NITE - Chemical Management Field

Latest GHS Classification Results by the Japanese Government (edited by NITE)

GENERAL INFORMATION

Item	Information
CAS RN	68157-60-8
Chemical Name	1-(2-Chloro-4-pyridyl)-3-phenylurea; Forchlorfenuron
Substance ID	m-nite-68157-60-8_v1
Download of Excel format	Excel file

REFERENCE INFORMATION

Item	Information
Guidance used for the classification (External link)	To Guidance List
UN GHS document (External link)	To UN GHS document
FAQ（GHS classification results by the Japanese Government）	To FAQ
List of Information Sources (Excel file)	List of Information Sources
List of Definitions/Abbreviations	Definitions/Abbreviations
Sample Label by MHLW (External link)	MHLW Website (in Japanese Only)
Sample SDS by MHLW (External link)	MHLW Website (in Japanese Only)
OECD/eChemPortal (External link)	To OECD/eChemPortal (External link)

PHYSICAL HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification	Classification year (FY)	GHS Classification Guidance for the Japanese Government
1	Explosives	Not classified (Not applicable)	- -	-	-	There are no chemical groups associated with explosive properties present in the molecule. It was classified as "Not classified (Not applicable)."	FY2019	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
2	Flammable gases	Not classified (Not applicable)	- -	-	-	Solid (GHS definition). It was classified as "Not classified (Not applicable)."	FY2019	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
3	Aerosols	Not classified (Not applicable)	- -	-	-	Not aerosol products. It was classified as "Not classified (Not applicable)."	FY2019	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
4	Oxidizing gases	Not classified (Not applicable)	- -	-	-	Solid (GHS definition). It was classified as "Not classified (Not applicable)."	FY2019	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
5	Gases under pressure	Not classified (Not applicable)	- -	-	-	Solid (GHS definition). It was classified as "Not classified (Not applicable)."	FY2019	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
6	Flammable liquids	Not classified (Not applicable)	- -	-	-	Solid (GHS definition). It was classified as "Not classified (Not applicable)."	FY2019	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
7	Flammable solids	Classification not possible	- -	-	-	No data available. Besides, there is information that it is combustible (GESTIS (Access on June 2019)).	FY2019	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
8	Self-reactive substances and mixtures	Not classified (Not applicable)	- -	-	-	There are no chemical groups associated with explosive or self-reactive properties present in the molecule. It was classified as "Not classified (Not applicable)."	FY2019	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
9	Pyrophoric liquids	Not classified (Not applicable)	- -	-	-	Solid (GHS definition). It was classified as "Not classified (Not applicable)."	FY2019	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
10	Pyrophoric solids	Classification not possible	- -	-	-	No data available.	FY2019	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
11	Self-heating substances and mixtures	Classification not possible	- -	-	-	No data available.	FY2019	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
12	Substances and mixtures which, in contact with water, emit flammable gases	Not classified (Not applicable)	- -	-	-	The chemical structure of the substance does not contain metals or metalloids (B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At). It was classified as "Not classified (Not applicable)."	FY2019	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
13	Oxidizing liquids	Not classified (Not applicable)	- -	-	-	Solid (GHS definition). It was classified as "Not classified (Not applicable)."	FY2019	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
14	Oxidizing solids	Not classified (Not applicable)	- -	-	-	The substance is an organic compound containing chlorine and oxygen (but not fluorine) which are chemically bonded only to carbon or hydrogen. It was classified as "Not classified (Not applicable)."	FY2019	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
15	Organic peroxides	Not classified (Not applicable)	- -	-	-	Organic compounds containing no bivalent -O-O- structure in the molecule. It was classified as "Not classified (Not applicable)."	FY2019	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
16	Corrosive to metals	Classification not possible	- -	-	-	Classification is not possible because test methods applicable to solid substances are not available.	FY2019	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
17	Desensitized explosives	Not classified	- -	-	-	There are no chemical groups associated with explosive properties present in the molecule. It was classified as "Not classified."	FY2019	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))

HEALTH HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification	Classification year (FY)	GHS Classification Guidance for the Japanese Government
1	Acute toxicity (Oral)	Not classified	- -	-	-	[Rationale for the Classification] Based on (1) and (2), it was classified as "Not classified." [Evidence Data] (1) LD50 for rats: male: 4,904 mg/kg, female: 4,899 mg/kg (EPA Pesticide (2004)) (2) LD50 for rats: 4,917 mg/kg (EC Draft Renewal Assessment Report (2016))	FY2019	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
1	Acute toxicity (Dermal)	Not classified	- -	-	-	[Rationale for the Classification] Based on (1), it was classified as "Not classified." [Evidence Data] (1) LD50 for rabbits: > 2,000 mg/kg (EPA Pesticide (2004), EC Draft Renewal Assessment Report (2016))	FY2019	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
1	Acute toxicity (Inhalation: Gases)	Not classified (Not applicable)	- -	-	-	[Rationale for the Classification] Solid (GHS definition). It was classified as "Not classified (Not applicable)."	FY2019	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
1	Acute toxicity (Inhalation: Vapours)	Classification not possible	- -	-	-	[Rationale for the Classification] Classification not possible due to lack of data.	FY2019	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
1	Acute toxicity (Inhalation: Dusts and mists)	Classification not possible	- -	-	-	[Rationale for the Classification] Based on (1), it was impossible to determine the category. Therefore, it was classified as "Classification not possible." [Evidence Data] (1) LC50 for rats: > 3.0 mg/L (EPA Pesticide (2004), EC Draft Renewal Assessment Report (2016))	FY2019	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
2	Skin corrosion/irritation	Not classified	- -	-	-	[Rationale for the Classification] Based on (1) and (2), it was classified as "Not classified." [Evidence Data] (1) In a skin irritation test in which 500 mg of this substance was applied semi-occlusively to the skin of rabbits for 4 hours, no symptoms of erythema, edema and so on were observed. Therefore, it was determined not to be an irritant to the skin (Japanese Journal of Pesticide Science Vol. 23, No.2 (Japan Crop Protection Association, 1998)). (2) In a test with rabbits, no irritation was observed (EPA Pesticide (2004)).	FY2019	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
3	Serious eye damage/eye irritation	Category 2B	- Warning	H320	P305+P351+P338 P337+P313 P264	[Rationale for the Classification] Based on (1) and (2), it was classified in Category 2B. [Evidence Data] (1) In an eye irritation test with rabbits, although irritative changes on the cornea and the iris were observed, these effects disappeared after 72 hours. Redness and edema on the conjunctiva were observed after 1 hour of administration, but, these signs disappeared after 72 hours. Therefore, this substance was irritating to the ocular-mucous membrane (Japanese Journal of Pesticide Science Vol. 23, No.2 (Japan Crop Protection Association, 1998)). (2) In a test with rabbits, mild irritation was observed (EPA Pesticide (2004)).	FY2019	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
4	Respiratory sensitization	Classification not possible	- -	-	-	[Rationale for the Classification] Classification not possible due to lack of data.	FY2019	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
4	Skin sensitization	Not classified	- -	-	-	[Rationale for the Classification] Based on (1) and (2), it was classified as "Not classified." [Evidence Data] (1) In a skin sensitization test (Maximization method, details unknown) with guinea pigs, no significant changes on the skin were observed, and it was determined to be negative (Japanese Journal of Pesticide Science Vol. 23, No.2 (Japan Crop Protection Association, 1998)). (2) In a test with guinea pigs, there is a report of a negative result (EPA Pesticide (2004)).	FY2019	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
5	Germ cell mutagenicity	Not classified	- -	-	-	[Rationale for the Classification] Based on (1) and (2), although positive findings were observed in some in vitro tests, negative results were shown in other in vitro and in vivo tests. According to expert judgments, this substance was classified as "Not classified." [Evidence Data] (1) As for in vivo, a mouse bone marrow micronucleus test and a rat hepatocyte unscheduled DNA synthesis test showed negative results (Japanese Journal of Pesticide Science Vol. 23, No.2 (Japan Crop Protection Association, 1998), EC Draft Renewal Assessment Report (2016)). (2) As for in vitro, bacterial reverse mutation tests and an in vitro mammalian cell chromosomal aberration test showed negative or positive results. On the other hand, an unscheduled DNA synthesis test by using primary cultures of rat liver cells showed a negative result (HSDB (Access on June 2019), Japanese Journal of Pesticide Science Vol. 23, No.2 (Japan Crop Protection Association, 1998), EC Draft Renewal Assessment Report (2016)).	FY2019	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
6	Carcinogenicity	Category 2	Warning	H351	P308+P313 P201 P202 P280 P405 P501	[Rationale for the Classification] Based on (2) and (3), test results of two animal species were negative, however, there are existing classification results in (1) and a report in (4) of an increase in the incidence of kidney tumors in mice in a test conducted in Japan. Therefore, this substance was classified in Category 2. [Evidence Data] (1) According to classification results by domestic and international organizations, it was classified as Carc.2 in EU CLP classification (EU CLP classification (Access on June 2019)). (2) In a 2-year toxicity test with rats dosed by feeding at the highest dosage of 7,500 ppm (male: 352 mg/kg/day, female: 518 mg/kg/day), no increase in the incidence of tumors was observed (EPA Pesticide (2004)). (3) In an 18-month toxicity test with mice dosed by feeding at up to 1,000 mg/kg/day, no increase in the incidence of tumors was observed (EPA Pesticide (2004)). (4) In a 2-year toxicity test with rats and mice by feeding, no incidence of tumors in rats was observed, however, in mice, an increase in the incidence of renal cortical epithelial tumors at a dosage of 10,000 ppm was observed in male (Japanese Journal of Pesticide Science Vol. 23, No.2 (Japan Crop Protection Association, 1998)).	FY2019	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
7	Reproductive toxicity	Category 2	Warning	H361	P308+P313 P201 P202 P280 P405 P501	[Rationale for the Classification] Based on (1) and (2), no reproductive toxicity was observed in 2-generation reproductive toxicity tests. Based on (3) and (4), there was no teratogenicity, but an increase in embryo resorption and a decrease in the number of live fetuses were observed at doses with maternal toxicity. Therefore, it was classified in Category 2. [Evidence Data] (1) In a two-generation reproductive toxicity test with rats by the oral route, there was parental toxicity (reduced body weight gain and so on), but no reproductive toxicity (Japanese Journal of Pesticide Science Vol. 23, No.2 (Japan Crop Protection Association, 1998)). (2) In a two-generation reproductive toxicity test with rats by the oral route, increased kidney weight, suppurative inflammation, cysts, suppurative pyelonephritis and interstitial nephritis in the kidney were observed in parental animals, and a decrease in pup viability was observed, but there was no reproductive toxicity (HSDB (Access on June 2019)). (3) In a developmental toxicity test in which this substance was administered daily by oral gavage to female rats on Days 6 through 15 of gestation, early and late embryo resorptions, a decrease in fetal body weight, unossified sternebra and reduced ossification of the 13th ribs were found at the dose where mortality (1/25 cases), lethargy, ataxia, scabbing on the abdomen and hind limb, transparent eyes and lower body weight were observed in maternal animals. There was no teratogenicity (HSDB (Access on June 2019)). (4) In a developmental toxicity test in which this substance was orally administered to female rabbits on Days 6 through 18 of gestation, abortion (2 cases), an increase in embryonic mortality and a trend toward a decrease in the number of live fetuses were found at the dose where decreases in body weight and feed consumption were observed in maternal animals. There was no teratogenicity (Japanese Journal of Pesticide Science Vol. 23, No.2 (Japan Crop Protection Association, 1998)).	FY2019	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
8	Specific target organ toxicity - Single exposure	Category 2 (central nervous system), Category 3 (respiratory tract irritation)	Warning	H371 H335	P308+P311 P260 P264 P270 P405 P501 P304+P340 P403+P233 P261 P271 P312	[Rationale for the Classification] There was no report on single exposure in humans. Based on information in (1) and (2) in experimental animals, it was classified in Category 2 (central nervous system) and Category 3 (respiratory tract irritation). There were reference data in (3) in which effects on the central nervous system were suggested, however, these data were not adopted as classification rationale due to unclear descriptions of dosages and administration routes. [Evidence Data] (1) In a single dose toxicity test with rats and mice, loss of reflex to sounds and contacts, decreased locomotor activity, rollover, lateral position, supine position, prone position, clonic convulsion, hypothermia, salivation, lacrimation with bloody secretions (eye), ptosis, closing eyelids and stained fur (Japanese Journal of Pesticide Science Vol. 23, No.2 (Japan Crop Protection Association, 1998)). There was no information on the doses where these effects were seen, but, they were supposed to be around LD50 (1,500-2,800 mg/kg, corresponding to or exceeding the range for Category 2). (2) In a single inhalation exposure test with rats, although the accurate exposure time was unknown, at an exposure concentration of 1.82 mg/L, reddened muzzle immediately after exposure to 1 day after exposure and discharges from the nostrils from 1 day after exposure to 5 days after exposure were observed (Japanese Journal of Pesticide Science Vol. 23, No.2 (Japan Crop Protection Association, 1998)). [Reference Data, etc.] (3) In a toxicity test by gavage or intravenous administration of a suspension of this substance in 0.3% CMC or a solution of this substance in 50% PEG-400 to male mice or male rats, decreased locomotor activity, anesthesia enhancing effects, analgesic effects and depressant effects of electro convulsion were observed as treatment-related effects. This substance was considered to affect the central nervous system suppressively. By behavior observations, decreased locomotor activity, gait abnormality and ptosis were observed in a dosage group of 1,000 mg/kg, and subsequently some test animals led to death. The cause of death was considered to be attributed to central nervous system suppression (Japanese Journal of Pesticide Science Vol. 23, No.2 (Japan Crop Protection Association, 1998)).	FY2019	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
9	Specific target organ toxicity - Repeated exposure	Classification not possible	- -	-	-	[Rationale for the Classification] Based on (1) to (3), it was classified as "Not classified" (oral). Besides, there was no information on other routes, therefore, classification was not possible due to lack of data. [Evidence Data] (1) In a 90-day toxicity test with mice dosed by feeding of this substance at 900-7,000 ppm, an increase or increasing tendency in bilirubin, increases in relative weight of the liver and kidney and an increased incidence of infiltration of lymphocytes into the interstitium and pelvis in the kidney were observed at 3,500 ppm or 7,000 ppm (converted guidance values: male: 609, 1,288 mg/kg/day, female: 788, 1,683 mg/kg/day, exceeding the range of Category 2) (HSDB (Access on June 2019)). (2) In a 90-day toxicity test with rats dosed by feeding of this substance at 200-5,000 ppm, an increase in liver weight was observed at 5,000 ppm (converted guidance value: 250 mg/kg/day, exceeding the range of Category 2) (HSDB (Access on June 2019)). (3) In a 24-month toxicity test with mice dosed by feeding of this substance at 50-10,000 ppm, proliferative lesions of the kidney and mild increases in adrenal subcapsular cell proliferation in males at or above 5,000 ppm (converted guidance value: 750 mg/kg/day, exceeding the range of Category 2), and atrophy and proliferative lesions including hyperplasia of the renal tubular epithelium in males at 10,000 ppm (converted guidance value: 750 mg/kg/day, exceeding the range of Category 2) were observed (Japanese Journal of Pesticide Science Vol. 23, No.2 (Japan Crop Protection Association, 1998)).	FY2019	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
10	Aspiration hazard	Classification not possible	- -	-	-	[Rationale for the Classification] Classification not possible due to lack of data.	FY2019	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))

ENVIRONMENTAL HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification	Classification year (FY)	GHS Classification Guidance for the Japanese Government
11	Hazardous to the aquatic environment Short term (Acute)	Category 2	- -	H401	P273 P501	It was classified in Category 2 from 48-hour EC50 = 5.3 mg/L for crustacea (Daphnia magna) (U.S. EPA OPP Pesticide Ecotoxicity Database, 2019).	FY2019	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
11	Hazardous to the aquatic environment Long term (Chronic)	Category 2	-	H411	P273 P391 P501	Reliable chronic toxicity data were not obtained. It was classified in Category 2 because it is not rapidly degradable (BIOWIN), and it was classified in Category 2 in acute toxicity.	FY2019	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
12	Hazardous to the ozone layer	Classification not possible	- -	-	-	Classification not possible due to lack of data.	FY2019	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))

NOTE:

GHS Classification Result by the Japanese Government is intended to provide a reference for preparing a GHS label or SDS for users. To include the same classification result in a label or SDS for Japan is NOT mandatory.
Users can cite or copy this classification result when preparing a GHS label or SDS. Please be aware, however, that the responsibility for a label or SDS prepared by citing or copying this classification result lies with users.
This GHS classification was conducted based on the information sources and the guidance for classification and judgement which are described in the GHS Classification Guidance for the Japanese Government etc. Using other literature, test results etc. as evidence and including different content from this classification result in a label or SDS are allowed.
Hazard statement and precautionary statement will show by hovering the mouse cursor over a code in the column of "Hazard statement" and "Precautionary statement," respectively. In the excel file, both the codes and statements are provided.
A blank or "-" in the column of "Classification" denotes that a classification for the hazard class was not conducted in the year.
An asterisk “*” in the column of “Classification” denotes that “Not classified (or No applicable)” and/or “Classification not possible” is applicable. Details are described in the column of “Rationale for the classification”. If no English translation is available for “Rationale for the classification,” please refer to the Japanese version of the results.

To GHS Information