NITE - Chemical Management Field

Latest GHS Classification Results by the Japanese Government (edited by NITE)

GENERAL INFORMATION

Item	Information
CAS RN	683-18-1
Chemical Name	Dibutyltin dichloride
Substance ID	m-nite-683-18-1_v1
Download of Excel format	Excel file

REFERENCE INFORMATION

Item	Information
Guidance used for the classification (External link)	To Guidance List
UN GHS document (External link)	To UN GHS document
FAQ（GHS classification results by the Japanese Government）	To FAQ
List of Information Sources (Excel file)	List of Information Sources
List of Definitions/Abbreviations	Definitions/Abbreviations
Sample Label by MHLW (External link)	MHLW Website (in Japanese Only)
Sample SDS by MHLW (External link)	MHLW Website (in Japanese Only)
OECD/eChemPortal (External link)	To OECD/eChemPortal (External link)

PHYSICAL HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification	Classification year (FY)	GHS Classification Guidance for the Japanese Government
1	Explosives	Not classified (Not applicable)	- -	-	-	There are no chemical groups associated with explosive properties present in the molecule.	FY2016	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
2	Flammable gases	Not classified (Not applicable)	- -	-	-	Solid (GHS definition).	FY2016	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
3	Aerosols	Not classified (Not applicable)	- -	-	-	Not aerosol products.	FY2016	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
4	Oxidizing gases	Not classified (Not applicable)	- -	-	-	Solid (GHS definition).	FY2016	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
5	Gases under pressure	Not classified (Not applicable)	- -	-	-	Solid (GHS definition).	FY2016	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
6	Flammable liquids	Not classified (Not applicable)	- -	-	-	Solid (GHS definition).	FY2016	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
7	Flammable solids	Classification not possible	- -	-	-	It is combustible (HSDB (Access on June 2016)), but the classification is not possible due to no data.	FY2016	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
8	Self-reactive substances and mixtures	Not classified (Not applicable)	- -	-	-	There are no chemical groups present in the molecule associated with explosive or self-reactive properties.	FY2016	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
9	Pyrophoric liquids	Not classified (Not applicable)	- -	-	-	Solid (GHS definition).	FY2016	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
10	Pyrophoric solids	Classification not possible	- -	-	-	No data available.	FY2016	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
11	Self-heating substances and mixtures	Classification not possible	- -	-	-	Test methods applicable to solid (melting point <= 140 deg C) substances are not available.	FY2016	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
12	Substances and mixtures which, in contact with water, emit flammable gases	Not classified	- -	-	-	It contains a metalloid (Sn), but it is estimated that it does not react vigorously with water because water solubility data of 92 mg/L was obtained (SRC (Access on June 2016)).	FY2016	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
13	Oxidizing liquids	Not classified (Not applicable)	- -	-	-	Solid (GHS definition).	FY2016	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
14	Oxidizing solids	Not classified (Not applicable)	- -	-	-	It contains chlorine, which is the anion of organotin salt and does not contribute to oxidation.	FY2016	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
15	Organic peroxides	Not classified (Not applicable)	- -	-	-	Organic compounds containing no bivalent -O-O- structure in the molecule	FY2016	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
16	Corrosive to metals	Classification not possible	- -	-	-	It is a solid substance with a melting point of 55 deg C or lower, but the classification is not possible due to no data.	FY2016	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
17	Desensitized explosives	-	- -	-	-	-	-	-

HEALTH HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification	Classification year (FY)	GHS Classification Guidance for the Japanese Government
1	Acute toxicity (Oral)	Category 3	Danger	H301	P301+P310 P264 P270 P321 P330 P405 P501	This substance was classified in Category 3 based on 3 reports of LD50 value of 58.28 mg/kg (SIDS (2009)), 100 mg/kg (PIM 586 (1994), HSDB (Access on June 2016)) and 219 mg/kg (SIDS (2009), CICAD 73 (2006)) for rats.	FY2016	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
1	Acute toxicity (Dermal)	Classification not possible	- -	-	-	Classification not possible due to lack of data.	FY2016	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
1	Acute toxicity (Inhalation: Gases)	Not classified (Not applicable)	- -	-	-	Solid (GHS definition)	FY2016	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
1	Acute toxicity (Inhalation: Vapours)	Not classified (Not applicable)	- -	-	-	Solid (GHS definition)	FY2016	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
1	Acute toxicity (Inhalation: Dusts and mists)	Category 2	Danger	H330	P304+P340 P403+P233 P260 P271 P284 P310 P320 P405 P501	Based on the report of LC50 value (4 hours) of 59 mg/m3 (SIDS (2009), CICAD 73 (2006)) for rats, this substance was classified in Category 2.	FY2016	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
2	Skin corrosion/irritation	Category 1	Danger	H314	P301+P330+P331 P303+P361+P353 P305+P351+P338 P304+P340 P260 P264 P280 P310 P321 P363 P405 P501	It is reported that this substance was highly irritating in a skin irritation test using rabbits (SIDS (2009)) and also corrosive in a dermal exposure test using rats (CICAD 73 (2006)). Irritation is also reported for humans (PIM 586 (1994), Environmental Risk Assessment for Chemical Substances Vol. 8 (Ministry of the Environment, 2010)), therefore, this substance was classified in Category 1.	FY2016	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
3	Serious eye damage/eye irritation	Category 1	Danger	H318	P305+P351+P338 P280 P310	Severe irritation was observed in an eye irritation test using rabbits (SIDS(2009)). Therefore, this substance was classified in Category 1.	FY2016	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
4	Respiratory sensitization	Classification not possible	- -	-	-	Classification not possible due to lack of data.	FY2016	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
4	Skin sensitization	Classification not possible	- -	-	-	Classification not possible due to lack of data.	FY2016	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
5	Germ cell mutagenicity	Category 2	Warning	H341	P308+P313 P201 P202 P280 P405 P501	As for in vivo, micronucleus tests using bone marrow cells of rats and mice were positive and negative (CICAD 73 (2006), Environmental Risk Assessment for Chemical Substances Vol.8 (Ministry of the Environment, 2010), SIDS (2009)). As for in vitro, the results of bacterial reverse mutation tests and in vitro mammalian cell gene mutation tests were positive or negative, and the chromosomal aberration test was positive (ATSDR (2005), CICAD 73 (2006), Environmental Risk Assessment for Chemical Substances Vol.8 (Ministry of the Environment, 2010), SIDS (2009)). Therefore, the substance was classified in Category 2 in accordance with the GHS classification guidance for the Japanese Government.	FY2016	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
6	Carcinogenicity	Classification not possible	- -	-	-	Since organotin compounds are classified in A4 by ACGIH (ACGIH (7th, 2001)), this substance was classified as "Classification not possible."	FY2016	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
7	Reproductive toxicity	Category 1B	Danger	H360	P308+P313 P201 P202 P280 P405 P501	As a result of dosing rats by feeding for 28 days including 2 weeks premating and mating for males and additionally through pregnancy and delivery and until the end of lactation for females, lower delivery index, decrease in the number of births, decrease in survival index and decrease in body weight gain in offsprings were observed at a dose where decrease in body weight gain (males and females), decrease in thymus weights and lymphocyte depletion (females), and an increase in ovarian cysts were observed in parent animals (Environmental Risk Assessment for Chemical Substances Vol.8 (Ministry of the Environment, 2010), SIDS (2009)). 　In addition, in multiple developmental toxicity studies using pregnant rats dosed in the organogenesis stage, an increase in post-implantation loss, a decrease in fetus body weight, and increases in the occurrence of various malformations such as external malformations (exencephalia, cleft of the mandible, cleft palate, ankyloglossia, umbilical hernia, etc.), skeletal malformations (fusion or absence of cervical or thoracic vertebral arches/bodies, fusion or absence of ribs, etc.), anophthalmia and microphthalmia etc. were observed in the fetus at less than or equal to the dose which suppressed body weight gain, a decrease in food consumption and some cases of death were observed in maternal animals (Environmental Document Risk Assessment Vol. 8 (Ministry of the Environment, 2010), SIDS (2009), CICAD 73 (2006)). 　Therefore, this substance was classified in Category 1B.	FY2016	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
8	Specific target organ toxicity - Single exposure	Category 1 (respiratory organs)	Danger	H370	P308+P311 P260 P264 P270 P321 P405 P501	No single exposure data in humans are available. 　As for experimental animals, it is described that in a 1-hour single inhalation exposure test using rats, bloody nasal discharge, and respiratory distress with gasping and wheezing were observed at doses of 0.64 mg/L (converted guidance value: 0.16 mg/L) or higher (SIDS (2009)). 　Therefore, this substance was classified in Category 1 (respiratory organs). 　Besides, it is reported that in a single oral exposure test using rats, apathy, dyspnoea, and diarrhea were observed at 200 mg/kg of near the lethal dose (SIDS (2009)). 　In addition, it is reported that dibutyltin oxide (CAS RN 818-08-6), dibutyltin maleate (CAS RN 78-04-6) and dibutyltin bis(2-ethylhexyl thioglycolate) (CAS RN 10584-98-2) undergo hydrolysis in artificial gastric juice and convert to this compound (Environmental Risk Assessment for Chemical Substances Vol.8 (Ministry of the Environment, 2010), SIDS (2009)). 　Moreover, it is reported that this compound, dibutyltin dilaurate (CAS RN 78-04-6), dibutyltin maleate, dibutyltin bis(2-ethylhexyl thioglycolate) and dibutyltin bis(isooctyl thioglycolate) (CAS RN 25168-24-5) are hydrolyzed to form dibutyltin oxide (Environmental Risk Assessment for Chemical Substances Vol.8 (Ministry of the Environment, 2010)).	FY2016	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
9	Specific target organ toxicity - Repeated exposure	Category 1 (liver, immune system)	Danger	H372	P260 P264 P270 P314 P501	No information in humans is available. 　As for the experimental animals, it is reported that in a 2-week repeated dose toxicity study using rats by feeding, effects on the immune system (decrease in relative weight of thymus, spleen and popliteal lymph nodes, and thymic atrophy) were observed at 0.005% (converted guidance value: 0.39 mg/kg/day), which is equivalent to Category 1, and effects on the liver (decrease in relative liver weight, severe proliferation of bile duct epithelial cells with pericholangitis or biliary fibrosis) and effects on the immune system (lymphoid depletion in thymus cortex) were observed at 0.015% (converted guidance value: 1.17 mg/kg/day) (Environmental Risk Assessment for Chemical Substances Vol.8 (Ministry of the Environment, 2010), CICAD 73 (2006)). 　In addition, likewise, in the 4-week or 6-week repeated dose toxicity test using rats administered by feeding, within the range of Category 1, depleted of lymphocytes in the thymus cortex, decrease in antibody response to sheep red blood cells and delay (decrease) in allograft rejection response for skin graft of tails from other rats etc. are reported (Environmental Risk Assessment for Chemical Substances Vol. 8 (Ministry of the Environment, 2010), CICAD 73 (2006), PIM 586 (1994)). 　Therefore, this substance was classified in Category 1 (liver, immune system). 　In addition, it is reported that dibutyltin oxide (CAS RN 818-08-6), dibutyltin maleate (CAS RN 78-04-6), dibutyltin bis(2-ethylhexyl thioglycolate) (CAS RN 10584-98-2) undergo hydrolysis in artificial gastric liquid and converted to this compound (Environmental Risk Assessment for Chemical Substances Vol.8 (Ministry of the Environment, 2010), SIDS (2009)). 　Moreover, it is reported that this compound, dibutyltin dilaurate (CAS RN 78-04-6), dibutyltin maleate, dibutyltin bis(2-ethylhexyl thioglycolate) and dibutyltin bis(isooctylthioglycolate) (CAS RN 25168-24-5) are hydrolyzed to form dibutyltin oxide (Environmental Risk Assessment for Chemical Substances Vol.8 (Ministry of the Environment, 2010)).	FY2016	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
10	Aspiration hazard	Classification not possible	- -	-	-	Classification not possible due to lack of data.	FY2016	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))

ENVIRONMENTAL HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification	Classification year (FY)	GHS Classification Guidance for the Japanese Government
11	Hazardous to the aquatic environment Short term (Acute)	Category 1	Warning	H400	P273 P391 P501	From 96-hour ErC50 = 0.04 mg/L for algae (Scenedesmus obliquus) (CICADs 73, 2006), it was classified in Category 1	FY2016	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
11	Hazardous to the aquatic environment Long term (Chronic)	Category 1	Warning	H410	P273 P391 P501	Due to being not rapidly degradable (BIOWIN), and 21-day NOEC = 10.5 microg/L for crustacea (Daphnia magna) (SIDS, 2006), it was classified in Category 1.	FY2016	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
12	Hazardous to the ozone layer	Classification not possible	- -	-	-	No data available.	FY2016	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))

NOTE:

GHS Classification Result by the Japanese Government is intended to provide a reference for preparing a GHS label or SDS for users. To include the same classification result in a label or SDS for Japan is NOT mandatory.
Users can cite or copy this classification result when preparing a GHS label or SDS. Please be aware, however, that the responsibility for a label or SDS prepared by citing or copying this classification result lies with users.
This GHS classification was conducted based on the information sources and the guidance for classification and judgement which are described in the GHS Classification Guidance for the Japanese Government etc. Using other literature, test results etc. as evidence and including different content from this classification result in a label or SDS are allowed.
Hazard statement and precautionary statement will show by hovering the mouse cursor over a code in the column of "Hazard statement" and "Precautionary statement," respectively. In the excel file, both the codes and statements are provided.
A blank or "-" in the column of "Classification" denotes that a classification for the hazard class was not conducted in the year.
An asterisk “*” in the column of “Classification” denotes that “Not classified (or No applicable)” and/or “Classification not possible” is applicable. Details are described in the column of “Rationale for the classification”. If no English translation is available for “Rationale for the classification,” please refer to the Japanese version of the results.

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