （10 Feb, 2006）
8	Specific target organ toxicity - Single exposure	Category 3 (Respiratory tract irritation)	Warning	H335	P304+P340 P403+P233 P261 P271 P312 P405 P501	Since there was knowledge which indicates respiratory irritant to humans (CICAD 14, 1999), it was considered as Category 3 (respiratory irritant). In addition, unlike other organotin compounds, about this product, effect is not observed in a nervous systems (CICAD 14, 1999).	FY2006	GHS Classification Manual （10 Feb, 2006）
9	Specific target organ toxicity - Repeated exposure	Category 1 (immune system)	Danger	H372	P260 P264 P270 P314 P501	Since the key virulence trait of this product is the influence on immune systems based on the knowledge acquired by animal studies(thymus dependence immune dysfunction) (CICAD 14, 1999), and since this knowledge is accepted in the guidance value of Category 1, it was classified into Category 1 (immune system).	FY2006	GHS Classification Manual （10 Feb, 2006）
10	Aspiration hazard	Classification not possible	- -	-	-	No data available	FY2006	GHS Classification Manual （10 Feb, 2006）

ENVIRONMENTAL HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification	Classification year (FY)	GHS Classification Guidance for the Japanese Government
11	Hazardous to the aquatic environment Short term (Acute)	Category 1	Warning	H400	P273 P391 P501	It was classified into Category 1 from 96-hour LC50=1.5microg/L of fishes (King salmon) (EHC116, 1990).	FY2006	GHS Classification Manual （10 Feb, 2006）
11	Hazardous to the aquatic environment Long term (Chronic)	Category 1	Warning	H410	P273 P391 P501	Classified into Category 1, since acute toxicity is Category 1,not rapidly degrading (BOD: 2% (existing chemical substances safety inspections data)), and bioaccumulative (BCF=12100 (existing chemical substances safety inspections data)).	FY2006	GHS Classification Manual （10 Feb, 2006）
12	Hazardous to the ozone layer	-	- -	-	-	-	-	-

NOTE:

GHS Classification Result by the Japanese Government is intended to provide a reference for preparing a GHS label or SDS for users. To include the same classification result in a label or SDS for Japan is NOT mandatory.
Users can cite or copy this classification result when preparing a GHS label or SDS. Please be aware, however, that the responsibility for a label or SDS prepared by citing or copying this classification result lies with users.
This GHS classification was conducted based on the information sources and the guidance for classification and judgement which are described in the GHS Classification Guidance for the Japanese Government etc. Using other literature, test results etc. as evidence and including different content from this classification result in a label or SDS are allowed.
Hazard statement and precautionary statement will show by hovering the mouse cursor over a code in the column of "Hazard statement" and "Precautionary statement," respectively. In the excel file, both the codes and statements are provided.
A blank or "-" in the column of "Classification" denotes that a classification for the hazard class was not conducted in the year.
An asterisk “*” in the column of “Classification” denotes that “Not classified (or No applicable)” and/or “Classification not possible” is applicable. Details are described in the column of “Rationale for the classification”. If no English translation is available for “Rationale for the classification,” please refer to the Japanese version of the results.

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