Item | Information |
---|---|
CAS RN | 583-78-8 |
Chemical Name | 2,5-Dichlorophenol |
Substance ID | m-nite-583-78-8_v1 |
Download of Excel format | Excel file |
Item | Information |
---|---|
Guidance used for the classification (External link) | To Guidance List |
UN GHS document (External link) | To UN GHS document |
FAQ(GHS classification results by the Japanese Government) | To FAQ |
List of Information Sources (Excel file) | List of Information Sources |
List of Definitions/Abbreviations | Definitions/Abbreviations |
Sample Label by MHLW (External link) | To Workplace Safety Site (MHLW) |
Sample SDS by MHLW (External link) | To Workplace Safety Site (MHLW) |
OECD/eChemPortal (External link) | To OECD/eChemPortal (External link) |
Hazard class | Classification | Pictogram Signal word |
Hazard statement (code) |
Precautionary statement (code) |
Rationale for the classification | Classification year (FY) | GHS Classification Guidance for the Japanese Government | |
---|---|---|---|---|---|---|---|---|
1 | Explosives | Not classified (Not applicable) |
- |
- | - | There are no chemical groups associated with explosive properties present in the molecule. | FY2012 | GHS Classification Guidance by the Japanese Government (July, 2010) |
2 | Flammable gases | Not classified (Not applicable) |
- |
- | - | Solid (GHS definition) | FY2012 | GHS Classification Guidance by the Japanese Government (July, 2010) |
3 | Aerosols | Not classified (Not applicable) |
- |
- | - | Not aerosol products. | FY2012 | GHS Classification Guidance by the Japanese Government (July, 2010) |
4 | Oxidizing gases | Not classified (Not applicable) |
- |
- | - | Solid (GHS definition) | FY2012 | GHS Classification Guidance by the Japanese Government (July, 2010) |
5 | Gases under pressure | Not classified (Not applicable) |
- |
- | - | Solid (GHS definition) | FY2012 | GHS Classification Guidance by the Japanese Government (July, 2010) |
6 | Flammable liquids | Not classified (Not applicable) |
- |
- | - | Solid (GHS definition) | FY2012 | GHS Classification Guidance by the Japanese Government (July, 2010) |
7 | Flammable solids | Classification not possible |
- |
- | - | No data available. Besides, there is the information: a flash point of 100 deg C [closed-cup] (NITE Chemical Risk Information Platform (NITE-CHRIP) (Access on Sep. 2012) (the original article: Acros reagent catalog)). | FY2012 | GHS Classification Guidance by the Japanese Government (July, 2010) |
8 | Self-reactive substances and mixtures | Not classified (Not applicable) |
- |
- | - | There are no chemical groups present in the molecule associated with explosive or self-reactive properties. | FY2012 | GHS Classification Guidance by the Japanese Government (July, 2010) |
9 | Pyrophoric liquids | Not classified (Not applicable) |
- |
- | - | Solid (GHS definition) | FY2012 | GHS Classification Guidance by the Japanese Government (July, 2010) |
10 | Pyrophoric solids | Classification not possible |
- |
- | - | No data available. | FY2012 | GHS Classification Guidance by the Japanese Government (July, 2010) |
11 | Self-heating substances and mixtures | Classification not possible |
- |
- | - | Test methods applicable to solid (melting point <= 140 deg C) substances are not available. | FY2012 | GHS Classification Guidance by the Japanese Government (July, 2010) |
12 | Substances and mixtures which, in contact with water, emit flammable gases | Not classified (Not applicable) |
- |
- | - | The chemical structure of the substance does not contain metals or metalloids (B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At). | FY2012 | GHS Classification Guidance by the Japanese Government (July, 2010) |
13 | Oxidizing liquids | Not classified (Not applicable) |
- |
- | - | Solid (GHS definition) | FY2012 | GHS Classification Guidance by the Japanese Government (July, 2010) |
14 | Oxidizing solids | Not classified (Not applicable) |
- |
- | - | The substance is an organic compound containing chlorine and oxygen (but not fluorine) which are chemically bonded only to carbon or hydrogen. | FY2012 | GHS Classification Guidance by the Japanese Government (July, 2010) |
15 | Organic peroxides | Not classified (Not applicable) |
- |
- | - | Organic compounds containing no bivalent -O-O- structure. | FY2012 | GHS Classification Guidance by the Japanese Government (July, 2010) |
16 | Corrosive to metals | Classification not possible |
- |
- | - | Test methods applicable to solid substances are not available. | FY2012 | GHS Classification Guidance by the Japanese Government (July, 2010) |
17 | Desensitized explosives | - |
- |
- | - | - | - | - |
Hazard class | Classification | Pictogram Signal word |
Hazard statement (code) |
Precautionary statement (code) |
Rationale for the classification | Classification year (FY) | GHS Classification Guidance for the Japanese Government | |
---|---|---|---|---|---|---|---|---|
1 | Acute toxicity (Oral) | Not classified |
- |
- | - | It was classified as "Not classified" in the Classification JIS (corresponding to Category 5 in UN GHS classification) based on an LD50 value of 2,475 mg/kg for rats (USEPA/HPV (2008), corresponding to List 1). | FY2012 | GHS Classification Guidance by the Japanese Government (July, 2010) |
1 | Acute toxicity (Dermal) | Not classified |
- |
- | - | It was classified as "Not classified" based on an LD50 value of > 8,000 mg/kg for rabbits (USEPA/HPV (2008)). | FY2012 | GHS Classification Guidance by the Japanese Government (July, 2010) |
1 | Acute toxicity (Inhalation: Gases) | Not classified (Not applicable) |
- |
- | - | Solid (GHS definition) | FY2012 | GHS Classification Guidance by the Japanese Government (July, 2010) |
1 | Acute toxicity (Inhalation: Vapours) | Classification not possible |
- |
- | - | No data available. | FY2012 | GHS Classification Guidance by the Japanese Government (July, 2010) |
1 | Acute toxicity (Inhalation: Dusts and mists) | Not classified |
- |
- | - | It was classified as "Not classified" based on an LC50 value of > 185 mg/L/4 hours for rats (USEPA/HPV (2008)). Besides, because the test concentration was higher than the saturated vapour pressure concentration (0.49 mg/L), a reference value of dust/mist was applied. | FY2012 | GHS Classification Guidance by the Japanese Government (July, 2010) |
2 | Skin corrosion/irritation | Classification not possible |
- |
- | - | No data available. Besides, in a 21-day repeated dermal administration test with rabbits at 1.0, 10, 100 mg/kg (6 hours/day), skin lesions at the application site consisting of thickening, encrustation, necrosis, leatherness, and foci in the dermis and epidermis were reported in all treated animals (USEPA/HPV (2008)). | FY2012 | GHS Classification Guidance by the Japanese Government (July, 2010) |
3 | Serious eye damage/eye irritation | Classification not possible |
- |
- | - | No data available. | FY2012 | GHS Classification Guidance by the Japanese Government (July, 2010) |
4 | Respiratory sensitization | Classification not possible |
- |
- | - | No data available. | FY2012 | GHS Classification Guidance by the Japanese Government (July, 2010) |
4 | Skin sensitization | Classification not possible |
- |
- | - | No data available. | FY2012 | GHS Classification Guidance by the Japanese Government (July, 2010) |
5 | Germ cell mutagenicity | Not classified |
- |
- | - | It was classified as "Not classified" based on a negative result in a micronucleus test with bone marrow cells after oral administration to mice (in vivo somatic cell mutagenicity test) (USEPA/HPV (2008)). Besides, as for in vitro tests, it is reported that it was negative in an Ames test (NTP DB (1979)) and negative in an HGPRT test with CHO cells (OECD TG476) (USEPA/HPV (2008)). | FY2012 | GHS Classification Guidance by the Japanese Government (July, 2010) |
6 | Carcinogenicity | Classification not possible |
- |
- | - | No data available. | FY2012 | GHS Classification Guidance by the Japanese Government (July, 2010) |
7 | Reproductive toxicity | Classification not possible |
- |
- | - | No data available. | FY2012 | GHS Classification Guidance by the Japanese Government (July, 2010) |
8 | Specific target organ toxicity - Single exposure | Category 2 (central nervous system), Category 3 (respiratory tract irritation) |
Warning |
H371 H335 |
P308+P311 P260 P264 P270 P405 P501 P304+P340 P403+P233 P261 P271 P312 |
In an acute oral toxicity test with rats (doses: 1,600, 2,500, 4,000 mg/kg), deaths occurred at all doses, and excessive breathing, equilibrium disturbance, tremor, and tonic-clonic spasms in the ventral region were observed in dead animals (USEPA/HPV (2008)), and in an acute oral toxicity test with mice (LD50: 1,600 mg/kg (males), 946 mg/kg (females)), increased respiration, tremors, slight convulsions followed by central nervous system depression were found as the primary toxic signs (HSDB (2009)). From the above reports, test doses corresponded to the guidance value range for Category 2, therefore it was classified in Category 2 (central nervous system). And it was classified in Category 3 (respiratory tract irritation) because clear nasal discharge, slight dyspnea, etc. were seen as a result of inhalation exposure to 50 mg/L in rats, and all the animals recovered after 24 hours (USEPA/HPV (2008)). | FY2012 | GHS Classification Guidance by the Japanese Government (July, 2010) |
9 | Specific target organ toxicity - Repeated exposure | Category 1 (liver, respiratory organs) |
Danger |
H372 | P260 P264 P270 P314 P501 |
In a 28-day repeated inhalation exposure test with rats (vapour: 0.1, 0.3, 1.0 mg/L, 5 days/week, 6 hours/day), ASAT in the liver function tests increased in males and females in the 1.0 mg/L group (converted guidance value: 0.3 mg/L), absolute liver weights decreased in males at or above 0.3 mg/L, and on histopathological examination, the incidence of foci and necrosis in the liver in the treated groups was slightly higher than in the control group. LOAEL was reported to be 0.1 mg/L (converted guidance value: 0.03 mg/L) based on the liver effects above (USEPA/HPV (2008)), and the dose (LOAEL) corresponded to the guidance values for Category 1. Therefore, it was classified in Category 1 (liver). And it is also described that inflammatory cell and lymphocyte infiltrate, macrophage aggregation, and alveolar septal fibrosis in the lung of all treated animals, and inflammation in the nasal cavity (mucosa) in the 1.0 mg/L group (converted guidance value: 0.3 mg/L) were observed in the test (USEPA/HPV (2008)), therefore it was classified in Category 1 (respiratory system). Besides, in a 21-day repeated dermal administration test with rabbits (doses: 1, 10, 100 mg/kg bw/day, 5 days/week, 6 hours/day), no systemic toxicity related to the administration of this substance was found, and NOAEL was reported to be 100 mg/kg bw/day (USEPA/HPV (2008)). | FY2012 | GHS Classification Guidance by the Japanese Government (July, 2010) |
10 | Aspiration hazard | Classification not possible |
- |
- | - | No data available. | FY2012 | GHS Classification Guidance by the Japanese Government (July, 2010) |
Hazard class | Classification | Pictogram Signal word |
Hazard statement (code) |
Precautionary statement (code) |
Rationale for the classification | Classification year (FY) | GHS Classification Guidance for the Japanese Government | |
---|---|---|---|---|---|---|---|---|
11 | Hazardous to the aquatic environment Short term (Acute) | Category 2 |
- |
H401 | P273 P501 |
It was classified in Category 2 from 96-hour LC50 = 3.29 mg/L for fish (Platichthys flesus) (AQUIRE, 2013). | FY2012 | GHS Classification Guidance by the Japanese Government (July, 2010) |
11 | Hazardous to the aquatic environment Long term (Chronic) | Category 2 |
- |
H411 | P273 P391 P501 |
Reliable chronic toxicity data were not obtained. It was classified in Category 2 because it is not rapidly degradable (a degradation rate by BOD: 5% (Biodegradation and Bioconcentration Results of Existing Chemical Substances under the Chemical Substances Control Law, 1982)), and it was classified in Category 2 in acute toxicity. | FY2012 | GHS Classification Guidance by the Japanese Government (July, 2010) |
12 | Hazardous to the ozone layer | Classification not possible |
- |
- | - | This substance is not listed in the Annexes to the Montreal Protocol. | FY2012 | GHS Classification Guidance by the Japanese Government (July, 2010) |
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