NITE - Chemical Management Field

Latest GHS Classification Results by the Japanese Government (edited by NITE)

GENERAL INFORMATION

Item	Information
CAS RN	60-29-7
Chemical Name	Diethyl ether
Substance ID	m-nite-60-29-7_v1
Download of Excel format	Excel file

REFERENCE INFORMATION

Item	Information
Guidance used for the classification (External link)	To Guidance List
UN GHS document (External link)	To UN GHS document
FAQ（GHS classification results by the Japanese Government）	To FAQ
List of Information Sources (Excel file)	List of Information Sources
List of Definitions/Abbreviations	Definitions/Abbreviations
Sample Label by MHLW (External link)	MHLW Website (in Japanese Only)
Sample SDS by MHLW (External link)	MHLW Website (in Japanese Only)
OECD/eChemPortal (External link)	To OECD/eChemPortal (External link)

PHYSICAL HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification	Classification year (FY)	GHS Classification Guidance for the Japanese Government
1	Explosives	Not classified (Not applicable)	- -	-	-	There are no chemical groups associated with explosive properties present in the molecule.	FY2017	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
2	Flammable gases	Not classified (Not applicable)	- -	-	-	Liquid (GHS definition)	FY2017	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
3	Aerosols	Not classified (Not applicable)	- -	-	-	Not aerosol products.	FY2017	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
4	Oxidizing gases	Not classified (Not applicable)	- -	-	-	Liquid (GHS definition)	FY2017	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
5	Gases under pressure	Not classified (Not applicable)	- -	-	-	Liquid (GHS definition)	FY2017	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
6	Flammable liquids	Category 1	Danger	H224	P303+P361+P353 P370+P378 P403+P235 P210 P233 P240 P241 P242 P243 P280 P501	Based on a flash point of -45 deg C (closed cup), and a boiling point of 35 deg C (ICSC (J) (2002)), it was classified in Category 1. Besides, it is classified in Class 3, PGI in UNRTDG (UN 1155).	FY2017	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
7	Flammable solids	Not classified (Not applicable)	- -	-	-	Liquid (GHS definition)	FY2017	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
8	Self-reactive substances and mixtures	Not classified (Not applicable)	- -	-	-	There are no chemical groups present in the molecule associated with explosive or self-reactive properties.	FY2017	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
9	Pyrophoric liquids	Not classified	- -	-	-	It is estimated that it does not ignite at normal temperatures from an autoignition temperature of 175 deg C (GESTIS (Access on September 2017)).	FY2017	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
10	Pyrophoric solids	Not classified (Not applicable)	- -	-	-	Liquid (GHS definition)	FY2017	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
11	Self-heating substances and mixtures	Classification not possible	- -	-	-	Test methods applicable to liquid substances are not available.	FY2017	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
12	Substances and mixtures which, in contact with water, emit flammable gases	Not classified (Not applicable)	- -	-	-	The chemical structure of the substance does not contain metals or metalloids (B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At).	FY2017	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
13	Oxidizing liquids	Not classified (Not applicable)	- -	-	-	The substance is an organic compound containing oxygen (but not fluorine or chlorine) which is chemically bonded only to carbon or hydrogen.	FY2017	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
14	Oxidizing solids	Not classified (Not applicable)	- -	-	-	Liquid (GHS definition)	FY2017	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
15	Organic peroxides	Not classified (Not applicable)	- -	-	-	Organic compounds containing no bivalent -O-O- structure in the molecule	FY2017	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
16	Corrosive to metals	Classification not possible	- -	-	-	Test methods applicable to low-temperature-boiling liquids are not available.	FY2017	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
17	Desensitized explosives	-	- -	-	-	-	-	-

HEALTH HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification	Classification year (FY)	GHS Classification Guidance for the Japanese Government
1	Acute toxicity (Oral)	Category 4	Warning	H302	P301+P312 P264 P270 P330 P501	It is reported that LD50 values for rats were 1,215-2,540 mg/kg (DFGOT vol. 13 (1999)), 1.7 mL/kg (1,207 mg/kg) (PATTY (6th, 2012)), and 3,560 mg/kg (PATTY (6th, 2012)). One case corresponds to Category 4 to "Not classified," one case corresponds to Category 4, and one case corresponds to "Not classified" (Category 5 in UN GHS classification). By adopting the category with higher hazard, it was classified in Category 4.	FY2017	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
1	Acute toxicity (Dermal)	Not classified	- -	-	-	Based on a report of an LD50 value of >20 mL/kg for rabbits (>14,200 mg/kg) (PATTY (6th, 2012)), it was classified as "Not classified." By using a new information source, the classification result was changed from the previous classification.	FY2017	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
1	Acute toxicity (Inhalation: Gases)	Not classified (Not applicable)	- -	-	-	Liquid (GHS definition)	FY2017	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
1	Acute toxicity (Inhalation: Vapours)	Not classified	- -	-	-	Based on reports of an LC50 value in a 4-hour inhalation test with rats of 32,000 ppm (PATTY (6th, 2012)), and an LC50 value in a 2.5-hour inhalation test with rats of 73,000 ppm (converted 4-hour equivalent value: 57,711ppm) (DFGOT Vol. 13 (1999)), it was classified as "Not classified." Besides, since the exposure concentrations are lower than 90% of the saturated vapor pressure level (710,053 ppm), the reference value in the unit of ppm was applied as vapor with little mist.	FY2017	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
1	Acute toxicity (Inhalation: Dusts and mists)	Classification not possible	- -	-	-	Classification not possible due to lack of data.	FY2017	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
2	Skin corrosion/irritation	Not classified	- -	-	-	There are descriptions that, in a skin irritation test with rabbits (non-occlusive application), it was not irritating (DFGOT Vol.13 (1999)), and that it is possible to be mildly irritating or no irritation was seen in a short duration (PATTY (6th, 2012)). Therefore, it was classified as "Not classified" (Category 3 in UN GHS classification) corresponding to mild irritation on the GHS classification guidance for the Japanese government.	FY2017	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
3	Serious eye damage/eye irritation	Category 2B	- Warning	H320	P305+P351+P338 P337+P313 P264	For the two eye irritation tests with rabbits, there are descriptions that mild and reversible irritation was observed, and that mild eye irritation of grade 2 (maximum value 10) was observed (DFGOT Vol. 13 (1999)). In addition, there is a description that mild and reversible injury occurred in the eyes though test animals were unknown (PATTY (6th, 2012)). Therefore, it was classified in Category 2B.	FY2017	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
4	Respiratory sensitization	Classification not possible	- -	-	-	Classification not possible due to lack of data.	FY2017	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
4	Skin sensitization	Classification not possible	- -	-	-	Classification not possible due to lack of data. Besides, there is a description that, in a sensitization test with guinea pigs, sensitization to this substance was not observed but the reliability of this test is questionable (DFGOT Vol. 13 (1999)).	FY2017	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
5	Germ cell mutagenicity	Classification not possible	- -	-	-	There is no in vivo data. As for in vitro, bacterial reverse mutation tests gave negative or ambiguous results, and it was negative in a sister chromatid exchange test with mammalian cultured cells (DFGOT Vol.13 (1999), NTP DB (Access on September 2017)). From the above, it was classified as "Classification not possible" according to the GHS classification guidance for the Japanese government.	FY2017	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
6	Carcinogenicity	Classification not possible	- -	-	-	Classification not possible due to lack of data.	FY2017	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
7	Reproductive toxicity	Category 2	Warning	H361	P308+P313 P201 P202 P280 P405 P501	There are reports that as a result of inhalation exposure in pregnant rats or mice during the organogenesis period, increased embryonic death, increased incidence of generalized edema (mouse), and reduced crown-rump lengths (rat) were observed. There is a report that as a result of inhalation exposure in pregnant rats during the early or late organogenesis period, early or late fetal resorptions and skeletal anomalies were observed. There is a report that cleft palate was seen when pregnant rats inhaled it during the organogenesis period, but this was not seen when pregnant mice were exposed (DFGOT Vol. 13 (1999), HSDB (Access on August 2017)). From the above, in many reports on developmental toxicity in experimental animals, obvious fetal toxicity and increases in the occurrence of malformations (in some reports) were observed in a situation where the presence or absence of maternal toxicity was unknown, therefore, it was judged as appropriate to classify the substance in Category 2 for this hazard class.	FY2017	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
8	Specific target organ toxicity - Single exposure	Category 3 (respiratory tract irritation, narcotic effects)	Warning	H335 H336	P304+P340 P403+P233 P261 P271 P312 P405 P501	As for humans, this substance has been used as an inhaled anesthetic since the middle 19th century (DFGOT Vol. 13 (1999), OEL Documentations (Japan Society For Occupational Health (JSOH), 1997)). There is a report that in a test with 10 volunteers, the subjects complained of irritation of the nasal mucosa after inhalation exposure at 200 ppm for 3 to 5 minutes (DFGOT Vol. 13 (1999), ACGIH (7th, 2001)). As for experimental animals, it is reported that in a single inhalation exposure test in mice (no description of exposure time), excitation and anesthesia were observed at 32,000 ppm, and the animals went under with deep anesthesia at 64,000 ppm, but recovered when the substance was removed from the atmosphere at the end of the exposure (PATTY (6th, 2012)). From the above, it was classified in Category 3 (respiratory tract irritation, narcotic effects).	FY2017	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
9	Specific target organ toxicity - Repeated exposure	Category 1 (central nervous system)	Danger	H372	P260 P264 P270 P314 P501	As for humans, it is reported that loss of appetite, exhaustion, headache, sleepiness, dizziness, excitation, and psychic disturbances were caused by chronic exposure (ACGIH (7th, 2001)). As for experimental animals, in a 13-week oral dose toxicity test with rats, there was no effect at 500 mg/kg/day exceeding the guidance value range for Category 2, only weight loss was reported at or above 2,000 mg/kg/day (IRIS (1990)). From the above, since effects on the central nervous system were seen in humans, it was classified in Category 1 (central nervous system). Besides, in the previous classification, the neurological symptoms in humans were considered to be transient, therefore, they were not adopted as evidence for classification. However, they were adopted as evidence for classification this time by using new information sources and emphasizing occurrence of mental disorders. Therefore, the classification result was different from the previous classification.	FY2017	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
10	Aspiration hazard	Classification not possible	- -	-	-	Classification not possible due to lack of data. Besides, in the previous classification, it was classified in Category 2 using the information source in List 3, however, the evidence was not based on reports of cases in humans etc. but general remarks. Also, according to Japanese Industrial Standards (JIS) for GHS classification (JIS Z 7252: 2014) revised after the previous classification, a substance can be allocated to only Category 1, not Category 2, for this hazard class.	FY2017	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))

ENVIRONMENTAL HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification	Classification year (FY)	GHS Classification Guidance for the Japanese Government
11	Hazardous to the aquatic environment Short term (Acute)	Not classified	- -	-	-	From 96-hour LC50 = 2,560 mg/L for fish (Pimephales promelas) (NLM HSDB: 2014, EPA AQUIRE: 2017, Geiger, D. L. et al. (1986)), and 24-hour EC50 (immobile) = 165 mg/L for crustacea (Daphnia magna) (NLM HSDB: 2014, EPA AQUIRE: 2017, Bringmann, G. et al. (1982)), it was classified as "Not classified."	FY2017	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
11	Hazardous to the aquatic environment Long term (Chronic)	Not classified	- -	-	-	Chronic toxicity data were not obtained. Due to being not rapidly degradable (non-biodegradable, a degradation rate by GC: 13% (J-CHECK, 1985)), and "Not classified" in acute toxicity, it was classified as "Not classified."	FY2017	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
12	Hazardous to the ozone layer	Classification not possible	- -	-	-	No data available.	FY2017	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))

NOTE:

GHS Classification Result by the Japanese Government is intended to provide a reference for preparing a GHS label or SDS for users. To include the same classification result in a label or SDS for Japan is NOT mandatory.
Users can cite or copy this classification result when preparing a GHS label or SDS. Please be aware, however, that the responsibility for a label or SDS prepared by citing or copying this classification result lies with users.
This GHS classification was conducted based on the information sources and the guidance for classification and judgement which are described in the GHS Classification Guidance for the Japanese Government etc. Using other literature, test results etc. as evidence and including different content from this classification result in a label or SDS are allowed.
Hazard statement and precautionary statement will show by hovering the mouse cursor over a code in the column of "Hazard statement" and "Precautionary statement," respectively. In the excel file, both the codes and statements are provided.
A blank or "-" in the column of "Classification" denotes that a classification for the hazard class was not conducted in the year.
An asterisk “*” in the column of “Classification” denotes that “Not classified (or No applicable)” and/or “Classification not possible” is applicable. Details are described in the column of “Rationale for the classification”. If no English translation is available for “Rationale for the classification,” please refer to the Japanese version of the results.

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