Item | Information |
---|---|
CAS RN | 611-06-3 |
Chemical Name | 2,4-Dichloro-1-nitrobenzene |
Substance ID | m-nite-611-06-3_v2 |
Download of Excel format | Excel file |
Item | Information |
---|---|
Guidance used for the classification (External link) | To Guidance List |
UN GHS document (External link) | To UN GHS document |
FAQ(GHS classification results by the Japanese Government) | To FAQ |
List of Information Sources (Excel file) | List of Information Sources |
List of Definitions/Abbreviations | Definitions/Abbreviations |
Sample Label by MHLW (External link) | MHLW Website (in Japanese Only) |
Sample SDS by MHLW (External link) | MHLW Website (in Japanese Only) |
OECD/eChemPortal (External link) | To OECD/eChemPortal (External link) |
Hazard class | Classification | Pictogram Signal word |
Hazard statement (code) |
Precautionary statement (code) |
Rationale for the classification | Classification year (FY) | GHS Classification Guidance for the Japanese Government | |
---|---|---|---|---|---|---|---|---|
1 | Explosives | Not classified |
- |
- | - | Although the nitro group is included in chemical structure and the calculation value of oxygen balance is -29, there is no data of onset of exothermic decomposition and decomposition energy. Since it was classified into Class 6.1 and PG II in the United Nations Recommendations on the Transport of Dangerous Goods (UN No.1578(ICSC, 1996)), it was classified into Not classified. | FY2008 | GHS Classification Guidance by the Japanese Government (Sep, 2008) |
2 | Flammable gases | Not classified (Not applicable) |
- |
- | - | Solid | FY2008 | GHS Classification Guidance by the Japanese Government (Sep, 2008) |
3 | Aerosols | Not classified (Not applicable) |
- |
- | - | Not aerosol products | FY2008 | GHS Classification Guidance by the Japanese Government (Sep, 2008) |
4 | Oxidizing gases | Not classified (Not applicable) |
- |
- | - | Solid | FY2008 | GHS Classification Guidance by the Japanese Government (Sep, 2008) |
5 | Gases under pressure | Not classified (Not applicable) |
- |
- | - | Solid | FY2008 | GHS Classification Guidance by the Japanese Government (Sep, 2008) |
6 | Flammable liquids | Not classified (Not applicable) |
- |
- | - | Solid | FY2008 | GHS Classification Guidance by the Japanese Government (Sep, 2008) |
7 | Flammable solids | Classification not possible |
- |
- | - | Classification not possible due to lack of data | FY2008 | GHS Classification Guidance by the Japanese Government (Sep, 2008) |
8 | Self-reactive substances and mixtures | Not classified |
- |
- | - | Although the nitro group is included in chemical structure, it was classified into Not classified, since it was classified into Class 6.1(not 4.1) and PG II in the United Nations Recommendations on the Transport of Dangerous Goods (UN No.1578(ICSC, 1996)). | FY2008 | GHS Classification Guidance by the Japanese Government (Sep, 2008) |
9 | Pyrophoric liquids | Not classified (Not applicable) |
- |
- | - | Solid | FY2008 | GHS Classification Guidance by the Japanese Government (Sep, 2008) |
10 | Pyrophoric solids | Not classified |
- |
- | - | Even if it contacts the normal temperature air, it does not ignite spontaneously (ignition temperature 500degC (IUCLID,2000)). | FY2008 | GHS Classification Guidance by the Japanese Government (Sep, 2008) |
11 | Self-heating substances and mixtures | Classification not possible |
- |
- | - | The test method applicable for substances becoming liquid or gas at 140degC of test temperature has not been established. | FY2008 | GHS Classification Guidance by the Japanese Government (Sep, 2008) |
12 | Substances and mixtures which, in contact with water, emit flammable gases | Not classified (Not applicable) |
- |
- | - | Metals or metalloids (B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At) are not included. | FY2008 | GHS Classification Guidance by the Japanese Government (Sep, 2008) |
13 | Oxidizing liquids | Not classified (Not applicable) |
- |
- | - | Solid | FY2008 | GHS Classification Guidance by the Japanese Government (Sep, 2008) |
14 | Oxidizing solids | Classification not possible |
- |
- | - | Although it is an organic compound including oxygen having chemically bound to elements other than carbon and hydrogen, classification is not possible due to lack of data. | FY2008 | GHS Classification Guidance by the Japanese Government (Sep, 2008) |
15 | Organic peroxides | Not classified (Not applicable) |
- |
- | - | The organic compound not including peroxy group in molecule. | FY2008 | GHS Classification Guidance by the Japanese Government (Sep, 2008) |
16 | Corrosive to metals | Classification not possible |
- |
- | - | Test methods applicable to solid substances are not available. | FY2008 | GHS Classification Guidance by the Japanese Government (Sep, 2008) |
17 | Desensitized explosives | - |
- |
- | - | - | - | - |
Hazard class | Classification | Pictogram Signal word |
Hazard statement (code) |
Precautionary statement (code) |
Rationale for the classification | Classification year (FY) | GHS Classification Guidance for the Japanese Government | |
---|---|---|---|---|---|---|---|---|
1 | Acute toxicity (Oral) | Category 4 |
Warning |
H302 | P301+P312 P264 P270 P330 P501 |
From LD50 value 990 mg/kg (SIDS (1996)) in the oral administration test employing rats, it was classified into Category 4. | FY2008 | GHS Classification Guidance by the Japanese Government (Sep, 2008) |
1 | Acute toxicity (Dermal) | Category 3 |
Danger |
H311 | P302+P352 P361+P364 P280 P312 P321 P405 P501 |
Since LD50 value of the dermal administration test employing rats was 921 mg/kg (SIDS (1996)), it was classified into Category 3. | FY2008 | GHS Classification Guidance by the Japanese Government (Sep, 2008) |
1 | Acute toxicity (Inhalation: Gases) | Not classified (Not applicable) |
- |
- | - | Since it was a solid by the definition of GHS and inhalation in gas was not assumed, it was classified into "Not applicable". | FY2008 | GHS Classification Guidance by the Japanese Government (Sep, 2008) |
1 | Acute toxicity (Inhalation: Vapours) | Classification not possible |
- |
- | - | Classification not possible due to lack of data | FY2008 | GHS Classification Guidance by the Japanese Government (Sep, 2008) |
1 | Acute toxicity (Inhalation: Dusts and mists) | Classification not possible |
- |
- | - | Classification not possible due to lack of data | FY2008 | GHS Classification Guidance by the Japanese Government (Sep, 2008) |
2 | Skin corrosion/irritation | Not classified |
- |
- | - | Based on descriptions "Slightly irritating" (SIDS (1996)) in the patch test with rabbits and "Slightly irritating" (IUCLID (2000)) in the skin irritation/corrosion test (OECD TG 404, GLP), it was classified into "Not classified". | FY2008 | GHS Classification Guidance by the Japanese Government (Sep, 2008) |
3 | Serious eye damage/eye irritation | Not classified |
- |
- | - | From the description of "Slightly irritating" (SIDS (1996)) and "Slightly irritating" in eye irritation/corrosion test (OECD TG 405, GLP) (IUCLID (2000)) in a rabbit, it was classified into "Not classified". | FY2008 | GHS Classification Guidance by the Japanese Government (Sep, 2008) |
4 | Respiratory sensitization | Classification not possible |
- |
- | - | Classification is not possible since there is no data. | FY2008 | GHS Classification Guidance by the Japanese Government (Sep, 2008) |
4 | Skin sensitization | Category 1 |
Warning |
H317 | P302+P352 P333+P313 P362+P364 P261 P272 P280 P321 P501 |
It was classified into Category 1 from description of possible sensitization (IUCLID (2000)) in the Maximization test employing guinea pig (OECD TG 406, GLP). | FY2008 | GHS Classification Guidance by the Japanese Government (Sep, 2008) |
5 | Germ cell mutagenicity | Classification not possible |
- |
- | - | Although there is a description of positive (SIDS (1996)) in the reverse mutation test employing in vitro bacteria and negative in the chromosome aberration test employing Chinese hamster culture cells (the Health, Labor and Welfare Ministry reports (Access on September 2008), SIDS (1996)), classification is not possible because there is no data of in vivo examination. | FY2008 | GHS Classification Guidance by the Japanese Government (Sep, 2008) |
6 | Carcinogenicity | Category 1B |
Danger |
H350 | P308+P313 P201 P202 P280 P405 P501 |
[Rationale for the Classification] Based on (1) and (2), clear evidence of carcinogenicity including malignant tumors was observed in two animal species, and based on (3), this substance is a target substance in the public announcement on guidelines in order to prevent the impairment of worker's health caused by the chemical substances decided by the Minister of Health, Labour and Welfare based on paragraph (3) of Article 28 of the Industrial Safety and Health Act, and emphasizing these, it was classified in Category 1B. Also, based on the new findings, the classification result was changed. [Evidence Data] (1) In a two-year carcinogenicity study with rats dosed by feeding, an increase in the incidence of kidney tumors (renal cell carcinoma, renal cell adenoma) was observed in males and females, and an increase in the incidence of adenoma of the preputial gland was observed in males (Results from Carcinogenicity Studies (Ministry of Health, Labour and Welfare, 2005), IARC 123 (2020)). (2) In a two-year carcinogenicity study with mice dosed by feeding, an increase in the incidence of liver tumors (hepatocellular adenoma, hepatocellular carcinoma, hepatoblastoma) and peritonea tumors (hemangiosarcoma) was observed in males and females (Results from Carcinogenicity Studies (Ministry of Health, Labour and Welfare, 2005), IARC 123 (2020)). (3) This substance is a target substance in the public announcement on guidelines in order to prevent the impairment of worker's health caused by the chemical substances decided by the Minister of Health, Labour and Welfare based on paragraph (3) of Article 28 of the Industrial Safety and Health Act (guidelines in order to prevent the impairment of worker's health, announcement No. 27 on February 7, 2020). (4) As for the carcinogenicity classification results by domestic and international assessment organizations, the IARC classified this substance in Group 2B (IARC 123 (2020)) and the Japan Society For Occupational Health (JSOH) classified it in Group 2B (Recommendation of Occupational Exposure Limits (2020): Classification in 2019). |
FY2021 | GHS Classification Guidance for the Japanese Government (FY2019 revised edition (Ver. 2.0)) |
7 | Reproductive toxicity | Category 2 |
Warning |
H361 | P308+P313 P201 P202 P280 P405 P501 |
In a combined repeated dose toxicity study and reproductive/developmental toxicity screening study in rats (OECD TG 422, GLP), it is reported that no effects on mating fertility and estrous cycles were observed, but at 200 mg/kg, the dose at which toxicities (effects on the liver and kidney) manifest themselves in mother rats, two animals were stillborn and three female offspring rats died during the breast-feeding period, so the substance has effects on female reproduction and generation/development of the offspring (Ministry of Health, Labor and Welfare Report (Access on September 2008), SIDS (1996)). Therefore, it was classified as Category 2. | FY2008 | GHS Classification Guidance by the Japanese Government (Sep, 2008) |
8 | Specific target organ toxicity - Single exposure | Classification not possible |
- |
- | - | Classification not possible due to lack of data | FY2008 | GHS Classification Guidance by the Japanese Government (Sep, 2008) |
9 | Specific target organ toxicity - Repeated exposure | Category 2 (liver, kidney) |
Warning |
H373 | P260 P314 P501 |
It is written in the combination test of repeated dose toxicity study and reproduction screening study in rats (OECD TG 422, GLP) that effects on liver (hypertrophy of hepatocytes, and necrosis, etc.) and kidney (creatinine low level, necrosis of tubular epithelium, basophilic tubule change, etc.) were found, and target organs were considered to be liver and kidney (Ministry of Health, Labour and Welfare reports (Access on September 2008), SIDS (1996)). Since these effects were found within the scope of the guidance value of Category 2, it was classified into Category 2 (liver, kidney). | FY2008 | GHS Classification Guidance by the Japanese Government (Sep, 2008) |
10 | Aspiration hazard | Classification not possible |
- |
- | - | Classification not possible due to lack of data | FY2008 | GHS Classification Guidance by the Japanese Government (Sep, 2008) |
Hazard class | Classification | Pictogram Signal word |
Hazard statement (code) |
Precautionary statement (code) |
Rationale for the classification | Classification year (FY) | GHS Classification Guidance for the Japanese Government | |
---|---|---|---|---|---|---|---|---|
11 | Hazardous to the aquatic environment Short term (Acute) | Category 2 |
- |
H401 | P273 P501 |
It was classified into Category 2 from 72 hours ErC50=2.0mg/L of the algae (Pseudokirchneriella subcapitata) (SIDS (2005)). | FY2008 | GHS Classification Guidance by the Japanese Government (Sep, 2008) |
11 | Hazardous to the aquatic environment Long term (Chronic) | Category 2 |
- |
H411 | P273 P391 P501 |
Since acute toxicity was Category 2 and there were no rapid degradability (not readily degradable, the decomposition by BOD(standard test method (4 weeks)): 0% (Existing Chemical Safety Inspections Data (1995)), it was classified into Category 2. | FY2008 | GHS Classification Guidance by the Japanese Government (Sep, 2008) |
12 | Hazardous to the ozone layer | - |
- |
- | - | - | - | - |
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