NITE - Chemical Management Field

Latest GHS Classification Results by the Japanese Government (edited by NITE)

GENERAL INFORMATION

Item	Information
CAS RN	67485-29-4
Chemical Name	5,5-dimethyl-perhydro-pyrimidin-2-one alpha-(4-trifluoromethylstyryl)-alpha-(4-trifluoromethyl)cinnamylidenehydrazone
Substance ID	m-nite-67485-29-4_v1
Download of Excel format	Excel file

REFERENCE INFORMATION

Item	Information
Guidance used for the classification (External link)	To Guidance List
UN GHS document (External link)	To UN GHS document
FAQ（GHS classification results by the Japanese Government）	To FAQ
List of Information Sources (Excel file)	List of Information Sources
List of Definitions/Abbreviations	Definitions/Abbreviations
Sample Label by MHLW (External link)	MHLW Website (in Japanese Only)
Sample SDS by MHLW (External link)	MHLW Website (in Japanese Only)
OECD/eChemPortal (External link)	To OECD/eChemPortal (External link)

PHYSICAL HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification	Classification year (FY)	GHS Classification Guidance for the Japanese Government
1	Explosives	Classification not possible	- -	-	-	The substance contains chemical groups (N-N) associated with explosive properties. No data are available.	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
2	Flammable gases	Not classified (Not applicable)	- -	-	-	Solid (GHS definition)	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
3	Aerosols	Not classified (Not applicable)	- -	-	-	Not aerosol products.	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
4	Oxidizing gases	Not classified (Not applicable)	- -	-	-	Solid (GHS definition)	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
5	Gases under pressure	Not classified (Not applicable)	- -	-	-	Solid (GHS definition)	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
6	Flammable liquids	Not classified (Not applicable)	- -	-	-	Solid (GHS definition)	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
7	Flammable solids	Classification not possible	- -	-	-	No data available.	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
8	Self-reactive substances and mixtures	Classification not possible	- -	-	-	The substance contains chemical groups (N-N) associated with explosive properties. No data are available.	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
9	Pyrophoric liquids	Not classified (Not applicable)	- -	-	-	Solid (GHS definition)	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
10	Pyrophoric solids	Classification not possible	- -	-	-	No data available.	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
11	Self-heating substances and mixtures	Classification not possible	- -	-	-	No data available.	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
12	Substances and mixtures which, in contact with water, emit flammable gases	Not classified (Not applicable)	- -	-	-	The chemical structure of the substance does not contain metals or metalloids (B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At).	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
13	Oxidizing liquids	Not classified (Not applicable)	- -	-	-	Solid (GHS definition)	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
14	Oxidizing solids	Not classified (Not applicable)	- -	-	-	The substance contains fluorine (but not oxygen or chlorine) which is chemically bonded only to carbon or hydrogen.	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
15	Organic peroxides	Not classified (Not applicable)	- -	-	-	Organic compounds containing no bivalent -O-O- structure in the molecule	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
16	Corrosive to metals	Classification not possible	- -	-	-	Test methods applicable to solid substances are not available.	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
17	Desensitized explosives	-	- -	-	-	-	-	-

HEALTH HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification	Classification year (FY)	GHS Classification Guidance for the Japanese Government
1	Acute toxicity (Oral)	Category 4	Warning	H302	P301+P312 P264 P270 P330 P501	Based on its rat LD50 values: 1131 mg/kg for male and 1300 mg/kg for female (HSDB (2009)), the substance was classified into Category 4.	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
1	Acute toxicity (Dermal)	Not classified	- -	-	-	Based on its rabbit LD50 of > 5000 mg/kg (HSDB (2009)), the substance was classified into "Not classified".	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
1	Acute toxicity (Inhalation: Gases)	Not classified (Not applicable)	- -	-	-	Solid (GHS definition)	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
1	Acute toxicity (Inhalation: Vapours)	Classification not possible	- -	-	-	No data available.	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
1	Acute toxicity (Inhalation: Dusts and mists)	Not classified	- -	-	-	Based on its rat LC50 of > 5000 mg/m3 (conversion value: > 5 mg/L), the substance was classified into "Not classified" using the JIS classification criteria (Category 5 or "Not classified" category using the United Nations classification). Since its saturated vapour pressure concentration is 5.39E-07 mg/L, we judged that the experiment was conducted in a mist state.	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
2	Skin corrosion/irritation	Not classified	- -	-	-	Since the substance is reported to be not irritating in rabbit tests (HSDB (2009)), not a skin irritant (HSDB (2009)), and not skin irritating in tests using guinea pigs (HSDB (2009)), it was classified into "Not classified".	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
3	Serious eye damage/eye irritation	Category 2B	- Warning	H320	P305+P351+P338 P337+P313 P264	In rabbit tests, though specific scores were not provided, corneal opacity, conjunctival redness, or chemosis appeared, and these symptoms were found to be reversible based on a 7-day observation. In addition, the substance was documented to cause moderate corneal irritation (HSDB (2009)) and reversible irritation in rabbit tests (HSDB (2009)). Based on this information, the substance was classified into Category 2B.	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
4	Respiratory sensitization	Classification not possible	- -	-	-	No data available.	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
4	Skin sensitization	Classification not possible	- -	-	-	The substance is documented to be not sensitizing in the tests using guinea pigs (HSDB (2009)), and not skin sensitizing (HSDB (2009)). This information indicates the placement of the substance into "Not classified" category; however, since these studies are based on List 2 datasets, the substance was classified into "Classification not possible".	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
5	Germ cell mutagenicity	Classification not possible	- -	-	-	Classification is not possible due to lack of in vivo test data using germ cells or somatic cells. Regarding in vitro studies, Ames tests (HSDB (2009)) and chromosomal aberration tests using CHO cells (HSDB (2009)) both yielded negative results.	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
6	Carcinogenicity	Classification not possible	- -	-	-	76-week oral administration tests using mice found tumorigenesis in the lung, thorax, or respiratory tracts, and development of bronchogenic carcinoma; but it is suspected that tumors were spontaneously generated (RTECS (2007)). Based on these documents alone, however, it is difficult to evaluate carcinogenicity of the test substance. Since there are no other appropriate animal study information available, the substance was classified into "Classification not possible".	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
7	Reproductive toxicity	Category 2	Warning	H361	P308+P313 P201 P202 P280 P405 P501	In 2-generation oral administration tests using rats (doses: 0, 25, 50 or 75 ppm), degeneration of seminiferous tubules was detected in male rat groups exposed to 50 ppm or higher doses; though its toxicity in parental animals is not clear, a decreased mating in F1 male groups treated with high doses, decreased pregnancy in F1 female groups, decreasing tendency in implantation rates, and decreased litter size were observed (HSDB (2009)). In addition, in forced oral administration tests using rats (doses: 0, 3, 10 or 30 mg/kg/day; days 6-15 of gestation), slight ossification delays such as incomplete supraoccipital ossification, and increased incidence of rudimentary ribs were identified at the exposure rate (30 mg/kg/day) which induces parental toxicity (HSDB (2009)). Though its effect on teratogenicity is not clear, because of observed decrease in pregnancy and implantation rates in F1 female and a decreased litter size, the substance was classified into Category 2.	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
8	Specific target organ toxicity - Single exposure	Classification not possible	- -	-	-	No data available.	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
9	Specific target organ toxicity - Repeated exposure	Category 2 (testis, kidney, nervous system)	Warning	H373	P260 P314 P501	In 28-day oral administration tests using rats (dose: 0, 50, 100, 200, 400 or 800 ppm), testicular lesions (especially focal tubular degeneration and formation of giant cells) were observed in male rat groups administered at >= 200 ppm (18.7 mg/kg/day: 90-day correction value: 5.81 mg/kg/day) (HSDB (2009)). In addition, in 91-day oral administration tests using rats (dose: 0, 25, 50, 100 or 200 ppm), the weight of testes decreased in all dose groups in a dose-dependent fashion, and testicular atrophy at >= 100 ppm (8.6 mg/kg/day) and mild prostatic atrophy at 200 ppm (17.0 mg/kg/day) were observed (HSDB (2009)). Furthermore, in 2-year oral administration tests using rats (dose: 0, 25, 50, 100 and 200 ppm), development of glomerulonephrosis was found in female groups treated with 50 ppm or higher and male groups treated with 25 ppm or higher in a dose-dependent fashion, and testicular atrophy was detected in male groups exposed to 50 ppm or higher (the symptom was especially notable at 100 and 200 ppm) (HSDB (2009)). Moreover, in 18-month oral administration tests using mice (dose: 0, 25, 100 and 200 ppm), chronic nephritis and kidney amyloidosis were identified in both sexes exposed to 50 ppm (conversion value: 7.5 mg/kg/day) or higher, and testicular degeneration occurred in male rats exposed to 50 ppm or higher. Also, in 91-day oral administration tests using dogs (dose: 0, 3, 6 or 12 mg/kg/day), tremors, convulsions, or wastage of muscle and subcutaneous fat were found in both sex groups exposed to 6 or 12 mg/kg/day; and mild to moderate bilateral testicular atrophy was observed in male groups exposed to 6 or 12 mg/kg/day (HSDB (2009)). Overall, effects of administration on the testes and kidney were detected in rats and mice at Category 1 guidance doses; and the effects on the nervous system in forms such as tremors and convulsions were recognized in dogs. Since these studies were based on List 2 data sets, the substance was classified into Category 2 for the testis, kidney and nervous system.	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
10	Aspiration hazard	Classification not possible	- -	-	-	No data available.	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）

ENVIRONMENTAL HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification	Classification year (FY)	GHS Classification Guidance for the Japanese Government
11	Hazardous to the aquatic environment Short term (Acute)	Category 1	Warning	H400	P273 P391 P501	Based on its 72-hour EC50 of 0.00018 mg/L for algae (Skeletonema) (ECOTOX, 2008), the substance was classified into Category 1.	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
11	Hazardous to the aquatic environment Long term (Chronic)	Category 1	Warning	H410	P273 P391 P501	Since its classification for acute toxicity is Category 1, and it is not rapidly degradable (SRC: BioWin V4.10), the substance was classified into Category 1.	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
12	Hazardous to the ozone layer	-	- -	-	-	-	-	-

NOTE:

GHS Classification Result by the Japanese Government is intended to provide a reference for preparing a GHS label or SDS for users. To include the same classification result in a label or SDS for Japan is NOT mandatory.
Users can cite or copy this classification result when preparing a GHS label or SDS. Please be aware, however, that the responsibility for a label or SDS prepared by citing or copying this classification result lies with users.
This GHS classification was conducted based on the information sources and the guidance for classification and judgement which are described in the GHS Classification Guidance for the Japanese Government etc. Using other literature, test results etc. as evidence and including different content from this classification result in a label or SDS are allowed.
Hazard statement and precautionary statement will show by hovering the mouse cursor over a code in the column of "Hazard statement" and "Precautionary statement," respectively. In the excel file, both the codes and statements are provided.
A blank or "-" in the column of "Classification" denotes that a classification for the hazard class was not conducted in the year.
An asterisk “*” in the column of “Classification” denotes that “Not classified (or No applicable)” and/or “Classification not possible” is applicable. Details are described in the column of “Rationale for the classification”. If no English translation is available for “Rationale for the classification,” please refer to the Japanese version of the results.

To GHS Information