NITE - Chemical Management Field

Latest GHS Classification Results by the Japanese Government (edited by NITE)

GENERAL INFORMATION

Item	Information
CAS RN	563-47-3
Chemical Name	3-Chloro-2-methyl-1-propene
Substance ID	m-nite-563-47-3_v1
Download of Excel format	Excel file

REFERENCE INFORMATION

Item	Information
Guidance used for the classification (External link)	To Guidance List
UN GHS document (External link)	To UN GHS document
FAQ（GHS classification results by the Japanese Government）	To FAQ
List of Information Sources (Excel file)	List of Information Sources
List of Definitions/Abbreviations	Definitions/Abbreviations
Sample Label by MHLW (External link)	To Workplace Safety Site (MHLW)
Sample SDS by MHLW (External link)	To Workplace Safety Site (MHLW)
OECD/eChemPortal (External link)	To OECD/eChemPortal (External link)

PHYSICAL HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification	Classification year (FY)	GHS Classification Guidance for the Japanese Government
1	Explosives	Not classified (Not applicable)	- -	-	-	There are no chemical groups associated with explosive properties present in the molecule.	FY2016	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
2	Flammable gases	Not classified (Not applicable)	- -	-	-	Liquid (GHS definition)	FY2016	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
3	Aerosols	Not classified (Not applicable)	- -	-	-	Not aerosol products.	FY2016	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
4	Oxidizing gases	Not classified (Not applicable)	- -	-	-	Liquid (GHS definition)	FY2016	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
5	Gases under pressure	Not classified (Not applicable)	- -	-	-	Liquid (GHS definition)	FY2016	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
6	Flammable liquids	Category 2	Danger	H225	P303+P361+P353 P370+P378 P403+P235 P210 P233 P240 P241 P242 P243 P280 P501	From a flash point of -12 deg C (closed-cup) and a boiling point of 72 deg C in ICSC(J) (2008), it corresponds to Category 2. Besides, it is classified in Class 3, PG II (UN2554) in UNRTDG.	FY2016	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
7	Flammable solids	Not classified (Not applicable)	- -	-	-	Liquid (GHS definition)	FY2016	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
8	Self-reactive substances and mixtures	Classification not possible	- -	-	-	There is an unsaturated bond (olefins) in the chemical structure, but the classification is not possible due to no data.	FY2016	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
9	Pyrophoric liquids	Not classified	- -	-	-	It is estimated that it does not ignite at normal temperatures from an autoignition temperature of 540 deg C (ICSC(J) (2008)).	FY2016	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
10	Pyrophoric solids	Not classified (Not applicable)	- -	-	-	Liquid (GHS definition)	FY2016	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
11	Self-heating substances and mixtures	Classification not possible	- -	-	-	Test methods applicable to liquid substances are not available.	FY2016	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
12	Substances and mixtures which, in contact with water, emit flammable gases	Not classified (Not applicable)	- -	-	-	The chemical structure of the substance does not contain metals or metalloids (B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At).	FY2016	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
13	Oxidizing liquids	Not classified (Not applicable)	- -	-	-	The substance is an organic compound containing chlorine (but not fluorine or oxygen) which is chemically bonded only to carbon or hydrogen.	FY2016	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
14	Oxidizing solids	Not classified (Not applicable)	- -	-	-	Liquid (GHS definition)	FY2016	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
15	Organic peroxides	Not classified (Not applicable)	- -	-	-	Organic compounds containing no bivalent -O-O- structure in the molecule	FY2016	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
16	Corrosive to metals	Classification not possible	- -	-	-	No data available.	FY2016	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
17	Desensitized explosives	-	- -	-	-	-	-	-

HEALTH HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification	Classification year (FY)	GHS Classification Guidance for the Japanese Government
1	Acute toxicity (Oral)	Category 4	Warning	H302	P301+P312 P264 P270 P330 P501	There are 3 reported LD50 values for rats of 215 mg/kg (DFGOT vol.4 (1992), BUA 109 (1993)), 848 mg/kg (Environmental Risk Assessment for Chemical Substances Vol. 9 (Ministry of the Environment, 2011)), and 1,240 mg/kg (DFGOT vol.4 (1992), BUA 109 (1993)). Since one value corresponds to Category 3, and two values correspond to Category 4, this substance was classified in Category 4 by adopting the Category which has larger number of reports.	FY2016	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
1	Acute toxicity (Dermal)	Not classified	- -	-	-	Based on a reported LD50 value of > 4,000 mg/kg (DFGOT vol. 4 (1992)) for rats, this substance was classified as "Not classified."	FY2016	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
1	Acute toxicity (Inhalation: Gases)	Not classified (Not applicable)	- -	-	-	Liquid (GHS definition)	FY2016	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
1	Acute toxicity (Inhalation: Vapours)	Category 3	Danger	H331	P304+P340 P403+P233 P261 P271 P311 P321 P405 P501	There are 2 reported LC50 values (4 hours) for rats of > 5,000 mg/m3 (converted value: >1,350 ppm) (Environmental Risk Assessment for Chemical Substances Vol. 9 (Ministry of the Environment, 2011)) and 1,240 ppm (DFGOT vol.4 (1992), BUA 109 (1993)). One value corresponds to Category 4 – "Not classified," and one value corresponds to Category 3. By adopting the more hazardous category, this substance was classified in Category 3. Besides, because the LC50 values are lower than 90% of the saturated vapor pressure concentration (136,520 ppm), the reference value in the unit of ppm was applied as vapour without mist.	FY2016	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
1	Acute toxicity (Inhalation: Dusts and mists)	Classification not possible	- -	-	-	Classification not possible due to lack of data.	FY2016	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
2	Skin corrosion/irritation	Category 1	Danger	H314	P301+P330+P331 P303+P361+P353 P305+P351+P338 P304+P340 P260 P264 P280 P310 P321 P363 P405 P501	It is reported to be corrosive to rabbit skin (DFGOT vol. 4 (1992)), and it is also reported to be irritating to the skin in humans (Environmental Risk Assessment for Chemical Substances Vol. 9 (Ministry of the Environment, 2011)). Therefore, it was classified in Category 1.	FY2016	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
3	Serious eye damage/eye irritation	Classification not possible	- -	-	-	There is a report that it was not irritating to the rabbit eyes (DFGOT vol.4 (1992)). However, because there are no data other than this one report, this substance was classified as "Classification not possible." Besides, this substance was classified in Category 1 for Skin Corrosion/Irritation, and it was classified in Category 1 according to the latest GHS of the sixth revised edition despite the information on a negative finding. Therefore, it is thought that this substance will be classified in Category 1 when the GHS Classification Guidance for the Japanese Government is revised in accordance with the latest GHS.	FY2016	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
4	Respiratory sensitization	Classification not possible	- -	-	-	Classification not possible due to lack of data.	FY2016	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
4	Skin sensitization	Category 1	Warning	H317	P302+P352 P333+P313 P362+P364 P261 P272 P280 P321 P501	A sensitization test using guinea pigs was positive (DFGOT vol. 4 (1992)), and skin sensitization is also reported in humans (Environmental Risk Assessment for Chemical Substances Vol. 9 (Ministry of the Environment, 2011)). Therefore, this substance was classified in Category 1.	FY2016	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
5	Germ cell mutagenicity	Classification not possible	- -	-	-	The substance was classified as "Classification not possible" because it was not possible to classify a substance as "Not classified" according to the revised GHS classification guidance for the Japanese government. As for in vivo, the results were negative in micronucleus tests using mouse bone marrow cells, negative and positive in chromosomal aberration tests using mouse bone marrow cells, and negative and positive in sister chromatid exchange tests using mouse bone marrow cells (DFGOT vol.4 (1992), IARC 63 (1995), NTP DB (Access on June 2016)). However, the reproducibility of the positive results in the chromosomal aberration test and the sister chromatid exchange test were not confirmed (NTP DB (Access on June 2016)). As for in vitro, the results were positive and negative in bacterial reverse mutation tests, and in cultured mammalian cell tests, a mouse lymphoma assay was positive, a gene mutation test was negative, and chromosomal aberration tests and sister chromatid exchange tests were positive (DFGOT vol.4 (1992), IARC 63 (1995), NTP DB (Access on June 2016)). From the above, it is judged that the positive results seen in vitro are not induced in in vivo systems.	FY2016	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
6	Carcinogenicity	Category 2	Warning	H351	P308+P313 P201 P202 P280 P405 P501	As for experimental animals, in carcinogenicity studies in which this substance was administered by gavage to rats and mice for 2 years, increases in the incidences of forestomach squamous cell papillomas and squamous cell carcinomas were observed in a dose-dependent manner in both rats and mice (NTP TR300 (1986)). In addition, in studies in which rats and mice were exposed to this substance by inhalation for 2 years, an increase in thyroid follicular adenoma in male rats, forestomach squamous cell papilloma in mice of both sexes, and an increase in Harderian gland adenomas in female mice were observed respectively (Results from Carcinogenicity Studies (Ministry of Health, Labour and Welfare, Access on June 2016)). As for classifications by other organizations, IARC, which classified this substance in Group 3 in the previous evaluation, preannounced that the classification will be changed to Group 2B in the latest evaluation (IARC 115 (in prep, Access on June 2016)). Elsewhere, NTP classified it as R (NTP RoC (13th, 2014)) and Japan Society For Occupational Health (JSOH) classified in Group 2B (Recommendation of Occupational Exposure Limits (2015)). From the above, this substance was classified in Category 2 for this hazard class.	FY2016	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
7	Reproductive toxicity	Category 2	Warning	H361	P308+P313 P201 P202 P280 P405 P501	It is described that as the results that male rats were given this substance by gavage for 14 days, the presence of spermatids, spermatocytes, and spermatogonia in seminiferous tubules were observed, and sloughing of the germinal epithelium was suggested, however, the authors considered it was secondary effects caused by general toxicity (DFGOT vol. 4 (1992)). However, in a combined repeated dose toxicity study with the reproduction/developmental toxicity screening test using rats dosed by gavage, a decrease in the number of live pups at birth was observed at 180 mg/kg/day where effects on total bilirubin and liver enzymes (in females, details unspecified), an increase in post-implantation embryo loss, and forestomach epithelial hyperplasia were observed in the parental animals (Environmental Risk Assessment for Chemical Substances Vol. 9 (Ministry of the Environment, 2011)). In summary, an increase in embryo death and a decrease in the number of live pups at birth were seen at the dose where general toxicity in parental animals was manifested. Therefore, this substance was classified in Category 2.	FY2016	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
8	Specific target organ toxicity - Single exposure	Category 3 (respiratory tract irritation, narcotic effects)	Warning	H335 H336	P304+P340 P403+P233 P261 P271 P312 P405 P501	In humans, it is described that by exposure to high concentrations of vapors of this substance, the upper respiratory mucosa are irritated, and gasping, refusal to breathe, coughing, pain, lacrimation, and headache occur, and coma may occur rapidly, and that by inhalation at low vapor concentrations, central nervous depression and moderate irritation of the respiratory system occur (HSDB (Access on June 2016)). In addition, although detailed dosage was not described, it is described that in a single oral dose test using rats, staggering, ataxia, abdominal position, reduced body temperature, trembling, and breathing difficulties were observed (BUA 109 (1993)). From the above, this substance was classified in Category 3 (respiratory tract irritation, narcotic effects). Besides, in the previous classification, this substance was classified in Category 2 (central nervous system) on the basis of a description that ataxia, sedative effects, tremors, and dyspnea were observed in an acute oral toxicity test using rats, and the symptoms resolved after 96 hours (IUCLID (2000)). However, since IUCLID could not be obtained during the research for this classification, it was not adopted as the evidence of the classification.	FY2016	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
9	Specific target organ toxicity - Repeated exposure	Category 1 (respiratory organs), Category 2 (blood system, kidney)	Danger Warning	H372 H373	P260 P264 P270 P314 P501	There is no information on humans. 　As for experimental animals, in 104-week studies using rats or mice exposed by inhalation, increased eosinophilic change in the respiratory epithelium at or above 50 ppm (0.19 mg/L), which is equivalent to Category 1, eosinophilic change and eosinophilic exudate in the olfactory epithelium, atrophy of the olfactory epithelium, and respiratory metaplasia of the olfactory epithelium at 100 ppm (0.37 mg/L) or above, which is equivalent to Category 2, and also forestomach hyperplasia at 200 ppm (0.74 mg/L) were reported. In a 13-week study using mice exposed by inhalation, effects on the stomach (hyperplasia of the forestomach mucosal epithelium) at or above 125 ppm (0.33 mg/L), which is equivalent to Category 2, and effects on the haemal system (a decrease in red blood cell count, etc.) at 250 ppm (0.67 mg/L) were reported (Results from Carcinogenicity Studies (Ministry of Health, Labour and Welfare, Access on June 2016)). 　Besides, in a 2-week inhalation toxicity study (5 days/week, 10 exposures) using mice conducted by the same testing institution, atrophy and desquamation of the olfactory mucosa epithelium in the nasal cavity at or above 270 ppm (converted guidance value: 0.11 mg/L), which is equivalent to Category 1, and death, decreases in red blood cell count, hemoglobin concentration, and hematocrit value, increased ALT, increase in hepatic centrilobular nuclei basophilic change in the kidney, and necrosis of the adrenal gland at or above 810 ppm (0.33 mg/L), which is equivalent to Category 2, were observed (Results from Carcinogenicity Studies (Ministry of Health, Labour and Welfare, Access on June 2016)). However, as the test period was short, and there were effects that were not seen in the 13-week test or in the 104-week study, the results of the 2-week study were not adopted as the evidence of the classification. 　As for the oral route, in a 103-week repeated dose toxicity study using rats and mice by gavage administration, forestomach basal cell hyperplasia, inflammation of the nasal cavity, and nephropathy/nephrosis were observed in rats at 75 mg/kg/day, which is equivalent Category 2, and also in mice at 100 mg/kg/day, which is equivalent to Category 2 (Environmental Risk Assessment for Chemical Substances Vol. 9 (Ministry of the Environment, 2011), NTP TR300 (1986)). 　Of the above findings, the findings in the forestomach observed on both inhalation and oral routes were deemed to be due to irritation, thus, the forestomach was not regarded as a target organ. 　Therefore, this substance was classified in Category 1 (respiratory organs) and Category 2 (haemal system, kidney). 　The classification was changed from the previous classification because new information was obtained.	FY2016	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
10	Aspiration hazard	Classification not possible	- -	-	-	Classification not possible due to lack of data. Besides, the kinematic viscosity is calculated to be 0.46 mm2/sec (20 degC) using numerical data (viscosity: 0.42 mPa*s, density (specific gravity): 0.917 (20 degC)) listed in HSDB (Access on June 2016).	FY2016	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))

ENVIRONMENTAL HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification	Classification year (FY)	GHS Classification Guidance for the Japanese Government
11	Hazardous to the aquatic environment Short term (Acute)	Category 2	- -	H401	P273 P501	From 24-hour EC50 = 7.2 mg/L for crustacea (Daphnia magna) (BUA 109, 1993), it was classified in Category 2.	FY2016	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
11	Hazardous to the aquatic environment Long term (Chronic)	Category 2	-	H411	P273 P391 P501	Reliable chronic toxicity data were not obtained. Due to being not rapidly degradable (a degradation rate by BOD after 10 days: about 30 % (Biodegradation and Bioconcentration Results of Existing Chemical Substances under the Chemical Substances Control Law, 1990)), and acute toxicity Category 2, it was classified in Category 2.	FY2016	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
12	Hazardous to the ozone layer	Classification not possible	- -	-	-	No data available.	FY2016	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))

NOTE:

GHS Classification Result by the Japanese Government is intended to provide a reference for preparing a GHS label or SDS for users. To include the same classification result in a label or SDS for Japan is NOT mandatory.
Users can cite or copy this classification result when preparing a GHS label or SDS. Please be aware, however, that the responsibility for a label or SDS prepared by citing or copying this classification result lies with users.
This GHS classification was conducted based on the information sources and the guidance for classification and judgement which are described in the GHS Classification Guidance for the Japanese Government etc. Using other literature, test results etc. as evidence and including different content from this classification result in a label or SDS are allowed.
Hazard statement and precautionary statement will show by hovering the mouse cursor over a code in the column of "Hazard statement" and "Precautionary statement," respectively. In the excel file, both the codes and statements are provided.
A blank or "-" in the column of "Classification" denotes that a classification for the hazard class was not conducted in the year.
An asterisk “*” in the column of “Classification” denotes that “Not classified (or No applicable)” and/or “Classification not possible” is applicable. Details are described in the column of “Rationale for the classification”. If no English translation is available for “Rationale for the classification,” please refer to the Japanese version of the results.

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