NITE - Chemical Management Field

Latest GHS Classification Results by the Japanese Government (edited by NITE)

GENERAL INFORMATION

Item	Information
CAS RN	6080-56-4
Chemical Name	Lead(II) acetate trihydrate
Substance ID	m-nite-6080-56-4_v1
Download of Excel format	Excel file

REFERENCE INFORMATION

Item	Information
Guidance used for the classification (External link)	To Guidance List
UN GHS document (External link)	To UN GHS document
FAQ（GHS classification results by the Japanese Government）	To FAQ
List of Information Sources (Excel file)	List of Information Sources
List of Definitions/Abbreviations	Definitions/Abbreviations
Sample Label by MHLW (External link)	MHLW Website (in Japanese Only)
Sample SDS by MHLW (External link)	MHLW Website (in Japanese Only)
OECD/eChemPortal (External link)	To OECD/eChemPortal (External link)

PHYSICAL HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification	Classification year (FY)	GHS Classification Guidance for the Japanese Government
1	Explosives	Not classified (Not applicable)	- -	-	-	Containing no chemical groups with explosive properties	FY2006	GHS Classification Manual （10 Feb, 2006）
2	Flammable gases	Not classified (Not applicable)	- -	-	-	Classified as "solid" according to GHS definition	FY2006	GHS Classification Manual （10 Feb, 2006）
3	Aerosols	Not classified (Not applicable)	- -	-	-	Not aerosol products	FY2006	GHS Classification Manual （10 Feb, 2006）
4	Oxidizing gases	Not classified (Not applicable)	- -	-	-	Classified as "solid" according to GHS definition	FY2006	GHS Classification Manual （10 Feb, 2006）
5	Gases under pressure	Not classified (Not applicable)	- -	-	-	Classified as "solid" according to GHS definition	FY2006	GHS Classification Manual （10 Feb, 2006）
6	Flammable liquids	Not classified (Not applicable)	- -	-	-	Classified as "solid" according to GHS definition	FY2006	GHS Classification Manual （10 Feb, 2006）
7	Flammable solids	Not classified	- -	-	-	Non-flammable (anhydride (ICSC, 2004))	FY2006	GHS Classification Manual （10 Feb, 2006）
8	Self-reactive substances and mixtures	Not classified (Not applicable)	- -	-	-	Containing no chemical groups with explosive or self-reactive properties	FY2006	GHS Classification Manual （10 Feb, 2006）
9	Pyrophoric liquids	Not classified (Not applicable)	- -	-	-	Classified as "solid" according to GHS definition	FY2006	GHS Classification Manual （10 Feb, 2006）
10	Pyrophoric solids	Not classified	- -	-	-	Non-combustible (anhydride (ICSC, 2004))	FY2006	GHS Classification Manual （10 Feb, 2006）
11	Self-heating substances and mixtures	Not classified	- -	-	-	Non-combustible (anhydride (ICSC, 2004))	FY2006	GHS Classification Manual （10 Feb, 2006）
12	Substances and mixtures which, in contact with water, emit flammable gases	Not classified	- -	-	-	Stable to water (water solubility: 1g/1.6mL (ordinary temperatures), 1g/0.5mL (boiled water) (Lide (84th, 2003))	FY2006	GHS Classification Manual （10 Feb, 2006）
13	Oxidizing liquids	Not classified (Not applicable)	- -	-	-	Classified as "solid" according to GHS definition	FY2006	GHS Classification Manual （10 Feb, 2006）
14	Oxidizing solids	Not classified (Not applicable)	- -	-	-	Organic compounds containing oxygen (but not fluorine and chlorine), with the oxygen bound to carbon and hydrogen (but not to other elements)	FY2006	GHS Classification Manual （10 Feb, 2006）
15	Organic peroxides	Not classified (Not applicable)	- -	-	-	Organic compounds containing no "-O-O-" structure	FY2006	GHS Classification Manual （10 Feb, 2006）
16	Corrosive to metals	Classification not possible	- -	-	-	Test methods applicable to solid substances are not available.	FY2006	GHS Classification Manual （10 Feb, 2006）
17	Desensitized explosives	-	- -	-	-	-	-	-

HEALTH HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification	Classification year (FY)	GHS Classification Guidance for the Japanese Government
1	Acute toxicity (Oral)	-	- Warning	-	-	Based on the rat LD50 (oral route) of 4,665mg/kg (RTECS (2005)).	FY2006	GHS Classification Manual （10 Feb, 2006）
1	Acute toxicity (Dermal)	Classification not possible	- -	-	-	No data available	FY2006	GHS Classification Manual （10 Feb, 2006）
1	Acute toxicity (Inhalation: Gases)	Not classified (Not applicable)	- -	-	-	Due to the fact that the substance is "solid" according to the GHS definition and inhalation of its gas is not expected.	FY2006	GHS Classification Manual （10 Feb, 2006）
1	Acute toxicity (Inhalation: Vapours)	Classification not possible	- -	-	-	No data available	FY2006	GHS Classification Manual （10 Feb, 2006）
1	Acute toxicity (Inhalation: Dusts and mists)	Classification not possible	- -	-	-	No data available	FY2006	GHS Classification Manual （10 Feb, 2006）
2	Skin corrosion/irritation	Classification not possible	- -	-	-	No data available	FY2006	GHS Classification Manual （10 Feb, 2006）
3	Serious eye damage/eye irritation	Classification not possible	- -	-	-	No data available	FY2006	GHS Classification Manual （10 Feb, 2006）
4	Respiratory sensitization	Classification not possible	- -	-	-	No data available	FY2006	GHS Classification Manual （10 Feb, 2006）
4	Skin sensitization	Classification not possible	- -	-	-	No data available	FY2006	GHS Classification Manual （10 Feb, 2006）
5	Germ cell mutagenicity	Category 2	Warning	H341	P308+P313 P201 P202 P280 P405 P501	Based on the data on Lead Acetate (II) (ID47, CAS: 301-04-2), though no data are available on Lead Acetate (II), Trihydrate per se.	FY2006	GHS Classification Manual （10 Feb, 2006）
6	Carcinogenicity	Category 2	Warning	H351	P308+P313 P201 P202 P280 P405 P501	Due to the fact that the substance is classified as Category R by NTP (2005), Group 2B by IARC (1987), Category A3 by ACGIH (2001) and Category 2B by Japan Society for Occupational Health.	FY2006	GHS Classification Manual （10 Feb, 2006）
7	Reproductive toxicity	Category 1A	Danger	H360	P308+P313 P201 P202 P280 P405 P501	Based on expert judgment, given the fact that lead has been known to possess developmental neurotoxic and reproductive toxic potentials in humans. As for the health hazards, refer to "ID168, Lead, CAS: 7439-92-1," "ID48, Lead Oxide (II); Litharge, CAS: 1317-36-8," and "ID47, Lead Acetate (II), CAS: 301-04-2."	FY2006	GHS Classification Manual （10 Feb, 2006）
8	Specific target organ toxicity - Single exposure	Category 1 (blood system, kidney, nervous system)	Danger	H370	P308+P311 P260 P264 P270 P321 P405 P501	Based on toxicity of inorganic lead compounds. Based on the human evidence: "The effects observed in acute and chronic studies are very similar for inorganic lead compounds. Inhalation or oral ingestion of inorganic lead has been reported to induce oral contraction and thirst, along with nausea, vomiting, upper abdominal discomfort, loss of appetite, abdominal pain and constipation suggesting gastrointestinal toxicity. The effects on hematopoietic function such as hemoglobin synthesis inhibition due to delta-aminolevulinic acid/heme synthetic enzyme inhibition and anemia caused by shortened survival of red blood cells are considered representative of toxic actions of inorganic lead. Kidney effects are evidenced by interstitial nephropathy and decreased urinary output along with proximal renal tubular damage showing Fanconi's syndrome represented by proteinuria, hematuria, urinary cast, glycosuria and aminoaciduria. Inorganic lead adversely affects the central and peripheral nervous systems, displaying in particular weakening of the muscle of the limbs, pain and spasm. There have been rare reports of adults exhibiting ataxia, headache, paresthesia, depression and coma indicative of toxic effects on the central nervous system when exposing to extremely high doses (details not shown). However, children are most sensitive to toxicity of lead, and neurodevelopmental toxicity manifested as restlessness, aggression, concentration difficulties and memory lapse has become serious problem in the U.S. "(CERI Hazard Data 2001-9 (2002)).	FY2006	GHS Classification Manual （10 Feb, 2006）
9	Specific target organ toxicity - Repeated exposure	Category 1 (blood system, kidney, nervous system)	Danger	H372	P260 P264 P270 P314 P501	Based on toxicity of inorganic lead compounds. Based on the human evidence: "The effects observed in acute and chronic studies are very similar for inorganic lead compounds. Inhalation or oral ingestion of inorganic lead has been reported to induce oral contraction and thirst, along with nausea, vomiting, upper abdominal discomfort, loss of appetite, abdominal pain and constipation suggesting gastrointestinal toxicity. The effects on hematopoietic function such as hemoglobin synthesis inhibition due to delta-aminolevulinic acid/heme synthetic enzyme inhibition and anemia caused by shortened survival of red blood cells are considered representative of toxic actions of inorganic lead. Kidney effects are evidenced by interstitial nephropathy and decreased urinary output along with proximal renal tubular damage showing Fanconi's syndrome represented by proteinuria, hematuria, urinary cast, glycosuria and aminoaciduria. Inorganic lead adversely affects the central and peripheral nervous systems, displaying in particular weakening of the muscle of the limbs, pain and spasm. There have been rare reports of adults exhibiting ataxia, headache, paresthesia, depression and coma indicative of toxic effects on the central nervous system when exposing to extremely high doses (details not shown). However, children are most sensitive to toxicity of lead, and neurodevelopmental toxicity manifested as restlessness, aggression, concentration difficulties and memory lapse has become serious problem in the U.S "(CERI Hazard Data 2001-9 (2002)).	FY2006	GHS Classification Manual （10 Feb, 2006）
10	Aspiration hazard	Classification not possible	- -	-	-	No data available	FY2006	GHS Classification Manual （10 Feb, 2006）

ENVIRONMENTAL HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification	Classification year (FY)	GHS Classification Guidance for the Japanese Government
11	Hazardous to the aquatic environment Short term (Acute)	Category 3	- -	H402	P273 P501	It was classified in Category 3 from 96-hour LC50 = 43.6 mg/L for fish (Pimephales promelas) (ECETOC TR91: 2003).	FY2018	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
11	Hazardous to the aquatic environment Long term (Chronic)	Category 3	- -	H412	P273 P501	Chronic toxicity data were not obtained. It was classified in Category 3 because it is not rapidly degradable and was classified in Category 3 in acute toxicity.	FY2018	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
12	Hazardous to the ozone layer	Classification not possible	- -	-	-	No data available.	FY2018	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))

NOTE:

GHS Classification Result by the Japanese Government is intended to provide a reference for preparing a GHS label or SDS for users. To include the same classification result in a label or SDS for Japan is NOT mandatory.
Users can cite or copy this classification result when preparing a GHS label or SDS. Please be aware, however, that the responsibility for a label or SDS prepared by citing or copying this classification result lies with users.
This GHS classification was conducted based on the information sources and the guidance for classification and judgement which are described in the GHS Classification Guidance for the Japanese Government etc. Using other literature, test results etc. as evidence and including different content from this classification result in a label or SDS are allowed.
Hazard statement and precautionary statement will show by hovering the mouse cursor over a code in the column of "Hazard statement" and "Precautionary statement," respectively. In the excel file, both the codes and statements are provided.
A blank or "-" in the column of "Classification" denotes that a classification for the hazard class was not conducted in the year.
An asterisk “*” in the column of “Classification” denotes that “Not classified (or No applicable)” and/or “Classification not possible” is applicable. Details are described in the column of “Rationale for the classification”. If no English translation is available for “Rationale for the classification,” please refer to the Japanese version of the results.

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