NITE - Chemical Management Field

Latest GHS Classification Results by the Japanese Government (edited by NITE)

GENERAL INFORMATION

Item	Information
CAS RN	611-19-8
Chemical Name	1-Chloro-2-(chloromethyl)benzene
Substance ID	m-nite-611-19-8_v1
Download of Excel format	Excel file

REFERENCE INFORMATION

Item	Information
Guidance used for the classification (External link)	To Guidance List
UN GHS document (External link)	To UN GHS document
FAQ（GHS classification results by the Japanese Government）	To FAQ
List of Information Sources (Excel file)	List of Information Sources
List of Definitions/Abbreviations	Definitions/Abbreviations
Sample Label by MHLW (External link)	MHLW Website (in Japanese Only)
Sample SDS by MHLW (External link)	MHLW Website (in Japanese Only)
OECD/eChemPortal (External link)	To OECD/eChemPortal (External link)

PHYSICAL HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification	Classification year (FY)	GHS Classification Guidance for the Japanese Government
1	Explosives	Not classified (Not applicable)	- -	-	-	There are no chemical groups associated with explosive properties present in the molecules.	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
2	Flammable gases	Not classified (Not applicable)	- -	-	-	Liquid	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
3	Aerosols	Not classified (Not applicable)	- -	-	-	Not aerosol products	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
4	Oxidizing gases	Not classified (Not applicable)	- -	-	-	Liquid	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
5	Gases under pressure	Not classified (Not applicable)	- -	-	-	Liquid	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
6	Flammable liquids	Not classified	- -	-	-	Since the flash point by Merck KGaA data from March 2009 is 109degC, it was classified into Not classified.	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
7	Flammable solids	Not classified (Not applicable)	- -	-	-	Liquid	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
8	Self-reactive substances and mixtures	Not classified (Not applicable)	- -	-	-	There are no chemical groups associated with explosive or self-reactive properties present in the molecule.	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
9	Pyrophoric liquids	Not classified	- -	-	-	Even if it contacts the normal temperature air, it does not ignite spontaneously (ignition point >600degC (Merck KGaA data from March 2009)).	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
10	Pyrophoric solids	Not classified (Not applicable)	- -	-	-	Liquid	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
11	Self-heating substances and mixtures	Classification not possible	- -	-	-	The test method suitable for liquid substances is not established.	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
12	Substances and mixtures which, in contact with water, emit flammable gases	Not classified (Not applicable)	- -	-	-	Metals or metalloids (B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At) are not included.	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
13	Oxidizing liquids	Not classified (Not applicable)	- -	-	-	Although it is an organic compound including chlorine, not fluorine and oxygen, this chlorine has not chemically bound to any elements other than carbon and hydrogen.	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
14	Oxidizing solids	Not classified (Not applicable)	- -	-	-	Liquid	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
15	Organic peroxides	Not classified (Not applicable)	- -	-	-	The organic compound not including peroxy group in molecule.	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
16	Corrosive to metals	Classification not possible	- -	-	-	Classification not possible due to lack of data	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
17	Desensitized explosives	-	- -	-	-	-	-	-

HEALTH HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification	Classification year (FY)	GHS Classification Guidance for the Japanese Government
1	Acute toxicity (Oral)	Category 4	Warning	H302	P301+P312 P264 P270 P330 P501	It was classified into Category 4 from LD50 value of 951 mg/kg (male), 783 mg/kg (female) (Health, Labor and Welfare Ministry report (Access on September 2008)), and low value of 783 mg/kg (SIDS (2004)) of the acute oral toxicity test (OECD TG 401, GLP) employing a rat.	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
1	Acute toxicity (Dermal)	Category 4	Warning	H312	P302+P352 P362+P364 P280 P312 P321 P501	The lower value 1,700 mg/kg was taken from LD50 value 1,700 mg/kg (male) and 2,200 mg/kg (female) (SIDS (2004)) of the dermal administration test employing a rabbit (FIFRA Pesticide Assessment Guidelines, GLP), and it was classified into Category 4.	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
1	Acute toxicity (Inhalation: Gases)	Not classified (Not applicable)	- -	-	-	Since it was a solid by the definition of GHS and inhalation in gas was not assumed, it was classified into "Not applicable".	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
1	Acute toxicity (Inhalation: Vapours)	Classification not possible	- -	-	-	Saturated vapor pressure level of this substance at 25degC is 1.3 mg/L (197 ppm) . Since LC50 value of the 1-hour vapor inhalation exposure test employing rats (Equivalent to OECD 403, GLP) is >1.14 mg/L (equivalent >173 ppm) (SIDS (2004)), the gas standard is applied. 4-hour equivalent LC50 value is >87 ppm, and since classification cannot be specified, classification is not possible.	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
1	Acute toxicity (Inhalation: Dusts and mists)	Category 4	Warning	H332	P304+P340 P261 P271 P312	Since LC50 value of 4-hour aerosol inhalation exposure test employing rats (OECD TG 403, GLP)is 2.8 mg/L (SIDS (2004)), it was classified into Category 4.	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
2	Skin corrosion/irritation	Not classified	- -	-	-	Although it seems to be classified into skin irritation Category 3 in the U.N. GHS from description of "mild skin irritation with less than score 2 in all three rabbits by application for four hours" (SIDS (2004)) in the skin irritation and corrosion test with rabbits (OECD TG 404, GLP), it was classified into "Not classified" because of unemployed category in the country.	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
3	Serious eye damage/eye irritation	Category 2A	Warning	H319	P305+P351+P338 P337+P313 P264 P280	"When it was dropped into the eyes of three rabbits and the eyes were washed 24 hours after and were observed for 14 days in the eye irritation/corrosion test employing rabbits (OECD TG 405, GLP), all eyes showed mild/moderate eye irritation. From the description of " The conjunctival effect survived in one rabbit after seven days but it disappeared after 14 days."(SIDS (2004)), it was classified into Category 2A.	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
4	Respiratory sensitization	Classification not possible	- -	-	-	Classification is not possible since there is no data.	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
4	Skin sensitization	Classification not possible	- -	-	-	Since it has been concluded that "although there is a data in 1936 that 8 of 13 guinea pig were positive, since the standard of judgment is not clear, it is not reliable" (SIDS (2004)), classification is not possible.	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
5	Germ cell mutagenicity	Not classified	- -	-	-	It was classified into "Not classified" based on the statement that the body cell in vivo mutagenicity test (micronucleus tests which employs rat erythrocytes) (OECD TG 474, GLP) was "negative" (SIDS (2004)).	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
6	Carcinogenicity	Classification not possible	- -	-	-	Since no evaluation by major international evaluation agencies is made and there is no data, classification is not possible.	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
7	Reproductive toxicity	Classification not possible	- -	-	-	There is a report of "effects on reproductive capacity and offspring at doses at which hyperplasia of anterior gastric wall and squamous epithelium, erosion and ulcers in females and decreased weight gain and feed intake in males and females were observed" in a combined repeated dose toxicity study and reproductive/developmental toxicity screening study using oral administration in rats (OECD TG 422, GLP) (Ministry of Health, Labor and Welfare Report (Access on September 2008), SIDS (2004)). Since this study was a simple test, however, and there is no other data, classification is not possible.	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
8	Specific target organ toxicity - Single exposure	Category 3 (narcotic effects, respiratory tract irritation)	Warning	H336 H335	P304+P340 P403+P233 P261 P271 P312 P405 P501	From descriptions of "The gait abnormality and locomotor activity reduction have been seen in the living animals" in the acute oral toxicity test employing rats (OECD TG 401, GLP) (Health, Labor and Welfare Ministry reports (Access on September 2008)) and "respiratory ability reduction and sensory irritation" (SIDS (2004)) in the inhalation exposure test employing mice, it was classified into Category 3 (Narcotic effects, Respiratory tract irritation).	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
9	Specific target organ toxicity - Repeated exposure	Category 1 (stomach, respiratory system, hematopoietic system)	Danger	H372	P260 P264 P270 P314 P501	It is written in the combination test of repeated oral toxicity study and reproduction screening study in rats (OECD TG 422, GLP) that there were hyperplasia of anterior gastric wall, increased flat epithelium, erosion, and ulceration in females, and hyaline droplet hyperpigmentation in proximal tubular epithelium of the kidney in males (Ministry of Health, Labour and Welfare reports (Access on September 2008), SIDS (2004)). On the other hand, it is written in repeated inhalation exposure test in rats (OECD TG 412, GLP) that "there were damage to nasal mucosa, trachea, and bronchi, and increase in bone marrow cells and erythrocytic cells" (SIDS (2004)). Effects on stomach, respiratory system, and blood system were found within the scope of the guidance value of Category 1. Since the kidney symptom can be said to be specific to male rats, it is not adopted. Therefore, it was classified into Category 1 (stomach, respiratory system, and blood system).	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
10	Aspiration hazard	Classification not possible	- -	-	-	Classification not possible due to lack of data	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）

ENVIRONMENTAL HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification	Classification year (FY)	GHS Classification Guidance for the Japanese Government
11	Hazardous to the aquatic environment Short term (Acute)	Category 1	Warning	H400	P273 P391 P501	It was classified into Category 1 from 96 hours LC50=0.27mg/L of the fish (Oryzias Latipes) (Environmental Agency eco-toxicity tests of chemicals (1998)).	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
11	Hazardous to the aquatic environment Long term (Chronic)	Category 1	Warning	H410	P273 P391 P501	Since acute toxicity was Category 1 and there were no rapid degradability (not readily degradable, the decomposition by BOD: 0% (standard test method (4 weeks)) (Existing Chemical Safety Inspections Data (2001))), it was classified into Category 1.	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
12	Hazardous to the ozone layer	-	- -	-	-	-	-	-

NOTE:

GHS Classification Result by the Japanese Government is intended to provide a reference for preparing a GHS label or SDS for users. To include the same classification result in a label or SDS for Japan is NOT mandatory.
Users can cite or copy this classification result when preparing a GHS label or SDS. Please be aware, however, that the responsibility for a label or SDS prepared by citing or copying this classification result lies with users.
This GHS classification was conducted based on the information sources and the guidance for classification and judgement which are described in the GHS Classification Guidance for the Japanese Government etc. Using other literature, test results etc. as evidence and including different content from this classification result in a label or SDS are allowed.
Hazard statement and precautionary statement will show by hovering the mouse cursor over a code in the column of "Hazard statement" and "Precautionary statement," respectively. In the excel file, both the codes and statements are provided.
A blank or "-" in the column of "Classification" denotes that a classification for the hazard class was not conducted in the year.
An asterisk “*” in the column of “Classification” denotes that “Not classified (or No applicable)” and/or “Classification not possible” is applicable. Details are described in the column of “Rationale for the classification”. If no English translation is available for “Rationale for the classification,” please refer to the Japanese version of the results.

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