NITE - Chemical Management Field

Latest GHS Classification Results by the Japanese Government (edited by NITE)

GENERAL INFORMATION

Item	Information
CAS RN	681-84-5
Chemical Name	Tetramethyl silicate
Substance ID	m-nite-681-84-5_v1
Download of Excel format	Excel file

REFERENCE INFORMATION

Item	Information
Guidance used for the classification (External link)	To Guidance List
UN GHS document (External link)	To UN GHS document
FAQ（GHS classification results by the Japanese Government）	To FAQ
List of Information Sources (Excel file)	List of Information Sources
List of Definitions/Abbreviations	Definitions/Abbreviations
Sample Label by MHLW (External link)	MHLW Website (in Japanese Only)
Sample SDS by MHLW (External link)	MHLW Website (in Japanese Only)
OECD/eChemPortal (External link)	To OECD/eChemPortal (External link)

PHYSICAL HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification	Classification year (FY)	GHS Classification Guidance for the Japanese Government
1	Explosives	Not classified (Not applicable)	- -	-	-	There are no chemical groups associated with explosive properties present in the molecule.	FY2010	GHS Classification Guidance by the Japanese Government （July, 2010）
2	Flammable gases	Not classified (Not applicable)	- -	-	-	Liquid (GHS definition)	FY2010	GHS Classification Guidance by the Japanese Government （July, 2010）
3	Aerosols	Not classified (Not applicable)	- -	-	-	Not aerosol products.	FY2010	GHS Classification Guidance by the Japanese Government （July, 2010）
4	Oxidizing gases	Not classified (Not applicable)	- -	-	-	Liquid (GHS definition)	FY2010	GHS Classification Guidance by the Japanese Government （July, 2010）
5	Gases under pressure	Not classified (Not applicable)	- -	-	-	Liquid (GHS definition)	FY2010	GHS Classification Guidance by the Japanese Government （July, 2010）
6	Flammable liquids	Category 2	Danger	H225	P303+P361+P353 P370+P378 P403+P235 P210 P233 P240 P241 P242 P243 P280 P501	Based on the reports of flash point 20 degC (closed-cup) (ICSC (J) (1997)), which is < 23 degC, and initial boiling point 121 degC (ICSC (J) (1997)), it is classified into Category 2.	FY2010	GHS Classification Guidance by the Japanese Government （July, 2010）
7	Flammable solids	Not classified (Not applicable)	- -	-	-	Liquid (GHS definition)	FY2010	GHS Classification Guidance by the Japanese Government （July, 2010）
8	Self-reactive substances and mixtures	Not classified (Not applicable)	- -	-	-	There are no chemical groups present in the molecule associated with explosive or self-reactive properties.	FY2010	GHS Classification Guidance by the Japanese Government （July, 2010）
9	Pyrophoric liquids	Classification not possible	- -	-	-	No data available.	FY2010	GHS Classification Guidance by the Japanese Government （July, 2010）
10	Pyrophoric solids	Not classified (Not applicable)	- -	-	-	Liquid (GHS definition)	FY2010	GHS Classification Guidance by the Japanese Government （July, 2010）
11	Self-heating substances and mixtures	Classification not possible	- -	-	-	Test methods applicable to liquid substances are not available.	FY2010	GHS Classification Guidance by the Japanese Government （July, 2010）
12	Substances and mixtures which, in contact with water, emit flammable gases	Classification not possible	- -	-	-	Classification is not possible since no data are available though the substance contains a metalloid (Si).	FY2010	GHS Classification Guidance by the Japanese Government （July, 2010）
13	Oxidizing liquids	Classification not possible	- -	-	-	Classification is not possible since no data are available though the substance is an organic compound containing oxygen which is chemically bonded to the elements other than carbon or hydrogen.	FY2010	GHS Classification Guidance by the Japanese Government （July, 2010）
14	Oxidizing solids	Not classified (Not applicable)	- -	-	-	Liquid (GHS definition)	FY2010	GHS Classification Guidance by the Japanese Government （July, 2010）
15	Organic peroxides	Not classified (Not applicable)	- -	-	-	Organic compounds containing no bivalent -O-O- structure in the molecule	FY2010	GHS Classification Guidance by the Japanese Government （July, 2010）
16	Corrosive to metals	Classification not possible	- -	-	-	No data available.	FY2010	GHS Classification Guidance by the Japanese Government （July, 2010）
17	Desensitized explosives	-	- -	-	-	-	-	-

HEALTH HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification	Classification year (FY)	GHS Classification Guidance for the Japanese Government
1	Acute toxicity (Oral)	Classification not possible	- -	-	-	The description that 700 mg/kg was the lethal dose for rats was reported (Assessment report in Holland (2004)). Since the category could not be specified from the data only, the classification was not possible.	FY2010	GHS Classification Guidance by the Japanese Government （July, 2010）
1	Acute toxicity (Dermal)	Not classified	- -	-	-	Based on the rabbit LD50 value of 17400 mg/kg (Assessment report in Holland (2004)), the substance was classified as "Not classified".	FY2010	GHS Classification Guidance by the Japanese Government （July, 2010）
1	Acute toxicity (Inhalation: Gases)	Not classified (Not applicable)	- -	-	-	Liquid (GHS definition)	FY2010	GHS Classification Guidance by the Japanese Government （July, 2010）
1	Acute toxicity (Inhalation: Vapours)	Category 1	Danger	H330	P304+P340 P403+P233 P260 P271 P284 P310 P320 P405 P501	Based on the rat LC50 value (4-hour) of 53 ppm (0.335 mg/L) (Assessment report in Holland (2004)), the substance was classified as Category 1. Since the test concentration (53 ppm) was lower than 90% of the saturated vapor pressure concentration (2800 ppm), the criterion values for gas were adopted. In addition, the rat LC50 value of 125 - 250 ppm (ACGIH (2001)) was reported in the "List 1" information source designated in the GHS classification guidance for the Japanese government. However, since it was the results of the range-finding study and the year of the report was as old as 1951, the datum was not adopted as the basis of the classification.	FY2010	GHS Classification Guidance by the Japanese Government （July, 2010）
1	Acute toxicity (Inhalation: Dusts and mists)	Classification not possible	- -	-	-	No data available.	FY2010	GHS Classification Guidance by the Japanese Government （July, 2010）
2	Skin corrosion/irritation	Classification not possible	- -	-	-	In the rabbit test, 30-minute application of the substance caused slight erythema, but substantial injury was not observed (Assessment report in Holland (2004)). The substance was classified as "Classification not possible" because no other data were available.	FY2010	GHS Classification Guidance by the Japanese Government （July, 2010）
3	Serious eye damage/eye irritation	Category 1	Danger	H318	P305+P351+P338 P280 P310	Instillation of the substance to rabbit eyes caused edema and necrosis of the eyelid, and the substance was concluded as very severe eye irritant (ACGIH (2001)). In another test, instillation of the substance caused inducing of burn, following inflammation of the eyelids, edema of the mucous membrane, necrosis of the iris, and opacity of the cornea (Assessment report in Holland (2004)). In another rabbit test, irritation index score was 9 by grading according to 10 ranks (Assessment report in Holland (2004)). In the industrial experience, both in the United States and Europe, it was confirmed that the severe ocular hazard by the substance ranging from eye pain to blindness (ACGIH (2001)). Based on the information, the substance was classified as Category 1.	FY2010	GHS Classification Guidance by the Japanese Government （July, 2010）
4	Respiratory sensitization	Classification not possible	- -	-	-	No data available.	FY2010	GHS Classification Guidance by the Japanese Government （July, 2010）
4	Skin sensitization	Classification not possible	- -	-	-	No data available.	FY2010	GHS Classification Guidance by the Japanese Government （July, 2010）
5	Germ cell mutagenicity	Classification not possible	- -	-	-	No data available.	FY2010	GHS Classification Guidance by the Japanese Government （July, 2010）
6	Carcinogenicity	Classification not possible	- -	-	-	No data available.	FY2010	GHS Classification Guidance by the Japanese Government （July, 2010）
7	Reproductive toxicity	Classification not possible	- -	-	-	No data available.	FY2010	GHS Classification Guidance by the Japanese Government （July, 2010）
8	Specific target organ toxicity - Single exposure	Category 2 (lung)	Warning	H371	P308+P311 P260 P264 P270 P405 P501	In the inhalation study (0.195 - 0.555 mg/L/4hrs) in rats, it was reported that the main findings at necropsy were pulmonary injuries which varied from diffuse small lesions extending to all lobes (Assessment report in Holland (2004)). And it was reported that pulmonary edema and histological abnormalities in the lung were found by inhalation exposure to guinea pigs at 0.63 mg/L/4hrs (Assessment report in Holland (2004)). It was also reported that pneumonitis was observed at concentrations of 7.63 to 13.2 mg/L/4hrs in the inhalation study in rabbits, and hemorrhagic and edematous changes were found in the wide area of the lung (Assessment report in Holland (2004)). Although the results described above corresponded to Category 1 judging from the guidance values, the information was obtained from the "List 2" information source designated in the GHS classification guidance for the Japanese government, and all of the studies were not in accordance with OECD TG and not GLP-compliant. Thus, the substance was classified as Category 2 (lung). In addition, it was reported that renal disturbances were found at 700 mg/kg in the oral dose study in rats (Assessment report in Holland (2004)), however, the dose level was lethal and no descriptions of histopathological findings were given. Therefore, the information was not adopted as the evidence to classify.	FY2010	GHS Classification Guidance by the Japanese Government （July, 2010）
9	Specific target organ toxicity - Repeated exposure	Category 1 (respiratory organs), Category 2 (kidney)	Danger Warning	H372 H373	P260 P264 P270 P314 P501	In the 28-day inhalation exposure study in rats, occurrence of the inflammatory changes of upper respiratory tract and bronchial tubes accompanied by severe pulmonary disease was seen at 0.187 mg/L (converted concentration as that of 90-day study: 0.058 mg/L) (ACGIH (2001)). As the effects of inhalation exposure to guinea pigs, hemorrhages and edema in the lungs were reported in addition to ocular changes (Assessment report in Holland (2004)). Since the effects in rats were observed within the dose range of Category 1 of the guidance values, the substance was classified as Category 1 (respiratory organs). Moreover, it was reported that renal disturbances were reported as toxic effect at the dose range of 40 - 240 mg/kg (converted dose level as that of 90-day study: 13.3 - 80 mg/kg/day) in the 30-day oral dose study in guinea pigs (Assessment report in Holland (2004)), and that the kidney was listed in one of the target organs of the substance (NIOSH Pocket Guide to Chemical Hazards (2005)). As described above, since the effective dose levels in the oral administration corresponded to Category 2, the substance was classified as Category 2 (kidney). In addition, ocular lesions were reported in the inhalation exposure studies in both rats and guinea pigs (Assessment report in Holland (2004)), however, they were considered as local effects, and Category 1 as a hazard class of serious eye damage/eye irritation was adopted. Thus, they were not evidenced to classify in this hazard class.	FY2010	GHS Classification Guidance by the Japanese Government （July, 2010）
10	Aspiration hazard	Classification not possible	- -	-	-	No data available.	FY2010	GHS Classification Guidance by the Japanese Government （July, 2010）

ENVIRONMENTAL HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification	Classification year (FY)	GHS Classification Guidance for the Japanese Government
11	Hazardous to the aquatic environment Short term (Acute)	Classification not possible	- -	-	-	No data available.	FY2010	GHS Classification Guidance by the Japanese Government （July, 2010）
11	Hazardous to the aquatic environment Long term (Chronic)	Classification not possible	- -	-	-	No data available.	FY2010	GHS Classification Guidance by the Japanese Government （July, 2010）
12	Hazardous to the ozone layer	Classification not possible	- -	-	-	This substance is not listed in Annexes to the Montreal Protocol.	FY2010	GHS Classification Guidance by the Japanese Government （July, 2010）

NOTE:

GHS Classification Result by the Japanese Government is intended to provide a reference for preparing a GHS label or SDS for users. To include the same classification result in a label or SDS for Japan is NOT mandatory.
Users can cite or copy this classification result when preparing a GHS label or SDS. Please be aware, however, that the responsibility for a label or SDS prepared by citing or copying this classification result lies with users.
This GHS classification was conducted based on the information sources and the guidance for classification and judgement which are described in the GHS Classification Guidance for the Japanese Government etc. Using other literature, test results etc. as evidence and including different content from this classification result in a label or SDS are allowed.
Hazard statement and precautionary statement will show by hovering the mouse cursor over a code in the column of "Hazard statement" and "Precautionary statement," respectively. In the excel file, both the codes and statements are provided.
A blank or "-" in the column of "Classification" denotes that a classification for the hazard class was not conducted in the year.
An asterisk “*” in the column of “Classification” denotes that “Not classified (or No applicable)” and/or “Classification not possible” is applicable. Details are described in the column of “Rationale for the classification”. If no English translation is available for “Rationale for the classification,” please refer to the Japanese version of the results.

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