NITE - Chemical Management Field

Latest GHS Classification Results by the Japanese Government (edited by NITE)

GENERAL INFORMATION

Item	Information
CAS RN	680-31-9
Chemical Name	hexamethylphosphoric triamide
Substance ID	m-nite-680-31-9_v1
Download of Excel format	Excel file

REFERENCE INFORMATION

Item	Information
Guidance used for the classification (External link)	To Guidance List
UN GHS document (External link)	To UN GHS document
FAQ（GHS classification results by the Japanese Government）	To FAQ
List of Information Sources (Excel file)	List of Information Sources
List of Definitions/Abbreviations	Definitions/Abbreviations
Sample Label by MHLW (External link)	MHLW Website (in Japanese Only)
Sample SDS by MHLW (External link)	MHLW Website (in Japanese Only)
OECD/eChemPortal (External link)	To OECD/eChemPortal (External link)

PHYSICAL HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification	Classification year (FY)	GHS Classification Guidance for the Japanese Government
1	Explosives	Not classified (Not applicable)	- -	-	-	There are no chemical groups associated with explosive properties present in the molecules.	FY2006	GHS Classification Manual （10 Feb, 2006）
2	Flammable gases	Not classified (Not applicable)	- -	-	-	Liquid (GHS definition)	FY2006	GHS Classification Manual （10 Feb, 2006）
3	Aerosols	Not classified (Not applicable)	- -	-	-	Not aerosol products	FY2006	GHS Classification Manual （10 Feb, 2006）
4	Oxidizing gases	Not classified (Not applicable)	- -	-	-	Liquid (GHS definition)	FY2006	GHS Classification Manual （10 Feb, 2006）
5	Gases under pressure	Not classified (Not applicable)	- -	-	-	Liquid (GHS definition)	FY2006	GHS Classification Manual （10 Feb, 2006）
6	Flammable liquids	Not classified	- -	-	-	Flash point: >93degC	FY2006	GHS Classification Manual （10 Feb, 2006）
7	Flammable solids	Not classified (Not applicable)	- -	-	-	Liquid (GHS definition)	FY2006	GHS Classification Manual （10 Feb, 2006）
8	Self-reactive substances and mixtures	Not classified (Not applicable)	- -	-	-	There are no chemical groups associated with explosive or self-reactive properties present in the molecule.	FY2006	GHS Classification Manual （10 Feb, 2006）
9	Pyrophoric liquids	Classification not possible	- -	-	-	No data available	FY2006	GHS Classification Manual （10 Feb, 2006）
10	Pyrophoric solids	Not classified (Not applicable)	- -	-	-	Liquid (GHS definition)	FY2006	GHS Classification Manual （10 Feb, 2006）
11	Self-heating substances and mixtures	Classification not possible	- -	-	-	Test methods applicable to liquid substances are not available	FY2006	GHS Classification Manual （10 Feb, 2006）
12	Substances and mixtures which, in contact with water, emit flammable gases	Classification not possible	- -	-	-	No data available	FY2006	GHS Classification Manual （10 Feb, 2006）
13	Oxidizing liquids	Classification not possible	- -	-	-	No data available	FY2006	GHS Classification Manual （10 Feb, 2006）
14	Oxidizing solids	Not classified (Not applicable)	- -	-	-	Liquid (GHS definition)	FY2006	GHS Classification Manual （10 Feb, 2006）
15	Organic peroxides	Not classified (Not applicable)	- -	-	-	Containing no -0-0- structure	FY2006	GHS Classification Manual （10 Feb, 2006）
16	Corrosive to metals	Classification not possible	- -	-	-	No data available	FY2006	GHS Classification Manual （10 Feb, 2006）
17	Desensitized explosives	-	- -	-	-	-	-	-

HEALTH HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification	Classification year (FY)	GHS Classification Guidance for the Japanese Government
1	Acute toxicity (Oral)	-	- Warning	-	-	Category 5 based on SPECIES: Rat; ENDPOINT: LD50; VALUE: :2650mg/kg; (male), 3360mg/kg; (female) REFERENCE SOURCE: ACGIH (7th, 2001) and IARC Vol. 15 (1977)	FY2006	GHS Classification Manual （10 Feb, 2006）
1	Acute toxicity (Dermal)	-	- Warning	-	-	It was set as Category 5 based on rabbit LD50 value: 2600mg/kg (ACGIH (7th, 2001) and IARC Vol.15 (1977)).	FY2006	GHS Classification Manual （10 Feb, 2006）
1	Acute toxicity (Inhalation: Gases)	Not classified (Not applicable)	- -	-	-	Liquid (GHS definition)	FY2006	GHS Classification Manual （10 Feb, 2006）
1	Acute toxicity (Inhalation: Vapours)	Classification not possible	- -	-	-	No data available	FY2006	GHS Classification Manual （10 Feb, 2006）
1	Acute toxicity (Inhalation: Dusts and mists)	Classification not possible	- -	-	-	Classification not possible due to lack of data	FY2006	GHS Classification Manual （10 Feb, 2006）
2	Skin corrosion/irritation	Category 2	Warning	H315	P302+P352 P332+P313 P362+P364 P264 P280 P321	Based on description that there was severe irritation in the skin irritation test in guinea pigs (RTECS (2005)), and description that it might indicate irritation when the human skin were touched (HSFS (2001)), it was set as Category 2.	FY2006	GHS Classification Manual （10 Feb, 2006）
3	Serious eye damage/eye irritation	Classification not possible	- -	-	-	Insufficient data available.	FY2006	GHS Classification Manual （10 Feb, 2006）
4	Respiratory sensitization	Classification not possible	- -	-	-	No data available	FY2006	GHS Classification Manual （10 Feb, 2006）
4	Skin sensitization	Classification not possible	- -	-	-	No data available	FY2006	GHS Classification Manual （10 Feb, 2006）
5	Germ cell mutagenicity	Category 1B	Danger	H340	P308+P313 P201 P202 P280 P405 P501	There is positive finding (IARC Vol. 15 (1977), IARC Vol. 71 (1999)) by the dominant lethal test using a mouse (rodent), and the classification in EU ANNEX I (2005) into Category 2; R46. So it is set as Category 1B.	FY2006	GHS Classification Manual （10 Feb, 2006）
6	Carcinogenicity	Category 2	Warning	H351	P308+P313 P201 P202 P280 P405 P501	It was classified into the category 2 in EU (EU ANNEX I (2005)). But it was classified into 2B in IARC (IARC 71 (1999)) and in Japan Assoc. of Industrial Health (industrial hygene academic society recommentation, 2005), A3 in ACGIH (ACGIH (7th, 2001)), and R in NTP (NTP RoC (11th, 2005)). So it was considered as Category 2.	FY2006	GHS Classification Manual （10 Feb, 2006）
7	Reproductive toxicity	Category 2	Warning	H361	P308+P313 P201 P202 P280 P405 P501	There is the description that in ACGIH (7th, 2001), "testicular atrophy and aspermia happen by oral administration to rat", in IARC Vol.15 (1977), "azoospermia, testes weight loss and gonad cell destruction are observed at the observation period for 23 weeks after 500mg/kg/day carries out repetitive oral administration for six days to rat." In addition, it was considered as category 2 based on the description that as human impact, to HSFS (2001) "a teste (males gonadal) may be destroyed", and the description that "a male teste is damaged and there is limited evidence to which it is supposed that spermatogenesis may be affected" in SITTIG (4th, 2002).	FY2006	GHS Classification Manual （10 Feb, 2006）
8	Specific target organ toxicity - Single exposure	Category 2 (respiratory system, kidney, central nervous system)	Warning	H371	P308+P311 P260 P264 P270 P405 P501	As effects on humans, based on a description that "lungs, kidneys, and central nervous systems are affected and then functional disorder and functional fall may be caused"(ICSC (J) (1994)), and on a description taht "noses and throats may be stimulated by inhalation"(HSFS (2001)), and on a description taht "noses, throats, and lungs are stimulated and damaged and nasal discharges may be caused and lungs can be changed through exposure"(SITTIG (4th, 2002)). So it was judged as Category 2 (respiratory systems, kidneys, central nervous systems).	FY2006	GHS Classification Manual （10 Feb, 2006）
9	Specific target organ toxicity - Repeated exposure	Category 1 (respiratory organs), Category 2 (kidney)	Danger Warning	H372 H373	P260 P264 P270 P314 P501	We have the description that the degeneration of the kidney nephric tubule epithelium was observed with 0.4 ppm exposure in the guidance value range of Category 2 in the three-month inhalation exposure test in the rat (ACGIH 7th, 2001), description that respiratory mucosal and lung dysfunction were observed with the dose in the guidance value range of Category 1 in the 6-to-24-month inhalation exposure test for the rat (IARC 71 (1999)), and the description that in the feeding administration tests for 52 to 72 days in the rat, bronchial mucosas damage was observed with just about the dose of the guidance value range of Category 2. Moreover, as the impact on human, there is a description that "respiratory tract, the kidney, and marrow may be affected"(ICSC (J) (1994)), and there's a description that the respiratory system is affected (HSFS (2001)), and there was description that it might effect on the kidney, lungs, and the respiratory tract (STIIG (4th, 2002)), therefore the target organs of this product were judged to be respiratory systems and the kidney, so we classified it as Category 1 and 2, respectively. In addition, for marrow, neither animal data nor the clinical case reports was clear.	FY2006	GHS Classification Manual （10 Feb, 2006）
10	Aspiration hazard	Classification not possible	- -	-	-	No data available	FY2006	GHS Classification Manual （10 Feb, 2006）

ENVIRONMENTAL HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification	Classification year (FY)	GHS Classification Guidance for the Japanese Government
11	Hazardous to the aquatic environment Short term (Acute)	Not classified	- -	-	-	It carried out the outside of Category from 48-hour LC50=6670000microg/L of Crustacea (Daphnia magna) (AQUIRE, 2003).	FY2006	GHS Classification Manual （10 Feb, 2006）
11	Hazardous to the aquatic environment Long term (Chronic)	Not classified	- -	-	-	Since not water-insoluble (water solubility=1.00*106mg/L(PHYSPROP Database, 2005)) and acute toxicity is low.	FY2006	GHS Classification Manual （10 Feb, 2006）
12	Hazardous to the ozone layer	-	- -	-	-	-	-	-

NOTE:

GHS Classification Result by the Japanese Government is intended to provide a reference for preparing a GHS label or SDS for users. To include the same classification result in a label or SDS for Japan is NOT mandatory.
Users can cite or copy this classification result when preparing a GHS label or SDS. Please be aware, however, that the responsibility for a label or SDS prepared by citing or copying this classification result lies with users.
This GHS classification was conducted based on the information sources and the guidance for classification and judgement which are described in the GHS Classification Guidance for the Japanese Government etc. Using other literature, test results etc. as evidence and including different content from this classification result in a label or SDS are allowed.
Hazard statement and precautionary statement will show by hovering the mouse cursor over a code in the column of "Hazard statement" and "Precautionary statement," respectively. In the excel file, both the codes and statements are provided.
A blank or "-" in the column of "Classification" denotes that a classification for the hazard class was not conducted in the year.
An asterisk “*” in the column of “Classification” denotes that “Not classified (or No applicable)” and/or “Classification not possible” is applicable. Details are described in the column of “Rationale for the classification”. If no English translation is available for “Rationale for the classification,” please refer to the Japanese version of the results.

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