NITE - Chemical Management Field

Latest GHS Classification Results by the Japanese Government (edited by NITE)

GENERAL INFORMATION

Item	Information
CAS RN	64742-47-8
Chemical Name	Petroleum distillates
Substance ID	m-nite-64742-47-8_v1
Download of Excel format	Excel file

REFERENCE INFORMATION

Item	Information
Guidance used for the classification (External link)	To Guidance List
UN GHS document (External link)	To UN GHS document
FAQ（GHS classification results by the Japanese Government）	To FAQ
List of Information Sources (Excel file)	List of Information Sources
List of Definitions/Abbreviations	Definitions/Abbreviations
Sample Label by MHLW (External link)	MHLW Website (in Japanese Only)
Sample SDS by MHLW (External link)	MHLW Website (in Japanese Only)
OECD/eChemPortal (External link)	To OECD/eChemPortal (External link)

PHYSICAL HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification	Classification year (FY)	GHS Classification Guidance for the Japanese Government
1	Explosives	Not classified (Not applicable)	- -	-	-	Due to dissociation of nitrogen and oxygen from hydrocarbon through the formation of ammonia and water, the saturation of unsaturated bonds and the deposition and separation of its metal components by the catalysts during the hydrorefining process, the substance does not contain chemical groups associated with explosive properties.	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
2	Flammable gases	Not classified (Not applicable)	- -	-	-	Liquid (GHS definition)	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
3	Aerosols	Not classified (Not applicable)	- -	-	-	Not aerosol products.	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
4	Oxidizing gases	Not classified (Not applicable)	- -	-	-	Liquid (GHS definition)	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
5	Gases under pressure	Not classified (Not applicable)	- -	-	-	Liquid (GHS definition)	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
6	Flammable liquids	Category 4	- Warning	H227	P370+P378 P210 P280 P403 P501	It was classified in Category 4 from flash points of 66-67 deg C (closed cup) (ICSC) and > 60 deg C (ZVG No. 90150 Jet fuel) (GESTIS (Accessed Jan. 2019)).	FY2018	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
7	Flammable solids	Not classified (Not applicable)	- -	-	-	Liquid (GHS definition)	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
8	Self-reactive substances and mixtures	Not classified (Not applicable)	- -	-	-	Due to dissociation of nitrogen and oxygen from hydrocarbon through the formation of ammonia and water, the saturation of unsaturated bonds and the deposition and separation of its metal components by the catalysts during the hydrorefining process, the substance does not contain chemical groups associated with explosive or self-reactive properties.	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
9	Pyrophoric liquids	Not classified	- -	-	-	Its autoignition point is > 200degC (1013kPa) (IUCLID (2000)), which is above 70degC.	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
10	Pyrophoric solids	Not classified (Not applicable)	- -	-	-	Liquid (GHS definition)	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
11	Self-heating substances and mixtures	Classification not possible	- -	-	-	Test methods applicable to liquid substances are not available.	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
12	Substances and mixtures which, in contact with water, emit flammable gases	Not classified (Not applicable)	- -	-	-	Due to deposition and separation of its metal components by the catalysts during the hydrorefining process, the substance does not contain metals or metalloids (B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At).	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
13	Oxidizing liquids	Not classified (Not applicable)	- -	-	-	Due to dissociation of oxygen from hydrocarbon through water formation, and the deposition and separation of its metal components by the catalysts during the hydrorefining process, we determined that the substance does not contain oxygen or halogen. Thus, it was classified into the "Not applicable" category.	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
14	Oxidizing solids	Not classified (Not applicable)	- -	-	-	Liquid (GHS definition)	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
15	Organic peroxides	Not classified (Not applicable)	- -	-	-	Due to dissociation of oxygen from hydrocarbon through water formation during the hydrorefining process, the substance is considered as an organic compound containing no bivalent -O-O- structure.	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
16	Corrosive to metals	Classification not possible	- -	-	-	No data available.	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
17	Desensitized explosives	-	- -	-	-	-	-	-

HEALTH HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification	Classification year (FY)	GHS Classification Guidance for the Japanese Government
1	Acute toxicity (Oral)	Not classified	- -	-	-	Based on its rat LD50 of > 15000 mg/kg bw (IUCLID (2000)), the substance was classified into "Not classified".	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
1	Acute toxicity (Dermal)	Classification not possible	- -	-	-	No data available.	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
1	Acute toxicity (Inhalation: Gases)	Not classified (Not applicable)	- -	-	-	Liquid (GHS definition)	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
1	Acute toxicity (Inhalation: Vapours)	Classification not possible	- -	-	-	No data available.	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
1	Acute toxicity (Inhalation: Dusts and mists)	Classification not possible	- -	-	-	No data available.	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
2	Skin corrosion/irritation	Not classified	- -	-	-	In the tests using rabbits (OECD TG 404) with an application duration of 4 hours and observation times of 24, 48, and 72 hours after application, the average Draize scores were 0.2 for erythema and 0.0 for edema (IUCLID (2000)). In other tests using rabbits (OECD TG 404 GLP), the average Draize scores were 1.7 for erythema and 0.7 for edema (IUCLID (2000)) or it was found to be not irritating (IUCLID (2000)). Based on these results, the substance was classified into "Not classified".	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
3	Serious eye damage/eye irritation	Not classified	- -	-	-	In the tests using rabbits (GLP), the substance was found to be not irritating (IUCLID (2000)). Thus, it was classified into "Not classified".	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
4	Respiratory sensitization	Classification not possible	- -	-	-	No data available.	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
4	Skin sensitization	Classification not possible	- -	-	-	No data available.	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
5	Germ cell mutagenicity	Classification not possible	- -	-	-	Negative results were acquired in the following tests: dominant lethal tests using mice that underwent inhalation exposure to diesel fuel (in vivo mutagenicity tests using germ cells) and micronucleus tests using bone marrow cells of mice that underwent oral administration of DMSO extract of Diesel 2 (CAS No: 64742-47-8) or cyclohexane/DMSO extract (in vivo mutagenicity tests using somatic cells) (ATSDR (1995)). However, these test results were based on extracts of test substances, and no positive results were found in any in vitro mutagenicity tests using several indices. Thus, the substance was classified into the "Classification not possible" category. As additional information, negative results were obtained in chromosomal aberration tests using bone marrow cells of rats that underwent intraperitoneal administration of kerosene (in vivo mutagenicity tests using somatic cells). However, these results cannot be confirmed as the toxicity on the treated animals or the target organ (bone marrow) was not documented (ATSDR (1995)). In in vitro mutagenicity tests (Ames tests), positive results were acquired using DMSO extract of Diesel 2 (CAS No: 64742-47-8) or cyclohexane/DMSO extract (ATSDR (1995)).	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
6	Carcinogenicity	Not classified	- -	-	-	Since jet fuel including kerosene (CAS: 8008-20-6) is rated as Group 3 by the IARC (IARC vol. 45, 1989), the test substances were classified into "Not classified".	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
7	Reproductive toxicity	Classification not possible	- -	-	-	Teratogenicity tests using rats that underwent kerosene inhalation exposure resulted negative (IUCLID (2000)). However, no information is available on reproductive functions and fertility of parental animals. As such, the test substance was classified into "Classification not possible".	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
8	Specific target organ toxicity - Single exposure	Classification not possible	- -	-	-	No data available.	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
9	Specific target organ toxicity - Repeated exposure	Classification not possible	- -	-	-	In 13-week oral administration tests using rats (OECD TG 409 GLP), no effects of administration were detected other than hepatocellular hypertrophy at the doses of 1000 mg/kg (male), 500 mg/kg (female), or 1000 mg/kg, which are higher than Category 2 guidance doses (IUCLID (2000)). Although these results indicate that the substance is to be placed in "Not classified" (oral route), they were acquired using List 2 datasets. Furthermore, no studies on other administration routes have been documented. Thus, the substance was classified into "Classification not possible". As relevant notes, although effects of alpha-2u-globlin on the kidney were detected in male rat groups administered at 100 mg/kg, these effects are considered to be specific to male rats and their toxicological significance to humans are unclear; thus, these results were not included in the evaluation.	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
10	Aspiration hazard	Classification not possible	- -	-	-	No data available.	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）

ENVIRONMENTAL HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification	Classification year (FY)	GHS Classification Guidance for the Japanese Government
11	Hazardous to the aquatic environment Short term (Acute)	Category 2	- -	H401	P273 P501	Based on its 96h LC50 of 2.2 mg/L for fish (bluegills) (Aquire 2009), the substance was classified into Category 2.	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
11	Hazardous to the aquatic environment Long term (Chronic)	Category 2	-	H411	P273 P391 P501	Since its classification for acute toxicity is Category 2, and there are data indicating its rapid degradability, the substance was classified into Category 2.	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
12	Hazardous to the ozone layer	-	- -	-	-	-	-	-

NOTE:

GHS Classification Result by the Japanese Government is intended to provide a reference for preparing a GHS label or SDS for users. To include the same classification result in a label or SDS for Japan is NOT mandatory.
Users can cite or copy this classification result when preparing a GHS label or SDS. Please be aware, however, that the responsibility for a label or SDS prepared by citing or copying this classification result lies with users.
This GHS classification was conducted based on the information sources and the guidance for classification and judgement which are described in the GHS Classification Guidance for the Japanese Government etc. Using other literature, test results etc. as evidence and including different content from this classification result in a label or SDS are allowed.
Hazard statement and precautionary statement will show by hovering the mouse cursor over a code in the column of "Hazard statement" and "Precautionary statement," respectively. In the excel file, both the codes and statements are provided.
A blank or "-" in the column of "Classification" denotes that a classification for the hazard class was not conducted in the year.
An asterisk “*” in the column of “Classification” denotes that “Not classified (or No applicable)” and/or “Classification not possible” is applicable. Details are described in the column of “Rationale for the classification”. If no English translation is available for “Rationale for the classification,” please refer to the Japanese version of the results.

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