NITE - Chemical Management Field

Latest GHS Classification Results by the Japanese Government (edited by NITE)

GENERAL INFORMATION

Item	Information
CAS RN	60-34-4
Chemical Name	Methylhydrazine
Substance ID	m-nite-60-34-4_v1
Download of Excel format	Excel file

REFERENCE INFORMATION

Item	Information
Guidance used for the classification (External link)	To Guidance List
UN GHS document (External link)	To UN GHS document
FAQ（GHS classification results by the Japanese Government）	To FAQ
List of Information Sources (Excel file)	List of Information Sources
List of Definitions/Abbreviations	Definitions/Abbreviations
Sample Label by MHLW (External link)	To Workplace Safety Site (MHLW)
Sample SDS by MHLW (External link)	To Workplace Safety Site (MHLW)
OECD/eChemPortal (External link)	To OECD/eChemPortal (External link)

PHYSICAL HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification	Classification year (FY)	GHS Classification Guidance for the Japanese Government
1	Explosives	Classification not possible	- -	-	-	Classification not possible due to lack of data on an exothermic decomposition energy.	FY2006	GHS Classification Manual （10 Feb, 2006）
2	Flammable gases	Not classified (Not applicable)	- -	-	-	Liquid (GHS definition)	FY2006	GHS Classification Manual （10 Feb, 2006）
3	Aerosols	Not classified (Not applicable)	- -	-	-	Not aerosol products	FY2006	GHS Classification Manual （10 Feb, 2006）
4	Oxidizing gases	Not classified (Not applicable)	- -	-	-	Liquid (GHS definition)	FY2006	GHS Classification Manual （10 Feb, 2006）
5	Gases under pressure	Not classified (Not applicable)	- -	-	-	Liquid (GHS definition)	FY2006	GHS Classification Manual （10 Feb, 2006）
6	Flammable liquids	Category 1	Danger	H224	P303+P361+P353 P370+P378 P403+P235 P210 P233 P240 P241 P242 P243 P280 P501	UNRTDG No. 2740, Class: 3; PG I. Flash point: -8.3degC. Boiling point 87.5degC	FY2006	GHS Classification Manual （10 Feb, 2006）
7	Flammable solids	Not classified (Not applicable)	- -	-	-	Liquid (GHS definition)	FY2006	GHS Classification Manual （10 Feb, 2006）
8	Self-reactive substances and mixtures	Type G	- -	-	-	UNRTDG Non-hazardrous Substance	FY2006	GHS Classification Manual （10 Feb, 2006）
9	Pyrophoric liquids	Not classified	- -	-	-	Since it is not classified as UNRTDG class 4.2 PG I and the ignition points was 196 degC (ICSC (J), (2004)), it was presupposed that it does not ignite spontaneously even if it contacts the air of normal temperatures.	FY2006	GHS Classification Manual （10 Feb, 2006）
10	Pyrophoric solids	Not classified (Not applicable)	- -	-	-	Liquid (GHS definition)	FY2006	GHS Classification Manual （10 Feb, 2006）
11	Self-heating substances and mixtures	Classification not possible	- -	-	-	Test methods applicable to liquid substances are not available	FY2006	GHS Classification Manual （10 Feb, 2006）
12	Substances and mixtures which, in contact with water, emit flammable gases	Not classified (Not applicable)	- -	-	-	The chemical structure of the substance does not contain metals or metaloids(B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At).	FY2006	GHS Classification Manual （10 Feb, 2006）
13	Oxidizing liquids	Not classified	- -	-	-	Reducing substance (ICSC(J), 2004)	FY2006	GHS Classification Manual （10 Feb, 2006）
14	Oxidizing solids	Not classified (Not applicable)	- -	-	-	Liquid (GHS definition)	FY2006	GHS Classification Manual （10 Feb, 2006）
15	Organic peroxides	Not classified (Not applicable)	- -	-	-	Organic compounds containing no -0-0- structure	FY2006	GHS Classification Manual （10 Feb, 2006）
16	Corrosive to metals	Classification not possible	- -	-	-	It is a moderate strong bases (ICSC (J) (2004)). However, there is no metal corrosion data and it cannot be classified.	FY2006	GHS Classification Manual （10 Feb, 2006）
17	Desensitized explosives	-	- -	-	-	-	-	-

HEALTH HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification	Classification year (FY)	GHS Classification Guidance for the Japanese Government
1	Acute toxicity (Oral)	Category 2	Danger	H300	P301+P310 P264 P270 P321 P330 P405 P501	SPECIES: Rat ENDPOINT: LD50 VALUE: 32 mg/kg REFERENCE SOURCE: PATTY (4th, 1994)	FY2006	GHS Classification Manual （10 Feb, 2006）
1	Acute toxicity (Dermal)	Category 2	Danger	H310	P302+P352 P361+P364 P262 P264 P270 P280 P310 P321 P405 P501	Based on rat LD50 value: 183mg/kg and rabbit LD50 value: 93mg/kg (ACGIH 7th, 2001, PATTY 4th, 1994), the rabbit lower value was adopted and it was set as Category 2.	FY2006	GHS Classification Manual （10 Feb, 2006）
1	Acute toxicity (Inhalation: Gases)	Not classified (Not applicable)	- -	-	-	Liquid (GHS definition)	FY2006	GHS Classification Manual （10 Feb, 2006）
1	Acute toxicity (Inhalation: Vapours)	Category 1	Danger	H330	P304+P340 P403+P233 P260 P271 P284 P310 P320 P405 P501	Based on rat LC50 (4 hours) values: 74ppm and 78ppm (equivalent of 0.14mg/L and 0.15mg/L) (ACGIH 7th, 2001, PATTY 4th, 1994) which vapor pressure indicate steam with almost no mist, it was classified as Category 1 by the ppm concentration standard.	FY2006	GHS Classification Manual （10 Feb, 2006）
1	Acute toxicity (Inhalation: Dusts and mists)	Classification not possible	- -	-	-	No data available	FY2006	GHS Classification Manual （10 Feb, 2006）
2	Skin corrosion/irritation	Category 2	Warning	H315	P302+P352 P332+P313 P362+P364 P264 P280 P321	Based on the description that erythema and edema were observed in dog skin application test, though the exposure time was unknown (ACGIH (7th, 2004) and PATTY (4th, 1994)) and that there is possibility of severe damage on human skin (PATTY (4th, 1994)), it was classified as Category 2.	FY2006	GHS Classification Manual （10 Feb, 2006）
3	Serious eye damage/eye irritation	Category 2A	Warning	H319	P305+P351+P338 P337+P313 P264 P280	It was set as Category 2A from description that damage serious to an eye may be seen by the humans of PATTY (4th, 1994).	FY2006	GHS Classification Manual （10 Feb, 2006）
4	Respiratory sensitization	Classification not possible	- -	-	-	No data	FY2006	GHS Classification Manual （10 Feb, 2006）
4	Skin sensitization	Classification not possible	- -	-	-	Although classified into Sh according to DFG, since there was no evidence that hypersensitivity was induced by skin contacts by humans, it did not meet the judgment criteria and it was decided not to be classified due to insufficiency of data.	FY2006	GHS Classification Manual （10 Feb, 2006）
5	Germ cell mutagenicity	Not classified	- -	-	-	The substance is regarded as outside the categories. Because there are negative results from the dominant lethal tests in mice, which are in vivo multi-generation mutagenicity tests using germ cells (ACGIH (7th, 2001), PATTY (4th, 1994)).	FY2006	GHS Classification Manual （10 Feb, 2006）
6	Carcinogenicity	Category 2	Warning	H351	P308+P313 P201 P202 P280 P405 P501	Since it was classified into A3 (ACGIH 7th, 2001) according to ACGIH, it was set as Category 2.	FY2006	GHS Classification Manual （10 Feb, 2006）
7	Reproductive toxicity	Category 2	Warning	H361	P308+P313 P201 P202 P280 P405 P501	Since although there was no descriptions about general toxicity of parent animals, there is the description that there is fetal malformation in oral administration test to pregnancy mouse and rabbit (HSDB (2005)), it is classified into the Category 2.	FY2006	GHS Classification Manual （10 Feb, 2006）
8	Specific target organ toxicity - Single exposure	Category 1 (blood, nervous system)	Danger	H370	P308+P311 P260 P264 P270 P321 P405 P501	Due to the descriptions that the effect on the blood was observed in human inhalation exposure example in PATTY (4th, 1994), that the convulsion was observed in the range of guidance value of Category 1 in the oral study using rat, and that the effect on the nervous system was observed in the inhalation exposure test using mouse with unknown concentrations. So it was classified into Category 1 (blood, nervous system) from description that .	FY2006	GHS Classification Manual （10 Feb, 2006）
9	Specific target organ toxicity - Repeated exposure	Category 1 (blood, liver, kidney, respiratory organs, adrenal gland)	Danger	H372	P260 P264 P270 P314 P501	It is classfied in Category 1 (blood, liver, kidney, respiratory organs, adrenal gland) from description in ACGIH (7th, 2001) that the influence on liver, the kidney, respiratory organs, or the adrenal gland were seen with the concentration of the guidance value range of Category 1 in the test which carried out inhalation exposure, over a long-term to the rat, the mouse, the dog, hamster, or ape.	FY2006	GHS Classification Manual （10 Feb, 2006）
10	Aspiration hazard	Classification not possible	- -	-	-	No data available	FY2006	GHS Classification Manual （10 Feb, 2006）

ENVIRONMENTAL HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification	Classification year (FY)	GHS Classification Guidance for the Japanese Government
11	Hazardous to the aquatic environment Short term (Acute)	Category 1	Warning	H400	P273 P391 P501	From 72-hour ErC50 = 0.28 mg/L for algae (Pseudokirchneriella subcapitata) (Results of Ecotoxicity tests of chemicals conducted by Ministry of the Environment in Japan, 2009), it was classified in Category 1.	FY2014	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0))
11	Hazardous to the aquatic environment Long term (Chronic)	Category 1	Warning	H410	P273 P391 P501	If chronic toxicity data are used, then it is classified in Category 1 due to lack of rapid degradability (a degradation rate by BOD: 0% (the existing chemicals survey program, 1992)), and 72-hour NOEC = 0.042 mg/L for algae (Pseudokirchneriella subcapitata) (Results of Ecotoxicity tests of chemicals conducted by Ministry of the Environment in Japan, 2009). If acute toxicity data are used for a trophic level for which chronic toxicity data are not obtained, then it is classified in Category 1 due to lack of rapid degradability (a degradation rate by BOD: 0% (the existing chemicals survey program, 1992)), and 96-hour LC50 = 0.38 mg/L for fish (Oryzias latipes) (Results of Ecotoxicity tests of chemicals conducted by Ministry of the Environment in Japan, 2009). It was classified in Category 1 from the above results.	FY2014	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0))
12	Hazardous to the ozone layer	Classification not possible	- -	-	-	This substance is not listed in Annexes to the Montreal Protocol.	FY2014	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0))

NOTE:

GHS Classification Result by the Japanese Government is intended to provide a reference for preparing a GHS label or SDS for users. To include the same classification result in a label or SDS for Japan is NOT mandatory.
Users can cite or copy this classification result when preparing a GHS label or SDS. Please be aware, however, that the responsibility for a label or SDS prepared by citing or copying this classification result lies with users.
This GHS classification was conducted based on the information sources and the guidance for classification and judgement which are described in the GHS Classification Guidance for the Japanese Government etc. Using other literature, test results etc. as evidence and including different content from this classification result in a label or SDS are allowed.
Hazard statement and precautionary statement will show by hovering the mouse cursor over a code in the column of "Hazard statement" and "Precautionary statement," respectively. In the excel file, both the codes and statements are provided.
A blank or "-" in the column of "Classification" denotes that a classification for the hazard class was not conducted in the year.
An asterisk “*” in the column of “Classification” denotes that “Not classified (or No applicable)” and/or “Classification not possible” is applicable. Details are described in the column of “Rationale for the classification”. If no English translation is available for “Rationale for the classification,” please refer to the Japanese version of the results.

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