NITE - Chemical Management Field

Latest GHS Classification Results by the Japanese Government (edited by NITE)

GENERAL INFORMATION

Item	Information
CAS RN	61-82-5
Chemical Name	3-Amino-1H-1,2,4-triazole, (alias Amitrole)
Substance ID	m-nite-61-82-5_v1
Download of Excel format	Excel file

REFERENCE INFORMATION

Item	Information
Guidance used for the classification (External link)	To Guidance List
UN GHS document (External link)	To UN GHS document
FAQ（GHS classification results by the Japanese Government）	To FAQ
List of Information Sources (Excel file)	List of Information Sources
List of Definitions/Abbreviations	Definitions/Abbreviations
Sample Label by MHLW (External link)	MHLW Website (in Japanese Only)
Sample SDS by MHLW (External link)	MHLW Website (in Japanese Only)
OECD/eChemPortal (External link)	To OECD/eChemPortal (External link)

PHYSICAL HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification	Classification year (FY)	GHS Classification Guidance for the Japanese Government
1	Explosives	Not classified (Not applicable)	- -	-	-	There are no chemical groups associated with explosive properties present in the molecules.	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）
2	Flammable gases	Not classified (Not applicable)	- -	-	-	Solid (GHS definition)	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）
3	Aerosols	Not classified (Not applicable)	- -	-	-	Not aerosol products	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）
4	Oxidizing gases	Not classified (Not applicable)	- -	-	-	Solid (GHS definition)	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）
5	Gases under pressure	Not classified (Not applicable)	- -	-	-	Solid (GHS definition)	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）
6	Flammable liquids	Not classified (Not applicable)	- -	-	-	Solid (GHS definition)	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）
7	Flammable solids	Not classified	- -	-	-	nonflammable(IUCLID(2000))	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）
8	Self-reactive substances and mixtures	Not classified (Not applicable)	- -	-	-	There are no chemical groups present in the molecule associated with explosive or self-reactive properties.	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）
9	Pyrophoric liquids	Not classified (Not applicable)	- -	-	-	Solid (GHS definition)	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）
10	Pyrophoric solids	Not classified	- -	-	-	Classified into Not classified since auto-ignition point is >225 degC (IUCLID (2000)) exceeding 70 degC.	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）
11	Self-heating substances and mixtures	Not classified	- -	-	-	nonflammable (IUCLID(2000))	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）
12	Substances and mixtures which, in contact with water, emit flammable gases	Not classified (Not applicable)	- -	-	-	The chemical structure of the substance does not contain metals or metalloids (B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At).	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）
13	Oxidizing liquids	Not classified (Not applicable)	- -	-	-	Solid (GHS definition)	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）
14	Oxidizing solids	Not classified (Not applicable)	- -	-	-	The substance is an organic compound containing no oxygen, fluorine or chlorine in the molecule.	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）
15	Organic peroxides	Not classified (Not applicable)	- -	-	-	Organic compounds containing no bivalent -O-O- structure	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）
16	Corrosive to metals	Classification not possible	- -	-	-	Test methods applicable to gaseous substances are not available. Information is available that the substance attacks steel and aluminum (ICSC (J) (1994)).	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）
17	Desensitized explosives	-	- -	-	-	-	-	-

HEALTH HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification	Classification year (FY)	GHS Classification Guidance for the Japanese Government
1	Acute toxicity (Oral)	Not classified	- -	-	-	Based on LD50 values of 25000 mg/kg (ACGIH (2001)) and 24600 mg/kg (EHC 158 (1994)) for rats, the substance was classified into "Not classified".	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）
1	Acute toxicity (Dermal)	Not classified	- -	-	-	Based on LD50 values of >2500 mg/kg for rats (EHC 158 (1994)) and >10000 mg/kg for rabbits (EHC 158 (1994)), the substance was classified as "Not classified".	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）
1	Acute toxicity (Inhalation: Gases)	Not classified (Not applicable)	- -	-	-	Solid (GHS definition)	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）
1	Acute toxicity (Inhalation: Vapours)	Classification not possible	- -	-	-	No data available.	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）
1	Acute toxicity (Inhalation: Dusts and mists)	Classification not possible	- -	-	-	Classification not possible due to lack of data. As relevant information, a LC50 (4h) value was >0.439 mg/L for rats (ACGIH (2001)).	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）
2	Skin corrosion/irritation	Not classified	- -	-	-	In two rabbit skin irritation tests, it is reported that mild erythema, which was resolved by 48-hour, was observed at the high-dose level only, and the irritancy of this substance was very mild (EHC 158 (1994), ACGIH (2001)). There are reports of mild cases of dermatitis due to occupational exposure and from patch tests, where a slight irritant effect was observed in three out of six volunteers after 24-hour application (EHC 158 (1994)). Based on these data, the irritancy of this substance is considered to be mild or very mild. The substance was classified as "Not classified" in JIS Classification (correspond to Category 3 in GHS classification).	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）
3	Serious eye damage/eye irritation	Category 2B	- Warning	H320	P305+P351+P338 P337+P313 P264	Although there is a report that mild irritation was observed in rabbit tests (EHC 158 (1994), ACGIH (2001), IUCLID (2000)), the majority of animals had recovered by 24-hour (EHC 158 (1994)). Based on the results, the substance was classified into Category 2B.	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）
4	Respiratory sensitization	Classification not possible	- -	-	-	No data available.	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）
4	Skin sensitization	Category 1	Warning	H317	P302+P352 P333+P313 P362+P364 P261 P272 P280 P321 P501	Based on positive results in a guinea pig maximization test (EHC 158 (1994), DFGOT vol. 18 (2002)) and a report of a case test in which a weed control operator with a history of contact dermatitis showed a strong positive reaction in a patch test, indicative of allergic contact dermatitis (DFGOT vol. 18 (2002), EHC 158 (1994)), the substance was classified into Category 1.	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）
5	Germ cell mutagenicity	Not classified	- -	-	-	Based on negative results in two dominant lethal tests by oral administration to mice (in vivo heritable mutagenicity tests) (EHC 158 (1994)) and three bone marrow micronucleus tests by oral or intraperitoneal administration to mice (in vivo somatic cell mutagenicity tests) (IARC 79 (2001), EHC 158 (1994)), the substance was classified as "Not classified". As relevant information, from in vitro mutagenicity tests, there are reports of negative in almost all bacterial mutation tests (including Ames tests) (IARC 79 (2001), EHC 158 (1994)), a negative mouse lymphoma L5178Y gene mutation test (IARC 79 (2001)), a partially positive Syrian hamster embryo cell gene mutation test (IARC 79 (2001)), negative chromosomal aberration tests using Chinese hamster V79 cells and human lymphocytes (IARC 79 (2001)), and a positive Syrian hamster embryo cell transformation tests (IARC 79 (2001), EHC 158 (1994)).	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）
6	Carcinogenicity	Not classified	- -	-	-	Although a number of assessment documents classified the substance in different categories, it was classified as "Not classified" in accordance with the latest classification of "Group 3" in IARC (IARC (2001). There was no significant increase in the incidence of tumours in a long-term oral test in rats (DFGOT vol. 4 (1992)), however, in other tests the incidences of tumours in the thyroid, liver and pituitary were increased (DFGOT vol. 4 (1992), IARC 7 (1974)). In an epidemiological test, tumours were recorded for the group exposed to amitrol (DFGOT vol. 4 (1992)), however, the IARC working group (IARC 7 (1974)) considered the results of this test to be inconclusive (DFGOT vol. 4 (1992)).	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）
7	Reproductive toxicity	Category 2	Warning	H361	P308+P313 P201 P202 P280 P405 P501	For the substance, in a rat one-generation test, pup mortality after weaning was increased (DFGOT vol. 18 (2002)). In a rat two-generation test, changes in the mating and reproductive parameters were observed (JMPR 926 (1997)). In mouse developmental toxicity tests, the incidence of resorptions was increased (DFGOT vol. 18 (2002)) and the incidence of fetal death was increased (JMPR 926 (1997)). In rabbit developmental toxicity tests, increase in the incidence of abortions and fetal morphological alterations such as anophthalmia and microphthalmia were observed (JMPR 856 (1997)). At these dose levels, parental general toxicity such as decreased body weight gain and organ weight change was observed. Based on the results, the substance was classified into Category 2.	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）
8	Specific target organ toxicity - Single exposure	Classification not possible	- -	-	-	Toxic effects were not observed in rats following inhalation exposure (439 mg/m3/4h) (ACGIH (2001)). In humans, effects on the lung and nervous systems are reported following oral or inhalation exposure to mixtures containing the substance (EHC 158 (1994), IARC 79 (2001)). Thiosyanate is suggested to be a cause (IARC 79 (2001)), however, involvement of the substance is not denied. Based on the available data, classification was not possible due to lack of data.	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）
9	Specific target organ toxicity - Repeated exposure	Category 1 (thyroid), Category 2 (liver)	Danger Warning	H372 H373	P260 P264 P270 P314 P501	In repeated oral dose tests in rats, hypertrophy and hyperplasia of the thyroid and goiter were observed at 0.5 - 15 mg/kg (90-day equivalents) (EHC 158 (1994), IARC 79 (2001), DFGOT vol. 18 (2002), JMPR 280 (1974), ACGIH (2001)). In addition, at a dose level of 35 mg/kg (90-day equivalence), vacuolization of the liver cells and steatosis were observed (EHC 158 (1994)). Based on the data and the guidance value ranges, the substance was classified into Category 1 (thyroid gland) and Category 2 (liver). (Above mentioned values of 0.5 mg/kg/day, 15 mg/kg/day and 35 mg/kg/day for rat tests were calculated from dietary concentration/treatment periods of 10 ppm/11 - 13 weeks, 316 ppm/100 days and 1000 ppm/63 days, respectively).	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）
10	Aspiration hazard	Classification not possible	- -	-	-	No data available.	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）

ENVIRONMENTAL HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification	Classification year (FY)	GHS Classification Guidance for the Japanese Government
11	Hazardous to the aquatic environment Short term (Acute)	Category 2	- -	H401	P273 P501	Classified into Category 2 from its 48h-EC50 = 1.54 mg/L for Crustacea (Daphnia magna) (EHC 158, 1994).	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）
11	Hazardous to the aquatic environment Long term (Chronic)	Category 2	-	H411	P273 P391 P501	Classified into Category 2 since its acute toxicity is Category 2 and it is not rapidly degradable (BOD degradation rate: 0% (Biodegradation and Bioconcentration of Chemical Substances under the Chemical Substances Control Law, 1989)).	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）
12	Hazardous to the ozone layer	Classification not possible	- -	-	-	This substance is not listed in Annexes to the Montreal Protocol.	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）

NOTE:

GHS Classification Result by the Japanese Government is intended to provide a reference for preparing a GHS label or SDS for users. To include the same classification result in a label or SDS for Japan is NOT mandatory.
Users can cite or copy this classification result when preparing a GHS label or SDS. Please be aware, however, that the responsibility for a label or SDS prepared by citing or copying this classification result lies with users.
This GHS classification was conducted based on the information sources and the guidance for classification and judgement which are described in the GHS Classification Guidance for the Japanese Government etc. Using other literature, test results etc. as evidence and including different content from this classification result in a label or SDS are allowed.
Hazard statement and precautionary statement will show by hovering the mouse cursor over a code in the column of "Hazard statement" and "Precautionary statement," respectively. In the excel file, both the codes and statements are provided.
A blank or "-" in the column of "Classification" denotes that a classification for the hazard class was not conducted in the year.
An asterisk “*” in the column of “Classification” denotes that “Not classified (or No applicable)” and/or “Classification not possible” is applicable. Details are described in the column of “Rationale for the classification”. If no English translation is available for “Rationale for the classification,” please refer to the Japanese version of the results.

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