Item | Information |
---|---|
CAS RN | 608-93-5 |
Chemical Name | 1,2,3,4,5-Pentachlorobenzene |
Substance ID | m-nite-608-93-5_v1 |
Download of Excel format | Excel file |
Item | Information |
---|---|
Guidance used for the classification (External link) | To Guidance List |
UN GHS document (External link) | To UN GHS document |
FAQ(GHS classification results by the Japanese Government) | To FAQ |
List of Information Sources (Excel file) | List of Information Sources |
List of Definitions/Abbreviations | Definitions/Abbreviations |
Sample Label by MHLW (External link) | To Workplace Safety Site (MHLW) |
Sample SDS by MHLW (External link) | To Workplace Safety Site (MHLW) |
OECD/eChemPortal (External link) | To OECD/eChemPortal (External link) |
Hazard class | Classification | Pictogram Signal word |
Hazard statement (code) |
Precautionary statement (code) |
Rationale for the classification | Classification year (FY) | GHS Classification Guidance for the Japanese Government | |
---|---|---|---|---|---|---|---|---|
1 | Explosives | Not classified (Not applicable) |
- |
- | - | There are no chemical groups associated with explosive properties present in the molecule. | FY2012 | GHS Classification Guidance by the Japanese Government (July, 2010) |
2 | Flammable gases | Not classified (Not applicable) |
- |
- | - | Solid (GHS definition) | FY2012 | GHS Classification Guidance by the Japanese Government (July, 2010) |
3 | Aerosols | Not classified (Not applicable) |
- |
- | - | Not aerosol products. | FY2012 | GHS Classification Guidance by the Japanese Government (July, 2010) |
4 | Oxidizing gases | Not classified (Not applicable) |
- |
- | - | Solid (GHS definition) | FY2012 | GHS Classification Guidance by the Japanese Government (July, 2010) |
5 | Gases under pressure | Not classified (Not applicable) |
- |
- | - | Solid (GHS definition) | FY2012 | GHS Classification Guidance by the Japanese Government (July, 2010) |
6 | Flammable liquids | Not classified (Not applicable) |
- |
- | - | Solid (GHS definition) | FY2012 | GHS Classification Guidance by the Japanese Government (July, 2010) |
7 | Flammable solids | Classification not possible |
- |
- | - | No data available. | FY2012 | GHS Classification Guidance by the Japanese Government (July, 2010) |
8 | Self-reactive substances and mixtures | Not classified (Not applicable) |
- |
- | - | There are no chemical groups present in the molecule associated with explosive or self-reactive properties. | FY2012 | GHS Classification Guidance by the Japanese Government (July, 2010) |
9 | Pyrophoric liquids | Not classified (Not applicable) |
- |
- | - | Solid (GHS definition) | FY2012 | GHS Classification Guidance by the Japanese Government (July, 2010) |
10 | Pyrophoric solids | Classification not possible |
- |
- | - | No data available. | FY2012 | GHS Classification Guidance by the Japanese Government (July, 2010) |
11 | Self-heating substances and mixtures | Classification not possible |
- |
- | - | Test methods applicable to solid (melting point <= 140 deg C) substances are not available. | FY2012 | GHS Classification Guidance by the Japanese Government (July, 2010) |
12 | Substances and mixtures which, in contact with water, emit flammable gases | Not classified (Not applicable) |
- |
- | - | The chemical structure of the substance does not contain metals or metalloids (B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At). | FY2012 | GHS Classification Guidance by the Japanese Government (July, 2010) |
13 | Oxidizing liquids | Not classified (Not applicable) |
- |
- | - | Solid (GHS definition) | FY2012 | GHS Classification Guidance by the Japanese Government (July, 2010) |
14 | Oxidizing solids | Not classified (Not applicable) |
- |
- | - | The substance is an organic compound containing chlorine (but not fluorine or oxygen) which is chemically bonded only to carbon or hydrogen. | FY2012 | GHS Classification Guidance by the Japanese Government (July, 2010) |
15 | Organic peroxides | Not classified (Not applicable) |
- |
- | - | Organic compounds containing no bivalent -O-O- structure. | FY2012 | GHS Classification Guidance by the Japanese Government (July, 2010) |
16 | Corrosive to metals | Classification not possible |
- |
- | - | Test methods applicable to solid substances are not available. | FY2012 | GHS Classification Guidance by the Japanese Government (July, 2010) |
17 | Desensitized explosives | - |
- |
- | - | - | - | - |
Hazard class | Classification | Pictogram Signal word |
Hazard statement (code) |
Precautionary statement (code) |
Rationale for the classification | Classification year (FY) | GHS Classification Guidance for the Japanese Government | |
---|---|---|---|---|---|---|---|---|
1 | Acute toxicity (Oral) | Category 4 |
Warning |
H302 | P301+P312 P264 P270 P330 P501 |
It was classified in Category 4 based on LD50 values of 1,125 mg/kg (males) and 1,080 mg/kg (females) for rats (EHC 128 (1991)). | FY2012 | GHS Classification Guidance by the Japanese Government (July, 2010) |
1 | Acute toxicity (Dermal) | Not classified |
- |
- | - | It was classified as "Not classified" in the Classification JIS (Category 5 in UN GHS classification or "Not classified") based on an LD50 value of > 2,500 mg/kg for rats (EHC 128 (1991)). | FY2012 | GHS Classification Guidance by the Japanese Government (July, 2010) |
1 | Acute toxicity (Inhalation: Gases) | Not classified (Not applicable) |
- |
- | - | Solid (GHS definition) | FY2012 | GHS Classification Guidance by the Japanese Government (July, 2010) |
1 | Acute toxicity (Inhalation: Vapours) | Classification not possible |
- |
- | - | No data available. | FY2012 | GHS Classification Guidance by the Japanese Government (July, 2010) |
1 | Acute toxicity (Inhalation: Dusts and mists) | Classification not possible |
- |
- | - | No data available. | FY2012 | GHS Classification Guidance by the Japanese Government (July, 2010) |
2 | Skin corrosion/irritation | Classification not possible |
- |
- | - | No data available. | FY2012 | GHS Classification Guidance by the Japanese Government (July, 2010) |
3 | Serious eye damage/eye irritation | Classification not possible |
- |
- | - | No data available. | FY2012 | GHS Classification Guidance by the Japanese Government (July, 2010) |
4 | Respiratory sensitization | Classification not possible |
- |
- | - | No data available. | FY2012 | GHS Classification Guidance by the Japanese Government (July, 2010) |
4 | Skin sensitization | Classification not possible |
- |
- | - | No data available. | FY2012 | GHS Classification Guidance by the Japanese Government (July, 2010) |
5 | Germ cell mutagenicity | Not classified |
- |
- | - | It was classified as "Not classified" from a negative result in a micronucleus test with peripheral blood after 90-day diet administration to mice (in vivo somatic cell mutagenicity test) (NTP DB (Access on Sep. 2012)). Besides, as for in vitro tests, it is reported that it was negative in an Ames test (NTP DB (1980)) and negative in a chromosomal aberration test with CHO cells (NTP DB (Access on Sep. 2012)). | FY2012 | GHS Classification Guidance by the Japanese Government (July, 2010) |
6 | Carcinogenicity | Classification not possible |
- |
- | - | It was classified as "Classification not possible" because it was classified in D in EPA (1986) (IRIS (2003)). | FY2012 | GHS Classification Guidance by the Japanese Government (July, 2010) |
7 | Reproductive toxicity | Category 2, |
Warning |
H361 H362 |
P308+P313 P201 P202 P260 P263 P264 P270 P280 P405 P501 |
In a developmental toxicity test by oral administration to pregnant rats during the organogenesis period, maternal animals did not show toxic signs, a trend toward a decrease in the number of live fetuses per litter and increased sternal defects were observed in the high dose group (200 mg/kg), and an increase in extra or fused ribs was reported in the treated groups (50-200 mg/kg) (PATTY (6th, 2012)). However, in another test with mice using the same treatment period and similar doses, increased liver weights were seen in maternal animals, but no adverse effects on the development of offspring were found (PATTY (6th, 2012)). From the above, because findings in rats did not constitute clear evidence to classify it in Category 1B, it was classified in Category 2. On the other hand, it was classified in the Additional category: Effects on or via lactation because tremors at or above 0.025% and increased preweaning mortality and reduced weight gain at 0.1% group were observed in the (preweaning) pups from maternal animals administered in the diet throughout a lactation period (Environmental Risk Assessment for Chemical Substances vol. 4 (Ministry of the Environment, 2005)). | FY2012 | GHS Classification Guidance by the Japanese Government (July, 2010) |
8 | Specific target organ toxicity - Single exposure | Category 2 (central nervous system) |
Warning |
H371 | P308+P311 P260 P264 P270 P405 P501 |
In acute toxicity tests with rats and mice (LD50 value: rats 1,080-1,125 mg/kg, mice 1,175-1,370 mg/kg), signs of decreased activity and tremors were observed at sublethal dose levels (corresponding to the guidance values for Category 2) in both animal species (EHC 128 (1991)), On the other hand, it is described that oral toxicity symptoms in rats and mice included tremors and central nervous system depression in reports on acute and subacute toxicity of pentachlorobenzene (HSDB (2010)), therefore it was classified in Category 2 (central nervous system). | FY2012 | GHS Classification Guidance by the Japanese Government (July, 2010) |
9 | Specific target organ toxicity - Repeated exposure | Category 2 (liver, kidney, thyroid) |
Warning |
H373 | P260 P314 P501 |
In a 13-week diet administration test with rats (doses: 0, 33, 100, 330, 1,000, or 2,000 ppm), hyaline droplet nephropathy specific to male rats including hyaline droplet accumulation in the tubular epithelium was observed in the kidney in treated males, and exacerbated spontaneous nephropathy characterized by renal tubular cell regeneration and intratubular protein casts was found in addition to pigmentation and mineralization in males at or above 330 ppm (16.5 mg/kg/day), corresponding to the guidance values for Category 2, and females at or above 1,000 ppm (50 mg/kg/day) (NTP TOX 6 (1991)). Therefore, it was classified in Category 2 (kidney). And increased sorbitol dehydrogenase concentrations indicative of slight liver damage as well as centrilobular hepatocellular hypertrophy and yellow-brown granules were seen in males at or above 330 ppm and females at or above 1,000 ppm, and in a 13-week diet administration test with mice using the same protocol, centrilobular hepatocellular hypertrophy with slight necrosis was observed. Therefore, it was classified in Category 2 (liver). Furthermore, it was classified in Category 2 (thyroid) because thyroid follicular cell hypertrophy and a significant decrease in thyroxin concentrations were found at 1,000 and 2,000 ppm (100 mg/kg/day) in the above test with rats. Besides, there are no case reports on occupational exposure or epidemiological surveys in humans (EHC 128 (1991)). | FY2012 | GHS Classification Guidance by the Japanese Government (July, 2010) |
10 | Aspiration hazard | Classification not possible |
- |
- | - | No data available. | FY2012 | GHS Classification Guidance by the Japanese Government (July, 2010) |
Hazard class | Classification | Pictogram Signal word |
Hazard statement (code) |
Precautionary statement (code) |
Rationale for the classification | Classification year (FY) | GHS Classification Guidance for the Japanese Government | |
---|---|---|---|---|---|---|---|---|
11 | Hazardous to the aquatic environment Short term (Acute) | Category 1 |
Warning |
H400 | P273 P391 P501 |
It was classified in Category 1 from 48-hour EC50 = 0.01 mg/L for for crustacea (Ceriodaphnia dubia) (CICAD 60, 2004). | FY2012 | GHS Classification Guidance by the Japanese Government (July, 2010) |
11 | Hazardous to the aquatic environment Long term (Chronic) | Category 1 |
Warning |
H410 | P273 P391 P501 |
If chronic toxicity data are used, then it is classified in Category 1 due to being not rapidly degradable (not readily degradable, a degradation rate by BOD: 0% (Biodegradation and Bioconcentration Results of Existing Chemical Substances under the Chemical Substances Control Law, 1982)), and 28-day NOEC = 0.018 mg/L for fish (Cyprinodon variegatus) (CICAD 60, 2004). If acute toxicity data are used for a trophic level for which chronic toxicity data are not obtained, then it is classified in Category 2 due to being not rapidly degradable (not readily degradable, a degradation rate by BOD: 0% (Biodegradation and Bioconcentration Results of Existing Chemical Substances under the Chemical Substances Control Law, 1982)), and 96-hour EC50 = 1.98 mg/L for algae (Skeletonema costatum) (EHC 128, 1991). By drawing a comparison between the above results, it was classified in Category 1. |
FY2012 | GHS Classification Guidance by the Japanese Government (July, 2010) |
12 | Hazardous to the ozone layer | Classification not possible |
- |
- | - | This substance is not listed in the Annexes to the Montreal Protocol. | FY2012 | GHS Classification Guidance by the Japanese Government (July, 2010) |
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