NITE - Chemical Management Field

Latest GHS Classification Results by the Japanese Government (edited by NITE)

GENERAL INFORMATION

Item	Information
CAS RN	584-79-2
Chemical Name	Allethrin (1RS-, cis- and trans- mixture)
Substance ID	m-nite-584-79-2_v1
Download of Excel format	Excel file

REFERENCE INFORMATION

Item	Information
Guidance used for the classification (External link)	To Guidance List
UN GHS document (External link)	To UN GHS document
FAQ（GHS classification results by the Japanese Government）	To FAQ
List of Information Sources (Excel file)	List of Information Sources
List of Definitions/Abbreviations	Definitions/Abbreviations
Sample Label by MHLW (External link)	To Workplace Safety Site (MHLW)
Sample SDS by MHLW (External link)	To Workplace Safety Site (MHLW)
OECD/eChemPortal (External link)	To OECD/eChemPortal (External link)

PHYSICAL HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification	Classification year (FY)	GHS Classification Guidance for the Japanese Government
1	Explosives	Not classified (Not applicable)	- -	-	-	There are no chemical groups associated with explosive properties present in the molecule.	FY2011	GHS Classification Guidance by the Japanese Government （July, 2010）
2	Flammable gases	Not classified (Not applicable)	- -	-	-	"Liquids" according to GHS definition.	FY2011	GHS Classification Guidance by the Japanese Government （July, 2010）
3	Aerosols	Not classified (Not applicable)	- -	-	-	Not an aerosol product.	FY2011	GHS Classification Guidance by the Japanese Government （July, 2010）
4	Oxidizing gases	Not classified (Not applicable)	- -	-	-	"Liquids" according to GHS definition.	FY2011	GHS Classification Guidance by the Japanese Government （July, 2010）
5	Gases under pressure	Not classified (Not applicable)	- -	-	-	"Liquids" according to GHS definition.	FY2011	GHS Classification Guidance by the Japanese Government （July, 2010）
6	Flammable liquids	Category 4	- Warning	H227	P370+P378 P210 P280 P403 P501	A flash point of > 60 degrees C and <= 93 degrees C may be judged from 66 degrees C [open-cup] in non-prescribed test method (eChemPortal (INCHEM UK PID) (Access on Oct. 2011)), therefore, it was classified in Category 4.	FY2011	GHS Classification Guidance by the Japanese Government （July, 2010）
7	Flammable solids	Not classified (Not applicable)	- -	-	-	"Liquids" according to GHS definition.	FY2011	GHS Classification Guidance by the Japanese Government （July, 2010）
8	Self-reactive substances and mixtures	Classification not possible	- -	-	-	There is a chemical group present in the molecule associated with a self-reactive property (strained ring), but the classification is not possible due to no data.	FY2011	GHS Classification Guidance by the Japanese Government （July, 2010）
9	Pyrophoric liquids	Classification not possible	- -	-	-	No data.	FY2011	GHS Classification Guidance by the Japanese Government （July, 2010）
10	Pyrophoric solids	Not classified (Not applicable)	- -	-	-	"Liquids" according to GHS definition.	FY2011	GHS Classification Guidance by the Japanese Government （July, 2010）
11	Self-heating substances and mixtures	Classification not possible	- -	-	-	No established test method suitable for liquid substances.	FY2011	GHS Classification Guidance by the Japanese Government （July, 2010）
12	Substances and mixtures which, in contact with water, emit flammable gases	Not classified (Not applicable)	- -	-	-	Not containing metals or semimetals (B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At).	FY2011	GHS Classification Guidance by the Japanese Government （July, 2010）
13	Oxidizing liquids	Not classified (Not applicable)	- -	-	-	An organic compound does not contain fluorine or chlorine but contains oxygen which is not chemically bonded to elements other than carbon or hydrogen.	FY2011	GHS Classification Guidance by the Japanese Government （July, 2010）
14	Oxidizing solids	Not classified (Not applicable)	- -	-	-	"Liquids" according to GHS definition.	FY2011	GHS Classification Guidance by the Japanese Government （July, 2010）
15	Organic peroxides	Not classified (Not applicable)	- -	-	-	An organic compound that does not contain -O-O- structure.	FY2011	GHS Classification Guidance by the Japanese Government （July, 2010）
16	Corrosive to metals	Classification not possible	- -	-	-	No data.	FY2011	GHS Classification Guidance by the Japanese Government （July, 2010）
17	Desensitized explosives	-	- -	-	-	-	-	-

HEALTH HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification	Classification year (FY)	GHS Classification Guidance for the Japanese Government
1	Acute toxicity (Oral)	Category 4	Warning	H302	P301+P312 P264 P270 P330 P501	There are 6 LD50 values for 3 each for male and female rats [2430 mg/kg, 920 mg/kg, 709 mg/kg (above for males), 720 mg/kg, 900 mg/kg, 1041mg/kg (above for females)] (EHC 87 (1989)), one for males of which corresponds to "Not classified" and other all five correspond to Category 4. It was classified in Category 4 from the majority.	FY2011	GHS Classification Guidance by the Japanese Government （July, 2010）
1	Acute toxicity (Dermal)	Not classified	- -	-	-	From an LD50 value of >2000 mg/kg for rats (EHC 87 (1989)), it was classified as "Not classified" in JIS classification (Category 5 or "Not classified" in UN GHS classification).	FY2011	GHS Classification Guidance by the Japanese Government （July, 2010）
1	Acute toxicity (Inhalation: Gases)	Not classified (Not applicable)	- -	-	-	"Liquids" according to GHS definition.	FY2011	GHS Classification Guidance by the Japanese Government （July, 2010）
1	Acute toxicity (Inhalation: Vapours)	Classification not possible	- -	-	-	No data.	FY2011	GHS Classification Guidance by the Japanese Government （July, 2010）
1	Acute toxicity (Inhalation: Dusts and mists)	Not classified	- -	-	-	From an LC50 value of >2 mg/L in a 24-hour exposure (converted to a 4-hour equivalent value 12 mg/L) and no deaths at 2000 mg/kg in rats as a result (EHC 87 (1989)), it was classified as "Not classified." Besides, a reference value of mists was applied because the test concentration (0.5 to 2 mg/L) is higher than the saturated vapour pressure concentration (1.98E-05 mg/L).	FY2011	GHS Classification Guidance by the Japanese Government （July, 2010）
2	Skin corrosion/irritation	Not classified	- -	-	-	The difference between an application with 0.5 mL of undiluted this substance to rabbit skins and untreated control animals was not observed. (EHC 87 (1989)) And another test using rabbits reported slightly irritant (EHC 87 (1989)). Therefore, it was classified as “Not classified” in JIS classification (Category 3 or “Not classified” in UN GHS classification).	FY2011	GHS Classification Guidance by the Japanese Government （July, 2010）
3	Serious eye damage/eye irritation	Category 2	Warning	H319	P305+P351+P338 P337+P313 P264 P280	Application with 0.1 mL of 10% or 50% solution of this substance to rabbit eyes caused eyelid closure and conjunctival hyperemia at 10 and 30 minutes after application respectively and eye discharge after 2 hours. (EHC 87 (1989)) Furthermore, there is the information that this substance causes mild primary irritation to rabbit eyes (HSGs (1989), corresponding to List 1). Though reported effects were mild in the above, because not an undiluted but diluted solution was applied, it was classified in Category 2.	FY2011	GHS Classification Guidance by the Japanese Government （July, 2010）
4	Respiratory sensitization	Classification not possible	- -	-	-	Lack of data. Besides, there is the information that multiple cases of respiratory allergy caused by exposure to pyrethroids were reported (HSDB (2009)).	FY2011	GHS Classification Guidance by the Japanese Government （July, 2010）
4	Skin sensitization	Category 1	Warning	H317	P302+P352 P333+P313 P362+P364 P261 P272 P280 P321 P501	It was classified in Category 1 because it is listed as a contact allergy substance in Contact Dermatitis (Frosch) (Contact Dermatitis 4th (2006)). Besides, signs of the site of application at the skin were not different from a control group, but slight lymphocytic and monocytic infiltration of the dermis were observed in a treated group in a histopathological test in a skin sensitization test using guinea pigs (EHC 87 (1989)). Furthermore, slight sensitization indicated in an Ear-Flank test using guinea pigs was reported (EHC 87 (1989)).	FY2011	GHS Classification Guidance by the Japanese Government （July, 2010）
5	Germ cell mutagenicity	Classification not possible	- -	-	-	The classification is not possible due to no in vivo test data. Besides, a negative or a positive in an Ames test (EHC 87 (1989), HSDB (2009)) and a positive in a chromosomal aberration test using Chinese hamsters (HSDB (2009)) are reported as in vitro tests.	FY2011	GHS Classification Guidance by the Japanese Government （July, 2010）
6	Carcinogenicity	Classification not possible	- -	-	-	Lack of data. Besides, a diet administration test given a racemic mixture of this substance to rats for 80 days (dietary levels 500, 1000, 2000 mg/kg) reported that oncogenicity was not found (EHC 87 (1989)), but it was classified as "Classification not possible" due to resulting only from rats.	FY2011	GHS Classification Guidance by the Japanese Government （July, 2010）
7	Reproductive toxicity	Classification not possible	- -	-	-	In a developmental toxicity test by oral administration in pregnant rats during an organogenetic period, increased maternal mortality in the highest dose group, but no effects on body weight and weight gain in maternal animals, no effects on a pregnancy index, implantations, numbers of live and dead fetuses, and resorptions were observed. And evidence of teratogenicity and fetal toxicity except for an increased number of the skeletal mutation (14 ribs) was not found. (EHC 87 (1989)). Also in an oral administration test in pregnant rabbits during an organogenetic period, indices of gestation and fetal development were not different from a control group, nor were observed dose-related morphological defects in fetal bones or an external surface. (EHC 87 (1989)) From the above, adverse effects on the development of the offspring were not observed, but it was classified as "Classification not possible" due to lack of data on effects on sexual function and fertility.	FY2011	GHS Classification Guidance by the Japanese Government （July, 2010）
8	Specific target organ toxicity - Single exposure	Category 2 (nervous system), Category 3 (respiratory tract irritation)	Warning	H371 H335	P308+P311 P260 P264 P270 P405 P501 P304+P340 P403+P233 P261 P271 P312	There is the information that the main toxic effects of this substance result from its action on the nervous system (EHC 87 (1989)). There is the information that the main adverse effect caused by dermal exposure to pyrethroids represented by this substance is paresthesia in humans (HSDB (2009)). And there is the information that common signs of systemic effects are dizziness, headache, and fatigue, a few frequent palpitations, chest tightness, and blurred vision, and the main life-threatening signs are coma and convulsions (HSDB (2009)). From the information from List 2 information, it was classified in Category 2 (nervous system). On the other hand, there is the information that the localized upper respiratory tract disorders such as rhinitis, sneezing, scratchy throat, oral edema, and laryngeal mucosal edema, and a cough, shortness of breath, wheezing, and chest pain considered as the localized lower respiratory tract disorders were observed in inhalation exposure. (HSDB (2009)) From the information, it was classified in Category 3 (respiratory tract irritation).	FY2011	GHS Classification Guidance by the Japanese Government （July, 2010）
9	Specific target organ toxicity - Repeated exposure	Category 2 (liver)	Warning	H373	P260 P314 P501	On the basis that consecutive increases of alkaline phosphatase activity and hepatocellular degeneration in a histopathological test were observed at 1000 ppm (36 mg/kg/day) or higher corresponding to a range of Category 2 in Guidance values in a 6-month diet administration test in dogs (0, 200, 1000, or 5000 ppm) (EHC 87 (1989)), it was classified in Category 2 (liver). Besides, tremor and convulsions at 10000 ppm (corresponding to 500 mg/kg/day) in a 16-week diet administration test in rats, hypertrophy of epithelial cells and papillary changes in the epithelium in the thyroids at 250 and 500 mg/kg in a 12-week gavage administration test in rats, and bronchopneumonia at 3 mg/L (converted to a 90-day 6-hour equivalent value 0.61 mg/L) in a 4-week inhalation exposure test (4 hours/day) in mice were reported. (EHC 87 (1989)) But those signs were observed at doses above the upper limit of Guidance values.	FY2011	GHS Classification Guidance by the Japanese Government （July, 2010）
10	Aspiration hazard	Classification not possible	- -	-	-	No data.	FY2011	GHS Classification Guidance by the Japanese Government （July, 2010）

ENVIRONMENTAL HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification	Classification year (FY)	GHS Classification Guidance for the Japanese Government
11	Hazardous to the aquatic environment Short term (Acute)	Category 1	Warning	H400	P273 P391 P501	It was classified in Category 1 from 96-hour LC50 = 0.0026 mg/L for fish (Oncorhynchus kisutch) (AQUIRE, 2012).	FY2011	GHS Classification Guidance by the Japanese Government （July, 2010）
11	Hazardous to the aquatic environment Long term (Chronic)	Category 1	Warning	H410	P273 P391 P501	Reliable chronic toxicity data were not obtained. It was classified in Category 1 due to lack of rapid degradability (a degradation rate by BOD: 2 % (the existing chemicals survey program, 2003)), and acute toxicity Category 1.	FY2011	GHS Classification Guidance by the Japanese Government （July, 2010）
12	Hazardous to the ozone layer	Classification not possible	- -	-	-	This substance is not listed in Annexes to the Montreal Protocol.	FY2011	GHS Classification Guidance by the Japanese Government （July, 2010）

NOTE:

GHS Classification Result by the Japanese Government is intended to provide a reference for preparing a GHS label or SDS for users. To include the same classification result in a label or SDS for Japan is NOT mandatory.
Users can cite or copy this classification result when preparing a GHS label or SDS. Please be aware, however, that the responsibility for a label or SDS prepared by citing or copying this classification result lies with users.
This GHS classification was conducted based on the information sources and the guidance for classification and judgement which are described in the GHS Classification Guidance for the Japanese Government etc. Using other literature, test results etc. as evidence and including different content from this classification result in a label or SDS are allowed.
Hazard statement and precautionary statement will show by hovering the mouse cursor over a code in the column of "Hazard statement" and "Precautionary statement," respectively. In the excel file, both the codes and statements are provided.
A blank or "-" in the column of "Classification" denotes that a classification for the hazard class was not conducted in the year.
An asterisk “*” in the column of “Classification” denotes that “Not classified (or No applicable)” and/or “Classification not possible” is applicable. Details are described in the column of “Rationale for the classification”. If no English translation is available for “Rationale for the classification,” please refer to the Japanese version of the results.

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