Item | Information |
---|---|
CAS RN | 6459-94-5 |
Chemical Name | Disodium 8-[[3,3'-Dimethyl-4'-[[4-[[(4-methylphenyl)sulfonyl]oxy]phenyl]azo]-1,1'-biphenyl-4-yl]azo]-7-hydroxy-1,3-naphthalenedisulfonate; C.I. Acid Red 114 |
Substance ID | m-nite-6459-94-5_v1 |
Download of Excel format | Excel file |
Item | Information |
---|---|
Guidance used for the classification (External link) | To Guidance List |
UN GHS document (External link) | To UN GHS document |
FAQ(GHS classification results by the Japanese Government) | To FAQ |
List of Information Sources (Excel file) | List of Information Sources |
List of Definitions/Abbreviations | Definitions/Abbreviations |
Sample Label by MHLW (External link) | MHLW Website (in Japanese Only) |
Sample SDS by MHLW (External link) | MHLW Website (in Japanese Only) |
OECD/eChemPortal (External link) | To OECD/eChemPortal (External link) |
Hazard class | Classification | Pictogram Signal word |
Hazard statement (code) |
Precautionary statement (code) |
Rationale for the classification | Classification year (FY) | GHS Classification Guidance for the Japanese Government | |
---|---|---|---|---|---|---|---|---|
1 | Explosives | Not classified (Not applicable) |
- |
- | - | There are no chemical groups associated with explosive properties present in the molecules. | FY2007 | GHS Classification Manual (10 Feb, 2006)/Technical Guidance Document on the GHS Classification (6 Dec, 2005) |
2 | Flammable gases | Not classified (Not applicable) |
- |
- | - | Solid | FY2007 | GHS Classification Manual (10 Feb, 2006)/Technical Guidance Document on the GHS Classification (6 Dec, 2005) |
3 | Aerosols | Not classified (Not applicable) |
- |
- | - | Not aerosol products. | FY2007 | GHS Classification Manual (10 Feb, 2006)/Technical Guidance Document on the GHS Classification (6 Dec, 2005) |
4 | Oxidizing gases | Not classified (Not applicable) |
- |
- | - | Solid | FY2007 | GHS Classification Manual (10 Feb, 2006)/Technical Guidance Document on the GHS Classification (6 Dec, 2005) |
5 | Gases under pressure | Not classified (Not applicable) |
- |
- | - | Solid | FY2007 | GHS Classification Manual (10 Feb, 2006)/Technical Guidance Document on the GHS Classification (6 Dec, 2005) |
6 | Flammable liquids | Not classified (Not applicable) |
- |
- | - | Solid | FY2007 | GHS Classification Manual (10 Feb, 2006)/Technical Guidance Document on the GHS Classification (6 Dec, 2005) |
7 | Flammable solids | Classification not possible |
- |
- | - | No data available. | FY2007 | GHS Classification Manual (10 Feb, 2006)/Technical Guidance Document on the GHS Classification (6 Dec, 2005) |
8 | Self-reactive substances and mixtures | Not classified (Not applicable) |
- |
- | - | There are no chemical groups present in the molecule associated with explosive or self-reactive properties. | FY2007 | GHS Classification Manual (10 Feb, 2006)/Technical Guidance Document on the GHS Classification (6 Dec, 2005) |
9 | Pyrophoric liquids | Not classified (Not applicable) |
- |
- | - | Solid | FY2007 | GHS Classification Manual (10 Feb, 2006)/Technical Guidance Document on the GHS Classification (6 Dec, 2005) |
10 | Pyrophoric solids | Classification not possible |
- |
- | - | No data available. | FY2007 | GHS Classification Manual (10 Feb, 2006)/Technical Guidance Document on the GHS Classification (6 Dec, 2005) |
11 | Self-heating substances and mixtures | Classification not possible |
- |
- | - | No data available. | FY2007 | GHS Classification Manual (10 Feb, 2006)/Technical Guidance Document on the GHS Classification (6 Dec, 2005) |
12 | Substances and mixtures which, in contact with water, emit flammable gases | Not classified (Not applicable) |
- |
- | - | The chemical structure of the substance does not contain metals or metalloids (B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At). | FY2007 | GHS Classification Manual (10 Feb, 2006)/Technical Guidance Document on the GHS Classification (6 Dec, 2005) |
13 | Oxidizing liquids | Not classified (Not applicable) |
- |
- | - | Solid | FY2007 | GHS Classification Manual (10 Feb, 2006)/Technical Guidance Document on the GHS Classification (6 Dec, 2005) |
14 | Oxidizing solids | Classification not possible |
- |
- | - | Classification not possible due to lack of data. | FY2007 | GHS Classification Manual (10 Feb, 2006)/Technical Guidance Document on the GHS Classification (6 Dec, 2005) |
15 | Organic peroxides | Not classified (Not applicable) |
- |
- | - | Organic compounds containing no bivalent -O-O- structure | FY2007 | GHS Classification Manual (10 Feb, 2006)/Technical Guidance Document on the GHS Classification (6 Dec, 2005) |
16 | Corrosive to metals | Classification not possible |
- |
- | - | No data available. | FY2007 | GHS Classification Manual (10 Feb, 2006)/Technical Guidance Document on the GHS Classification (6 Dec, 2005) |
17 | Desensitized explosives | - |
- |
- | - | - | - | - |
Hazard class | Classification | Pictogram Signal word |
Hazard statement (code) |
Precautionary statement (code) |
Rationale for the classification | Classification year (FY) | GHS Classification Guidance for the Japanese Government | |
---|---|---|---|---|---|---|---|---|
1 | Acute toxicity (Oral) | Classification not possible |
- |
- | - | No data available. | FY2007 | GHS Classification Manual (10 Feb, 2006)/Technical Guidance Document on the GHS Classification (6 Dec, 2005) |
1 | Acute toxicity (Dermal) | Classification not possible |
- |
- | - | No data available. | FY2007 | GHS Classification Manual (10 Feb, 2006)/Technical Guidance Document on the GHS Classification (6 Dec, 2005) |
1 | Acute toxicity (Inhalation: Gases) | Not classified (Not applicable) |
- |
- | - | Since the substance is a solid, it was classified into the "Not applicable" category. | FY2007 | GHS Classification Manual (10 Feb, 2006)/Technical Guidance Document on the GHS Classification (6 Dec, 2005) |
1 | Acute toxicity (Inhalation: Vapours) | Classification not possible |
- |
- | - | No data available. | FY2007 | GHS Classification Manual (10 Feb, 2006)/Technical Guidance Document on the GHS Classification (6 Dec, 2005) |
1 | Acute toxicity (Inhalation: Dusts and mists) | Classification not possible |
- |
- | - | No data available. | FY2007 | GHS Classification Manual (10 Feb, 2006)/Technical Guidance Document on the GHS Classification (6 Dec, 2005) |
2 | Skin corrosion/irritation | Classification not possible |
- |
- | - | No data available. | FY2007 | GHS Classification Manual (10 Feb, 2006)/Technical Guidance Document on the GHS Classification (6 Dec, 2005) |
3 | Serious eye damage/eye irritation | Classification not possible |
- |
- | - | No data available. | FY2007 | GHS Classification Manual (10 Feb, 2006)/Technical Guidance Document on the GHS Classification (6 Dec, 2005) |
4 | Respiratory sensitization | Classification not possible |
- |
- | - | No data available. | FY2007 | GHS Classification Manual (10 Feb, 2006)/Technical Guidance Document on the GHS Classification (6 Dec, 2005) |
4 | Skin sensitization | Classification not possible |
- |
- | - | No data available. | FY2007 | GHS Classification Manual (10 Feb, 2006)/Technical Guidance Document on the GHS Classification (6 Dec, 2005) |
5 | Germ cell mutagenicity | Classification not possible |
- |
- | - | C.I. Acid Red 114 (CAS: 6459-94-5) did not induce unscheduled DNA synthesis in an in-vivo genotoxicity test using somatic cell (IARC 57, 1993). Since no other appropriate in vivo test results are available, classification is not possible due to insufficient test results available. As additional background information, C.I. Acid Red 114 induced a positive response in a reverse mutation test using Salmonella typhimurium (IARC 57, 1993). | FY2007 | GHS Classification Manual (10 Feb, 2006)/Technical Guidance Document on the GHS Classification (6 Dec, 2005) |
6 | Carcinogenicity | Category 2 |
Warning |
H351 | P308+P313 P201 P202 P280 P405 P501 |
Since C.I. Acid Red 114 (CAS: 6459-94-5) is rated as "2B" by both the IARC and the Japan Society for Occupational Health, it was classified into Category 2. | FY2007 | GHS Classification Manual (10 Feb, 2006)/Technical Guidance Document on the GHS Classification (6 Dec, 2005) |
7 | Reproductive toxicity | Classification not possible |
- |
- | - | No data available. | FY2007 | GHS Classification Manual (10 Feb, 2006)/Technical Guidance Document on the GHS Classification (6 Dec, 2005) |
8 | Specific target organ toxicity - Single exposure | Classification not possible |
- |
- | - | No data available. | FY2007 | GHS Classification Manual (10 Feb, 2006)/Technical Guidance Document on the GHS Classification (6 Dec, 2005) |
9 | Specific target organ toxicity - Repeated exposure | Category 2 (kidney, lymph node, pancreas) |
Warning |
H373 | P260 P314 P501 |
In the study in which C.I. Acid Red 114 (CAS: 6459-94-5) was administered to female and male rats in drinking water for 13 weeks, the following were observed: karyomegaly and regeneration of tubule epithelial cells in females, and centrilobular pallor in the liver, pigmentation, reticulum cellular hyperplasia of the mesenteric lymph node, and degeneration of pancreatic acinar cells in males (NTP TR 405, 1991). Based on this report, we determined that the kidney, lymph node, and pancreas are target organs. Since these effects were seen at doses that fall under Category 2, C.I. Acid Red 114 (CAS: 6459-94-5) is classified into Category 2 for the kidney, lymph node, and pancreas. | FY2007 | GHS Classification Manual (10 Feb, 2006)/Technical Guidance Document on the GHS Classification (6 Dec, 2005) |
10 | Aspiration hazard | Classification not possible |
- |
- | - | No data available. | FY2007 | GHS Classification Manual (10 Feb, 2006)/Technical Guidance Document on the GHS Classification (6 Dec, 2005) |
Hazard class | Classification | Pictogram Signal word |
Hazard statement (code) |
Precautionary statement (code) |
Rationale for the classification | Classification year (FY) | GHS Classification Guidance for the Japanese Government | |
---|---|---|---|---|---|---|---|---|
11 | Hazardous to the aquatic environment Short term (Acute) | Classification not possible |
- |
- | - | No data available. | FY2007 | GHS Classification Manual (10 Feb, 2006)/Technical Guidance Document on the GHS Classification (6 Dec, 2005) |
11 | Hazardous to the aquatic environment Long term (Chronic) | Classification not possible |
- |
- | - | No data available. | FY2007 | GHS Classification Manual (10 Feb, 2006)/Technical Guidance Document on the GHS Classification (6 Dec, 2005) |
12 | Hazardous to the ozone layer | - |
- |
- | - | - | - | - |
|