NITE - Chemical Management Field

Latest GHS Classification Results by the Japanese Government (edited by NITE)

GENERAL INFORMATION

Item	Information
CAS RN	67-72-1
Chemical Name	Ethane, hexachloro-
Substance ID	m-nite-67-72-1_v1
Download of Excel format	Excel file

REFERENCE INFORMATION

Item	Information
Guidance used for the classification (External link)	To Guidance List
UN GHS document (External link)	To UN GHS document
FAQ（GHS classification results by the Japanese Government）	To FAQ
List of Information Sources (Excel file)	List of Information Sources
List of Definitions/Abbreviations	Definitions/Abbreviations
Sample Label by MHLW (External link)	MHLW Website (in Japanese Only)
Sample SDS by MHLW (External link)	MHLW Website (in Japanese Only)
OECD/eChemPortal (External link)	To OECD/eChemPortal (External link)

PHYSICAL HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification	Classification year (FY)	GHS Classification Guidance for the Japanese Government
1	Explosives	Not classified (Not applicable)	- -	-	-	There are no chemical groups associated with explosive properties present in the molecules.	FY2006	GHS Classification Manual （10 Feb, 2006）
2	Flammable gases	Not classified (Not applicable)	- -	-	-	Solid (GHS definition)	FY2006	GHS Classification Manual （10 Feb, 2006）
3	Aerosols	Not classified (Not applicable)	- -	-	-	Not aerosol products	FY2006	GHS Classification Manual （10 Feb, 2006）
4	Oxidizing gases	Not classified (Not applicable)	- -	-	-	Solid (GHS definition)	FY2006	GHS Classification Manual （10 Feb, 2006）
5	Gases under pressure	Not classified (Not applicable)	- -	-	-	Solid (GHS definition)	FY2006	GHS Classification Manual （10 Feb, 2006）
6	Flammable liquids	Not classified (Not applicable)	- -	-	-	Solid (GHS definition)	FY2006	GHS Classification Manual （10 Feb, 2006）
7	Flammable solids	Not classified	- -	-	-	Non-combustible (ICSC (J), 1993; etc.)	FY2006	GHS Classification Manual （10 Feb, 2006）
8	Self-reactive substances and mixtures	Not classified (Not applicable)	- -	-	-	There are no chemical groups associated with explosive or self-reactive properties present in the molecule.	FY2006	GHS Classification Manual （10 Feb, 2006）
9	Pyrophoric liquids	Not classified (Not applicable)	- -	-	-	Solid (GHS definition)	FY2006	GHS Classification Manual （10 Feb, 2006）
10	Pyrophoric solids	Not classified	- -	-	-	Non-combustible (ICSC (J), 1993; etc.)	FY2006	GHS Classification Manual （10 Feb, 2006）
11	Self-heating substances and mixtures	Not classified	- -	-	-	Non-combustible (ICSC(J) (1993); etc)	FY2006	GHS Classification Manual （10 Feb, 2006）
12	Substances and mixtures which, in contact with water, emit flammable gases	Not classified (Not applicable)	- -	-	-	The chemical structure of the substance does not contain metals or metaloids(B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At).	FY2006	GHS Classification Manual （10 Feb, 2006）
13	Oxidizing liquids	Not classified (Not applicable)	- -	-	-	Solid (GHS definition)	FY2006	GHS Classification Manual （10 Feb, 2006）
14	Oxidizing solids	Not classified (Not applicable)	- -	-	-	Organic compounds containing chlorine (but not oxygen and fluorine) and the chlorine is chemically bonded only to carbon and hydrogen (but not to other elements).	FY2006	GHS Classification Manual （10 Feb, 2006）
15	Organic peroxides	Not classified (Not applicable)	- -	-	-	Containing no -0-0- structure	FY2006	GHS Classification Manual （10 Feb, 2006）
16	Corrosive to metals	Classification not possible	- -	-	-	Although a potential of corroding iron is suggested (ICSC (J) (1993)), test methods suitable for a solids material are not established.	FY2006	GHS Classification Manual （10 Feb, 2006）
17	Desensitized explosives	-	- -	-	-	-	-	-

HEALTH HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification	Classification year (FY)	GHS Classification Guidance for the Japanese Government
1	Acute toxicity (Oral)	-	- Warning	-	-	Rat LD50 value: 4460mg/kg (ACGIH 7th (2001), PATTY 4th (1994), ATSDR (1997), NTP TR361(1989)), 7080mg/kg (PATTY 4th (1994), ATSDR (1997), NTP TR361 (1989)), 5900mg/kg (PATTY 4th (1994), NTP TR361 (1989)), 4489mg/kg (ATSDR (1997)) and 6000mg/kg (NTP TR361 (1989)). calculated based on the values above. Since the calculated values was 4767mg/kg, it was classified to category 5.	FY2006	GHS Classification Manual （10 Feb, 2006）
1	Acute toxicity (Dermal)	Not classified	- -	-	-	Based on rabbit LD50 values: 32000mg/kg or >32000mg/kg (ACGIH 7th, 2001, PATTY 4th, 1994, NTP TR361, 1989, ATSDR, 1997), it was set as the outside of Category.	FY2006	GHS Classification Manual （10 Feb, 2006）
1	Acute toxicity (Inhalation: Gases)	Not classified (Not applicable)	- -	-	-	Solid (GHS definition)	FY2006	GHS Classification Manual （10 Feb, 2006）
1	Acute toxicity (Inhalation: Vapours)	Classification not possible	- -	-	-	No data available	FY2006	GHS Classification Manual （10 Feb, 2006）
1	Acute toxicity (Inhalation: Dusts and mists)	Not classified	- -	-	-	LC50 value was not indicated from description that two examples died among six examples in the test using the rat by 5900ppm 8-hour exposure (4-hour equivalent 114 mg/L) (IARC 73 (1999), ATSDR (1997)). But lethal concentration was over 20 times of the limit of 4. Therefore, it was judged as the outside of category.	FY2006	GHS Classification Manual （10 Feb, 2006）
2	Skin corrosion/irritation	Category 3	- Warning	-	-	There is description that irritation was not acknowledged in the test applied to the skin of the rabbit (PATTY (4th, 1994), NTP TR361 (1989), and ATSDR (1997)). But it was set as Category 3 from description that slight skin irritation was acknowledged in the example of repetitive exposure of the humans (IARC 73 (1999), ATSDR (1997)).	FY2006	GHS Classification Manual （10 Feb, 2006）
3	Serious eye damage/eye irritation	Category 2B	- Warning	H320	P305+P351+P338 P337+P313 P264	There is the descriptions that in the test applied to the eyes of the rabbit, the ocular irritant property which recovered 72 hours after administration was acknowledged (PATTY (4th, 1994), NTP TR361 (1989) and ATSDR (1997)). Therefore we judged that ocular irritant property was slight and classified it as Category 2B.	FY2006	GHS Classification Manual （10 Feb, 2006）
4	Respiratory sensitization	Classification not possible	- -	-	-	No data	FY2006	GHS Classification Manual （10 Feb, 2006）
4	Skin sensitization	Not classified	- -	-	-	Based on the description that sensitizing property was not acknowledged in the skin sensitivity test using the guinea pigs in ACGIH (7th, 2001), PATTY (4th, 1994), NTP TR361 (1989) and ATSDR (1997), we classified it to be Out Of Category.	FY2006	GHS Classification Manual （10 Feb, 2006）
5	Germ cell mutagenicity	Classification not possible	- -	-	-	Although there is a positive result (IARC 73, 1999) in a joint examination with somatic DNA of a rat and a mouse which is an in vivo genotoxicity study using a somatic, there is no positive result by in vitro mutagenicity test. So it cannot classify	FY2006	GHS Classification Manual （10 Feb, 2006）
6	Carcinogenicity	Category 2	Warning	H351	P308+P313 P201 P202 P280 P405 P501	It was classified into C (IRIS, 2006) in EPA in 1994. But it was classified in group 2B (IARC 73, 1999) in IARC, A3 (ACGIH 7th, 2001) in ACGIH, and R (NTP RoC 11th, 2005) in NTP. So it was considered as Category 2 according to ACGIH which is latest assessment document.	FY2006	GHS Classification Manual （10 Feb, 2006）
7	Reproductive toxicity	Not classified	- -	-	-	It was considered as out of Category based on the description that specific reproductive toxicity was not observed at the dose in which general toxicity is observed in a dam animals in oral administration and an inhalation exposure test using pregnancy rat (ACGIH (7th, 2001), PATTY (4th, 1994), IARC 73 (1999), IRIS (2006), ATSDR (1997), NTP TR361 (1989)).	FY2006	GHS Classification Manual （10 Feb, 2006）
8	Specific target organ toxicity - Single exposure	Classification not possible	- -	-	-	Insufficient data available.	FY2006	GHS Classification Manual （10 Feb, 2006）
9	Specific target organ toxicity - Repeated exposure	Category 2 (kidney, nervous system)	Warning	H373	P260 P314 P501	Based on the description that the influence on the kidney was observed among male and females with the dose of the guidance value range of Category 2 in the oral study using the rats (ACGIH (7th, 2001), PATTY (4th, 1994), IARC 73 (1999), NTP TR361 (1989), IRIS (2006), ATSDR (1997)), and based on the description that the effects on the nervous system was observed with the concentration of the guidance value range of Category 2 in the inhalation exposure test using the dogs (ACGIH (7th, 2001), IARC 73 (1999), NTP TR361 (1989), IRIS (2006), and ATSDR (1997)), we cateforized it as Category 2 (the kidney, nervous system).	FY2006	GHS Classification Manual （10 Feb, 2006）
10	Aspiration hazard	Classification not possible	- -	-	-	No data available	FY2006	GHS Classification Manual （10 Feb, 2006）

ENVIRONMENTAL HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification	Classification year (FY)	GHS Classification Guidance for the Japanese Government
11	Hazardous to the aquatic environment Short term (Acute)	Category 1	Warning	H400	P273 P391 P501	It was classified into Category 1 from 96-hour LC50=0.97mg/L of fishes (Bluegill) (ECETOC TR91, 2003).	FY2006	GHS Classification Manual （10 Feb, 2006）
11	Hazardous to the aquatic environment Long term (Chronic)	Category 1	Warning	H410	P273 P391 P501	Classified into Category 1, Classified into Category 1, since acute toxicity was Category 1, and not rapidly degrading (BOD: 0% (existing chemical safety inspections data)), though less bio-accumulative (BCF=8.5 (existing chemical safety inspections data)).	FY2006	GHS Classification Manual （10 Feb, 2006）
12	Hazardous to the ozone layer	-	- -	-	-	-	-	-

NOTE:

GHS Classification Result by the Japanese Government is intended to provide a reference for preparing a GHS label or SDS for users. To include the same classification result in a label or SDS for Japan is NOT mandatory.
Users can cite or copy this classification result when preparing a GHS label or SDS. Please be aware, however, that the responsibility for a label or SDS prepared by citing or copying this classification result lies with users.
This GHS classification was conducted based on the information sources and the guidance for classification and judgement which are described in the GHS Classification Guidance for the Japanese Government etc. Using other literature, test results etc. as evidence and including different content from this classification result in a label or SDS are allowed.
Hazard statement and precautionary statement will show by hovering the mouse cursor over a code in the column of "Hazard statement" and "Precautionary statement," respectively. In the excel file, both the codes and statements are provided.
A blank or "-" in the column of "Classification" denotes that a classification for the hazard class was not conducted in the year.
An asterisk “*” in the column of “Classification” denotes that “Not classified (or No applicable)” and/or “Classification not possible” is applicable. Details are described in the column of “Rationale for the classification”. If no English translation is available for “Rationale for the classification,” please refer to the Japanese version of the results.

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