NITE - Chemical Management Field

Latest GHS Classification Results by the Japanese Government (edited by NITE)

GENERAL INFORMATION

Item	Information
CAS RN	56425-91-3
Chemical Name	Flurprimidol
Substance ID	m-nite-56425-91-3_v1
Download of Excel format	Excel file

REFERENCE INFORMATION

Item	Information
Guidance used for the classification (External link)	To Guidance List
UN GHS document (External link)	To UN GHS document
FAQ（GHS classification results by the Japanese Government）	To FAQ
List of Information Sources (Excel file)	List of Information Sources
List of Definitions/Abbreviations	Definitions/Abbreviations
Sample Label by MHLW (External link)	MHLW Website (in Japanese Only)
Sample SDS by MHLW (External link)	MHLW Website (in Japanese Only)
OECD/eChemPortal (External link)	To OECD/eChemPortal (External link)

PHYSICAL HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification	Classification year (FY)	GHS Classification Guidance for the Japanese Government
1	Explosives	Not classified (Not applicable)	- -	-	-	There are no chemical groups associated with explosive properties present in the molecule.	FY2011	GHS Classification Guidance by the Japanese Government （July, 2010）
2	Flammable gases	Not classified (Not applicable)	- -	-	-	"Solids" according to GHS definition.	FY2011	GHS Classification Guidance by the Japanese Government （July, 2010）
3	Aerosols	Not classified (Not applicable)	- -	-	-	Not an aerosol product.	FY2011	GHS Classification Guidance by the Japanese Government （July, 2010）
4	Oxidizing gases	Not classified (Not applicable)	- -	-	-	"Solids" according to GHS definition.	FY2011	GHS Classification Guidance by the Japanese Government （July, 2010）
5	Gases under pressure	Not classified (Not applicable)	- -	-	-	"Solids" according to GHS definition.	FY2011	GHS Classification Guidance by the Japanese Government （July, 2010）
6	Flammable liquids	Not classified (Not applicable)	- -	-	-	"Solids" according to GHS definition.	FY2011	GHS Classification Guidance by the Japanese Government （July, 2010）
7	Flammable solids	Classification not possible	- -	-	-	No data.	FY2011	GHS Classification Guidance by the Japanese Government （July, 2010）
8	Self-reactive substances and mixtures	Not classified (Not applicable)	- -	-	-	There are no chemical groups present in the molecule associated with explosive or self-reactive properties.	FY2011	GHS Classification Guidance by the Japanese Government （July, 2010）
9	Pyrophoric liquids	Not classified (Not applicable)	- -	-	-	"Solids" according to GHS definition.	FY2011	GHS Classification Guidance by the Japanese Government （July, 2010）
10	Pyrophoric solids	Classification not possible	- -	-	-	No data.	FY2011	GHS Classification Guidance by the Japanese Government （July, 2010）
11	Self-heating substances and mixtures	Classification not possible	- -	-	-	No established test method suitable for solid substances with a melting point of 140 degrees C or lower.	FY2011	GHS Classification Guidance by the Japanese Government （July, 2010）
12	Substances and mixtures which, in contact with water, emit flammable gases	Not classified (Not applicable)	- -	-	-	Not containing metals or semimetals (B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At).	FY2011	GHS Classification Guidance by the Japanese Government （July, 2010）
13	Oxidizing liquids	Not classified (Not applicable)	- -	-	-	"Solids" according to GHS definition.	FY2011	GHS Classification Guidance by the Japanese Government （July, 2010）
14	Oxidizing solids	Not classified (Not applicable)	- -	-	-	An organic compound that contains oxygen and fluorine which are not chemically bonded to elements other than carbon or hydrogen.	FY2011	GHS Classification Guidance by the Japanese Government （July, 2010）
15	Organic peroxides	Not classified (Not applicable)	- -	-	-	An organic compound that does not contain -O-O- structure.	FY2011	GHS Classification Guidance by the Japanese Government （July, 2010）
16	Corrosive to metals	Classification not possible	- -	-	-	No established test method suitable for solid substances.	FY2011	GHS Classification Guidance by the Japanese Government （July, 2010）
17	Desensitized explosives	-	- -	-	-	-	-	-

HEALTH HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification	Classification year (FY)	GHS Classification Guidance for the Japanese Government
1	Acute toxicity (Oral)	Category 4	Warning	H302	P301+P312 P264 P270 P330 P501	From two LD50 values for rats (males 1413 mg/kg, females 1875 mg/kg) (Agricultural chemicals times supplement "Agricultural chemicals technology information" No. 18 (1995), corresponding to List 2), it was classified in Category 4.	FY2011	GHS Classification Guidance by the Japanese Government （July, 2010）
1	Acute toxicity (Dermal)	Not classified	- -	-	-	From an LD50 value of >5000 mg/kg for rats (Agricultural chemicals times supplement "Agricultural chemicals technology information" No. 18 (1995)), it was classified as "Not classified."	FY2011	GHS Classification Guidance by the Japanese Government （July, 2010）
1	Acute toxicity (Inhalation: Gases)	Not classified (Not applicable)	- -	-	-	"Solids" according to GHS definition.	FY2011	GHS Classification Guidance by the Japanese Government （July, 2010）
1	Acute toxicity (Inhalation: Vapours)	Classification not possible	- -	-	-	No data.	FY2011	GHS Classification Guidance by the Japanese Government （July, 2010）
1	Acute toxicity (Inhalation: Dusts and mists)	Category 4	Warning	H332	P304+P340 P261 P271 P312	From an LC50 value of 1.1 mg/L/4 for rats (RTECS (2003): original literature; National Technical Information Service OTS0536993), it was classified in Category 4. Besides, an LC50 value of > 5.231 mg/L for rats whose exposure duration was unknown was described in another test. (Agricultural chemicals times supplement "Agricultural chemicals technology information" No. 18 (1995)) Furthermore, it was considered to be a test by dust because the LC50 value was higher than the saturated vapour pressure concentration (4.21E-06 mg/L).	FY2011	GHS Classification Guidance by the Japanese Government （July, 2010）
2	Skin corrosion/irritation	Classification not possible	- -	-	-	It was assessed as slightly irritating from erythema in all animals and edema in 4 animals after application of a 50% preparation to 6 rabbits. (Agricultural chemicals times supplement "Agricultural chemicals technology information" No. 18 (1995)) But the test, details of which such as exposure duration, skin reaction intensity and duration were unknown, was conducted on the 50% preparation, therefore, it was classified as "Classification not possible" due to lack of data.	FY2011	GHS Classification Guidance by the Japanese Government （July, 2010）
3	Serious eye damage/eye irritation	Category 2B	- Warning	H320	P305+P351+P338 P337+P313 P264	It was assessed as slightly irritating because irritating changes in cornea and conjunctiva in all animals and irritating changes in the iris in two animals observed after application of a 50% preparation of this substance in three rabbits reversed within 48 hours after application. (Agricultural chemicals times supplement "Agricultural chemicals technology information" No. 18 (1995)). Therefore, it was classified in Category 2B.	FY2011	GHS Classification Guidance by the Japanese Government （July, 2010）
4	Respiratory sensitization	Classification not possible	- -	-	-	No data.	FY2011	GHS Classification Guidance by the Japanese Government （July, 2010）
4	Skin sensitization	Classification not possible	- -	-	-	It was reported that this substance was negative sensitizing in a Buehler test in guinea pigs on a 50% preparation. (Agricultural chemicals times supplement "Agricultural chemicals technology information" No. 18 (1995)) But it was classified as "Classification not possible" due to data from List 2 and unknown sensitized animal ratio.	FY2011	GHS Classification Guidance by the Japanese Government （July, 2010）
5	Germ cell mutagenicity	Classification not possible	- -	-	-	The classification is not possible due to no in vivo test data. Besides, both an Ames test and a chromosomal aberration test using Chinese hamster ovary cells reported negatives as in vitro tests. (Agricultural chemicals times supplement "Agricultural chemicals technology information" No. 18 (1995))	FY2011	GHS Classification Guidance by the Japanese Government （July, 2010）
6	Carcinogenicity	Classification not possible	- -	-	-	Lack of data. Besides, a 2-year diet administration test using rats and mice did not mention carcinogenicity. (IRIS (2002)) Furthermore, quoting from IRIS, it is remarked that "this substance/agent has not undergone a complete evaluation and determination under US EPA's IRIS program for evidence of human carcinogenic potential." (IRIS (2002))	FY2011	GHS Classification Guidance by the Japanese Government （July, 2010）
7	Reproductive toxicity	Category 2	Warning	H361	P308+P313 P201 P202 P280 P405 P501	In a two-generation reproductive toxicity test by diet administration prior to mating in male and female rats, hepatocellular vacuolization and hypertrophy at 100 ppm (7.3 mg/kg/day) or higher in parent animals as general toxicity, decreased fertility and decreased survival in gestation with a decrease in litter size through two generations, changes in sex cycle accompanied by prolonged estrus, and decreased neonatal survival at the highest concentration of 1000 ppm (74 mg/kg/day) were also observed. (IRIS (2002)) Therefore it was classified in Category 2. Besides, in a developmental toxicity test by oral administration in an organogenetic period in rats or rabbits, adverse effects on the development of the offspring including teratogenicity were not reported. (IRIS (2002))	FY2011	GHS Classification Guidance by the Japanese Government （July, 2010）
8	Specific target organ toxicity - Single exposure	Classification not possible	- -	-	-	No data.	FY2011	GHS Classification Guidance by the Japanese Government （July, 2010）
9	Specific target organ toxicity - Repeated exposure	Category 2 (liver, adrenal gland)	Warning	H373	P260 P314 P501	In a 3-month diet administration test in mice, dose-dependent elevated alkaline phosphatase and centrilobular hypertrophy of hepatocytes were observed at doses of 450 ppm (67.5 mg/kg/day) or higher. (Agricultural chemicals times supplement "Agricultural chemicals technology information" No. 18 (1995)) In a 2-year diet administration test in rats, increased cholesterol and triglycerides, fatty changes in livers, and eosinophilic changes of hepatocytes were observed at 1000 ppm (41.2 mg/kg/day). (IRIS (2002)) Because these doses corresponded to Category 2 in Guidance values, it was classified in Category 2 (liver). On the other hand, in a 90-day or 1-year diet administration test in dogs, degeneration in zona fasciculata and zona reticularis of adrenal cortex characterized by eosinophilic degeneration, vacuolation and cortical atrophy in animals at doses of 30 mg/kg/day or higher were reported as histopathological signs. (IRIS (2002)) Because the doses corresponded to Category 2 in Guidance values, it was classified in Category 2 (adrenal gland).	FY2011	GHS Classification Guidance by the Japanese Government （July, 2010）
10	Aspiration hazard	Classification not possible	- -	-	-	No data.	FY2011	GHS Classification Guidance by the Japanese Government （July, 2010）

ENVIRONMENTAL HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification	Classification year (FY)	GHS Classification Guidance for the Japanese Government
11	Hazardous to the aquatic environment Short term (Acute)	Category 3	- -	H402	P273 P501	It was classified in Category 3 from 48-hour EC50 = 11.8 mg/L for crustacea (Daphnia magna) (AQUIRE, 2012).	FY2011	GHS Classification Guidance by the Japanese Government （July, 2010）
11	Hazardous to the aquatic environment Long term (Chronic)	Category 3	- -	H412	P273 P501	Reliable chronic toxicity data were not obtained. Due to lack of rapid degradability (BIOWIN), and acute toxicity Category 3, it was classified in Category 3.	FY2011	GHS Classification Guidance by the Japanese Government （July, 2010）
12	Hazardous to the ozone layer	Classification not possible	- -	-	-	This substance is not listed in Annexes to the Montreal Protocol.	FY2011	GHS Classification Guidance by the Japanese Government （July, 2010）

NOTE:

GHS Classification Result by the Japanese Government is intended to provide a reference for preparing a GHS label or SDS for users. To include the same classification result in a label or SDS for Japan is NOT mandatory.
Users can cite or copy this classification result when preparing a GHS label or SDS. Please be aware, however, that the responsibility for a label or SDS prepared by citing or copying this classification result lies with users.
This GHS classification was conducted based on the information sources and the guidance for classification and judgement which are described in the GHS Classification Guidance for the Japanese Government etc. Using other literature, test results etc. as evidence and including different content from this classification result in a label or SDS are allowed.
Hazard statement and precautionary statement will show by hovering the mouse cursor over a code in the column of "Hazard statement" and "Precautionary statement," respectively. In the excel file, both the codes and statements are provided.
A blank or "-" in the column of "Classification" denotes that a classification for the hazard class was not conducted in the year.
An asterisk “*” in the column of “Classification” denotes that “Not classified (or No applicable)” and/or “Classification not possible” is applicable. Details are described in the column of “Rationale for the classification”. If no English translation is available for “Rationale for the classification,” please refer to the Japanese version of the results.

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