Item | Information |
---|---|
CAS RN | 6317-18-6 |
Chemical Name | Methylene bis(thiocyanate) |
Substance ID | m-nite-6317-18-6_v1 |
Download of Excel format | Excel file |
Item | Information |
---|---|
Guidance used for the classification (External link) | To Guidance List |
UN GHS document (External link) | To UN GHS document |
FAQ(GHS classification results by the Japanese Government) | To FAQ |
List of Information Sources (Excel file) | List of Information Sources |
List of Definitions/Abbreviations | Definitions/Abbreviations |
Sample Label by MHLW (External link) | MHLW Website (in Japanese Only) |
Sample SDS by MHLW (External link) | MHLW Website (in Japanese Only) |
OECD/eChemPortal (External link) | To OECD/eChemPortal (External link) |
Hazard class | Classification | Pictogram Signal word |
Hazard statement (code) |
Precautionary statement (code) |
Rationale for the classification | Classification year (FY) | GHS Classification Guidance for the Japanese Government | |
---|---|---|---|---|---|---|---|---|
1 | Explosives | Not classified (Not applicable) |
- |
- | - | There are no chemical groups associated with explosive properties present in the molecule. | FY2011 | GHS Classification Guidance by the Japanese Government (July, 2010) |
2 | Flammable gases | Not classified (Not applicable) |
- |
- | - | "Solids" according to GHS definition. | FY2011 | GHS Classification Guidance by the Japanese Government (July, 2010) |
3 | Aerosols | Not classified (Not applicable) |
- |
- | - | Not an aerosol product. | FY2011 | GHS Classification Guidance by the Japanese Government (July, 2010) |
4 | Oxidizing gases | Not classified (Not applicable) |
- |
- | - | "Solids" according to GHS definition. | FY2011 | GHS Classification Guidance by the Japanese Government (July, 2010) |
5 | Gases under pressure | Not classified (Not applicable) |
- |
- | - | "Solids" according to GHS definition. | FY2011 | GHS Classification Guidance by the Japanese Government (July, 2010) |
6 | Flammable liquids | Not classified (Not applicable) |
- |
- | - | "Solids" according to GHS definition. | FY2011 | GHS Classification Guidance by the Japanese Government (July, 2010) |
7 | Flammable solids | Classification not possible |
- |
- | - | No data. | FY2011 | GHS Classification Guidance by the Japanese Government (July, 2010) |
8 | Self-reactive substances and mixtures | Not classified (Not applicable) |
- |
- | - | There are no chemical groups present in the molecule associated with explosive or self-reactive properties. | FY2011 | GHS Classification Guidance by the Japanese Government (July, 2010) |
9 | Pyrophoric liquids | Not classified (Not applicable) |
- |
- | - | "Solids" according to GHS definition. | FY2011 | GHS Classification Guidance by the Japanese Government (July, 2010) |
10 | Pyrophoric solids | Classification not possible |
- |
- | - | No data. | FY2011 | GHS Classification Guidance by the Japanese Government (July, 2010) |
11 | Self-heating substances and mixtures | Classification not possible |
- |
- | - | No established test method suitable for solid substances with a melting point of 140 degrees C or lower. | FY2011 | GHS Classification Guidance by the Japanese Government (July, 2010) |
12 | Substances and mixtures which, in contact with water, emit flammable gases | Not classified (Not applicable) |
- |
- | - | Not containing metals or semimetals (B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At). | FY2011 | GHS Classification Guidance by the Japanese Government (July, 2010) |
13 | Oxidizing liquids | Not classified (Not applicable) |
- |
- | - | "Solids" according to GHS definition. | FY2011 | GHS Classification Guidance by the Japanese Government (July, 2010) |
14 | Oxidizing solids | Not classified (Not applicable) |
- |
- | - | An organic compound does not contain oxygen, fluorine, or chlorine. | FY2011 | GHS Classification Guidance by the Japanese Government (July, 2010) |
15 | Organic peroxides | Not classified (Not applicable) |
- |
- | - | An organic compound that does not contain -O-O- structure. | FY2011 | GHS Classification Guidance by the Japanese Government (July, 2010) |
16 | Corrosive to metals | Classification not possible |
- |
- | - | No established test method suitable for solid substances. | FY2011 | GHS Classification Guidance by the Japanese Government (July, 2010) |
17 | Desensitized explosives | - |
- |
- | - | - | - | - |
Hazard class | Classification | Pictogram Signal word |
Hazard statement (code) |
Precautionary statement (code) |
Rationale for the classification | Classification year (FY) | GHS Classification Guidance for the Japanese Government | |
---|---|---|---|---|---|---|---|---|
1 | Acute toxicity (Oral) | Category 3 |
Danger |
H301 | P301+P310 P264 P270 P321 P330 P405 P501 |
All of 3 LD50 values for rats [55 mg/kg bw (NTP TOX 32 (1993)), 84.9 mg/kg (males), 68.3 mg/kg (females) (EPA RED (1997))] correspond to Category 3. Besides, it is classified in T; R25 in EU classification (EC-JRC (ESIS) (Access on Nov. 2011)). |
FY2011 | GHS Classification Guidance by the Japanese Government (July, 2010) |
1 | Acute toxicity (Dermal) | Not classified |
- |
- | - | From an LD50 value of >2000 mg/kg for rats (EPA RED (1997)), it was classified as "Not classified" in JIS classification (Category 5 or "Not classified" in UN GHS classification). | FY2011 | GHS Classification Guidance by the Japanese Government (July, 2010) |
1 | Acute toxicity (Inhalation: Gases) | Not classified (Not applicable) |
- |
- | - | "Solids" according to GHS definition. | FY2011 | GHS Classification Guidance by the Japanese Government (July, 2010) |
1 | Acute toxicity (Inhalation: Vapours) | Classification not possible |
- |
- | - | No data. | FY2011 | GHS Classification Guidance by the Japanese Government (July, 2010) |
1 | Acute toxicity (Inhalation: Dusts and mists) | Category 1 |
Danger |
H330 | P304+P340 P403+P233 P260 P271 P284 P310 P320 P405 P501 |
On the basis that an LC50 value was 0.0077 mg/L/4h for rats (EPA RED (1997)), it was classified in Category 1. Besides, issues of the test method were pointed out such as a size of particles and a difference between a nominal dose and a measured concentration. This data was used for the classification because it was finally judged to have potent toxicity (EPA REC (1997)). |
FY2011 | GHS Classification Guidance by the Japanese Government (July, 2010) |
2 | Skin corrosion/irritation | Category 2 |
Warning |
H315 | P302+P352 P332+P313 P362+P364 P264 P280 P321 |
On the basis that a dermal irritation test (Draize method) reported a primary irritation index (PII) of 2<=PII<=5 and assessed as a moderate to severe dermal irritant (EPA RED (1997)), it was classified in Category 2. Besides, it is classified in C; R34 in EU classification (EC-JRC (ESIS) (Access on Nov. 2011)). |
FY2011 | GHS Classification Guidance by the Japanese Government (July, 2010) |
3 | Serious eye damage/eye irritation | Category 1 |
Danger |
H318 | P305+P351+P338 P280 P310 |
All of six rabbits showed discomfort immediately after application of 50 mg and showed severe irritation signs accompanied by severe erythema (necrosis), moderate edema, and copious discharge after 10 minutes. On the basis that it was judged as corrosive from the unanimous response in all of 6 animals 1 hour after application (HSDB (2010)), it was classified in Category 1. |
FY2011 | GHS Classification Guidance by the Japanese Government (July, 2010) |
4 | Respiratory sensitization | Classification not possible |
- |
- | - | No data. | FY2011 | GHS Classification Guidance by the Japanese Government (July, 2010) |
4 | Skin sensitization | Category 1 |
Warning |
H317 | P302+P352 P333+P313 P362+P364 P261 P272 P280 P321 P501 |
A maximization test in guinea pigs on a 5% solution of antimicrobial agent Cytox3522 containing this substance reported highly sensitizing and a positive rate of 100% (20/20) in a challenge test conducted with a 0.1% solution of this substance (NTP TOX 32 (1993)). From the report, it was classified in Category 1. Besides, it is classified in R43 in EU classification (EC-JRC (ESIS) (Access on Nov. 2011)). |
FY2011 | GHS Classification Guidance by the Japanese Government (July, 2010) |
5 | Germ cell mutagenicity | Not classified |
- |
- | - | Both a micronucleus test using peripheral blood after oral administration in mice and a micronucleus test using bone marrow after intraperitoneal administration in mice (in vivo somatic cell mutagenicity test) reported negatives (NTP DB (Access on Nov. 2011), EPA RED (1997)). From the above, it was classified as "Not classified." Besides, as in vitro tests, a negative in an Ames test (NTP DB (1986), EPA RED (1997)), a positive in a chromosomal aberration test using CHO cells (EPA RED (1997)), and a positive in a mouse lymphoma test (EPA RED (1997)) were reported respectively. |
FY2011 | GHS Classification Guidance by the Japanese Government (July, 2010) |
6 | Carcinogenicity | Classification not possible |
- |
- | - | Because it was classified in Group D in EPA carcinogenicity assessment (EPA RED (1997)), it was classified as "Classification not possible." Besides, a 78-week gavage oral administration test using mice reported a significant increase in alveolar adenomas in the lung in males. And a 2-year gavage oral administration test using rats reported an increase in adrenal pheochromocytomas in males (a total of benign and malignant carcinomas, but not statistically significant) (EPA RED (1997)). |
FY2011 | GHS Classification Guidance by the Japanese Government (July, 2010) |
7 | Reproductive toxicity | Not classified |
- |
- | - | In an oral administration two-generation reproductive test in rats, signs of respiratory difficulty, piloerection, and abdominal swelling were observed. And deaths occurred at the highest dose. But adverse effects on reproductive parameters such as cprecoital interval, duration of gestation, gestation index, fertility index, and adverse effects on development parameters of the offspring such as a live pup number and survival index during lactation were not obsereved. (EPA RED (1997) On the other hand, in oral administration developmental toxicity tests in rats and rabbits during an organogenetic or gestation period, maternal rats showed slight decreases in body weights and food consumption. And maternal rabbits showed signs such as respiratory difficulty, ataxia, a decrease in motor activity, loss of righting reflex, and tremors and deaths at the highest dose. But neither effects on parameters such as gestation index, numbers of corpora lutea and implantations, and a percent of pre- and post-implantation loss nor signs of teratogenicity were observed in both species (EPA RED (1997)). It was classified as "Not classified" because neither adverse effects on sexual function and fertility in parent animals nor adverse effects on the development of the offspring were found from the above. |
FY2011 | GHS Classification Guidance by the Japanese Government (July, 2010) |
8 | Specific target organ toxicity - Single exposure | Category 2 (systemic) |
Warning |
H371 | P308+P311 P260 P264 P270 P405 P501 |
In an acute oral toxicity test in rats (doses: 50.1, 63.1, 79.4, 100, 126, 158 mg/kg), reduced appetite and activity, increasing weakness and prostration were observed in a 14-day observation period. And deaths occurred in groups of 50 mg/kg or higher 1 to 24 hours after dosing. (HSDB (2010)) Furthermore, in an acute dermal toxicity test in rabbits (doses: 158, 251, 398, 631, 1000 mg/kg), reduced appetite and activity, progressive weakness, and prostration were observed within 14 days after dosing. And deaths occurred in groups of 398 mg/kg or higher. (HSDB (2010)) It is difficult to specify target organs from data obtained in both routes. And the doses in both oral and dermal routes correspond to Category 1 in Guidance values. But it was classified in Category 2 (systemic toxicity) due to List 2 data. |
FY2011 | GHS Classification Guidance by the Japanese Government (July, 2010) |
9 | Specific target organ toxicity - Repeated exposure | Category 1 (blood system) |
Danger |
H372 | P260 P264 P270 P314 P501 |
In a 13-week oral administration test in rats (0, 1, 2, 4, 8, and 16 mg/kg/day), a sign of anemia, which was evidenced by decreases in red blood cell count, hemoglobin concentration, and hematocrit, was observed at 4 mg/kg or higher in males and at 8 mg/kg or higher in females. (NTP DB C61916 (1995)) In a 52-week oral administration test in dogs (0, 0.5, 2.0 or 5.0 mg/kg/day), marginally low red blood cell count, hemoglobin concentration, and hematocrit were observed in a 5 mg/kg/day group. (EPA RED (1997)) Because the above effects were at the doses corresponding to Category 1 in Guidance values, it was classified in Category 1 (blood system). Besides, in a 13-week oral administration test in rats, effects on forestomach consisting of hyperplasia of squamous epithelium mucosa and hyperkeratosis were observed. But the findings of a stomach and respiratory tract were not used as bases for classification because respiratory changes were considered to be caused by direct contact with this highly irritant substance in forced oral dosage conducted by hands. |
FY2011 | GHS Classification Guidance by the Japanese Government (July, 2010) |
10 | Aspiration hazard | Classification not possible |
- |
- | - | No data. | FY2011 | GHS Classification Guidance by the Japanese Government (July, 2010) |
Hazard class | Classification | Pictogram Signal word |
Hazard statement (code) |
Precautionary statement (code) |
Rationale for the classification | Classification year (FY) | GHS Classification Guidance for the Japanese Government | |
---|---|---|---|---|---|---|---|---|
11 | Hazardous to the aquatic environment Short term (Acute) | Category 1 |
Warning |
H400 | P273 P391 P501 |
It was classified in Category 1 from 96-hour LC50 = 0.036 mg/L for crustacea (Mysidopsis bahia) (U.S. EPA: RED, 1996; AQUIRE, 2012). | FY2011 | GHS Classification Guidance by the Japanese Government (July, 2010) |
11 | Hazardous to the aquatic environment Long term (Chronic) | Category 1 |
Warning |
H410 | P273 P391 P501 |
If chronic toxicity data are used, then it is classified in Category 1 from non-rapidly degradable (a degradation rate by BOD: 0 % (the existing chemicals survey program, 1995)) and NOEC = 5.8 ppb for crustacea (Daphnia magna) (U.S. EPA: RED, 1996). If acute toxicity data are used for trophic levels for which chronic toxicity data are lacking, then it is classified in Category 1 from non-rapidly degradable (a degradation rate by BOD: 0 % (the existing chemicals survey program, 1995)), 96-hour LC50 = 0.036 mg/L for crustacea (Mysidopsis bahia), and 96-hour LC50 = 0.089 mg/L for fish (both U.S. EPA: RED, 1996; AQUIRE, 2012). From the above results, it was classified in Category 1. |
FY2011 | GHS Classification Guidance by the Japanese Government (July, 2010) |
12 | Hazardous to the ozone layer | Classification not possible |
- |
- | - | This substance is not listed in Annexes to the Montreal Protocol. | FY2011 | GHS Classification Guidance by the Japanese Government (July, 2010) |
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