NITE - Chemical Management Field

Latest GHS Classification Results by the Japanese Government (edited by NITE)

GENERAL INFORMATION

Item	Information
CAS RN	60-09-3
Chemical Name	4-aminoazobenzene
Substance ID	m-nite-60-09-3_v1
Download of Excel format	Excel file

REFERENCE INFORMATION

Item	Information
Guidance used for the classification (External link)	To Guidance List
UN GHS document (External link)	To UN GHS document
FAQ（GHS classification results by the Japanese Government）	To FAQ
List of Information Sources (Excel file)	List of Information Sources
List of Definitions/Abbreviations	Definitions/Abbreviations
Sample Label by MHLW (External link)	MHLW Website (in Japanese Only)
Sample SDS by MHLW (External link)	MHLW Website (in Japanese Only)
OECD/eChemPortal (External link)	To OECD/eChemPortal (External link)

PHYSICAL HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification	Classification year (FY)	GHS Classification Guidance for the Japanese Government
1	Explosives	Not classified (Not applicable)	- -	-	-	The substance contains consecutive nitrogen atoms (azo group). It is an aromatic azo group and does not meet the criteria of chemical groups associated with explosive properties, therefore it is determined as "Not applicable".	FY2010	GHS Classification Guidance by the Japanese Government （July, 2010）
2	Flammable gases	Not classified (Not applicable)	- -	-	-	Solid (GHS definition)	FY2010	GHS Classification Guidance by the Japanese Government （July, 2010）
3	Aerosols	Not classified (Not applicable)	- -	-	-	Not aerosol products.	FY2010	GHS Classification Guidance by the Japanese Government （July, 2010）
4	Oxidizing gases	Not classified (Not applicable)	- -	-	-	Solid (GHS definition)	FY2010	GHS Classification Guidance by the Japanese Government （July, 2010）
5	Gases under pressure	Not classified (Not applicable)	- -	-	-	Solid (GHS definition)	FY2010	GHS Classification Guidance by the Japanese Government （July, 2010）
6	Flammable liquids	Not classified (Not applicable)	- -	-	-	Solid (GHS definition)	FY2010	GHS Classification Guidance by the Japanese Government （July, 2010）
7	Flammable solids	Classification not possible	- -	-	-	No data available.	FY2010	GHS Classification Guidance by the Japanese Government （July, 2010）
8	Self-reactive substances and mixtures	Not classified (Not applicable)	- -	-	-	The substance contains consecutive nitrogen atoms (azo group). It is an aromatic azo group and does not meet the criteria of chemical groups associated with explosive properties, therefore it is determined as "Not applicable".	FY2010	GHS Classification Guidance by the Japanese Government （July, 2010）
9	Pyrophoric liquids	Not classified (Not applicable)	- -	-	-	Solid (GHS definition)	FY2010	GHS Classification Guidance by the Japanese Government （July, 2010）
10	Pyrophoric solids	Classification not possible	- -	-	-	No data available.	FY2010	GHS Classification Guidance by the Japanese Government （July, 2010）
11	Self-heating substances and mixtures	Classification not possible	- -	-	-	Test methods applicable to solid (melting point <= 140 degC) substances are not available.	FY2010	GHS Classification Guidance by the Japanese Government （July, 2010）
12	Substances and mixtures which, in contact with water, emit flammable gases	Not classified (Not applicable)	- -	-	-	The chemical structure of the substance does not contain metals or metalloids (B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At).	FY2010	GHS Classification Guidance by the Japanese Government （July, 2010）
13	Oxidizing liquids	Not classified (Not applicable)	- -	-	-	Solid (GHS definition)	FY2010	GHS Classification Guidance by the Japanese Government （July, 2010）
14	Oxidizing solids	Not classified (Not applicable)	- -	-	-	Organic compounds containing no oxygen, fluorine or chlorine	FY2010	GHS Classification Guidance by the Japanese Government （July, 2010）
15	Organic peroxides	Not classified (Not applicable)	- -	-	-	Organic compounds containing no bivalent -O-O- structure	FY2010	GHS Classification Guidance by the Japanese Government （July, 2010）
16	Corrosive to metals	Classification not possible	- -	-	-	Test methods applicable to solid substances are not available.	FY2010	GHS Classification Guidance by the Japanese Government （July, 2010）
17	Desensitized explosives	-	- -	-	-	-	-	-

HEALTH HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification	Classification year (FY)	GHS Classification Guidance for the Japanese Government
1	Acute toxicity (Oral)	Category 4	Warning	H302	P301+P312 P264 P270 P330 P501	Based on the rat LD50 values of 1450 mg/kg and 1640 mg/kg (BUA 21 (2000)), the substance was classified as Category 4.	FY2010	GHS Classification Guidance by the Japanese Government （July, 2010）
1	Acute toxicity (Dermal)	Not classified	- -	-	-	Based on the rat LD50 values of > 2000 mg/kg (guideline 84/449/EEC, GLP-compliant) (BUA 217 (2000)), the substance was classified as "Not classified". As relevant information, no animal death was observed at 2000 mg/kg.	FY2010	GHS Classification Guidance by the Japanese Government （July, 2010）
1	Acute toxicity (Inhalation: Gases)	Not classified (Not applicable)	- -	-	-	Solid (GHS definition)	FY2010	GHS Classification Guidance by the Japanese Government （July, 2010）
1	Acute toxicity (Inhalation: Vapours)	Classification not possible	- -	-	-	No data available.	FY2010	GHS Classification Guidance by the Japanese Government （July, 2010）
1	Acute toxicity (Inhalation: Dusts and mists)	Classification not possible	- -	-	-	Although the rat LC50 value of > 2.8 mg/L/4hrs (OECD TG 403, GLP-compliant) was reported (BUA 217 (2000)). However, because the value did not specify the category, and the classification was not possible. According to the description of "aerosol" in the original report, the test substance was judged as dust/mist.	FY2010	GHS Classification Guidance by the Japanese Government （July, 2010）
2	Skin corrosion/irritation	Not classified	- -	-	-	The substance was classified as "Not classified" based on the documented cases that no irritating effect to rabbit skin was caused either by pure or technical-grade of the substance (BUA 217 (2000)).	FY2010	GHS Classification Guidance by the Japanese Government （July, 2010）
3	Serious eye damage/eye irritation	Not classified	- -	-	-	The substance was classified as "Not classified" based on the documented cases that technical-grade of the substance caused slight irritation to rabbit eyes, and that in the case of pure substance, such effect was not observed and rabbits eyes exhibited only temporary reddening due to mechanical irritation after treatment (BUA 217 (2000)).	FY2010	GHS Classification Guidance by the Japanese Government （July, 2010）
4	Respiratory sensitization	Classification not possible	- -	-	-	No data available.	FY2010	GHS Classification Guidance by the Japanese Government （July, 2010）
4	Skin sensitization	Category 1	Warning	H317	P302+P352 P333+P313 P362+P364 P261 P272 P280 P321 P501	In the epidemiological studies for the cohort of patients who revealed dermatitis or eczema, and for workers who were occupationally exposed, there were numerous reports that the substance caused an apparent positive reaction in patch tests (BUA 217 (2000)). Moreover, several case reports that subjects with dermatitis revealed the apparent positive reaction by the substance in patch tests (BUA 217 (2000)). The substance was classified as Category 1 because these documents were regarded as enough evidence indicating the substance concerned causing allergic contact dermatitis in humans.	FY2010	GHS Classification Guidance by the Japanese Government （July, 2010）
5	Germ cell mutagenicity	Category 2	Warning	H341	P308+P313 P201 P202 P280 P405 P501	The substance was classified as Category 2 based on the positive results in the micronucleus test using bone marrow cells and peripheral reticulocytes of mice intraperitoneally administered (in vivo mutagenicity test in somatic cells) (BUA 217 (2000)). As relevant information, positive results were reported in the sister chromatid exchange test using bone marrow of mice intraperitoneally administered and in the DNA damage test using liver of rats intraperitoneally administered (in vivo genotoxicity test in somatic cell for both tests) (BUA 217 (2000)). As relevant information, as for in vitro study, positive results in the Ames test were reported (NTP DB (Access on Jul. 2009)).	FY2010	GHS Classification Guidance by the Japanese Government （July, 2010）
6	Carcinogenicity	Category 2	Warning	H351	P308+P313 P201 P202 P280 P405 P501	The substance was classified as Category 2 based on the criteria of "Group 2B" in the carcinogenicity assessment of the IARC (IARC Suppl. 7 (1987)) and "Group 2B" in Japan Society For Occupational Health (JSOH) (Recommendations for allowable concentrations, proposed in 1991). As relevant information, in the 104-week dietary administration test in male rats, carcinomas in the liver, which was not found in the control group were observed (IARC 8 (1975)). In the test that this substance was applied to the abdominal skin twice a week over the life of the rat, skin tumors which were not found in the control group were observed (IARC 8 (1975)).	FY2010	GHS Classification Guidance by the Japanese Government （July, 2010）
7	Reproductive toxicity	Classification not possible	- -	-	-	The classification was not possible due to lack of sufficient data. As relevant information, it was reported that the estrous cycle was completely inhibited in the female rat after 7 to 35 days of application by feeding (BUA 217 (2000)). It was also reported that the dye solvent, aminoazobenzene, induced malformations in mice (Birth Defects, 3rd (2000)). However, the details were unclear about both studies.	FY2010	GHS Classification Guidance by the Japanese Government （July, 2010）
8	Specific target organ toxicity - Single exposure	Category 2 (blood)	Warning	H371	P308+P311 P260 P264 P270 P405 P501	In the 4-hour inhalation study (OECD TG 403, GLP-compliant) in rats exposed at the concentrations of 0.023 - 2.8 mg/L (dusts/mists), in addition to dose dependent increases in methemoglobin concentration, clinical symptoms such as bradypnea and cyanosis were observed in the middle and high dose groups (0.341 - 2.8 mg/L) (BUA 217 (2000)). Cyanosis was also observed in the dermal study (guideline 84/449/EEC, GLP-compliant) in rats applied at 2000 mg/kg (BUA 217 (2000)). As described above, since dose-dependent increases in methemoglobin level and accompanying clinical signs occurred at the dose levels equivalent to Category 2 of the guidance values, the substance was classified as Category 2 (blood).	FY2010	GHS Classification Guidance by the Japanese Government （July, 2010）
9	Specific target organ toxicity - Repeated exposure	Classification not possible	- -	-	-	The classification was not possible due to lack of sufficient data. As relevant information, hemolytic anemia with disturbed erythrocyte maturation, formation of Howell-Jolly bodies, hemosiderin deposition in the liver, spleen and kidneys, and centrilobular hyaline degeneration in the liver were observed at the dose of 0.1% (converted dose level as that of 90-day study: approx. 20 mg/kg/day) after 35 - 41 days in the feeding study in rats (BUA 217 (2000)). However, it was described that the data were insufficient as the evidence because the study was conducted with only one dose group without control group and the test method had deficiency (BUA 217 (2000)).	FY2010	GHS Classification Guidance by the Japanese Government （July, 2010）
10	Aspiration hazard	Classification not possible	- -	-	-	No data available.	FY2010	GHS Classification Guidance by the Japanese Government （July, 2010）

ENVIRONMENTAL HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification	Classification year (FY)	GHS Classification Guidance for the Japanese Government
11	Hazardous to the aquatic environment Short term (Acute)	Category 1	Warning	H400	P273 P391 P501	Classified into Category 1 from its 48h-EC50 = 0.07 mg/L for crustacea (Cerodaphnia dubia) (BUA 217, 2000).	FY2010	GHS Classification Guidance by the Japanese Government （July, 2010）
11	Hazardous to the aquatic environment Long term (Chronic)	Category 1	Warning	H410	P273 P391 P501	Classified into Category 1 since its acute toxicity is Category 1 and it is not rapidly degradable (BOD degradation rate: 0% (Biodegradation and Bioconcentration of Existing Chemical Substances under the Chemical Substances Control Law, 2002)).	FY2010	GHS Classification Guidance by the Japanese Government （July, 2010）
12	Hazardous to the ozone layer	Classification not possible	- -	-	-	This substance is not listed in Annexes to the Montreal Protocol.	FY2010	GHS Classification Guidance by the Japanese Government （July, 2010）

NOTE:

GHS Classification Result by the Japanese Government is intended to provide a reference for preparing a GHS label or SDS for users. To include the same classification result in a label or SDS for Japan is NOT mandatory.
Users can cite or copy this classification result when preparing a GHS label or SDS. Please be aware, however, that the responsibility for a label or SDS prepared by citing or copying this classification result lies with users.
This GHS classification was conducted based on the information sources and the guidance for classification and judgement which are described in the GHS Classification Guidance for the Japanese Government etc. Using other literature, test results etc. as evidence and including different content from this classification result in a label or SDS are allowed.
Hazard statement and precautionary statement will show by hovering the mouse cursor over a code in the column of "Hazard statement" and "Precautionary statement," respectively. In the excel file, both the codes and statements are provided.
A blank or "-" in the column of "Classification" denotes that a classification for the hazard class was not conducted in the year.
An asterisk “*” in the column of “Classification” denotes that “Not classified (or No applicable)” and/or “Classification not possible” is applicable. Details are described in the column of “Rationale for the classification”. If no English translation is available for “Rationale for the classification,” please refer to the Japanese version of the results.

To GHS Information