Item | Information |
---|---|
CAS RN | 603-35-0 |
Chemical Name | Triphenylphosphine |
Substance ID | m-nite-603-35-0_v1 |
Download of Excel format | Excel file |
Item | Information |
---|---|
Guidance used for the classification (External link) | To Guidance List |
UN GHS document (External link) | To UN GHS document |
FAQ(GHS classification results by the Japanese Government) | To FAQ |
List of Information Sources (Excel file) | List of Information Sources |
List of Definitions/Abbreviations | Definitions/Abbreviations |
Sample Label by MHLW (External link) | To Workplace Safety Site (MHLW) |
Sample SDS by MHLW (External link) | To Workplace Safety Site (MHLW) |
OECD/eChemPortal (External link) | To OECD/eChemPortal (External link) |
Hazard class | Classification | Pictogram Signal word |
Hazard statement (code) |
Precautionary statement (code) |
Rationale for the classification | Classification year (FY) | GHS Classification Guidance for the Japanese Government | |
---|---|---|---|---|---|---|---|---|
1 | Explosives | Not classified (Not applicable) |
- |
- | - | There are no chemical groups associated with explosive properties present in the molecule. | FY2010 | GHS Classification Guidance by the Japanese Government (July, 2010) |
2 | Flammable gases | Not classified (Not applicable) |
- |
- | - | Solid (GHS definition) | FY2010 | GHS Classification Guidance by the Japanese Government (July, 2010) |
3 | Aerosols | Not classified (Not applicable) |
- |
- | - | Not aerosol products. | FY2010 | GHS Classification Guidance by the Japanese Government (July, 2010) |
4 | Oxidizing gases | Not classified (Not applicable) |
- |
- | - | Solid (GHS definition) | FY2010 | GHS Classification Guidance by the Japanese Government (July, 2010) |
5 | Gases under pressure | Not classified (Not applicable) |
- |
- | - | Solid (GHS definition) | FY2010 | GHS Classification Guidance by the Japanese Government (July, 2010) |
6 | Flammable liquids | Not classified (Not applicable) |
- |
- | - | Solid (GHS definition) | FY2010 | GHS Classification Guidance by the Japanese Government (July, 2010) |
7 | Flammable solids | Classification not possible |
- |
- | - | No data available. | FY2010 | GHS Classification Guidance by the Japanese Government (July, 2010) |
8 | Self-reactive substances and mixtures | Not classified (Not applicable) |
- |
- | - | There are no chemical groups present in the molecule associated with explosive or self-reactive properties. | FY2010 | GHS Classification Guidance by the Japanese Government (July, 2010) |
9 | Pyrophoric liquids | Not classified (Not applicable) |
- |
- | - | Solid (GHS definition) | FY2010 | GHS Classification Guidance by the Japanese Government (July, 2010) |
10 | Pyrophoric solids | Classification not possible |
- |
- | - | No data available. | FY2010 | GHS Classification Guidance by the Japanese Government (July, 2010) |
11 | Self-heating substances and mixtures | Classification not possible |
- |
- | - | Test methods applicable to solid (melting point <= 140 degC) substances are not available. | FY2010 | GHS Classification Guidance by the Japanese Government (July, 2010) |
12 | Substances and mixtures which, in contact with water, emit flammable gases | Not classified |
- |
- | - | Although the substance contains a metalloid (P), the water solubility data 0.279 mg/L (Howard (1997)) is obtained. Therefore it is considered that the substance does not react vigorously with water. | FY2010 | GHS Classification Guidance by the Japanese Government (July, 2010) |
13 | Oxidizing liquids | Not classified (Not applicable) |
- |
- | - | Solid (GHS definition) | FY2010 | GHS Classification Guidance by the Japanese Government (July, 2010) |
14 | Oxidizing solids | Not classified (Not applicable) |
- |
- | - | Organic compounds containing no oxygen, fluorine or chlorine | FY2010 | GHS Classification Guidance by the Japanese Government (July, 2010) |
15 | Organic peroxides | Not classified (Not applicable) |
- |
- | - | Organic compounds containing no bivalent -O-O- structure | FY2010 | GHS Classification Guidance by the Japanese Government (July, 2010) |
16 | Corrosive to metals | Classification not possible |
- |
- | - | Test methods applicable to solid substances are not available. | FY2010 | GHS Classification Guidance by the Japanese Government (July, 2010) |
17 | Desensitized explosives | - |
- |
- | - | - | - | - |
Hazard class | Classification | Pictogram Signal word |
Hazard statement (code) |
Precautionary statement (code) |
Rationale for the classification | Classification year (FY) | GHS Classification Guidance for the Japanese Government | |
---|---|---|---|---|---|---|---|---|
1 | Acute toxicity (Oral) | Category 4 |
Warning |
H302 | P301+P312 P264 P270 P330 P501 |
Based on the rat LD50 values (SIDS (Access on Dec. 2010)) of 700 mg/kg (vehicle: olive oil), 800 - 1600 mg/kg (vehicle: unknown), 991 - 1309 mg/kg (vehicle: peanut oil), > 6400 mg/kg (vehicle: aqueous suspension with tragacanth), 33100 - 34100 (vehicle: suspension with 1% methanol aqueous solution) and 4290 mg/kg (vehicle: unknown), because the LD50 values were 700 mg/kg and 991 - 1309 mg/kg in the case of using oils for the vehicles, the substance was classified as Category 4. In the case of the aqueous suspension, the substance was classified as "Not classified". | FY2010 | GHS Classification Guidance by the Japanese Government (July, 2010) |
1 | Acute toxicity (Dermal) | Not classified |
- |
- | - | Based on the rabbit LD50 values (SIDS (Access on Dec. 2010)) of > 4000 mg/kg (vehicle: 50% suspension with alcohol), > 5000 mg/kg (vehicle: unknown) and > 2000 mg/kg (vehicle: unknown), and on rat LD50 value (SIDS (Access on Dec. 2010)) of > 2500 mg/kg (vehicle: 50% suspension with alcohol), the substance was classified as "Not classified" in the JIS classification (corresponding to Category 5 or "Not classified" in the UN-GHS classification). | FY2010 | GHS Classification Guidance by the Japanese Government (July, 2010) |
1 | Acute toxicity (Inhalation: Gases) | Not classified (Not applicable) |
- |
- | - | Solid (GHS definition) | FY2010 | GHS Classification Guidance by the Japanese Government (July, 2010) |
1 | Acute toxicity (Inhalation: Vapours) | Classification not possible |
- |
- | - | No data available. | FY2010 | GHS Classification Guidance by the Japanese Government (July, 2010) |
1 | Acute toxicity (Inhalation: Dusts and mists) | Not classified |
- |
- | - | Based on the rat LC50 value of > 12.5 mg/L/4hrs (SIDS (Access on Dec. 2010)), the substance was classified as "Not classified". This study was carried out with dust or mist generated by nebulizing the substance which melted at 95 - 115 degrees centigrade (melting point: 80.5 degrees centigrade). As relevant information, the saturated vapor pressure concentration was 0.0001 mg/L (SRC Phys Prop (Access on Dec. 2010). | FY2010 | GHS Classification Guidance by the Japanese Government (July, 2010) |
2 | Skin corrosion/irritation | Category 2 |
Warning |
H315 | P302+P352 P332+P313 P362+P364 P264 P280 P321 |
In the skin irritation test in rabbits in which 50% suspension of the substance in ethanol was occlusively applied for up to 1, 5, 15 minutes and 20 hours, 20-hour exposure caused mild erythema on the back and ears of the male rabbits after 24 hours, and symptoms disappeared in 7 days (SIDS (Access on Dec. 2010)). In another rabbit test in which treatment of suspension in olive oil (10%, 20% and 50%) for 20-hour, 20% suspension on the back caused very slight erythema after 1 and 2 days of application (symptoms disappeared in 3 days), and 50% suspension on the ears caused marked erythema associated with edema over 4 days (SIDS (Access on Dec. 2010)). It was also reported that open exposure of the substance caused "slightly irritating" by judging from the grade 3 for irritation (mean score was unclear) and "moderately irritating" by judging from the Draize score of 2.63 to 8.00 after 24 and 72 hours (SIDS (Access on Dec. 2010)). In the guinea pig test, the substance resulted as "slightly irritating" (SIDS (Access on Dec. 2010)). Based on these documents, the substance was classified as Category 2. | FY2010 | GHS Classification Guidance by the Japanese Government (July, 2010) |
3 | Serious eye damage/eye irritation | Category 2 |
Warning |
H319 | P305+P351+P338 P337+P313 P264 P280 |
In the rabbit test in which the solid substance was directly inserted into the conjunctival sac of 2 animals, erythema with slight to significant conjunctival edema were observed in one animal at 1 to 24 hours after instillation, and corneal opacity was observed in one animal after 8 days (SIDS (Access on Dec. 2010)). In another rabbit test, instillation of the 10% olive oil solution for 2 animals caused erythema after 10 minutes, and erythema and edema after 1 to 3 hours. Symptoms disappeared after 24 hours of instillation (SIDS (Access on Dec. 2010)). It was also reported that the substance caused "slight injury" by judging from the grade 3 (mean score was unclear) and caused conjunctival erythema in 5 of 6 animals and chemosis in 4 of 6 animals (no corneal involvement) (SIDS (Access on Dec. 2010)). Based on these documents, the substance was classified as Category 2. | FY2010 | GHS Classification Guidance by the Japanese Government (July, 2010) |
4 | Respiratory sensitization | Classification not possible |
- |
- | - | No data available. | FY2010 | GHS Classification Guidance by the Japanese Government (July, 2010) |
4 | Skin sensitization | Category 1 |
Warning |
H317 | P302+P352 P333+P313 P362+P364 P261 P272 P280 P321 P501 |
The substance was classified as Category 1 based on the information that positive rate was 80% in the sensitization tests (using adjuvant) using female guinea pigs. As relevant information, the substance was classified as "Sh" in the assessment of MAK/BAT (MAK/BAT (2009)). | FY2010 | GHS Classification Guidance by the Japanese Government (July, 2010) |
5 | Germ cell mutagenicity | Not classified |
- |
- | - | The substance was classified as "Not classified" based on the negative results in the micronucleus test using mice intraperitoneally administered (in vivo mutagenicity test in somatic cells) (SIDS (Access on Dec. 2010)). As relevant information, as for in vitro studies, negative results in the Ames test using bacteria and the micronucleus test using Chinese hamster were reported (SIDS (Access on Dec. 2010)). | FY2010 | GHS Classification Guidance by the Japanese Government (July, 2010) |
6 | Carcinogenicity | Classification not possible |
- |
- | - | No data available. | FY2010 | GHS Classification Guidance by the Japanese Government (July, 2010) |
7 | Reproductive toxicity | Classification not possible |
- |
- | - | In the oral administration study in wistar rats (day 6 - 19 postcoitum) (OECD TG414, GLP-compliant), at the high dose level of 90 mg/kg/day, general toxicity (blood system and liver) of the maternal animal was observed. But, no effect on gestational parameters and fetal development were observed (SIDS (Access on Dec. 2010)). In the 3-month oral administration study in male and female wistar rats (OECD TG408, GLP-compliant), the general toxicity (blood system and liver) was seen at 60 mg/kg/day. On the other hand, changes in the weights of reproductive organs were not seen in 120 mg/kg/day (SIDS (Access on Dec. 2010)). However, since there was no data for the development of postnatal offspring, the classification was not possible. | FY2010 | GHS Classification Guidance by the Japanese Government (July, 2010) |
8 | Specific target organ toxicity - Single exposure | Category 3 (Respiratory tract irritation) |
Warning |
H335 | P304+P340 P403+P233 P261 P271 P312 P405 P501 |
In the acute inhalation study in rats (dust, 12.5 mg/L: equivalent to 'Not classified' according to the guidance document), clinical signs consisting of respiratory irritation, salivation, lacrimation were observed, but no macroscopic observations and no organ weight changes were detected in the tissues examined (SIDS (Access on Dec. 2010)). In the acute oral study in rats (6400 mg/kg group: equivalent to "Not classified" according to the guidance document), dyspnea and apathy were reported without any abnormalities in the organs (SIDS (Access on Dec. 2010)). It was also reported in the acute dermal studies in rabbits (4000 mg/kg) or rats (2500 mg/kg) that no pathological changes were found in the surviving animals (SIDS (Access on Dec. 2010)). Based on the information described above, the substance was classified as Category 3 (respiratory tract irritation). | FY2010 | GHS Classification Guidance by the Japanese Government (July, 2010) |
9 | Specific target organ toxicity - Repeated exposure | Category 1 (nerve, heart), Category 2 (liver) |
Danger Warning |
H372 H373 |
P260 P264 P270 P314 P501 |
In the 3-month oral dose study in male and female rats (OECD TG 408, GLP-compliant), shortening in prothrombin time, decreases in AST and ALT, an increase in liver weight in females, and centrilobular hypertrophy of the liver in both sexes were observed at the dose level of 60 mg/kg/day (equivalent to Category 2) (SIDS (Access on Dec. 2010)). In the 4-week oral dose toxicity study in ten female Wistar rats, hypothermia, unstable gait, piloerection, pale skin, decreased serum cholinesterase activity, elevation of erythrocyte cholinesterase activity, erosion and ulcer in stomach, liver enlargement, axonal degeneration in proximal sciatic nerve were observed at 7.8 mg/kg/day (converted value as that of 90-day study) (equivalent to Category 1) (SIDS (Access on Dec. 2010)). Moreover, in the oral dose toxicity studies in rabbits and dogs, neuronal disorder (ataxia, listlessness of extremities) with injuries in the brain and spinal cord, and cardiac enlargement were observed at the dose levels equivalent to Category 1 of the guidance values (SIDS (Access on Dec. 2010)). Furthermore, in the 5-week (dust) inhalation study in male and female beagle dogs, neuronal disorder of hind limbs at the dose level of 0.028 mg/L/day (converted value as that of 90-day study) (equivalent to Category 2), and scattered degeneration in the spinal cord at the dose level of 0.0097 mg/L/day (converted value as that of 90-day study) (equivalent to Category 1) were reported (SIDS (Access on Dec. 2010)). In the 4-week (dust) inhalation study in male and female beagle dogs, neuronal disorder (impaired gait) at the dose level of 0.0294 mg/L/day (converted value as that of 90-day study) (equivalent to Category 2), and histopathological changes in central nervous system at the dose level of 0.0056 mg/L/day (converted value as that of 90-day study) (equivalent to Category 1) were also reported (SIDS (Access on Dec. 2010)). Therefore, the target organs were considered as the nervous system, heart and liver, and the substance was conclusively classified as Category 1 (nervous system, heart), Category 2 (liver). | FY2010 | GHS Classification Guidance by the Japanese Government (July, 2010) |
10 | Aspiration hazard | Classification not possible |
- |
- | - | No data available. | FY2010 | GHS Classification Guidance by the Japanese Government (July, 2010) |
Hazard class | Classification | Pictogram Signal word |
Hazard statement (code) |
Precautionary statement (code) |
Rationale for the classification | Classification year (FY) | GHS Classification Guidance for the Japanese Government | |
---|---|---|---|---|---|---|---|---|
11 | Hazardous to the aquatic environment Short term (Acute) | Not classified |
- |
- | - | Classified as "Not classified" since its acute toxicity was not detected for algae, crustacea or fish at concentrations up to the water solubility (0.09 mg/L (SIDS, 2002)). | FY2010 | GHS Classification Guidance by the Japanese Government (July, 2010) |
11 | Hazardous to the aquatic environment Long term (Chronic) | Category 4 |
- |
H413 | P273 P501 |
Classified into Category 4 since it is poorly soluble substance for which no acute toxicity is reported at levels up to the water solubility, and it is not rapidly degradable (SIDS, 2002) and its Log Kow = 5.69 (PHYSPROP Database, 2011). | FY2010 | GHS Classification Guidance by the Japanese Government (July, 2010) |
12 | Hazardous to the ozone layer | Classification not possible |
- |
- | - | This substance is not listed in Annexes to the Montreal Protocol. | FY2010 | GHS Classification Guidance by the Japanese Government (July, 2010) |
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