Item | Information |
---|---|
CAS RN | 610-39-9 |
Chemical Name | 3,4-Dinitrotoluene |
Substance ID | m-nite-610-39-9_v2 |
Download of Excel format | Excel file |
Item | Information |
---|---|
Guidance used for the classification (External link) | To Guidance List |
UN GHS document (External link) | To UN GHS document |
FAQ(GHS classification results by the Japanese Government) | To FAQ |
List of Information Sources (Excel file) | List of Information Sources |
List of Definitions/Abbreviations | Definitions/Abbreviations |
Sample Label by MHLW (External link) | MHLW Website (in Japanese Only) |
Sample SDS by MHLW (External link) | MHLW Website (in Japanese Only) |
OECD/eChemPortal (External link) | To OECD/eChemPortal (External link) |
Hazard class | Classification | Pictogram Signal word |
Hazard statement (code) |
Precautionary statement (code) |
Rationale for the classification | Classification year (FY) | GHS Classification Guidance for the Japanese Government | |
---|---|---|---|---|---|---|---|---|
1 | Explosives | Not classified |
- |
- | - | There is a chemical group associated with explosive properties, a nitro group, present in the molecule, but because it is classified in Division 6.1 in UNRTDG (UN3454), and it does not correspond to explosives, hazards of the highest precedence, it was classified as "Not classified." | FY2020 | GHS Classification Guidance for the Japanese Government (FY2019 revised edition (Ver. 2.0)) |
2 | Flammable gases | Not classified (Not applicable) |
- |
- | - | Solid (GHS definition). It was classified as "Not classified." | FY2020 | GHS Classification Guidance for the Japanese Government (FY2019 revised edition (Ver. 2.0)) |
3 | Aerosols | Not classified (Not applicable) |
- |
- | - | Not aerosol products. It was classified as "Not classified." | FY2020 | GHS Classification Guidance for the Japanese Government (FY2019 revised edition (Ver. 2.0)) |
4 | Oxidizing gases | Not classified (Not applicable) |
- |
- | - | Solid (GHS definition). It was classified as "Not classified." | FY2020 | GHS Classification Guidance for the Japanese Government (FY2019 revised edition (Ver. 2.0)) |
5 | Gases under pressure | Not classified (Not applicable) |
- |
- | - | Solid (GHS definition). It was classified as "Not classified." | FY2020 | GHS Classification Guidance for the Japanese Government (FY2019 revised edition (Ver. 2.0)) |
6 | Flammable liquids | Not classified (Not applicable) |
- |
- | - | Solid (GHS definition). It was classified as "Not classified." | FY2020 | GHS Classification Guidance for the Japanese Government (FY2019 revised edition (Ver. 2.0)) |
7 | Flammable solids | Classification not possible |
- |
- | - | No data available. Besides, there is information that it is combustible (ICSC (2005)). | FY2020 | GHS Classification Guidance for the Japanese Government (FY2019 revised edition (Ver. 2.0)) |
8 | Self-reactive substances and mixtures | Type G |
- |
- | - | There is a chemical group associated with explosive properties, a nitro group, present in the molecule, but because it is classified in Division 6.1 in UNRTDG (UN3454), and it is considered to be not applicable to self-reactive substances and mixtures, hazards of the highest precedence, it was classified in Type G. | FY2020 | GHS Classification Guidance for the Japanese Government (FY2019 revised edition (Ver. 2.0)) |
9 | Pyrophoric liquids | Not classified (Not applicable) |
- |
- | - | Solid (GHS definition). It was classified as "Not classified." | FY2020 | GHS Classification Guidance for the Japanese Government (FY2019 revised edition (Ver. 2.0)) |
10 | Pyrophoric solids | Not classified |
- |
- | - | It was classified as "Not classified" because it is classified in Division 6.1 in UNRTDG (UN3454), and it does not correspond to pyrophoric substances, hazards of the highest precedence. | FY2020 | GHS Classification Guidance for the Japanese Government (FY2019 revised edition (Ver. 2.0)) |
11 | Self-heating substances and mixtures | Classification not possible |
- |
- | - | Classification is not possible because test methods applicable to solid (melting point <= 140 deg C) substances are not available. | FY2020 | GHS Classification Guidance for the Japanese Government (FY2019 revised edition (Ver. 2.0)) |
12 | Substances and mixtures which, in contact with water, emit flammable gases | Not classified (Not applicable) |
- |
- | - | The chemical structure of the substance does not contain metals or metalloids (B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At). It was classified as "Not classified." |
FY2020 | GHS Classification Guidance for the Japanese Government (FY2019 revised edition (Ver. 2.0)) |
13 | Oxidizing liquids | Not classified (Not applicable) |
- |
- | - | Solid (GHS definition). It was classified as "Not classified." | FY2020 | GHS Classification Guidance for the Japanese Government (FY2019 revised edition (Ver. 2.0)) |
14 | Oxidizing solids | Classification not possible |
- |
- | - | The substance is an organic compound containing oxygen (but not fluorine or chlorine), which is chemically bonded to the element other than carbon or hydrogen (N). However, the classification is not possible due to no data. | FY2020 | GHS Classification Guidance for the Japanese Government (FY2019 revised edition (Ver. 2.0)) |
15 | Organic peroxides | Not classified (Not applicable) |
- |
- | - | Organic compounds containing no bivalent -O-O- structure in the molecule. It was classified as "Not classified." | FY2020 | GHS Classification Guidance for the Japanese Government (FY2019 revised edition (Ver. 2.0)) |
16 | Corrosive to metals | Classification not possible |
- |
- | - | Classification is not possible because test methods applicable to solid substances are not available. | FY2020 | GHS Classification Guidance for the Japanese Government (FY2019 revised edition (Ver. 2.0)) |
17 | Desensitized explosives | Not classified |
- |
- | - | There is a chemical group associated with explosive properties, a nitro group, present in the molecule, but this substance was classified as "Not classified" for desensitized explosives because a pure substance does not correspond to any hazard class in explosives. | FY2020 | GHS Classification Guidance for the Japanese Government (FY2019 revised edition (Ver. 2.0)) |
Hazard class | Classification | Pictogram Signal word |
Hazard statement (code) |
Precautionary statement (code) |
Rationale for the classification | Classification year (FY) | GHS Classification Guidance for the Japanese Government | |
---|---|---|---|---|---|---|---|---|
1 | Acute toxicity (Oral) | Category 4 |
Warning |
H302 | P301+P312 P264 P270 P330 P501 |
[Please also refer to dinitrotoluene (isomer mixture) (CAS RN 25321-14-6) when the classification result for this substance is "Classification not possible" for health hazards. Information on dinitrotoluene is considered to be useful, although effects of each isomer on health hazards could not be identified in dinitrotoluene (isomer mixture).] [Rationale for the Classification] It was classified in Category 4 from (1) - (3). [Evidence Data] (1) LD50 for rats: 807 mg/kg (Environmental Risk Assessment for Chemical Substances vol. 5 (Ministry of the Environment, 2006), GESTIS (Access on April 2020), HSDB (Access on April 2020)) (2) LD50 for rats: males: 907 mg/kg, females: 807 mg/kg (MAK (DFG) vol.6 (1994)) (3) LD50 for rats: 1,072 mg/kg (MAK (DFG) vol.6 (1994)) |
FY2020 | GHS Classification Guidance for the Japanese Government (FY2019 revised edition (Ver. 2.0)) |
1 | Acute toxicity (Dermal) | Classification not possible |
- |
- | - | [Rationale for the Classification] Classification not possible due to lack of data. |
FY2020 | GHS Classification Guidance for the Japanese Government (FY2019 revised edition (Ver. 2.0)) |
1 | Acute toxicity (Inhalation: Gases) | Not classified |
- |
- | - | [Rationale for the Classification] Solid (GHS definition). It was classified as "Not classified." |
FY2020 | GHS Classification Guidance for the Japanese Government (FY2019 revised edition (Ver. 2.0)) |
1 | Acute toxicity (Inhalation: Vapours) | Classification not possible |
- |
- | - | [Rationale for the Classification] Classification not possible due to lack of data. |
FY2020 | GHS Classification Guidance for the Japanese Government (FY2019 revised edition (Ver. 2.0)) |
1 | Acute toxicity (Inhalation: Dusts and mists) | Classification not possible |
- |
- | - | [Rationale for the Classification] Classification not possible due to lack of data. |
FY2020 | GHS Classification Guidance for the Japanese Government (FY2019 revised edition (Ver. 2.0)) |
2 | Skin corrosion/irritation | Not classified |
- |
- | - | [Rationale for the Classification] It was classified as "Not classified" from (1) - (3). The classification result was changed due to new data obtained. [Evidence Data] (1) This substance was slightly irritating in a skin irritation test with rabbits (Draize test) (Risk Assessment Report (Ministry of Health, Labour and Welfare, 2009), MAK (DFG) vol.6 (1994), ACGIH (7th, 2001)). (2) This substance was slightly irritating in a skin irritation test with rabbits (modified Draize test) (GESTIS (Access on April 2020)). (3) This substance is a skin irritant (HSDB (Access on April 2020)). |
FY2020 | GHS Classification Guidance for the Japanese Government (FY2019 revised edition (Ver. 2.0)) |
3 | Serious eye damage/eye irritation | Not classified |
- |
- | - | [Rationale for the Classification] It was classified as "Not classified" from (1), (2). The classification result was changed due to new data obtained. [Evidence Data] (1) Any of six isomers of dinitrotoluene, including this substance, was not irritating to the rabbit eye in an eye irritation test with rabbits (Draize test) (Risk Assessment Report (Ministry of Health, Labour and Welfare, 2009), MAK (DFG) vol.6 (1994), ACGIH (7th, 2001)). (2) This substance did not irritate the rabbit skin and eye (GESTIS (Access on April 2020)). |
FY2020 | GHS Classification Guidance for the Japanese Government (FY2019 revised edition (Ver. 2.0)) |
4 | Respiratory sensitization | Classification not possible |
- |
- | - | [Rationale for the Classification] Classification not possible due to lack of data. |
FY2020 | GHS Classification Guidance for the Japanese Government (FY2019 revised edition (Ver. 2.0)) |
4 | Skin sensitization | Not classified |
- |
- | - | [Rationale for the Classification] It was classified as "Not classified" from (1). Because the previous classification was considered to be based on the result on 2,6-DNT, and negative data on this substance were found, the classification result was changed. [Evidence Data] (1) This substance was reported to be negative in a skin sensitization test with guinea pigs (10 animals, sex: unknown) (maximization test) (Risk Assessment Report (Ministry of Health, Labour and Welfare, 2009), Initial Risk Assessment Report (NITE, CERI, NEDO, 2005), ATSDR (2016), MAK (DFG) vol.6 (1994), GESTIS (Access on April 2020)). |
FY2020 | GHS Classification Guidance for the Japanese Government (FY2019 revised edition (Ver. 2.0)) |
5 | Germ cell mutagenicity | Classification not possible |
- |
- | - | [Rationale for the Classification] The classification is not possible due to no in vivo data from (1), (2). [Evidence Data] (1) There are no in vivo data. (2) As for in vitro, it was reported to be positive and negative in bacterial reverse mutation tests (ATSDR (2016)). [Reference Data, etc.] (3) It was classified in Muta. 2 in EU CLP classification. |
FY2020 | GHS Classification Guidance for the Japanese Government (FY2019 revised edition (Ver. 2.0)) |
6 | Carcinogenicity | Classification not possible |
- |
- | - | [Rationale for the Classification] There is a classification result by other organizations in (1), but because its rationale is unclear, and there are no other carcinogenicity data, the classification is not possible. [Evidence Data] (1) As for classification results by domestic and international organizations, it was classified in Carc. 1B in EU CLP (EU CLP classification (Access on April 2020)). |
FY2020 | GHS Classification Guidance for the Japanese Government (FY2019 revised edition (Ver. 2.0)) |
7 | Reproductive toxicity | Classification not possible |
- |
- | - | [Rationale for the Classification] Classification was not possible due to lack of data. [Reference Data, etc.] (1) For various DNT isomers (2,3-DNT, 2,4-DNT, 2,5-DNT, 2,6-DNT, this substance, 3,5-DNT), 14-day repeated dose toxicity studies using male rats were conducted. As a result, it was found that 2,4-DNT, 2,6-DNT, and 3,5-DNT had effects on the male reproductive organs (such as testicular atrophy, a decrease in testicular weight, degeneration of the seminiferous tubules, and multinucleated giant cell formation in the testis). On the other hand, 2,3-DNT, 2,5-DNT, and this substance had no effects on the male reproductive organs (such as testicular and epididymal weight and histopathological effects) (ATSDR (2016)). (2) In the EU CLP classification, it was classified as Repr.2 (Classification in EU CLP (Access on April 2020)). |
FY2020 | GHS Classification Guidance for the Japanese Government (FY2019 revised edition (Ver. 2.0)) |
8 | Specific target organ toxicity - Single exposure | Category 2 (blood system), Category 3 (narcotic effects) |
Warning |
H371 H336 |
P308+P311 P260 P264 P270 P405 P501 P304+P340 P403+P233 P261 P271 P312 |
[Rationale for the Classification] There was no report on effects on humans exposed to this substance. Based on (2) and (3), hematological toxicity and depression of the central nervous system were known as acute intoxication by dinitrotoluene, and the information (4) on this substance also indicated related findings. Therefore, it was classified in Category 2 (blood system) and Category 3 (narcotic effects). The information in the information sources was reviewed and the classification result was changed from the previous classification. [Evidence Data] (1) The general composition of dinitrotoluene is about 75% of 2,4-DNT and about 20% of 2,6-DNT (Initial Risk Assessment Report (NITE, CERI, NEDO), 2005)). (2) There was a statement about dinitrotoluene that acute intoxication in humans was caused by formation of methemoglobin, which produced cyanosis, headache, irritability, dizziness, weakness, nausea, vomiting, dyspnea, drowsiness, unconsciousness, and possible death (ACGIH (7th, 2001)). (3) There was a statement about dinitrotoluene that acute intoxication in experimental animals included central nervous system depression, respiratory depression, muscular incoordination, and cyanosis (ACGIH (7th, 2001)). (4) There was information about this substance that in acute toxicity tests by oral administration to rats and mice, depression of the central nervous system including depression of the respiratory center, coordination disorders, loss of muscle coordination, and bluish discoloration of the skin were observed. The oral LD50 values were 810 to 1,070 mg/kg for rats and 750 to 1,410 mg/kg for mice (GESTIS (Access on May 2020)). |
FY2020 | GHS Classification Guidance for the Japanese Government (FY2019 revised edition (Ver. 2.0)) |
9 | Specific target organ toxicity - Repeated exposure | Category 1 (blood system), Category 2 (nervous system) |
Danger Warning |
H372 H373 |
P260 P264 P270 P314 P501 |
[Rationale for the Classification] Based on (1) to (3), it was classified in Category 1 (blood system) and Category 2 (nervous system). The basis for the previous classification was not adopted due to lack of details, and the classification result was changed from the previous classification. [Evidence Data] (1) The general composition of dinitrotoluene is about 75% of 2,4-DNT and about 20% of 2,6-DNT (Initial Risk Assessment Report (NITE, CERI, NEDO, 2005)). (2) Results of occupational exposure studies and studies in laboratory animals identified the blood system (methemoglobinemia, anemia, and compensatory hematopoiesis) as the most sensitive target of dinitrotoluene-induced toxicity (ATSDR (2016)). (3) It was reported that in an oral toxicity test with rats dosed with this substance for 14 days, extramedullary hematopoiesis and lymphoid hyperplasia in the spleen were observed in males at 57 mg/kg/day (converted guidance value: 9 mg/kg/day, within the range for Category 1); and a decrease in body weight, facial twitching, hypoactivity, staring, myocardial fibrosis, inflammation and necrosis, proximal tubule degeneration, renal tubular basophilia, and lymphocytic infiltration in the kidney were observed in males at 227 mg/kg/day (converted guidance value: 35 mg/kg/day, within the range for Category 2) (ATSDR (2016)). [Reference Data, etc.] (4) Available human data provided only limited evidence, as studies did not include appropriate control groups and exposure concentrations were not reported (ATSDR (2016)). |
FY2020 | GHS Classification Guidance for the Japanese Government (FY2019 revised edition (Ver. 2.0)) |
10 | Aspiration hazard | Classification not possible |
- |
- | - | [Rationale for the Classification] Classification not possible due to lack of data. |
FY2020 | GHS Classification Guidance for the Japanese Government (FY2019 revised edition (Ver. 2.0)) |
Hazard class | Classification | Pictogram Signal word |
Hazard statement (code) |
Precautionary statement (code) |
Rationale for the classification | Classification year (FY) | GHS Classification Guidance for the Japanese Government | |
---|---|---|---|---|---|---|---|---|
11 | Hazardous to the aquatic environment Short term (Acute) | Category 1 |
Warning |
H400 | P273 P391 P501 |
It was classified in Category 1 from 96-hour EC50 = 0.74 mg/L for algae (Chlorella pyrenoidosa) (Initial Risk Assessment (NITE, CERI, NEDO, 2005)). | FY2020 | GHS Classification Guidance for the Japanese Government (FY2019 revised edition (Ver. 2.0)) |
11 | Hazardous to the aquatic environment Long term (Chronic) | Category 1 |
Warning |
H410 | P273 P391 P501 |
If chronic toxicity data are used, then it is classified in Category 2 because it is not rapidly degradable (BIOWIN) and due to 21-day NOEC = 0.32 mg/L for crustacea (Daphnia magna) (Initial Risk Assessment (NITE, CERI, NEDO, 2005)). If acute toxicity data are used for a trophic level for which chronic toxicity data are not obtained, then it is classified in Category 1 because it is not rapidly degradable (BIOWIN) and due to 96-hour EC50 = 0.74 mg/L for algae (Chlorella pyrenoidosa) (Initial Risk Assessment (NITE, CERI, NEDO, 2005)). By drawing a comparison between the above results, it was classified in Category 1. |
FY2020 | GHS Classification Guidance for the Japanese Government (FY2019 revised edition (Ver. 2.0)) |
12 | Hazardous to the ozone layer | Classification not possible |
- |
- | - | This substance is not listed in the Annexes to the Montreal Protocol. | FY2020 | GHS Classification Guidance for the Japanese Government (FY2019 revised edition (Ver. 2.0)) |
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