Item | Information |
---|---|
CAS RN | 640-19-7 |
Chemical Name | 2-fluoroacetamide |
Substance ID | m-nite-640-19-7_v1 |
Download of Excel format | Excel file |
Item | Information |
---|---|
Guidance used for the classification (External link) | To Guidance List |
UN GHS document (External link) | To UN GHS document |
FAQ(GHS classification results by the Japanese Government) | To FAQ |
List of Information Sources (Excel file) | List of Information Sources |
List of Definitions/Abbreviations | Definitions/Abbreviations |
Sample Label by MHLW (External link) | MHLW Website (in Japanese Only) |
Sample SDS by MHLW (External link) | MHLW Website (in Japanese Only) |
OECD/eChemPortal (External link) | To OECD/eChemPortal (External link) |
Hazard class | Classification | Pictogram Signal word |
Hazard statement (code) |
Precautionary statement (code) |
Rationale for the classification | Classification year (FY) | GHS Classification Guidance for the Japanese Government | |
---|---|---|---|---|---|---|---|---|
1 | Explosives | Not classified (Not applicable) |
- |
- | - | There are no chemical groups associated with explosive properties present in the molecules. | FY2006 | GHS Classification Manual (10 Feb, 2006) |
2 | Flammable gases | Not classified (Not applicable) |
- |
- | - | Solid (GHS definition) | FY2006 | GHS Classification Manual (10 Feb, 2006) |
3 | Aerosols | Not classified (Not applicable) |
- |
- | - | Not aerosol products | FY2006 | GHS Classification Manual (10 Feb, 2006) |
4 | Oxidizing gases | Not classified (Not applicable) |
- |
- | - | Solid (GHS definition) | FY2006 | GHS Classification Manual (10 Feb, 2006) |
5 | Gases under pressure | Not classified (Not applicable) |
- |
- | - | Solid (GHS definition) | FY2006 | GHS Classification Manual (10 Feb, 2006) |
6 | Flammable liquids | Not classified (Not applicable) |
- |
- | - | Solid (GHS definition) | FY2006 | GHS Classification Manual (10 Feb, 2006) |
7 | Flammable solids | Not classified |
- |
- | - | There is a statement of "it sublimates with heating " in Merck (13th, 2001), and it was considered as out of Category. | FY2006 | GHS Classification Manual (10 Feb, 2006) |
8 | Self-reactive substances and mixtures | Not classified (Not applicable) |
- |
- | - | There are no chemical groups associated with explosive or self-reactive properties present in the molecule. | FY2006 | GHS Classification Manual (10 Feb, 2006) |
9 | Pyrophoric liquids | Not classified (Not applicable) |
- |
- | - | Solid (GHS definition) | FY2006 | GHS Classification Manual (10 Feb, 2006) |
10 | Pyrophoric solids | Not classified |
- |
- | - | Non-pyrophoric when in contact with air at a room temperature and used as agricultural chemicals. | FY2006 | GHS Classification Manual (10 Feb, 2006) |
11 | Self-heating substances and mixtures | Classification not possible |
- |
- | - | No data available | FY2006 | GHS Classification Manual (10 Feb, 2006) |
12 | Substances and mixtures which, in contact with water, emit flammable gases | Not classified (Not applicable) |
- |
- | - | The chemical structure of the substance does not contain metals or metaloids(B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At). | FY2006 | GHS Classification Manual (10 Feb, 2006) |
13 | Oxidizing liquids | Not classified (Not applicable) |
- |
- | - | Solid (GHS definition) | FY2006 | GHS Classification Manual (10 Feb, 2006) |
14 | Oxidizing solids | Not classified (Not applicable) |
- |
- | - | Organic compounds containing fluorine and the fluorine is chemically bonded only to carbon (but not to other elements). | FY2006 | GHS Classification Manual (10 Feb, 2006) |
15 | Organic peroxides | Not classified (Not applicable) |
- |
- | - | Organic compounds containing no -0-0- structure | FY2006 | GHS Classification Manual (10 Feb, 2006) |
16 | Corrosive to metals | Classification not possible |
- |
- | - | Test methods applicable to solid substances are not available. | FY2006 | GHS Classification Manual (10 Feb, 2006) |
17 | Desensitized explosives | - |
- |
- | - | - | - | - |
Hazard class | Classification | Pictogram Signal word |
Hazard statement (code) |
Precautionary statement (code) |
Rationale for the classification | Classification year (FY) | GHS Classification Guidance for the Japanese Government | |
---|---|---|---|---|---|---|---|---|
1 | Acute toxicity (Oral) | Category 2 |
Danger |
H300 | P301+P310 P264 P270 P321 P330 P405 P501 |
The higher toxic value (LD50= 5.75mg/kg) was adopted between rat LD50= 5.75mg/kg (RTECS (2003)) and 13mg/kg (HSDB (2003)). It was classified as category 2. | FY2006 | GHS Classification Manual (10 Feb, 2006) |
1 | Acute toxicity (Dermal) | Category 2 |
Danger |
H310 | P302+P352 P361+P364 P262 P264 P270 P280 P310 P321 P405 P501 |
It was set as Category 2 from rat LD50= 80mg/kg. | FY2006 | GHS Classification Manual (10 Feb, 2006) |
1 | Acute toxicity (Inhalation: Gases) | Not classified (Not applicable) |
- |
- | - | Solid (GHS definition) | FY2006 | GHS Classification Manual (10 Feb, 2006) |
1 | Acute toxicity (Inhalation: Vapours) | Category 1 |
Danger |
H330 | P304+P340 P403+P233 P260 P271 P284 P310 P320 P405 P501 |
Saturated concentration of this product (sublimates) is calculated to be 4.1mg/L from vapor pressure of 132Pa (25degC), and about 0.14mg/L of inhalation toxicity study concentration is considered as vapor. Therefore, the highger toxic value (LC50 (4 hours) = 0.1366mg/L = 43.3ppm) was adopted among rat LC50 (4 hours) = 0.1366mg/L (male) and 0.1445mg/L (female), (Biomed Environ Sci (2000)). And it was classified as Category 1. | FY2006 | GHS Classification Manual (10 Feb, 2006) |
1 | Acute toxicity (Inhalation: Dusts and mists) | Classification not possible |
- |
- | - | No data available | FY2006 | GHS Classification Manual (10 Feb, 2006) |
2 | Skin corrosion/irritation | Classification not possible |
- |
- | - | No data available | FY2006 | GHS Classification Manual (10 Feb, 2006) |
3 | Serious eye damage/eye irritation | Classification not possible |
- |
- | - | No data available | FY2006 | GHS Classification Manual (10 Feb, 2006) |
4 | Respiratory sensitization | Classification not possible |
- |
- | - | No data available | FY2006 | GHS Classification Manual (10 Feb, 2006) |
4 | Skin sensitization | Classification not possible |
- |
- | - | No data available | FY2006 | GHS Classification Manual (10 Feb, 2006) |
5 | Germ cell mutagenicity | Classification not possible |
- |
- | - | Classification not possible due to lack of data | FY2006 | GHS Classification Manual (10 Feb, 2006) |
6 | Carcinogenicity | Classification not possible |
- |
- | - | No data available | FY2006 | GHS Classification Manual (10 Feb, 2006) |
7 | Reproductive toxicity | Category 2 |
Warning |
H361 | P308+P313 P201 P202 P280 P405 P501 |
The spermatid developmental abnormalities and testicular seminiferous epithelium influence are reported in the male rats (HSDB (2003)). Moreover, in a female mice, influence on pregnancy by medication of this substance (allongement of gestational age, the increase in prenatal death and the cyanosis of child, breathing difficulty, and the loss of survival rate) is reported (HSDB (2003)). And the description of ICSC (J) (2002) to humans (it is shown in the animal studies that reproductive and developmental toxicity may be caused by people). So it was considered as Category 2. | FY2006 | GHS Classification Manual (10 Feb, 2006) |
8 | Specific target organ toxicity - Single exposure | Category 2 (cardiovascular system, respiratory system) |
Warning |
H371 | P308+P311 P260 P264 P270 P405 P501 |
The substance was classified as Category 2 (cardio-vascular system, respiratory system). Based on the reports about humans in Priority 2 (it may affect the cardio-vascular system, causing arrhythmia (ICSC (J) (2002)). Symptoms such as respiratory depression, cyanosis and ventricular fibrillation as well as vomiting, diarrhea, convulsions, coma and cardiac failure, are observed (SITTIG(4th, 2002)). Judging from the guidance values, the results from an inhalation test in rats (effects on lungs, airways, liver and kidneys) correspond to Category 1, but these results were obtained at the LC50 of 0.7, which is close to the lethal dose, and the data are not from Priority 1 or 2, so the classification criteria are not met. Therefore, the substance was classified as Category 2 according to the technical guidelines. | FY2006 | GHS Classification Manual (10 Feb, 2006) |
9 | Specific target organ toxicity - Repeated exposure | Classification not possible |
- |
- | - | No data available | FY2006 | GHS Classification Manual (10 Feb, 2006) |
10 | Aspiration hazard | Classification not possible |
- |
- | - | No data available | FY2006 | GHS Classification Manual (10 Feb, 2006) |
Hazard class | Classification | Pictogram Signal word |
Hazard statement (code) |
Precautionary statement (code) |
Rationale for the classification | Classification year (FY) | GHS Classification Guidance for the Japanese Government | |
---|---|---|---|---|---|---|---|---|
11 | Hazardous to the aquatic environment Short term (Acute) | Classification not possible |
- |
- | - | Insufficient data available. | FY2006 | GHS Classification Manual (10 Feb, 2006) |
11 | Hazardous to the aquatic environment Long term (Chronic) | Classification not possible |
- |
- | - | Classification not possible due to lack of data | FY2006 | GHS Classification Manual (10 Feb, 2006) |
12 | Hazardous to the ozone layer | - |
- |
- | - | - | - | - |
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