Item | Information |
---|---|
CAS RN | 56-36-0 |
Chemical Name | tributyltin acetate |
Substance ID | m-nite-56-36-0_v1 |
Download of Excel format | Excel file |
Item | Information |
---|---|
Guidance used for the classification (External link) | To Guidance List |
UN GHS document (External link) | To UN GHS document |
FAQ(GHS classification results by the Japanese Government) | To FAQ |
List of Information Sources (Excel file) | List of Information Sources |
List of Definitions/Abbreviations | Definitions/Abbreviations |
Sample Label by MHLW (External link) | MHLW Website (in Japanese Only) |
Sample SDS by MHLW (External link) | MHLW Website (in Japanese Only) |
OECD/eChemPortal (External link) | To OECD/eChemPortal (External link) |
Hazard class | Classification | Pictogram Signal word |
Hazard statement (code) |
Precautionary statement (code) |
Rationale for the classification | Classification year (FY) | GHS Classification Guidance for the Japanese Government | |
---|---|---|---|---|---|---|---|---|
1 | Explosives | Not classified (Not applicable) |
- |
- | - | There are no chemical groups associated with explosive properties present in the molecules. | FY2006 | GHS Classification Manual (10 Feb, 2006) |
2 | Flammable gases | Not classified (Not applicable) |
- |
- | - | Solid (GHS definition) | FY2006 | GHS Classification Manual (10 Feb, 2006) |
3 | Aerosols | Not classified (Not applicable) |
- |
- | - | Not aerosol products | FY2006 | GHS Classification Manual (10 Feb, 2006) |
4 | Oxidizing gases | Not classified (Not applicable) |
- |
- | - | Solid (GHS definition) | FY2006 | GHS Classification Manual (10 Feb, 2006) |
5 | Gases under pressure | Not classified (Not applicable) |
- |
- | - | Solid (GHS definition) | FY2006 | GHS Classification Manual (10 Feb, 2006) |
6 | Flammable liquids | Not classified (Not applicable) |
- |
- | - | Solid (GHS definition) | FY2006 | GHS Classification Manual (10 Feb, 2006) |
7 | Flammable solids | Classification not possible |
- |
- | - | No data available | FY2006 | GHS Classification Manual (10 Feb, 2006) |
8 | Self-reactive substances and mixtures | Not classified (Not applicable) |
- |
- | - | There are no chemical groups associated with explosive or self-reactive properties present in the molecule. | FY2006 | GHS Classification Manual (10 Feb, 2006) |
9 | Pyrophoric liquids | Not classified (Not applicable) |
- |
- | - | Solid (GHS definition) | FY2006 | GHS Classification Manual (10 Feb, 2006) |
10 | Pyrophoric solids | Not classified |
- |
- | - | It was a kind of tributyl tins, and since tributyl tins were once used as antifouling agents for hulls or fishing implements, it was considered not to ignite spontaneously even if it contacted the normal temperature air. Thus it was defined as "out of Category". | FY2006 | GHS Classification Manual (10 Feb, 2006) |
11 | Self-heating substances and mixtures | Classification not possible |
- |
- | - | Test methods applicable to solid (melting point <= 140degC) substances are not available. | FY2006 | GHS Classification Manual (10 Feb, 2006) |
12 | Substances and mixtures which, in contact with water, emit flammable gases | Not classified |
- |
- | - | It was a kind of tributyl tins, and since tributyl tins was once used as a antifouling agent of a hull or fishing implements, it was considered to be stable to water and carried out the outside of category. | FY2006 | GHS Classification Manual (10 Feb, 2006) |
13 | Oxidizing liquids | Not classified (Not applicable) |
- |
- | - | Solid (GHS definition) | FY2006 | GHS Classification Manual (10 Feb, 2006) |
14 | Oxidizing solids | Classification not possible |
- |
- | - | No data available | FY2006 | GHS Classification Manual (10 Feb, 2006) |
15 | Organic peroxides | Not classified (Not applicable) |
- |
- | - | Organic compounds containing no -0-0- structure | FY2006 | GHS Classification Manual (10 Feb, 2006) |
16 | Corrosive to metals | Classification not possible |
- |
- | - | Test methods applicable to solid substances are not available. | FY2006 | GHS Classification Manual (10 Feb, 2006) |
17 | Desensitized explosives | - |
- |
- | - | - | - | - |
Hazard class | Classification | Pictogram Signal word |
Hazard statement (code) |
Precautionary statement (code) |
Rationale for the classification | Classification year (FY) | GHS Classification Guidance for the Japanese Government | |
---|---|---|---|---|---|---|---|---|
1 | Acute toxicity (Oral) | Category 3 |
Danger |
H301 | P301+P310 P264 P270 P321 P330 P405 P501 |
Category 3 based on SPECIES: Rat; ENDPOINT: LD50; VALUE: 50-100 mg/kg (ACGIH 7th, 2001) and 99 mg/kg (Patty, 5th, 2001; RTECS, 2004) | FY2006 | GHS Classification Manual (10 Feb, 2006) |
1 | Acute toxicity (Dermal) | Classification not possible |
- |
- | - | No data available | FY2006 | GHS Classification Manual (10 Feb, 2006) |
1 | Acute toxicity (Inhalation: Gases) | Not classified (Not applicable) |
- |
- | - | Solid (GHS definition) | FY2006 | GHS Classification Manual (10 Feb, 2006) |
1 | Acute toxicity (Inhalation: Vapours) | Classification not possible |
- |
- | - | No data available | FY2006 | GHS Classification Manual (10 Feb, 2006) |
1 | Acute toxicity (Inhalation: Dusts and mists) | Classification not possible |
- |
- | - | No data available | FY2006 | GHS Classification Manual (10 Feb, 2006) |
2 | Skin corrosion/irritation | Category 3 |
Warning |
- | - | From the knowledge that the skin is stimulated and a burn injury is caused (HSFS, 1999), and that tributyltin compounds or organic tin compounds indicate skin irritation (DFGOT 1, 1991-atty 5th, 2001; ATSDR, 2005), it was judged that it had slight skin irritation leastways, and was set as category 3. | FY2006 | GHS Classification Manual (10 Feb, 2006) |
3 | Serious eye damage/eye irritation | Category 2A |
Warning |
H319 | P305+P351+P338 P337+P313 P264 P280 |
From knowledge that an eye is stimulated and a burn is caused (HSFS, 1999), and eye irritation is indicated with the organic tin compound (ACGIH 7th, 2001; Patty 5th, 2001; ATSDR, 2005), it is set as Category 2A-2B. In addition, detailed categorization is difficult. | FY2006 | GHS Classification Manual (10 Feb, 2006) |
4 | Respiratory sensitization | Classification not possible |
- |
- | - | No data available | FY2006 | GHS Classification Manual (10 Feb, 2006) |
4 | Skin sensitization | Classification not possible |
- |
- | - | No data available | FY2006 | GHS Classification Manual (10 Feb, 2006) |
5 | Germ cell mutagenicity | Classification not possible |
- |
- | - | No data available | FY2006 | GHS Classification Manual (10 Feb, 2006) |
6 | Carcinogenicity | Classification not possible |
- |
- | - | The organotin compounds is classified into A4 (it cannot classify into a the human carcinogens) in ACGIH. On the other hand, there is also a knowledge that a certain kind of organotin compounds induces cancer to animals (ATSDR, 2005) and data of its this product themselves cannot be found. Therefore, it cannot be classified since the data is insufficient. | FY2006 | GHS Classification Manual (10 Feb, 2006) |
7 | Reproductive toxicity | Category 2 |
Warning |
H361 | P308+P313 P201 P202 P280 P405 P501 |
Since embryo fetus fatality and the developmental abnormality (the craniofacial and skeletal muscle system) were seen in the teratogenicity study using rat in the dose which indicates maternal toxicity (ATSDR, 2005; RTECS, 2004), it was set as Category 2. | FY2006 | GHS Classification Manual (10 Feb, 2006) |
8 | Specific target organ toxicity - Single exposure | Category 1 (central nervous system), Category 2 (gastrointestinal system), Category 3 (respiratory tract irritation) |
Danger Warning |
H370 H371 H335 |
P308+P311 P260 P264 P270 P321 P405 P501 P304+P340 P403+P233 P261 P271 P312 |
Since in the guidance value of Category 2, gastrointestinal bleedings was observed in the mouse (ATSDR, 2005), and the influence of the central nervous system on human (ATSDR, 2005; ACGIH 7th, 2001; Patty 5th, 2001) and the potential of respiratory irritant (ATSDR, 2005; ACGIH 7th, 2001) as an organic tin compounds are descrived, it was considered as Category 1 (central nervous system), Category 2 (alimentary system), and Category 3 (respiratory irritant). | FY2006 | GHS Classification Manual (10 Feb, 2006) |
9 | Specific target organ toxicity - Repeated exposure | Category 1 (immune system) |
Danger |
H372 | P260 P264 P270 P314 P501 |
Although own data of this product could not be found, since the impacts of effects on the human immune system was suggested by as an organic tin compounds (ATSDR, 2005;ACGIH 7th, 2001-atty 5th, 2001), it was classified into Category 1 (immune systems). | FY2006 | GHS Classification Manual (10 Feb, 2006) |
10 | Aspiration hazard | Classification not possible |
- |
- | - | No data available | FY2006 | GHS Classification Manual (10 Feb, 2006) |
Hazard class | Classification | Pictogram Signal word |
Hazard statement (code) |
Precautionary statement (code) |
Rationale for the classification | Classification year (FY) | GHS Classification Guidance for the Japanese Government | |
---|---|---|---|---|---|---|---|---|
11 | Hazardous to the aquatic environment Short term (Acute) | Category 1 |
Warning |
H400 | P273 P391 P501 |
It was classified into Category 1 from 48-hour LC50=3.3microg TBT/L (tributyltin acetate concentration equivalent: 4.0microg/L) of Crustacea (Daphnia magna) (EHC15, 1980). | FY2006 | GHS Classification Manual (10 Feb, 2006) |
11 | Hazardous to the aquatic environment Long term (Chronic) | Category 1 |
Warning |
H410 | P273 P391 P501 |
Classified into Category 1, since acute toxicity is Category 1,not rapidly degrading (it hydrolyzed, and tributyltin hydroxides was generated, and remained (existing chemical substances safety inspections data)), and bioaccumulative (BCF=9210 of tributyltin hydroxides (existing chemical substances safety inspections data)). | FY2006 | GHS Classification Manual (10 Feb, 2006) |
12 | Hazardous to the ozone layer | - |
- |
- | - | - | - | - |
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