NITE - Chemical Management Field

Latest GHS Classification Results by the Japanese Government (edited by NITE)

GENERAL INFORMATION

Item	Information
CAS RN	598-62-9
Chemical Name	Manganese carbonate
Substance ID	m-nite-598-62-9_v1
Download of Excel format	Excel file

REFERENCE INFORMATION

Item	Information
Guidance used for the classification (External link)	To Guidance List
UN GHS document (External link)	To UN GHS document
FAQ（GHS classification results by the Japanese Government）	To FAQ
List of Information Sources (Excel file)	List of Information Sources
List of Definitions/Abbreviations	Definitions/Abbreviations
Sample Label by MHLW (External link)	To Workplace Safety Site (MHLW)
Sample SDS by MHLW (External link)	To Workplace Safety Site (MHLW)
OECD/eChemPortal (External link)	To OECD/eChemPortal (External link)

PHYSICAL HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification	Classification year (FY)	GHS Classification Guidance for the Japanese Government
1	Explosives	Not classified (Not applicable)	- -	-	-	There are no chemical groups associated with explosive properties present in the molecule.	FY2016	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
2	Flammable gases	Not classified (Not applicable)	- -	-	-	Solid (GHS definition).	FY2016	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
3	Aerosols	Not classified (Not applicable)	- -	-	-	Not aerosol products.	FY2016	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
4	Oxidizing gases	Not classified (Not applicable)	- -	-	-	Solid (GHS definition).	FY2016	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
5	Gases under pressure	Not classified (Not applicable)	- -	-	-	Solid (GHS definition).	FY2016	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
6	Flammable liquids	Not classified (Not applicable)	- -	-	-	Solid (GHS definition).	FY2016	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
7	Flammable solids	Not classified	- -	-	-	It is not combustible (GESTIS (Access on July 2016)).	FY2016	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
8	Self-reactive substances and mixtures	Not classified (Not applicable)	- -	-	-	There are no chemical groups present in the molecule associated with explosive or self-reactive properties.	FY2016	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
9	Pyrophoric liquids	Not classified (Not applicable)	- -	-	-	Solid (GHS definition).	FY2016	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
10	Pyrophoric solids	Not classified	- -	-	-	It is not combustible (GESTIS (Access on July 2016)).	FY2016	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
11	Self-heating substances and mixtures	Not classified	- -	-	-	It is not combustible (GESTIS (Access on July 2016)).	FY2016	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
12	Substances and mixtures which, in contact with water, emit flammable gases	Not classified	- -	-	-	It contains a metal (Mn), but it is estimated that it does not react vigorously with water due to the water solubility data of 0.065 g/L measured (GESTIS (Access on July 2016)).	FY2016	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
13	Oxidizing liquids	Not classified (Not applicable)	- -	-	-	Solid (GHS definition).	FY2016	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
14	Oxidizing solids	Classification not possible	- -	-	-	It is an inorganic compound containing oxygen (but not halogen), but the classification is not possible due to no data.	FY2016	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
15	Organic peroxides	Not classified (Not applicable)	- -	-	-	It is an inorganic compound.	FY2016	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
16	Corrosive to metals	Classification not possible	- -	-	-	Test methods applicable to solid substances are not available.	FY2016	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
17	Desensitized explosives	-	- -	-	-	-	-	-

HEALTH HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification	Classification year (FY)	GHS Classification Guidance for the Japanese Government
1	Acute toxicity (Oral)	Classification not possible	- -	-	-	Classification not possible due to lack of data.	FY2016	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
1	Acute toxicity (Dermal)	Classification not possible	- -	-	-	Classification not possible due to lack of data.	FY2016	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
1	Acute toxicity (Inhalation: Gases)	Not classified (Not applicable)	- -	-	-	Solid (GHS definition)	FY2016	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
1	Acute toxicity (Inhalation: Vapours)	Not classified (Not applicable)	- -	-	-	Solid (GHS definition)	FY2016	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
1	Acute toxicity (Inhalation: Dusts and mists)	Classification not possible	- -	-	-	Classification not possible due to lack of data.	FY2016	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
2	Skin corrosion/irritation	Classification not possible	- -	-	-	Classification not possible due to lack of data.	FY2016	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
3	Serious eye damage/eye irritation	Classification not possible	- -	-	-	Classification not possible due to lack of data.	FY2016	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
4	Respiratory sensitization	Classification not possible	- -	-	-	Classification not possible due to lack of data.	FY2016	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
4	Skin sensitization	Classification not possible	- -	-	-	Classification not possible due to lack of data. Additionally, although details are unknown, it has been reported that a manganese salt did not cause lymph node cell proliferation in a screening test for contact allergens using mice (Initial Risk Assessment Report (NITE, CERI, NEDO, 2008)).	FY2016	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
5	Germ cell mutagenicity	Classification not possible	- -	-	-	Classification not possible due to lack of data.	FY2016	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
6	Carcinogenicity	Classification not possible	- -	-	-	Classification not possible due to lack of data.	FY2016	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
7	Reproductive toxicity	Category 1B	Danger	H360	P308+P313 P201 P202 P280 P405 P501	There is no data available for this substance itself, but data for inorganic manganese compounds may be available for classification. In a test in which manganese chloride tetrahydrate was subcutaneously administered to pregnant mice (Gestation days 6 to 15), at doses in which suppression of maternal weight gain and reduction in feed intake were observed in maternal animals or even at lower doses, increased embryo resorptions, renal hypoplasia, and wavy ribs were observed in fetuses (Initial Risk Assessment Report (NITE, CERI, NEDO, 2008), CICAD 12 (1999)). Also, in a test in which manganese chloride was intravenously administered to pregnant rats during organogenesis (Gestation days 6 to 17), fetal death, skeletal anomality, wavy ribs, bending of limbs were observed even at doses lower than that of the maternal toxicity (suppression of body weight gain, implantation number reduction) was observed (Initial Risk Assessment Report (NITE, CERI, NEDO, 2008), CICAD 12 (1999)). In addition, it is also reported that increased exencephaly and embryo resorptions were observed in a single intraperitoneal administration of manganese sulfate to pregnant mice on the 8th day of gestation, and at higher doses, inhibition of implantation was observed (Initial Risk Assessment Report (NITE, CERI, NEDO, 2008)). On the other hand, in a test in which manganese chloride was administered by drinking water to pregnant rats, throughout the pregnancy period, even at doses exceeding the expression of maternal toxicity (suppression of body weight gain, decrease in water intake), low body weight of the offspring was the only observation seen (Initial Risk Assessment Report (NITE, CERI, NEDO, 2008)). As described above, although it is limited to some extent, the toxicity information on the inorganic manganese compounds including this substance showed fetal toxicities such as fetal death, skeletal abnormalities, external malformation, and inhibition of implantation in the fetuses through injection routes such as subcutaneous, intravenous or intraperitoneal injection. Although weak as epidemiological evidence, on the basis of case reports of impotence or decreased libido observed in manganese addicts, and on the basis of embryotoxicity observed in studies using experimental animals, the Japan Society for Occupational Health classified manganese and its compounds in Group 2 of reproductive toxicity (OEL Documentations Vol.56 (Japan Society For Occupational Health (JSOH), 2014), Recommendation of Occupational Exposure Limits (Japan Society For Occupational Health (JSOH), 2016)). Therefore, from the results of studies on inorganic manganese compounds using experimental animals, it was deemed appropriate to classify this substance in Category 1B for this hazard class.	FY2016	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
8	Specific target organ toxicity - Single exposure	Category 1 (respiratory organs)	Danger	H370	P308+P311 P260 P264 P270 P321 P405 P501	No data is available for single exposure tests in humans or experimental animals. It is reported that single inhalation exposure to particles of manganese dioxide (CAS RN 1313-13-9), which is an insoluble manganese compound like this substance, lead to an inflammatory response in human lungs, and its symptoms were coughs, bronchitis, pneumonitis and reduction of lung function (CICAD 12 (1999)). Therefore, it is thought that this substance affects the respiratory organs in the similar manner to manganese dioxide. From the above, this substance was classified in Category 1 (respiratory organs).	FY2016	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
9	Specific target organ toxicity - Repeated exposure	Category 1 (nervous system, respiratory organs)	Danger	H372	P260 P264 P270 P314 P501	It is reported that the water solubility of this substance is 8 mg/kg (Initial Risk Assessment Report (NITE, CERI, NEDO, 2008), and it is insoluble in water (HSDB (Access on August 2016)). 　As for humans, it is reported that in a production plant of manganese dioxide and manganese salt, exposure to manganese dioxide, manganese tetroxide, and manganese salts (sulfate, carbonate, nitrate) caused effects on neurobehavioral function (Initial Risk Assessment Report (NITE, CERI, NEDO, 2008), ATSDR (2012)). However, the relevance to this substance is unclear. 　As for experimental animals, there is not enough information available for the rationale of classification. 　However, the most common inorganic manganese substances are manganese dioxide, manganese carbonate, manganese silicate, and manganese trioxide. In general, it is indicated that exposure to excess manganese for 14 days or less (acute duration) or up to a year (intermediate duration) has an effect on the respiratory system and the nervous system, with no effect on other organ systems (CICAD 63 (2004), CICAD 12 (1999)). Also in humans, due to occupational exposure to manganese dioxide, insoluble manganese similar to this substance, occurrence of neurotoxicity due to manganese poisoning was reported and it was reported that in addition to deterioration in visual simple reaction time and eye-hand coordination, rigidity of the hands was observed (SIDS (2012), Initial Risk Assessment Report (NITE, CERI, NEDO, 2008), ATSDR (2012)). ATSDR (2012) examined the epidemiological research report in detail, and like the occupational exposure report at the above-mentioned alkaline battery plant, the neurological effects associated with prolonged low-level manganese exposure generally have been subtle changes including deficits in tests of neuromotor or cognitive functions and altered mood states. However, it is concluded that inhalation exposure to high levels of manganese compounds, mainly manganese dioxide, can lead to symptoms, which are mild initially but evolve to include dull affects, altered gait, fine tremors, and psychiatric disturbances (ATSDR (2012)). Also, many case reports reveal that respiratory disorders (coughs, bronchitis, pneumonia etc.) occur with manganese compounds mainly composed of manganese dioxide (ATSDR (2012)). 　From the above, this substance was classified in Category 1 (nervous system, respiratory organs).	FY2016	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
10	Aspiration hazard	Classification not possible	- -	-	-	Classification not possible due to lack of data.	FY2016	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))

ENVIRONMENTAL HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification	Classification year (FY)	GHS Classification Guidance for the Japanese Government
11	Hazardous to the aquatic environment Short term (Acute)	Classification not possible	- -	-	-	No data available.	FY2016	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
11	Hazardous to the aquatic environment Long term (Chronic)	Classification not possible	- -	-	-	No data available.	FY2016	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
12	Hazardous to the ozone layer	Classification not possible	- -	-	-	No data available.	FY2016	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))

NOTE:

GHS Classification Result by the Japanese Government is intended to provide a reference for preparing a GHS label or SDS for users. To include the same classification result in a label or SDS for Japan is NOT mandatory.
Users can cite or copy this classification result when preparing a GHS label or SDS. Please be aware, however, that the responsibility for a label or SDS prepared by citing or copying this classification result lies with users.
This GHS classification was conducted based on the information sources and the guidance for classification and judgement which are described in the GHS Classification Guidance for the Japanese Government etc. Using other literature, test results etc. as evidence and including different content from this classification result in a label or SDS are allowed.
Hazard statement and precautionary statement will show by hovering the mouse cursor over a code in the column of "Hazard statement" and "Precautionary statement," respectively. In the excel file, both the codes and statements are provided.
A blank or "-" in the column of "Classification" denotes that a classification for the hazard class was not conducted in the year.
An asterisk “*” in the column of “Classification” denotes that “Not classified (or No applicable)” and/or “Classification not possible” is applicable. Details are described in the column of “Rationale for the classification”. If no English translation is available for “Rationale for the classification,” please refer to the Japanese version of the results.

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