NITE - Chemical Management Field

Latest GHS Classification Results by the Japanese Government (edited by NITE)

GENERAL INFORMATION

Item	Information
CAS RN	64742-94-5
Chemical Name	Solvent naphtha (petroleum), heavy arom.; Kerosine - unspecified
Substance ID	m-nite-64742-94-5_v1
Download of Excel format	Excel file

REFERENCE INFORMATION

Item	Information
Guidance used for the classification (External link)	To Guidance List
UN GHS document (External link)	To UN GHS document
FAQ（GHS classification results by the Japanese Government）	To FAQ
List of Information Sources (Excel file)	List of Information Sources
List of Definitions/Abbreviations	Definitions/Abbreviations
Sample Label by MHLW (External link)	MHLW Website (in Japanese Only)
Sample SDS by MHLW (External link)	MHLW Website (in Japanese Only)
OECD/eChemPortal (External link)	To OECD/eChemPortal (External link)

PHYSICAL HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification	Classification year (FY)	GHS Classification Guidance for the Japanese Government
1	Explosives	Not classified (Not applicable)	- -	-	-	Due to dissociation of nitrogen and oxygen from hydrocarbon through the formation of ammonia and water, the saturation of unsaturated bonds and the deposition and separation of its metal components by the catalysts during the hydrorefining process, the substance does not contain chemical groups associated with explosive properties.	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
2	Flammable gases	Not classified (Not applicable)	- -	-	-	Liquid (GHS definition)	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
3	Aerosols	Not classified (Not applicable)	- -	-	-	Not aerosol products.	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
4	Oxidizing gases	Not classified (Not applicable)	- -	-	-	Liquid (GHS definition)	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
5	Gases under pressure	Not classified (Not applicable)	- -	-	-	Liquid (GHS definition)	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
6	Flammable liquids	Category 4	- Warning	H227	P370+P378 P210 P280 P403 P501	Based on its documented flash points: 58degC, >= 62degC, and 65degC (all closed cup tests, IUCLID, 2000), the substance was classified into Category 4.	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
7	Flammable solids	Not classified (Not applicable)	- -	-	-	Liquid (GHS definition)	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
8	Self-reactive substances and mixtures	Not classified (Not applicable)	- -	-	-	Due to dissociation of nitrogen and oxygen from hydrocarbon through the formation of ammonia and water, the saturation of unsaturated bonds and the deposition and separation of its metal components by the catalysts during the hydrorefining process, the substance does not contain chemical groups associated with explosive or self-reactive properties.	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
9	Pyrophoric liquids	Not classified	- -	-	-	Its autoignition point is documented to be > 200degC, > 450degC or 550degC (IUCLID, 2000). The substance was categorized into "Not classified" as its autoignition point is >= 70degC according to the classification guidelines.	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
10	Pyrophoric solids	Not classified (Not applicable)	- -	-	-	Liquid (GHS definition)	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
11	Self-heating substances and mixtures	Classification not possible	- -	-	-	Test methods applicable to liquid substances are not available.	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
12	Substances and mixtures which, in contact with water, emit flammable gases	Not classified (Not applicable)	- -	-	-	Due to deposition and separation of its metal components by the catalysts during the hydrorefining process, the substance does not contain metals or metalloids (B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At).	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
13	Oxidizing liquids	Not classified (Not applicable)	- -	-	-	Due to dissociation of oxygen from hydrocarbon through water formation, and the deposition and separation of its metal components by the catalysts during the hydrorefining process, the substance does not contain oxygen or halogen.	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
14	Oxidizing solids	Not classified (Not applicable)	- -	-	-	Liquid (GHS definition)	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
15	Organic peroxides	Not classified (Not applicable)	- -	-	-	Due to dissociation of oxygen from hydrocarbon through water formation during the hydrorefining process, the substance is considered as an organic compound containing no bivalent -O-O- structure.	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
16	Corrosive to metals	Classification not possible	- -	-	-	No data available.	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
17	Desensitized explosives	-	- -	-	-	-	-	-

HEALTH HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification	Classification year (FY)	GHS Classification Guidance for the Japanese Government
1	Acute toxicity (Oral)	Not classified	- -	-	-	Its documented rat LD50 values are: 4.5 ml/kg, 13.3 ml/kg, 12.3 ml/kg (assuming that the density of the substance is 0.82 g/cm3 at 15degC (IUCLID, 2000), conversion values are 3690, 10906, and 10086 mg/kg, respectively) (EHC 20, 1982), and 7050 mg/kg bw (IUCLID, 2000). Based on these values, the substance was classified into "Not classified".	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
1	Acute toxicity (Dermal)	Not classified	- -	-	-	Its documented rabbit LD50 values are: 5.0 ml/kg (assuming that the density of the substance is 0.82 g/cm3 at 15degC (IUCLID, 2000), conversion value is 4100 mg/kg)(EHC 20, 1982), which is reported in three separate studies, and > 3160 mg/kg bw (IUCLID, 2000), which is reported in two tests. Based on these values, the substance was classified into "Not classified" (Category 5 in the United Nations classification).	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
1	Acute toxicity (Inhalation: Gases)	Not classified (Not applicable)	- -	-	-	Liquid (GHS definition)	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
1	Acute toxicity (Inhalation: Vapours)	Classification not possible	- -	-	-	Its rat LC50 value (4-8h) is documented to be > 0.38 mg/L (> 66 ppm) (EHC 20, 1982). Its saturated vapour pressure concentration is approximately 69 to 1579 ppm (calculated based on its vapour pressure of 0.07-1.6 hPa at 20degC (IUCLID, 2000)). Since the LC50 value is less than 90% of the saturated vapour pressure concentration, it is assumed that the test was carried out in a vapour state with almost no included mists, and categorization was conducted using ppmV concentration criteria. As a result, we were unable to categorize the substance with its LC50 value (4-8h) of > 0.38 mg/L (> 66 ppm). Thus, it was classified into "Classification not possible".	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
1	Acute toxicity (Inhalation: Dusts and mists)	Classification not possible	- -	-	-	Its documented rat LC50 values (4h) are > 2450 ppm, > 580 ppm, and > 553 ppm. Its saturated vapour pressure concentration is approximately 69 to 1579 ppm (calculated based on its vapour pressure of 0.07-1.6 hPa at 20degC (IUCLID, 2000)). Among these LC 50 values acquired, only the value of > 2450 ppm was classified assuming that it was acquired under a mist state. However, because its molecular weight could not be specified, the unit of the LC50 could not be converted from ppm to mg/L; thus, the substance was classified into the "Classification not possible" category. Similarly, in other studies, molecular weight of the test substance cannot be determined, disenabling the comparison of the molecular weight with the saturated vapour pressure concentration. Consequently, we cannot determine if the experiment was conducted in a vapor or mist state, and thus, classification is not possible.	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
2	Skin corrosion/irritation	Category 2	Warning	H315	P302+P352 P332+P313 P362+P364 P264 P280 P321	In two human studies (GLP-compliant), in which 26 people were applied with this substance on the upper-arm skin under sealed conditions for 2.5 days, the substance was found to be not irritating (IUCLID, 2000). However, it is documented in a clinical study that the more aromatic solvents, in particular, can cause a significant degree of primary skin irritation (EHC 20, 1982). Seven rabbit tests documented include three tests by EHC 20 (1982); one of them found the substance moderately irritating with Draize score of 2.79 (equivalent to Category 2), while two other tests also found the substance moderately irritating with Draize scores of 2.04 and 2.17 (both scores are equivalent to "Not classified" category. They are also equivalent to Category 3 in the United Nations classification). In addition, four tests (GLP-compliant) by the IUCLID (2000) found that the substance is moderately irritating in two tests, and slightly irritating in two other tests. Based on these results, the substance was classified into Category 2 for conservative estimate.	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
3	Serious eye damage/eye irritation	Category 2	Warning	H319	P305+P351+P338 P337+P313 P264 P280	Of four rabbit tests documented, three tests by EHC 20 (1982) found the substance moderately irritating, and one test by the IUCLID (2000) found it slightly irritating. Based on these results, the substance was classified into Category 2. Due to lack of information on eye recovery, refined categorization was not attempted.	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
4	Respiratory sensitization	Classification not possible	- -	-	-	No data available.	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
4	Skin sensitization	Classification not possible	- -	-	-	Human patch tests (GLP-compliant) found the substance not sensitizing (IUCLID, 2000). Similarly, maximization tests (GLP-compliant) using guinea pigs also found the substance not irritating (IUCLID, 2000). These results indicate that the substance is to be rated as "Not classified". However, since these results were obtained using List 2 datasets, the substance was classified into "Classification not possible".	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
5	Germ cell mutagenicity	Not classified	- -	-	-	Micronucleus tests using mouse bone marrow (GLP-compliant) gave negative results (IUCLID, 2000); thus, the substance was classified into "Not classified". With regard to in vitro tests, Ames tests gave negative results (EHC 20, 1982; IUCLID, 2000) while cytogenetic tests yielded positive results (EHC 20, 1982).	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
6	Carcinogenicity	Not classified	- -	-	-	In 12-month inhalation tests using Wister strain rats, mammary adenocarcinoma was detected in female rats applied with 1.83 mg/L for 6 months, glioblastoma in the brain was detected in male rats applied with 0.47 mg/L for 12 months, splenic lymphoma was found in male rats applied with 1.83 mg/L, and leiomyoma of the uterus was found in female rats applied with 1.83 mg/L (IARC 47, 1989). Despite these results, the IARC documented that the study was of insufficient duration to allow an evaluation of carcinogenicity, and petroleum solvents as a whole is classified into Group 3 (equivalent to "Not classified" category) (IARC 47, 1989). Based on these results, the substance was classified into "Not classified" in accordance with the IARC's evaluation.	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
7	Reproductive toxicity	Classification not possible	- -	-	-	In inhalation tests using rats (GLP tests), no effects of administration were observed on parental animals as well as offspring in terms of induction of teratogenicity, changes in sex ratio, embryotoxicity, and inhibition of fetal development at the doses of 106 or 364 ppm (EHC 20, 1982; IUCLID, 2000). In addition, in oral administration tests using rats (GLP tests), no effects of administration on fetuses were detected, while notable decrease in body weight gain or food intake was detected in parental animals, at the highest dose of 450 mg/kg bw (IUCLID, 2000). However, since the tests did not provide the effects on fertility in parents, the substance was classified into the "Classification not possible" category.	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
8	Specific target organ toxicity - Single exposure	Category 3 (respiratory tract irritation, narcotic effects)	Warning	H335 H336	P304+P340 P403+P233 P261 P271 P312 P405 P501	In 8-hour inhalation tests using rats, nasal and ocular irritation, and progressive loss of coordination were observed (IARC 47, 1989). In dermal administration tests using rabbits, drowsiness and changes in motor activity were detected (RTECS, 2006; original literature: National Technical Information Service. OTS0534724). According to a description in Patty 5th (2001), regarding acute toxicity through oral, dermal or inhalation route, the substance is associated with eye, nasal or throat irritation, vertigo and nausea, dyspnea, CNS depression, and coma. Based on these results, the substance was classified into Category 3 (respiratory tract irritation and narcotic effects).	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
9	Specific target organ toxicity - Repeated exposure	Classification not possible	- -	-	-	In 13-week inhalation exposure tests using rats, dogs or cats, no severe toxic effects were detected in any of the species at the dose of 0.38 mg/L (EHC 20, 1982; IARC 47, 1989). In addition, in 13-week inhalation exposure tests using rats, notable functional disorder of the organs was not detected other than an increase in organ weight (liver and kidney) and low-grade anemia at the doses (1.8, 3.7, and 7.4 mg/L) that are above the upper limit of guidance values (IARC 47, 1989). Based on these results, the substance was classified into "Not classified" for inhalation route. In 13-week oral administration tests using rats, effects of the administration on the liver, stomach, thyroid gland or bladder were detected (IUCLID, 2000). However, since the tests were conducted using doses (300, 600, and 1000 mg/kg bw /day) that were above the upper limit of guidance values, classification was not possible. As relevant notes, Patty 5th (2001) reported, with regard to the signs of chronic toxicity, that depending on the amount of benzene content, depression of the central nervous system and mild to severe changes in the hematopoietic system may occur.	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
10	Aspiration hazard	Classification not possible	- -	-	-	In aspiration and mortality studies using rats, a half of test animals died (5 out of 10 rats) (EHC 20, 1982). In addition, the substance, at 10% concentration or higher, is categorized into EU Phrase R65 by the EU. However, due to insufficient data available, the substance was classified into "Classification not possible".	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）

ENVIRONMENTAL HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification	Classification year (FY)	GHS Classification Guidance for the Japanese Government
11	Hazardous to the aquatic environment Short term (Acute)	Category 1	Warning	H400	P273 P391 P501	Since its 48h EC50 = 0.95 mg/L for crustaceans (Daphnia magna) (IUCLID 2000), the substance was classified into Category 1.	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
11	Hazardous to the aquatic environment Long term (Chronic)	Category 1	Warning	H410	P273 P391 P501	Since its classification for acute toxicity is Category 1, and there are no data indicating that the substance is rapidly degradable, it was classified into Category 1.	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
12	Hazardous to the ozone layer	-	- -	-	-	-	-	-

NOTE:

GHS Classification Result by the Japanese Government is intended to provide a reference for preparing a GHS label or SDS for users. To include the same classification result in a label or SDS for Japan is NOT mandatory.
Users can cite or copy this classification result when preparing a GHS label or SDS. Please be aware, however, that the responsibility for a label or SDS prepared by citing or copying this classification result lies with users.
This GHS classification was conducted based on the information sources and the guidance for classification and judgement which are described in the GHS Classification Guidance for the Japanese Government etc. Using other literature, test results etc. as evidence and including different content from this classification result in a label or SDS are allowed.
Hazard statement and precautionary statement will show by hovering the mouse cursor over a code in the column of "Hazard statement" and "Precautionary statement," respectively. In the excel file, both the codes and statements are provided.
A blank or "-" in the column of "Classification" denotes that a classification for the hazard class was not conducted in the year.
An asterisk “*” in the column of “Classification” denotes that “Not classified (or No applicable)” and/or “Classification not possible” is applicable. Details are described in the column of “Rationale for the classification”. If no English translation is available for “Rationale for the classification,” please refer to the Japanese version of the results.

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