Item | Information |
---|---|
CAS RN | 650-51-1 |
Chemical Name | Sodium 2,2,2-trichloroacetate |
Substance ID | m-nite-650-51-1_v1 |
Download of Excel format | Excel file |
Item | Information |
---|---|
Guidance used for the classification (External link) | To Guidance List |
UN GHS document (External link) | To UN GHS document |
FAQ(GHS classification results by the Japanese Government) | To FAQ |
List of Information Sources (Excel file) | List of Information Sources |
List of Definitions/Abbreviations | Definitions/Abbreviations |
Sample Label by MHLW (External link) | MHLW Website (in Japanese Only) |
Sample SDS by MHLW (External link) | MHLW Website (in Japanese Only) |
OECD/eChemPortal (External link) | To OECD/eChemPortal (External link) |
Hazard class | Classification | Pictogram Signal word |
Hazard statement (code) |
Precautionary statement (code) |
Rationale for the classification | Classification year (FY) | GHS Classification Guidance for the Japanese Government | |
---|---|---|---|---|---|---|---|---|
1 | Explosives | Not classified (Not applicable) |
- |
- | - | There are no chemical groups associated with explosive properties present in the molecule. | FY2016 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
2 | Flammable gases | Not classified (Not applicable) |
- |
- | - | Solid (GHS definition). | FY2016 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
3 | Aerosols | Not classified (Not applicable) |
- |
- | - | Not aerosol products. | FY2016 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
4 | Oxidizing gases | Not classified (Not applicable) |
- |
- | - | Solid (GHS definition). | FY2016 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
5 | Gases under pressure | Not classified (Not applicable) |
- |
- | - | Solid (GHS definition). | FY2016 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
6 | Flammable liquids | Not classified (Not applicable) |
- |
- | - | Solid (GHS definition). | FY2016 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
7 | Flammable solids | Classification not possible |
- |
- | - | No data available. | FY2016 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
8 | Self-reactive substances and mixtures | Not classified (Not applicable) |
- |
- | - | There are no chemical groups present in the molecule associated with explosive or self-reactive properties. | FY2016 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
9 | Pyrophoric liquids | Not classified (Not applicable) |
- |
- | - | Solid (GHS definition). | FY2016 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
10 | Pyrophoric solids | Classification not possible |
- |
- | - | No data available. | FY2016 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
11 | Self-heating substances and mixtures | Classification not possible |
- |
- | - | No data available. | FY2016 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
12 | Substances and mixtures which, in contact with water, emit flammable gases | Classification not possible |
- |
- | - | No data available. | FY2016 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
13 | Oxidizing liquids | Not classified (Not applicable) |
- |
- | - | Solid (GHS definition). | FY2016 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
14 | Oxidizing solids | Not classified (Not applicable) |
- |
- | - | The substance is an organic compound containing chlorine and oxygen (but not fluorine) which are chemically bonded only to carbon or hydrogen. | FY2016 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
15 | Organic peroxides | Not classified (Not applicable) |
- |
- | - | Organic compounds containing no bivalent -O-O- structure in the molecule | FY2016 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
16 | Corrosive to metals | Classification not possible |
- |
- | - | Test methods applicable to solid substances are not available. | FY2016 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
17 | Desensitized explosives | - |
- |
- | - | - | - | - |
Hazard class | Classification | Pictogram Signal word |
Hazard statement (code) |
Precautionary statement (code) |
Rationale for the classification | Classification year (FY) | GHS Classification Guidance for the Japanese Government | |
---|---|---|---|---|---|---|---|---|
1 | Acute toxicity (Oral) | Not classified |
- |
- | - | Based on the LD50 values of 3,320 mg/kg for rats (HSDB (Accessed in June 2016), BUA 167 (1995)), 3,000 to 5,000 mg/kg (HSDB (Accessed in June 2016)), 5,060 mg/kg (BUA 167 (1995)), 6,200 mg/kg (BUA 167 (1995)) and 6,900 mg/kg (BUA 167 (1995)), the substance was classified as "Not classified." | FY2016 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
1 | Acute toxicity (Dermal) | Not classified |
- |
- | - | Based on the LD50 value of >2,000 mg/kg for rats for both sexes (BUA 167 (1995)), the substance was classified as "Not classified." | FY2016 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
1 | Acute toxicity (Inhalation: Gases) | Not classified (Not applicable) |
- |
- | - | Solid (GHS definition) | FY2016 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
1 | Acute toxicity (Inhalation: Vapours) | Not classified (Not applicable) |
- |
- | - | Solid (GHS definition) | FY2016 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
1 | Acute toxicity (Inhalation: Dusts and mists) | Not classified |
- |
- | - | Based on the LC50 value (4 hours) of >32,540 mg/m3 for rats (BUA 167 (1995)), the substance was classified as "Not classified." | FY2016 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
2 | Skin corrosion/irritation | Not classified |
- |
- | - | The substance was classified as "Not classified" because in a skin irritation test using rabbits occlusively applied with a 90% solution (1% aqueous methylhydroxyethyl cellulose) for 24 hours, no irritation was observed (BUA 167 (1995)). Even when the rabbits were occlusively applied with the same solution for 8 hours/day, 5 days, no irritation was observed (BUA 167 (1995)). | FY2016 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
3 | Serious eye damage/eye irritation | Category 2B |
Warning |
H320 | P305+P351+P338 P337+P313 P264 |
In an eye irritation test using rabbits applied with a 90% solution (medium: 1% aqueous methylhydroxyethyl cellulose), an erythema occurred which subsided but continued even after 48 hours (BUA 167 (1995)). Therefore, the substance was classified in Category 2B. |
FY2016 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
4 | Respiratory sensitization | Classification not possible |
- |
- | - | Classification not possible due to lack of data. | FY2016 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
4 | Skin sensitization | Classification not possible |
- |
- | - | Classification not possible due to lack of data. Besides, it is reported that in a skin sensitization test (maximization test) using guinea pigs, trichloroacetic acid was negative (BUA 167 (1995)), but no data on its sodium salt were available. |
FY2016 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
5 | Germ cell mutagenicity | Classification not possible |
- |
- | - | Classification not possible due to lack of data. | FY2016 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
6 | Carcinogenicity | Category 2 |
Warning |
H351 | P308+P313 P201 P202 P280 P405 P501 |
No carcinogenicity data is available for humans. As for experimental animals, in several carcinogenicity studies using mice administered with drinking water containing trichloroacetic acid (TCA) neutralized with sodium hydroxide, an increase in the incidence of liver tumours (hepatocellular adenoma/ hepatocellular carcinoma) in both male and female were observed. TCA was classified as Group 2B by IARC (IARC 106 (2014)). As for the carcinogenicity classification of TCA, ACGIH classified it as A3 (ACGIH (7th, 2001)) and EPA classified it as S (IRIS Summary (2011)). From the above, this substance was classified in Category 2 because it is considered that the classifications by other organizations based on the results of animal studies, are applicable to the carcinogenicity classification of this substance. | FY2016 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
7 | Reproductive toxicity | Category 2 |
Warning |
H361 | P308+P313 P201 P202 P280 P405 P501 |
No data were available for this substance itself. However, in a study using pregnant rats administered (gestation days 6 through 15) by gavage with trichloroacetic acid (TCA), an increase in the frequency of cardiovascular system malformations and skeletal malformations as well as an increase in embryo absorption and a decrease in fetus weights, were observed at the doses where maternal toxicity (a decrease in weight gain, an increase in kidney and spleen weights) were observed (ACGIH (7th, 2001), HSDB (Access on June 2015)). These results were also applied to the classification of this substance, and it was classified in Category 2 for this hazard class. | FY2016 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
8 | Specific target organ toxicity - Single exposure | Category 2 (respiratory organs), Category 3 (narcotic effects) |
Warning |
H371 H336 |
P308+P311 P260 P264 P270 P405 P501 P304+P340 P403+P233 P261 P271 P312 |
It is reported that in humans, painful irritation of the nasal and pharyngeal cavities, the trachea and the lungs were seen after inhalation of this substance (BUA 167 (1995)). The substance was classified in Category 2 (respiratory organs) because the source of this information is listed in List 2. Moreover, it is described that ataxia, sedation, decreased reflexes, and coma were observed in a single-dose oral exposure study using rats, and that sedation and coma were observed in a single-dose oral exposure using dogs although no details on the doses are available (BUA 167 (1995)). Therefore, the substance was classified in Category 3 (narcotic effects). | FY2016 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
9 | Specific target organ toxicity - Repeated exposure | Classification not possible |
- |
- | - | As for humans, it is reported that eye irritation from inhalation and coughs from irritation on the respiratory organs were observed. However, no effects were reported as specific target toxicity in repeated exposure. As for experimental animals, in 4-month or 104-week repeated dose toxicity studies using rats administered by feeding, retardation of body weights gain was reported in the doses above Category 2, but no severe effects were observed (BUA 167 (1995)). In a 90-day repeated dose toxicity study using dogs administered by feeding, retardation of body weights gain, disturbed general state, necrosis of gum and mucous membrane in mouth, anemia, leukocytosis, urinary findings, damages of the liver, cardiac muscle and skeletal muscle, and impaired spermatogenesis were reported at 2,000 ppm (120 mg/kg/day), which is above Category 2 (BUA 167 (1995)). The substance was classified as "Classification not possible" because no effects were reported within a range of up to Category 2. |
FY2016 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
10 | Aspiration hazard | Classification not possible |
- |
- | - | Classification not possible due to lack of data. | FY2016 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
Hazard class | Classification | Pictogram Signal word |
Hazard statement (code) |
Precautionary statement (code) |
Rationale for the classification | Classification year (FY) | GHS Classification Guidance for the Japanese Government | |
---|---|---|---|---|---|---|---|---|
11 | Hazardous to the aquatic environment Short term (Acute) | Classification not possible |
- |
- | - | The data of 96-hour LC50 > 2000 mg/L was obtained for fish (Ictalurus punctatus) (AQUIRE, 2016, Clemens and Sneed, 1959), and it was indicated that there were no effects in the data. However, because this substance is classified in Category 1 for both acute and chronic aquatic environment hazards by EU, and there is a possible concern for hazards, it was classified as "Classification not possible" not as "Not classified." | FY2016 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
11 | Hazardous to the aquatic environment Long term (Chronic) | Classification not possible |
- |
- | - | Reliable chronic toxicity data were not obtained. Although 96-hour LC50 of > 2000 mg/L for fish (Ictalurus punctatus) (AQUIRE, 2016, Clemens and Sneed, 1959), this substance is classified in Category 1 for both acute and chronic aquatic environment hazards by EU, and there is a possible concern for hazards. Therefore, it was classified as "Classification not possible" not as "Not classified." |
FY2016 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
12 | Hazardous to the ozone layer | Classification not possible |
- |
- | - | No data available. | FY2016 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
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