Item | Information |
---|---|
CAS RN | 67375-30-8 |
Chemical Name | (S)-alpha-Cyano-3-phenoxybenzyl 3-(2,2-dichlorovinyl)-2,2-dimethyl-cis-cyclopropanecarboxylate; alpha-Cypermethrin |
Substance ID | m-nite-67375-30-8_v1 |
Download of Excel format | Excel file |
Item | Information |
---|---|
Guidance used for the classification (External link) | To Guidance List |
UN GHS document (External link) | To UN GHS document |
FAQ(GHS classification results by the Japanese Government) | To FAQ |
List of Information Sources (Excel file) | List of Information Sources |
List of Definitions/Abbreviations | Definitions/Abbreviations |
Sample Label by MHLW (External link) | MHLW Website (in Japanese Only) |
Sample SDS by MHLW (External link) | MHLW Website (in Japanese Only) |
OECD/eChemPortal (External link) | To OECD/eChemPortal (External link) |
Hazard class | Classification | Pictogram Signal word |
Hazard statement (code) |
Precautionary statement (code) |
Rationale for the classification | Classification year (FY) | GHS Classification Guidance for the Japanese Government | |
---|---|---|---|---|---|---|---|---|
1 | Explosives | Not classified (Not applicable) |
- |
- | - | Containing no chemical groups with explosive properties | FY2006 | GHS Classification Manual (10 Feb, 2006) |
2 | Flammable gases | Not classified (Not applicable) |
- |
- | - | Classified as "solid" according to GHS definition | FY2006 | GHS Classification Manual (10 Feb, 2006) |
3 | Aerosols | Not classified (Not applicable) |
- |
- | - | Not aerosol products | FY2006 | GHS Classification Manual (10 Feb, 2006) |
4 | Oxidizing gases | Not classified (Not applicable) |
- |
- | - | Classified as "solid" according to GHS definition | FY2006 | GHS Classification Manual (10 Feb, 2006) |
5 | Gases under pressure | Not classified (Not applicable) |
- |
- | - | Classified as "solid" according to GHS definition | FY2006 | GHS Classification Manual (10 Feb, 2006) |
6 | Flammable liquids | Not classified (Not applicable) |
- |
- | - | Classified as "solid" according to GHS definition | FY2006 | GHS Classification Manual (10 Feb, 2006) |
7 | Flammable solids | Classification not possible |
- |
- | - | No data available | FY2006 | GHS Classification Manual (10 Feb, 2006) |
8 | Self-reactive substances and mixtures | Classification not possible |
- |
- | - | Classification not possible due to lack of data, though containing unsaturated bonds (olefin) | FY2006 | GHS Classification Manual (10 Feb, 2006) |
9 | Pyrophoric liquids | Not classified (Not applicable) |
- |
- | - | Classified as "solid" according to GHS definition | FY2006 | GHS Classification Manual (10 Feb, 2006) |
10 | Pyrophoric solids | Classification not possible |
- |
- | - | No data available | FY2006 | GHS Classification Manual (10 Feb, 2006) |
11 | Self-heating substances and mixtures | Classification not possible |
- |
- | - | Test methods applicable to liquid substances are not available (melting point: 78-81degC (HSDB, 2006), test temperature: 140degC). | FY2006 | GHS Classification Manual (10 Feb, 2006) |
12 | Substances and mixtures which, in contact with water, emit flammable gases | Not classified (Not applicable) |
- |
- | - | Containing no metals or metalloids (B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At) | FY2006 | GHS Classification Manual (10 Feb, 2006) |
13 | Oxidizing liquids | Not classified (Not applicable) |
- |
- | - | Classified as "solid" according to GHS definition | FY2006 | GHS Classification Manual (10 Feb, 2006) |
14 | Oxidizing solids | Not classified (Not applicable) |
- |
- | - | Organic compounds containing oxygen and chlorine (but not fluorine), with the oxygen and chlorine bound to carbon and hydrogen respectively (but not to other elements) | FY2006 | GHS Classification Manual (10 Feb, 2006) |
15 | Organic peroxides | Not classified (Not applicable) |
- |
- | - | Organic compounds containing no "-O-O-" structure | FY2006 | GHS Classification Manual (10 Feb, 2006) |
16 | Corrosive to metals | Classification not possible |
- |
- | - | Test methods applicable to solid substances are not available | FY2006 | GHS Classification Manual (10 Feb, 2006) |
17 | Desensitized explosives | - |
- |
- | - | - | - | - |
Hazard class | Classification | Pictogram Signal word |
Hazard statement (code) |
Precautionary statement (code) |
Rationale for the classification | Classification year (FY) | GHS Classification Guidance for the Japanese Government | |
---|---|---|---|---|---|---|---|---|
1 | Acute toxicity (Oral) | Category 2 |
Danger |
H300 | P301+P310 P264 P270 P321 P330 P405 P501 |
Based on the LD50 value of 40mg/kg calculated from the testing data of rat LD50 (oral route) of 79mg/kg (MOE Risk Assessment vol. 4 (2005)), 40mg/kg, 80mg/kg and 368mg/kg (EHC 142 (1992)). | FY2006 | GHS Classification Manual (10 Feb, 2006) |
1 | Acute toxicity (Dermal) | Classification not possible |
- |
- | - | Insufficient data available | FY2006 | GHS Classification Manual (10 Feb, 2006) |
1 | Acute toxicity (Inhalation: Gases) | Not classified (Not applicable) |
- |
- | - | Due to the fact that the substance is "solid" according to the GHS definition and inhalation of its gas is not expected. |
FY2006 | GHS Classification Manual (10 Feb, 2006) |
1 | Acute toxicity (Inhalation: Vapours) | Classification not possible |
- |
- | - | Insufficient data available | FY2006 | GHS Classification Manual (10 Feb, 2006) |
1 | Acute toxicity (Inhalation: Dusts and mists) | Classification not possible |
- |
- | - | Insufficient data available | FY2006 | GHS Classification Manual (10 Feb, 2006) |
2 | Skin corrosion/irritation | Category 2 |
Warning |
H315 | P302+P352 P332+P313 P362+P364 P264 P280 P321 |
Based on the description in the report on rabbit eye irritation tests (EHC 142 (1992)): "Mildly irritating." | FY2006 | GHS Classification Manual (10 Feb, 2006) |
3 | Serious eye damage/eye irritation | Category 1 |
Danger |
H318 | P305+P351+P338 P280 P310 |
Based on the description in the report on rabbit eye irritation tests (EHC 142 (1992)): "Severe eye irritant," "The vascularization of the cornea and iritis were considered to be irreversible." The substance is thus considered to have irreversible effects on the eye and thus classified as Category 1. The effects induced may differ depending on the type of formulation (such as "EC" and "SC"). |
FY2006 | GHS Classification Manual (10 Feb, 2006) |
4 | Respiratory sensitization | Classification not possible |
- |
- | - | No data available | FY2006 | GHS Classification Manual (10 Feb, 2006) |
4 | Skin sensitization | Classification not possible |
- |
- | - | The results of guinea pig Maximization tests and Buehler tests reported in EHC 142 (1992) suggest no evidence of skin sensitization, whereas the substance is considered positive for sensitization according to EU Risk Phrase. These inconsistent data do not allow the presence or absence of sensitization to be determined, and thus classification is not possible. | FY2006 | GHS Classification Manual (10 Feb, 2006) |
5 | Germ cell mutagenicity | Not classified |
- |
- | - | Based on the absence of data on multi-generation mutagenicity tests and germ cell mutagenicity tests in vivo, and negative data on somatic cell mutagenicity tests in vivo (chromosome aberration tests), described in EHC 142 (1992). |
FY2006 | GHS Classification Manual (10 Feb, 2006) |
6 | Carcinogenicity | Classification not possible |
- |
- | - | No data available | FY2006 | GHS Classification Manual (10 Feb, 2006) |
7 | Reproductive toxicity | Classification not possible |
- |
- | - | Classification is not possible since no data are available regarding adult reproduction, though no definitive evidence of pup reproductive toxicity was observed in any of the teratogenicity studies with rats and rabbits, described in MOE Risk Assessment vol. 4 (2005). |
FY2006 | GHS Classification Manual (10 Feb, 2006) |
8 | Specific target organ toxicity - Single exposure | Category 1 (nervous system) |
Danger |
H370 | P308+P311 P260 P264 P270 P321 P405 P501 |
Based on the evidence from animal studies: "clonic convulsions, piloerection, salivation and splayed hind-leg gait were found" (EHC 142 (1992)), "ataxia, dyspnea, salivary gland dysfunction" (RTECS (2006)). The effects on experimental animals were observed at dosing levels within the guidance value ranges for Category 1. |
FY2006 | GHS Classification Manual (10 Feb, 2006) |
9 | Specific target organ toxicity - Repeated exposure | Category 1 (nervous system), Category 2 (blood system, liver) |
Danger Warning |
H372 H373 |
P260 P264 P270 P314 P501 |
Based on the human evidence: "The substance induces neurotoxicity that affects the axons of the peripheral and central nervous systems via sodium channels" (MOE Risk Assessment vol. 4 (2005)). Also based on the evidence from animal studies including "ataxia and abnormal gait, hyperactivity, hunchback position, elevated ALAT/ASAT levels," "decreased hemoglobin level and increased platelet counts; increased lymphocyte counts and decreased acidophile counts in males; decreased mean red blood cell volume and mean corpuscular hemoglobin, and increased blood level of urea in females" (MOE Risk Assessment vol. 4 (2005)), "abnormal gait and hypersensitivity were observed; decreases in protein and increases in urea levels were observed in both sexes" (EHC 142 (1992)). The effects on experimental animals were observed at dosing levels within the guidance value ranges for Category 1 (nervous system) and Category 2 (liver, blood system). |
FY2006 | GHS Classification Manual (10 Feb, 2006) |
10 | Aspiration hazard | Classification not possible |
- |
- | - | No data available | FY2006 | GHS Classification Manual (10 Feb, 2006) |
Hazard class | Classification | Pictogram Signal word |
Hazard statement (code) |
Precautionary statement (code) |
Rationale for the classification | Classification year (FY) | GHS Classification Guidance for the Japanese Government | |
---|---|---|---|---|---|---|---|---|
11 | Hazardous to the aquatic environment Short term (Acute) | Category 1 |
Warning |
H400 | P273 P391 P501 |
It was classified into Category 1 from 48 hours EC50=0.0003mg/L of the crustacea (Daphnia magna) (EHC142, 1992). | FY2006 | GHS Classification Manual (10 Feb, 2006) |
11 | Hazardous to the aquatic environment Long term (Chronic) | Category 1 |
Warning |
H410 | P273 P391 P501 |
Since acute toxicity was Category 1 and there was no rapidly degrading (BIOWIN), and since there wasbio-accumulation (log Kow=6.94 (PHYSPROP Database, 2005)), it was classified into Category 1. | FY2006 | GHS Classification Manual (10 Feb, 2006) |
12 | Hazardous to the ozone layer | - |
- |
- | - | - | - | - |
|