NITE - Chemical Management Field

Latest GHS Classification Results by the Japanese Government (edited by NITE)

GENERAL INFORMATION

Item	Information
CAS RN	675106-31-7
Chemical Name	Alumina fiber
Substance ID	m-nite-675106-31-7_v1
Download of Excel format	Excel file

REFERENCE INFORMATION

Item	Information
Guidance used for the classification (External link)	To Guidance List
UN GHS document (External link)	To UN GHS document
FAQ（GHS classification results by the Japanese Government）	To FAQ
List of Information Sources (Excel file)	List of Information Sources
List of Definitions/Abbreviations	Definitions/Abbreviations
Sample Label by MHLW (External link)	MHLW Website (in Japanese Only)
Sample SDS by MHLW (External link)	MHLW Website (in Japanese Only)
OECD/eChemPortal (External link)	To OECD/eChemPortal (External link)

PHYSICAL HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification	Classification year (FY)	GHS Classification Guidance for the Japanese Government
1	Explosives	Not classified (Not applicable)	- -	-	-	There are no chemical groups associated with explosive properties present in the molecule.	FY2016	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
2	Flammable gases	Not classified (Not applicable)	- -	-	-	Solid (GHS definition).	FY2016	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
3	Aerosols	Not classified (Not applicable)	- -	-	-	Not aerosol products.	FY2016	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
4	Oxidizing gases	Not classified (Not applicable)	- -	-	-	Solid (GHS definition).	FY2016	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
5	Gases under pressure	Not classified (Not applicable)	- -	-	-	Solid (GHS definition).	FY2016	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
6	Flammable liquids	Not classified (Not applicable)	- -	-	-	Solid (GHS definition).	FY2016	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
7	Flammable solids	Not classified	- -	-	-	It is not combustible (ICSC (2000)).	FY2016	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
8	Self-reactive substances and mixtures	Not classified (Not applicable)	- -	-	-	There are no chemical groups present in the molecule associated with explosive or self-reactive properties.	FY2016	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
9	Pyrophoric liquids	Not classified (Not applicable)	- -	-	-	Solid (GHS definition).	FY2016	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
10	Pyrophoric solids	Not classified	- -	-	-	It is not combustible (ICSC (2000)).	FY2016	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
11	Self-heating substances and mixtures	Not classified	- -	-	-	It is not combustible (ICSC (2000)).	FY2016	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
12	Substances and mixtures which, in contact with water, emit flammable gases	Not classified	- -	-	-	it is estimated that it does not react vigorously with water because the observation result of being insoluble in water was obtained (ICSC (2000)).	FY2016	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
13	Oxidizing liquids	Not classified (Not applicable)	- -	-	-	Solid (GHS definition).	FY2016	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
14	Oxidizing solids	Classification not possible	- -	-	-	It is an inorganic compound containing oxygen, but the classification is not possible due to no data.	FY2016	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
15	Organic peroxides	Not classified (Not applicable)	- -	-	-	It is an inorganic compound.	FY2016	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
16	Corrosive to metals	Classification not possible	- -	-	-	Test methods applicable to solid substances are not available.	FY2016	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
17	Desensitized explosives	-	- -	-	-	-	-	-

HEALTH HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification	Classification year (FY)	GHS Classification Guidance for the Japanese Government
1	Acute toxicity (Oral)	Classification not possible	- -	-	-	This substance is a fibrous substance containing aluminum oxide (72 to 97%) and silicon dioxide (3 to 28%). In addition, refractory ceramic fiber (CAS RN 142844-00-6) (amorphous artificial mineral fibers containing aluminum oxide (30 to 60%), silicon dioxide (40 to 60%) and RnOm (0 to 20%) (R is Zr or Cr)) has a similar composition to this substance, thus its information was listed as reference. 　　Classification not possible due to lack of data. 　Besides, the LD50 value for rats of aluminum oxide (CAS RN 1344-28-1), which is a component of this substance, is reported as > 5,000 mg/kg (HSDB (Access on May 2016)).	FY2016	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
1	Acute toxicity (Dermal)	Classification not possible	- -	-	-	Classification not possible due to lack of data.	FY2016	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
1	Acute toxicity (Inhalation: Gases)	Not classified (Not applicable)	- -	-	-	Solid (GHS definition)	FY2016	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
1	Acute toxicity (Inhalation: Vapours)	Not classified (Not applicable)	- -	-	-	Solid (GHS definition)	FY2016	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
1	Acute toxicity (Inhalation: Dusts and mists)	Classification not possible	- -	-	-	Classification not possible due to lack of data.	FY2016	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
2	Skin corrosion/irritation	Classification not possible	- -	-	-	Classification not possible due to lack of data.	FY2016	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
3	Serious eye damage/eye irritation	Classification not possible	- -	-	-	Classification not possible due to lack of data.	FY2016	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
4	Respiratory sensitization	Classification not possible	- -	-	-	Classification not possible due to lack of data.	FY2016	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
4	Skin sensitization	Classification not possible	- -	-	-	Classification not possible due to lack of data.	FY2016	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
5	Germ cell mutagenicity	Classification not possible	- -	-	-	Classification not possible due to lack of data. 　Besides, refractory ceramic fiber (CAS RN 142844-00-6) is regarded as genotoxic because it was positive in several reports in both in vitro chromosomal aberration tests, micronucleus tests and there are many reports that it is positive in other genotoxicity tests as well. However, it is also reported that the genotoxicity of refractory ceramic fiber is weak (Risk Assessment Report (Ministry of Health, Labor and Welfare, 2014)). As a mechanism of expression of genotoxicity by fibrous substances, it is described that active oxygen species (ROS) that occur persistently and over a prolonged period from inflammatory cells are thought to play an important role in DNA damage, and that the genotoxicity is not primary but secondary (Risk Assessment Report (Ministry of Health, Labor and Welfare, 2014)).	FY2016	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
6	Carcinogenicity	Classification not possible	- -	-	-	It is described that in a study using rats intrapleurally given aluminum oxide fibers, an increase in pleural sarcomas was observed in four of six samples, and carcinogenic potential was indicated in animal experiments (DFGOT Vol. 8 (1997)). 　On the other hand, in a 2-year study using rats exposed by inhalation to high-alumina, low-silica wool fiber (HT fiber), no increase in tumor was observed, and induction of mesothelioma was not observed in a study of intraperitoneal administration (IARC 81 (2001)). IARC did not evaluate the carcinogenicity of HT fibers since no human data were available, and concluded that there is inadequate evidence in experimental animals for the carcinogenicity (IARC 81 (2001)). Based on the opinion of IARC, this substance was classified as "Classification not possible" for the carcinogenicity. 　In addition, regarding refractory ceramic fiber (CAS RN 142844-00-6), with sufficient evidence for carcinogenicity in experimental animals, IARC has classified the substance in Group 2B, ACGIH classified it in A2, and the Japan Society For Occupational Health classified it in Group 2B (artificial mineral fiber, ceramic fiber, micro glass fiber) (Risk Assessment Report (Ministry of Health, Labor and Welfare, 2014)). Therefore, these classifications are equivalent to Category 2 or 1B.	FY2016	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
7	Reproductive toxicity	Classification not possible	- -	-	-	Classification not possible due to lack of data.	FY2016	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
8	Specific target organ toxicity - Single exposure	Classification not possible	- -	-	-	Classification not possible due to lack of data. As for alumina fiber (CAS RN 675106-31-7), there is no single exposure data in either humans or experimental animals. 　Besides, as for refractory ceramic fiber (CAS RN 142844-00-6), although the information source is listed in List 3, it is described that it may cause mechanical irritation to the respiratory tract, eyes and skin as effects of short-term exposure (ICSC (2012)).	FY2016	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
9	Specific target organ toxicity - Repeated exposure	Classification not possible	- -	-	-	Classification not possible due to lack of data. 　There is no information on this substance (crystalline artificial mineral fiber containing aluminum oxide (72 to 97%) and silicon dioxide (3 to 28%)). 　Besides, it is reported that in a 104-week inhalation toxicity study using rats at the concentration of 30 mg/m3 of high-alumina, low-silica wool fiber (MMVF 34) containing magnesium oxide, calcium oxide, etc. in addition to aluminum oxide and silicon dioxide (aluminum oxide: 23.2%, silicon dioxide: 38.9%, calcium oxide: 15.0%, magnesium oxide: 9.6%, etc.) or rock wool (MMVF 21) (aluminum oxide: 13.8%, silicon dioxide: 45.9%, calcium oxide: 17.0%, magnesium oxide: 9.5%, etc.), the mortality rate for MMVF 34 did not differ from that for the control group, and that lung fibrosis was observed for rock wool, but not for MMVF 34 (IARC 81 (2002), Kamstrup et al., (1998)). In addition, as for refractory ceramic fiber (CAS RN 142844-00-6) (amorphous artificial mineral fibers containing aluminum oxide (30 to 60%), silicon dioxide (40 to 60%) and RnOm (0 to 20%) (R is Zr or Cr)), it is reported that in a 12-month inhalation toxicity study using rats, macrophage infiltration and microgranuloma formation were observed in the lung at 0.003 mg/L, which is equivalent to Category 1 (IARC 81 (2002)).	FY2016	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
10	Aspiration hazard	Classification not possible	- -	-	-	Classification not possible due to lack of data.	FY2016	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))

ENVIRONMENTAL HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification	Classification year (FY)	GHS Classification Guidance for the Japanese Government
11	Hazardous to the aquatic environment Short term (Acute)	Classification not possible	- -	-	-	No data available.	FY2016	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
11	Hazardous to the aquatic environment Long term (Chronic)	Classification not possible	- -	-	-	No data available.	FY2016	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
12	Hazardous to the ozone layer	Classification not possible	- -	-	-	No data available.	FY2016	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))

NOTE:

GHS Classification Result by the Japanese Government is intended to provide a reference for preparing a GHS label or SDS for users. To include the same classification result in a label or SDS for Japan is NOT mandatory.
Users can cite or copy this classification result when preparing a GHS label or SDS. Please be aware, however, that the responsibility for a label or SDS prepared by citing or copying this classification result lies with users.
This GHS classification was conducted based on the information sources and the guidance for classification and judgement which are described in the GHS Classification Guidance for the Japanese Government etc. Using other literature, test results etc. as evidence and including different content from this classification result in a label or SDS are allowed.
Hazard statement and precautionary statement will show by hovering the mouse cursor over a code in the column of "Hazard statement" and "Precautionary statement," respectively. In the excel file, both the codes and statements are provided.
A blank or "-" in the column of "Classification" denotes that a classification for the hazard class was not conducted in the year.
An asterisk “*” in the column of “Classification” denotes that “Not classified (or No applicable)” and/or “Classification not possible” is applicable. Details are described in the column of “Rationale for the classification”. If no English translation is available for “Rationale for the classification,” please refer to the Japanese version of the results.

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