Item | Information |
---|---|
CAS RN | 62-38-4 |
Chemical Name | Acetoxyphenylmercury (II) |
Substance ID | m-nite-62-38-4_v1 |
Download of Excel format | Excel file |
Item | Information |
---|---|
Guidance used for the classification (External link) | To Guidance List |
UN GHS document (External link) | To UN GHS document |
FAQ(GHS classification results by the Japanese Government) | To FAQ |
List of Information Sources (Excel file) | List of Information Sources |
List of Definitions/Abbreviations | Definitions/Abbreviations |
Sample Label by MHLW (External link) | MHLW Website (in Japanese Only) |
Sample SDS by MHLW (External link) | MHLW Website (in Japanese Only) |
OECD/eChemPortal (External link) | To OECD/eChemPortal (External link) |
Hazard class | Classification | Pictogram Signal word |
Hazard statement (code) |
Precautionary statement (code) |
Rationale for the classification | Classification year (FY) | GHS Classification Guidance for the Japanese Government | |
---|---|---|---|---|---|---|---|---|
1 | Explosives | Not classified (Not applicable) |
- |
- | - | There are no chemical groups associated with explosive properties present in the molecules. | FY2009 | GHS Classification Guidance by the Japanese Government (March, 2009) |
2 | Flammable gases | Not classified (Not applicable) |
- |
- | - | Solid (GHS definition) | FY2009 | GHS Classification Guidance by the Japanese Government (March, 2009) |
3 | Aerosols | Not classified (Not applicable) |
- |
- | - | Not aerosol products. | FY2009 | GHS Classification Guidance by the Japanese Government (March, 2009) |
4 | Oxidizing gases | Not classified (Not applicable) |
- |
- | - | Solid (GHS definition) | FY2009 | GHS Classification Guidance by the Japanese Government (March, 2009) |
5 | Gases under pressure | Not classified (Not applicable) |
- |
- | - | Solid (GHS definition) | FY2009 | GHS Classification Guidance by the Japanese Government (March, 2009) |
6 | Flammable liquids | Not classified (Not applicable) |
- |
- | - | Solid (GHS definition) | FY2009 | GHS Classification Guidance by the Japanese Government (March, 2009) |
7 | Flammable solids | Classification not possible |
- |
- | - | No data available. | FY2009 | GHS Classification Guidance by the Japanese Government (March, 2009) |
8 | Self-reactive substances and mixtures | Not classified (Not applicable) |
- |
- | - | There are no chemical groups present in the molecule associated with explosive or self-reactive properties. | FY2009 | GHS Classification Guidance by the Japanese Government (March, 2009) |
9 | Pyrophoric liquids | Not classified (Not applicable) |
- |
- | - | Solid (GHS definition) | FY2009 | GHS Classification Guidance by the Japanese Government (March, 2009) |
10 | Pyrophoric solids | Classification not possible |
- |
- | - | No data available. | FY2009 | GHS Classification Guidance by the Japanese Government (March, 2009) |
11 | Self-heating substances and mixtures | Classification not possible |
- |
- | - | No data available. | FY2009 | GHS Classification Guidance by the Japanese Government (March, 2009) |
12 | Substances and mixtures which, in contact with water, emit flammable gases | Not classified |
- |
- | - | The substance is slightly soluble in water, heavier than water and sinks in water (Hommel (1996)). Water solubility is 0.44 g/100 mL (20 degC) (ICSC (J) (2000)). | FY2009 | GHS Classification Guidance by the Japanese Government (March, 2009) |
13 | Oxidizing liquids | Not classified (Not applicable) |
- |
- | - | Solid (GHS definition) | FY2009 | GHS Classification Guidance by the Japanese Government (March, 2009) |
14 | Oxidizing solids | Classification not possible |
- |
- | - | Classification is not possible since no data are available though the substance is an organic compound containing oxygen which is chemically bonded to atoms except carbon or hydrogen. | FY2009 | GHS Classification Guidance by the Japanese Government (March, 2009) |
15 | Organic peroxides | Not classified (Not applicable) |
- |
- | - | Organic compounds containing no bivalent -O-O- structure | FY2009 | GHS Classification Guidance by the Japanese Government (March, 2009) |
16 | Corrosive to metals | Classification not possible |
- |
- | - | Test methods applicable to solid substances are not available. Information is available that aluminum is not suitable for containers since it is subjected to a corrosive action (Hommel (1996)). | FY2009 | GHS Classification Guidance by the Japanese Government (March, 2009) |
17 | Desensitized explosives | - |
- |
- | - | - | - | - |
Hazard class | Classification | Pictogram Signal word |
Hazard statement (code) |
Precautionary statement (code) |
Rationale for the classification | Classification year (FY) | GHS Classification Guidance for the Japanese Government | |
---|---|---|---|---|---|---|---|---|
1 | Acute toxicity (Oral) | Category 2 |
Danger |
H300 | P301+P310 P264 P270 P321 P330 P405 P501 |
Based on a LD50 value of 22 mg/kg (HSDB (2005)) for rats, the substance was classified into Category 2. | FY2009 | GHS Classification Guidance by the Japanese Government (March, 2009) |
1 | Acute toxicity (Dermal) | Classification not possible |
- |
- | - | No data available. | FY2009 | GHS Classification Guidance by the Japanese Government (March, 2009) |
1 | Acute toxicity (Inhalation: Gases) | Not classified (Not applicable) |
- |
- | - | Solid (GHS definition) | FY2009 | GHS Classification Guidance by the Japanese Government (March, 2009) |
1 | Acute toxicity (Inhalation: Vapours) | Classification not possible |
- |
- | - | No data available. | FY2009 | GHS Classification Guidance by the Japanese Government (March, 2009) |
1 | Acute toxicity (Inhalation: Dusts and mists) | Classification not possible |
- |
- | - | No data available. | FY2009 | GHS Classification Guidance by the Japanese Government (March, 2009) |
2 | Skin corrosion/irritation | Category 1 |
Danger |
H314 | P301+P330+P331 P303+P361+P353 P305+P351+P338 P304+P340 P260 P264 P280 P310 P321 P363 P405 P501 |
In a patch test in which a 0.1% solution of the substance was applied to humans for 24-hour, a vesicular rash (grade of 4+) was observed, and this substance was judged to be a primary irritant (RTECS (2008): Archives of Dermatology 106, 129 (1972)). Redness, pain, blurred vision and severe deep burns are reported following exposure to this substance (ICSC (J) (2005)). In EU classification, the substance is classified into R34 (EU-Annex I (access on May 2009)). Based on the data, the substance was classified into Category 1. | FY2009 | GHS Classification Guidance by the Japanese Government (March, 2009) |
3 | Serious eye damage/eye irritation | Category 1 |
Danger |
H318 | P305+P351+P338 P280 P310 |
As information in documents in List 3, redness, pain, blurred vision and severe deep burns are reported following exposure to the substance (ICSC (J) (2005)). In a rabbit standard Draize test, "severe" result is reported (RTECS (2008)). The substance is classified into Category 1 and skin corrosive substance. Based on these data, the substance was classified into Category 1. | FY2009 | GHS Classification Guidance by the Japanese Government (March, 2009) |
4 | Respiratory sensitization | Classification not possible |
- |
- | - | No data available. | FY2009 | GHS Classification Guidance by the Japanese Government (March, 2009) |
4 | Skin sensitization | Category 1 |
Warning |
H317 | P302+P352 P333+P313 P362+P364 P261 P272 P280 P321 P501 |
In a guinea pig Buhler test, positive results were obtained in 14/18 (77.8%) animals (DFGOT vol. 15 (2001)). Based on the data, the substance was classified into Category 1. In humans, patch tests were carried out with a 0.01% solution of the substance and positive results were obtained in 29 (1.4%) of the 2030 patients tested (21 of these were only weakly positive) (DFGOT vol. 15 (2001)). In other patch tests with 0.01% and 0.05% solutions, positive rates were 1.4% and 5.8%, respectively (DFGOT vol. 15 (2001)). The substance is classified as Sh in DFG. | FY2009 | GHS Classification Guidance by the Japanese Government (March, 2009) |
5 | Germ cell mutagenicity | Classification not possible |
- |
- | - | Although there is a report that an increased incidence of SCE was found in the lymphocytes of 38 Argentinean children who were exposed to phenylmercuric acetate used as a disinfectant in nappies, but 9 months after the end of exposure, the incidence of SCE was no longer increased (in vivo somatic cell mutagenicity) (DFGOT vol. 15 (2001)), the details are unknown. Classification was not possible due to lack of sufficient data from in vivo mutagenicity tests. As relevant information, from in vitro mutagenicity tests, there is a report of a negative Ames test (NTP DB (access on May 2009)). | FY2009 | GHS Classification Guidance by the Japanese Government (March, 2009) |
6 | Carcinogenicity | Classification not possible |
- |
- | - | Classification not possible due to lack of data. In a 103-week oral (in drinking water) test in male rats, the incidence of tumors in the high dose group was significantly increased in comparison to the control group. The increase in number of incidences were a result of an increase in the incidence of renal cell adenomas (DFGOT vol. 15 (2001)). | FY2009 | GHS Classification Guidance by the Japanese Government (March, 2009) |
7 | Reproductive toxicity | Category 2 |
Warning |
H361 | P308+P313 P201 P202 P280 P405 P501 |
It is reported that acetoxyphenylmercury is a strong teratogen for more than one animal species as it induces disorder of the central nervous system and eye, and anury in mice, multiple malformation in rats and rabbits, and exencephaly in hamsters (Birth Defects (3rd, 2000)). When hamsters, rats and mice were administered by stomach tube from days 5 - 12 of gestation, embryotoxic effects induced were resorptions, dead fetuses, and retardation of development. Teratogenic effects were diminished cranial ossification, edemata of body, hematomas and open eyes (HSDB (2009)). Although there are reports of teratogenicity in more than one animal species, the data are in assessment documents in List 2, therefore the substance was classified into Category 2. | FY2009 | GHS Classification Guidance by the Japanese Government (March, 2009) |
8 | Specific target organ toxicity - Single exposure | Classification not possible |
- |
- | - | There is a report that a single dose exposure to rats caused hematological effects such as morphological alterations in erythrocytes and inhibited platelet factor (HSDB (2009)). However, since required information about test method and results are not reported, classification was not possible. | FY2009 | GHS Classification Guidance by the Japanese Government (March, 2009) |
9 | Specific target organ toxicity - Repeated exposure | Category 1 (kidney, nervous system) |
Danger |
H372 | P260 P264 P270 P314 P501 |
In a 2-year oral test in rats, nephropathy was observed at dietary phenylmercuric acetate concentrations of 0.042 mg/kg/day and higher. Renal lesions were observed at 0.21 mg/kg/day and higher concentrations in both sexes (IRIS (2002)). In rats given phenylmercuric acetate at concentrations of 0.71 - 7.1 mg/kg/day in drinking water for 2-year, pigment deposits were found in the renal cortex and the incidence and severity of age-related chronic nephrosis were increased. The authors suggested that the mechanism of the carcinogenicity could involve the effects of the substance (DFGOT vol. 15 (2001)). Since these renal lesions were noted at dose levels within the guidance value range for Category 1, the substance was classified into Category 1 (kidney). A 39-year-old farmer who had treated seeds with phenylmercuric acetate for 6 – 7 seasons died within several months of developing severe neurological toxicity (ATSDR (1999)). A 39-year-old farmer exposed while dusting oat seeds with the substance, excreted large amounts of mercury in the urine, died of an apparently progressive neurologic disease resembling amylotrophic lateral sclerosis (HSDB (2009)). Based on these case reports of neuropathy where the involvement of the exposure is suggested, the substance was classified into Category 1 (nervous system). There is another exposure case report which describes a swollen mouth, reddened and tender gums, a thin blue line at the gums and carious teeth (ATSDR (1999)), however, these symptoms can not affect the alimentary system severely, therefore the data was not used as the basis of classification. As for effects on the respiratory system, there is a case report where dyspnea and respiratory depression were observed and an autopsy revealed purulent bronchopneumonia. However, it is unclear whether the respiratory effects were direct effects of the phenylmercuric acetate or secondary to the severe neurotoxicity also seen in this subject (ATSDR (1999)). Based on this uncertainty this respiratory system data was not used as the basis of classification. | FY2009 | GHS Classification Guidance by the Japanese Government (March, 2009) |
10 | Aspiration hazard | Classification not possible |
- |
- | - | No data available. | FY2009 | GHS Classification Guidance by the Japanese Government (March, 2009) |
Hazard class | Classification | Pictogram Signal word |
Hazard statement (code) |
Precautionary statement (code) |
Rationale for the classification | Classification year (FY) | GHS Classification Guidance for the Japanese Government | |
---|---|---|---|---|---|---|---|---|
11 | Hazardous to the aquatic environment Short term (Acute) | Category 1 |
Warning |
H400 | P273 P391 P501 |
Classified into Category 1 from its 96h-LC50 = 8.6 microg/L for fish (Rainbow trout) (AQUIRE, 2010). | FY2009 | GHS Classification Guidance by the Japanese Government (March, 2009) |
11 | Hazardous to the aquatic environment Long term (Chronic) | Category 1 |
Warning |
H410 | P273 P391 P501 |
Classified into Category 1 since its acute toxicity is Category 1 and the behavior in water and bioaccumulative property are unknown from which it is a metal compound. | FY2009 | GHS Classification Guidance by the Japanese Government (March, 2009) |
12 | Hazardous to the ozone layer | Classification not possible |
- |
- | - | This substance is not listed in Annexes to the Montreal Protocol. | FY2009 | GHS Classification Guidance by the Japanese Government (March, 2009) |
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