Item | Information |
---|---|
CAS RN | 67-66-3 |
Chemical Name | Chloroform |
Substance ID | m-nite-67-66-3_v2 |
Download of Excel format | Excel file |
Item | Information |
---|---|
Guidance used for the classification (External link) | To Guidance List |
UN GHS document (External link) | To UN GHS document |
FAQ(GHS classification results by the Japanese Government) | To FAQ |
List of Information Sources (Excel file) | List of Information Sources |
List of Definitions/Abbreviations | Definitions/Abbreviations |
Sample Label by MHLW (External link) | MHLW Website (in Japanese Only) |
Sample SDS by MHLW (External link) | MHLW Website (in Japanese Only) |
OECD/eChemPortal (External link) | To OECD/eChemPortal (External link) |
Hazard class | Classification | Pictogram Signal word |
Hazard statement (code) |
Precautionary statement (code) |
Rationale for the classification | Classification year (FY) | GHS Classification Guidance for the Japanese Government | |
---|---|---|---|---|---|---|---|---|
1 | Explosives | Not classified (Not applicable) |
- |
- | - | There are no chemical groups associated with explosive properties present in the molecule. | FY2015 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
2 | Flammable gases | Not classified (Not applicable) |
- |
- | - | Liquid (GHS definition) | FY2015 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
3 | Aerosols | Not classified (Not applicable) |
- |
- | - | Not aerosol products. | FY2015 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
4 | Oxidizing gases | Not classified (Not applicable) |
- |
- | - | Liquid (GHS definition) | FY2015 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
5 | Gases under pressure | Not classified (Not applicable) |
- |
- | - | Liquid (GHS definition) | FY2015 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
6 | Flammable liquids | Not classified |
- |
- | - | It is not combustible (ISCS (2004)). |
FY2015 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
7 | Flammable solids | Not classified (Not applicable) |
- |
- | - | Liquid (GHS definition) | FY2015 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
8 | Self-reactive substances and mixtures | Not classified (Not applicable) |
- |
- | - | There are no chemical groups present in the molecule associated with explosive or self-reactive properties. | FY2015 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
9 | Pyrophoric liquids | Not classified |
- |
- | - | It is not combustible (ISCS (2004)). |
FY2015 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
10 | Pyrophoric solids | Not classified (Not applicable) |
- |
- | - | Liquid (GHS definition) | FY2015 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
11 | Self-heating substances and mixtures | Not classified |
- |
- | - | It is not combustible (ISCS (2004)). |
FY2015 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
12 | Substances and mixtures which, in contact with water, emit flammable gases | Not classified (Not applicable) |
- |
- | - | The chemical structure of the substance does not contain metals or metalloids (B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At). | FY2015 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
13 | Oxidizing liquids | Not classified (Not applicable) |
- |
- | - | The substance is an organic compound containing chlorine (but not fluorine or oxygen) which is chemically bonded only to carbon or hydrogen. | FY2015 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
14 | Oxidizing solids | Not classified (Not applicable) |
- |
- | - | Liquid (GHS definition) | FY2015 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
15 | Organic peroxides | Not classified (Not applicable) |
- |
- | - | Organic compounds containing no bivalent -O-O- structure in the molecule | FY2015 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
16 | Corrosive to metals | Classification not possible |
- |
- | - | No data available. | FY2015 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
17 | Desensitized explosives | - |
- |
- | - | - | - | - |
Hazard class | Classification | Pictogram Signal word |
Hazard statement (code) |
Precautionary statement (code) |
Rationale for the classification | Classification year (FY) | GHS Classification Guidance for the Japanese Government | |
---|---|---|---|---|---|---|---|---|
1 | Acute toxicity (Oral) | Category 4 |
Warning |
H302 | P301+P312 P264 P270 P330 P501 |
[Rationale for the Classification] Based on (1) to (4), it was classified in Category 4. [Evidence Data] (1) LD50 for rats (males): 908 mg/kg (OECD TG 401) (Initial Risk Assessment Report (NITE, CERI, NEDO, 2005), Risk Assessment Report (Beverages) (Food Safety Commission of Japan, 2009), DFG MAK (2000)) (2) LD50 for rats (females): 1,117 mg/kg (OECD TG 401) (Initial Risk Assessment Report (NITE, CERI, NEDO, 2005), Risk Assessment Report (Beverages) (Food Safety Commission of Japan, 2009), DFG MAK (2000)) (3) LD50 for rats (males): 445 mg/kg (Initial Risk Assessment Report (NITE, CERI, NEDO, 2005), ATSDR, (1997), CLH Report (2010)) (4) LD50 for rats (males): 2,000 mg/kg (ATSDR (1997), DFG MAK (2000), Initial Risk Assessment Report (NITE, CERI, NEDO, 2005)) |
FY2021 | GHS Classification Guidance for the Japanese Government (FY2019 revised edition (Ver. 2.0)) |
1 | Acute toxicity (Dermal) | Not classified |
- |
- | - | [Rationale for the Classification] Based on (1), the data on rabbits was adopted and it was classified as "Not classified." [Evidence Data] (1) LD50 for rabbits: > 3,980 mg/kg (AICIS IMAP (2014)) [Reference Data, etc.] (2) LD50 for mice: between 696 to 3,245 mg/kg (Hazard Assessment Report (CERI, NITE, 2006)) |
FY2021 | GHS Classification Guidance for the Japanese Government (FY2019 revised edition (Ver. 2.0)) |
1 | Acute toxicity (Inhalation: Gases) | Not classified (Not applicable) |
- |
- | - | [Rationale for the Classification] Liquid (GHS definition). It was classified as "Not classified." |
FY2021 | GHS Classification Guidance for the Japanese Government (FY2019 revised edition (Ver. 2.0)) |
1 | Acute toxicity (Inhalation: Vapours) | Category 3 |
Danger |
H331 | P304+P340 P403+P233 P261 P271 P311 P321 P405 P501 |
[Rationale for the Classification] Based on (1) to (3), it was classified in Category 3 by adopting the category with the higher hazard. Also, since the exposure concentration was lower than 90% of the saturated vapor pressure concentration (233,290 ppm), it was judged to be a vapor and classified based on the reference value in units of ppmV. Based on the new findings, the classification result was changed. [Evidence Data] (1) LC50 (6 hours) for rats: 9.2 g/m3 (converted 4-hour equivalent value: 11.3 g/m3, 2,310 ppm) (Risk Assessment Documents (National Institute of Advanced Industrial Science and Technology, 2007), EURAR (2007), AICIS IMAP (2014)) (2) LC50 (4 hours) for rats: 9,770 ppm (ATSDR (1997), US AEGL (2012)) (3) LC50 (4 hours) for rats: 47,702 mg/m3 (9,775 ppm) (Environmental Risk Assessment for Chemical Substances (Ministry of the Environment, 1999)) [Reference Data, etc.] (4) This substance was classified in Category 3 in the EU CLH. |
FY2021 | GHS Classification Guidance for the Japanese Government (FY2019 revised edition (Ver. 2.0)) |
1 | Acute toxicity (Inhalation: Dusts and mists) | Classification not possible |
- |
- | - | [Rationale for the Classification] Classification not possible due to lack of data. |
FY2021 | GHS Classification Guidance for the Japanese Government (FY2019 revised edition (Ver. 2.0)) |
2 | Skin corrosion/irritation | Category 2 |
Warning |
H315 | P302+P352 P332+P313 P362+P364 P264 P280 P321 |
There are reports from skin irritation tests with rabbits that as a result of a 24-hour application of an undiluted solution of this substance to abdominal skin, mild hyperemia, moderate necrosis, and eschar formation were observed (EHC 163 (1994), Hazard Assessment Report (CERI, NITE, 2008)), and that severe irritation was observed by an application of an undiluted solution of this substance (DFG Vol.14 (2000)). In addition, there is a report that as a result of an application of this substance 1-4 times to rabbit ears, slight hyperemia and epidermolysis were observed (EHC 163 (1994), Hazard Assessment Report (CERI, NITE, 2008)). There is a description that this substance is irritating to the skin (OEL Documentations (Japan Society For Occupational Health (JSOH), 2005), CICAD 58 (2004)). From the above, it was classified in Category 2. Besides, this substance was classified as "Skin. Irrit. 2 H315" in EU CLP classification (ECHA CL Inventory (Access on September 2015)). The category was changed because there was no information on irreversible effects. | FY2015 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
3 | Serious eye damage/eye irritation | Category 1 |
Danger |
H318 | P305+P351+P338 P280 P310 |
There is a report that in an eye irritation test with rabbits, as a result of an application of this substance, severe irritation with mydriasis, keratitis and corneal opacity was observed, and the symptoms resolved in 2-3 weeks for 4 animals, but the symptom of corneal opacity persisted even after 3 weeks in one (EHC 163 (1994)). In addition, there is a report that slight irritation of the conjunctiva and corneal injury were observed (EHC 163 (1994), Hazard Assessment Report (CERI, NITE, 2008)), and a description that this substance was irritating to the eyes (OEL Documentations (Japan Society For Occupational Health (JSOH), 2005), CICAD 58 (2004)). From the above, since the symptom did not completely resolve 3 weeks after administration, it was classified in Category 1. Besides, this substance was classified as "Eye. Irrit. 2 H319" in EU CLP classification (ECHA CL Inventory (Access on September 2015)). | FY2015 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
4 | Respiratory sensitization | Classification not possible |
- |
- | - | Classification not possible due to lack of data. |
FY2015 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
4 | Skin sensitization | Classification not possible |
- |
- | - | Classification not possible due to lack of data. | FY2015 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
5 | Germ cell mutagenicity | Category 2 |
Warning |
H341 | P308+P313 P201 P202 P280 P405 P501 |
As for in vivo, a gene mutation test with the liver of transgenic mice was negative, micronucleus tests with liver and kidney cells of rats and a mouse bone marrow micronucleus test gave positive or negative results, chromosomal aberration tests with bone marrow cells of rats, mice and hamsters were approximately positive, sister chromatid exchange tests with mouse bone marrow cells were positive and negative results, a DNA breakage test with the kidney of rats was negative, DNA binding (DNA adduct) tests with the liver and kidney of rats and mice gave weakly positive and negative results, unscheduled DNA synthesis tests with the liver of rats and mice were negative, and DNA repair tests with the liver and kidney of mice were negative (Hazard Assessment Report (CERI, NITE, 2008), EU-RAR (2007), CICAD 58 (2004), DFGOT Vol. 14 (2000), IARC 73 (1999), CEPA (2001), ATSDR (1997)). As for in vitro, bacterial reverse mutation tests gave positive or negative results, a gene mutation test and a mouse lymphoma test with mammalian cultured cells gave positive or negative results, a chromosomal aberration test was negative, sister chromatid exchange tests gave positive or negative results, and an unscheduled DNA synthesis test was negative (Hazard Assessment Report (CERI, NITE, 2008), EU-RAR (2007), DFGOT Vol. 14 (2000), IARC 73 (1999), ATSDR (1997), CEPA (2001)). From the above, there were positive results in in-vivo somatic cell mutagenicity tests, and it was classified in Category 2 according to the GHS classification guidance for the Japanese government. | FY2015 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
6 | Carcinogenicity | Category 2 |
Warning |
H351 | P308+P313 P201 P202 P280 P405 P501 |
As for humans, in epidemiological studies on oral exposure to this substance via drinking water, there are case reports on an excessive risk of multi-site cancers, especially urinary bladder cancers and colorectal cancers. However, the possibility of effects from the by-product, trihalomethane, is high, and in reports on carcinogenic effects due to inhalation exposure to this substance in the workplace, power by statistical analysis was low, and it was pointed out that the reliability was doubtful for an excess risk of prostate cancer and lung cancer. Based on the above, IARC concluded that there was inadequate evidence in humans for carcinogenicity with this substance (IARC 73 (1999)). On the other hand, as for experimental animals, by pointing out that in 3 tests with mice by the oral route and one test with mice by the inhalation route, renal tubule tumors were observed, hepatocellular tumors were also observed in one test, and renal tubule tumors were observed in 3 tests with rats by the oral route, IARC concluded that there was sufficient evidence for carcinogenicity in experimental animals and classified it in Group 2B in 1999 (IARC 73 (1999)). As for the classification of carcinogenicity of this substance by other organizations, ACGIH classified it in A3 (ACGIH (7th, 2001)), Japan Society For Occupational Health (JSOH) in 2B (Recommendation of Occupational Exposure Limits (2015)), EU in Carc. 2 (EU-RAR (2007)), EPA as "L (Likely to be carcinogenic to humans)" under high-exposure conditions that lead to cytotoxicity and regenerative hyperplasia and as "NL (Not likely to be carcinogenic to humans)" under other conditions in 1988 classification (IRIS Summary (Access on August 2015)), and NTP as R (NTP RoC (13th, 2014)), respectively. From the above, the classification results by other organizations including IARC are almost consistent, therefore, it was classified in Category 2 for this hazard class. |
FY2015 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
7 | Reproductive toxicity | Category 2 |
Warning |
H361 | P308+P313 P201 P202 P280 P405 P501 |
As for humans, it is described that an association between occupational exposure to this substance and an increased risk of spontaneous abortions was reported, but this was a situation involving simultaneous exposure to other solvents (IRIS Tox Review (2001)). In addition, there is a report that a correlation was found between the concentration of this substance and inhibition of intrauterine growth of fetuses due to oral exposure to this substance via drinking water, but the possibility of effects by trihalomethane which was generated by chlorine disinfection, was pointed out (IRIS Tox Review (2001)). As above, there was no reliable information on adverse effects on human fertility specifically due to exposure to this substance. As for experimental animals, there is a description that in a multigeneration reproductive test with mice by the oral route (drinking water), in the F1 and F2 generation animals of the high dose group, there was a significant decrease in the breeding index (a decrease in pregnancy index, a decrease in number of litters, a decrease in birth rate) as well as decreased body weight gain and a survival rate (DFGOT Vol. 14 (2000), Hazard Assessment Report (CERI, NITE, 2008)). On the other hand, as for developmental toxicity effects, in a developmental toxicity test with pregnant rats exposed by inhalation during the organogenesis period (gestational day 6-15), in rats, an increased incidence of malformations (tailless, anal atresia, missing ribs), as well as low values of fetal body weight and craniocaudal length, skeletal variations (delayed ossification, wavy ribs), and subcutaneous edema was observed in fetuses at the doses (30, 95 ppm) where maternal toxicity was manifested (DFGOT Vol. 14 (2000), CICAD 58 (2004), Hazard Assessment Report (CERI, NITE, 2008)). In addition, there is a description that also in a test in which pregnant mice were exposed by inhalation at 100 ppm during the organogenesis period (gestational day 8-15), decreased body weight gain and a slight decrease in a pregnancy rate in maternal animals, and an increase in the incidence of cleft palate as a malformation as well as fetotoxicity (low values of fetal body weight and craniocaudal length, delayed ossification) in the fetuses were observed (DFGOT Vol. 14 (2000), Hazard Assessment Report (CERI, NITE, 2008)). Besides, it is reported that in developmental toxicity tests with pregnant rats or pregnant rabbits dosed by gavage during the organogenesis period, fetotoxicity was slight (only a low value of fetal body weight or delayed ossification) or no effect was found even at the doses where maternal toxicity was manifested (DFGOT Vol. 14 (2000), CICAD 58 (2004), Hazard Assessment Report (CERI, NITE, 2008)). From the above, since in the inhalation route, developmental toxicity effects including malformations were observed at the doses where maternal toxicity was manifested in experimental animals, it was classified in Category 2 for this hazard class. |
FY2015 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
8 | Specific target organ toxicity - Single exposure | Category 1 (respiratory organs, cardiovascular system, liver, kidney), Category 3 (narcotic effects) |
Danger Warning |
H370 H336 |
P308+P311 P260 P264 P270 P321 P405 P501 P304+P340 P403+P233 P261 P271 P312 |
This substance is irritating to the respiratory tract (EU-RAR (2007)). There are multiple acute toxicity data both in humans and in experimental animals. As for humans, there is a history that the substance was used as an anesthetic. Narcotic effects, cough, dizziness, lethargy, hypoesthesia, headache, nausea, vomiting, abdominal pain, weakness, unconsciousness, coma, convulsive seizures, rapid respiration, respiration center paralysis, consciousness disturbed, acute respiratory failure, cardiac arrhythmia, cardiovascular system depression effect, ventricular fibrillation, jaundice, hepatocellular degeneration and necrosis, renal tubular necrosis, and renal failure by inhalation exposure, and abdominal pain, nausea, vomiting, diarrhea, gastrointestinal tract irritation, respiration center paralysis, convulsive seizures, coma, oliguria, albuminuria, kidney damage, swelling, hyaline and fatty degeneration of the renal tubule epithelium, liver damage, and hepatocyte necrosis by oral ingestion were reported (Hazard Assessment Report (CERI, NITE, 2008), DFGOT Vol. 14 (2000), IARC 73 (1999), Environmental Risk Assessment for Chemical Substances Vol.2 (Ministry of the Environment, 2003), PATTY (6th, 2012), OEL Documentations (Japan Society For Occupational Health (JSOH), 2005), EU-RAR (2007), CICAD 58 (2004), ATSDR (1997), ACGIH (7th, 2001), IPCS, PIM 121 (1993)). As for experimental animals, in oral administration in rats and mice (corresponding to Category 1), incoordination, sedation, narcotic effects, centrilobular fatty infiltration and necrosis of the liver, centrilobular hepatocytes necrosis, regenerative proliferation of the proximal tubular epithelial cells of the renal cortex, cell proliferation of the kidney, and severe necrosis in the kidney were reported. In inhalation exposure in rats and mice (corresponding to Category 1), narcotic effects, fatty infiltration of the liver, hepatocyte necrosis, necrosis of the renal proximal and distal tubules, and calcification of the renal cortex were reported. In dermal administration in rabbits (corresponding to Category 1), renal tubular degeneration was observed (Hazard Assessment Report (CERI, NITE, 2008), DFGOT Vol. 14 (2000), IARC 73 (1999), OEL Documentations (Japan Society For Occupational Health (JSOH), 2005), EU-RAR (2007), CICAD 58 (2004), DFGOT Vol. 14 (2000), ATSDR (1997), ACGIH (7th, 2001), PATTY (6th, 2012), CEPA (2001)). From the above, since this substance affects the respiratory organs, cardiovascular system, liver, and kidney in addition to respiratory tract irritation and narcotic effects, it was classified in Category 1 (respiratory organs, cardiovascular system, liver, kidney), and Category 3 (narcotic effects). |
FY2015 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
9 | Specific target organ toxicity - Repeated exposure | Category 1 (central nervous system, respiratory organs, liver, kidney) |
Danger |
H372 | P260 P264 P270 P314 P501 |
As for humans, there is a description that all 13 workers exposed to chloroform at a concentration of approximately 1,950 mg/m3 for up to 6 months showed jaundice, and 1-2.9 mg/L blood chloroform was detected in 5 of them (DFGOT Vol. 14 (2000)). There is a description that jaundice was observed in 18 workers who were exposed to chloroform at concentrations of 80-160 mg/m3 for 4 months or more in another factory (DFGOT Vol. 14 (2000)). In addition, there is a description that in workers exposed to chloroform at 14-400 ppm (68-1,950 mg/m3) for 1-6 months, symptoms such as development of hepatitis, jaundice, nausea and vomiting were observed, and the development of hepatitis occurred even at exposure concentrations of 2-205 ppm (9.7-1,000 mg/m3) (PATTY (6th, 2012)). Moreover, there is a description that 17 out of 68 workers exposed to 10-1,000 mg/m3 of chloroform in a pharmaceutical plant for 1-4 years were diagnosed with hepatomegaly. It is also described that hepatitis in 3 of them, fatty liver in 14, splenomegaly in 10 were seen (Environmental Risk Assessment for Chemical Substances Vol.2 (Ministry of the Environment, 2003)). As for experimental animals, in tests in which mice were dosed by gavage or drinking water for 13 weeks, and a test in which rats were dosed by gavage for 3 weeks, at doses corresponding to Category 2 (converted guidance value: 14.8-60 mg/kg/day), effects on the liver (enlargement, degeneration and fatty change of hepatocytes, early hepatic cirrhosis like change, etc.), kidney (chronic inflammation, degeneration and necrosis of the proximal tubules, etc.), spleen (atrophy of the white pulp, a decrease in the number of antibody-forming cells) were observed. In addition, also in a test in which dogs were dosed by gavage via capsules for 7.5 years, an increased serum ALT value in addition to fatty change of the liver was observed at 15 mg/kg/day (converted guidance value: 12.9 mg/kg/day) (Hazard Assessment Report (CERI, NITE, 2008), Environmental Risk Assessment for Chemical Substances Vol.2 (Ministry of the Environment, 2003)). Moreover, in the inhalation route, in multiple tests in which rats and mice were exposed by inhalation (estimated as vapour) for 13 weeks or 2 years, from the concentrations corresponding to Category 1 (converted guidance value: 0.01-0.106 mg/L/6 hr/day), the same tissue changes as the above were observed in the liver and kidney, in addition, effects on the nasal cavity (bone hypertrophy, atrophy and metaplasia of the olfactory epithelium, eosinophilic changes in the olfactory epithelia and respiratory epithelia) were also observed (Hazard Assessment Report (CERI, NITE, 2008), OEL Documentations (Japan Society For Occupational Health (JSOH), 2005)). From the above, the central nervous system (nausea, vomiting) and liver were considered as the target organs from the human findings, and the respiratory organs, liver, and kidney were considered as the target organs from the findings in experimental animals. Therefore, it was classified in Category 1 (central nervous system, respiratory organs, liver, kidney). Besides, as for the spleen, since there were little findings in humans, and the possibility of secondary effects due to severe hepatotoxicity such as cirrhosis could not be denied, it was excluded from the target organs. |
FY2015 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
10 | Aspiration hazard | Classification not possible |
- |
- | - | Classification not possible due to lack of data. | FY2015 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
Hazard class | Classification | Pictogram Signal word |
Hazard statement (code) |
Precautionary statement (code) |
Rationale for the classification | Classification year (FY) | GHS Classification Guidance for the Japanese Government | |
---|---|---|---|---|---|---|---|---|
11 | Hazardous to the aquatic environment Short term (Acute) | Category 3 |
- |
H402 | P273 P501 |
From 72-hour EC50 = 13.3 mg/L for algae (Chlamydomonas reinhardtii) (ECETOC TR91, 2003, CICAD 58, 2004, EU-RAR, 2007), it was classified in Category 3. | FY2015 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
11 | Hazardous to the aquatic environment Long term (Chronic) | Category 1 |
Warning |
H410 | P273 P391 P501 |
If chronic toxicity data are used, then it is classified in Category 1 due to being not rapidly degradable (a degradation rate by 14-day BOD = 0%, a degradation rate by GC = 4.6%, non-biodegradable (Official Bulletin of Ministry of International Trade and Industry, 1980)), and 21-day NOEC = 0.059 mg/L for fish (Oncorhynchus mykiss) (Environmental Risk Assessment for Chemical Substances vol. 2 (Ministry of the Environment, 2003)). If acute toxicity data are used for a trophic level for which chronic toxicity data are not obtained, then it is classified in Category 3 due to being not rapidly degradable and 72-hour EC50 = 13.3 mg/L for algae (Chlamydomonas reinhardtii) (ECETOC TR91, 2003, CICAD 58, 2004, EU-RAR, 2007). By drawing a comparison between the above results, it was classified in Category 1. |
FY2015 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
12 | Hazardous to the ozone layer | Classification not possible |
- |
- | - | No data available. | FY2015 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
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